{"id":"https://openalex.org/W2587095588","doi":"https://doi.org/10.1186/s13058-017-0807-8","title":"Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2\u2212 breast cancer that had progressed during or after prior endocrine therapy","display_name":"Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2\u2212 breast cancer that had progressed during or after prior endocrine therapy","publication_year":2017,"publication_date":"2017-02-10","ids":{"openalex":"https://openalex.org/W2587095588","doi":"https://doi.org/10.1186/s13058-017-0807-8","mag":"2587095588","pmid":"https://pubmed.ncbi.nlm.nih.gov/28183331","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5301372"},"language":"en","primary_location":{"id":"doi:10.1186/s13058-017-0807-8","doi":"https://doi.org/10.1186/s13058-017-0807-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-017-0807-8","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-017-0807-8","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-017-0807-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063676677","display_name":"Antonino Musolino","orcid":"https://orcid.org/0000-0002-7979-6261","observed_orcids":["https://orcid.org/0000-0002-7979-6261"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I4210135416","display_name":"Ospedale di Parma","ror":"https://ror.org/03jg24239","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210135416"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonino Musolino","raw_affiliation_strings":["Medical Oncology Unit, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy. amusolino@ao.pr.it","Medical Oncology Unit, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy. amusolino@ao.pr.it","institution_ids":["https://openalex.org/I124601658","https://openalex.org/I4210135416"]},{"raw_affiliation_string":"Medical Oncology Unit, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy","institution_ids":["https://openalex.org/I124601658","https://openalex.org/I4210135416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071553983","display_name":"Mario Campone","orcid":"https://orcid.org/0000-0002-5196-5908","observed_orcids":["https://orcid.org/0000-0002-5196-5908"]},"institutions":[{"id":"https://openalex.org/I4210106090","display_name":"Institut de Canc\u00e9rologie de l'Ouest","ror":"https://ror.org/01m6as704","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210106090"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mario Campone","raw_affiliation_strings":["Institut de Cancerologie de l'Ouest, Ren\u00e9 Gauducheau, Saint-Herblain, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Cancerologie de l'Ouest, Ren\u00e9 Gauducheau, Saint-Herblain, France","institution_ids":["https://openalex.org/I4210106090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007579054","display_name":"Patrick Neven","orcid":"https://orcid.org/0000-0002-1434-9460","observed_orcids":["https://orcid.org/0000-0002-1434-9460"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Patrick Neven","raw_affiliation_strings":["Hospital Gasthuisberg, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Gasthuisberg, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088946926","display_name":"Neelima Denduluri","orcid":"https://orcid.org/0000-0002-6075-6809","observed_orcids":["https://orcid.org/0000-0002-6075-6809"]},"institutions":[{"id":"https://openalex.org/I4210122908","display_name":"Virginia Cancer Specialists","ror":"https://ror.org/03tbabt10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122908"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelima Denduluri","raw_affiliation_strings":["Virginia Cancer Specialists, US Oncology Research, Arlington, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Cancer Specialists, US Oncology Research, Arlington, VA, USA","institution_ids":["https://openalex.org/I4210122908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102881127","display_name":"Carlos H. Barrios","orcid":"https://orcid.org/0000-0001-6021-667X","observed_orcids":["https://orcid.org/0000-0001-6021-667X"]},"institutions":[{"id":"https://openalex.org/I45643870","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","ror":"https://ror.org/025vmq686","country_code":"BR","type":"education","lineage":["https://openalex.org/I45643870"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos H. Barrios","raw_affiliation_strings":["Pontificia Universidade Cat\u00f3lica do Rio Grande do Sul School of Medicine, Porto Alegre, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pontificia Universidade Cat\u00f3lica do Rio Grande do Sul School of Medicine, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I45643870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051629490","display_name":"Javier Cort\u00e9s","orcid":"https://orcid.org/0000-0001-7623-1583","observed_orcids":["https://orcid.org/0000-0001-7623-1583"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]},{"id":"https://openalex.org/I4387155398","display_name":"Vall d'Hebron Institute of Oncology","ror":"https://ror.org/054xx3904","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155398"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Cortes","raw_affiliation_strings":["Ramon y Cajal University Hospital, Madrid, Spain","Vall d'Hebron Institute of Oncology, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ramon y Cajal University Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Vall d'Hebron Institute of Oncology, Barcelona, Spain","institution_ids":["https://openalex.org/I4387155398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904379","display_name":"Kimberly Blackwell","orcid":"https://orcid.org/0009-0009-3644-861X","observed_orcids":["https://orcid.org/0009-0009-3644-861X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Blackwell","raw_affiliation_strings":["Duke University Medical Center, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090789911","display_name":"Hatem Hussein Soliman","orcid":"https://orcid.org/0000-0001-6644-2264","observed_orcids":["https://orcid.org/0000-0001-6644-2264"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hatem Soliman","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010028400","display_name":"Zsuzsanna Kah\u00e1n","orcid":"https://orcid.org/0000-0002-5021-8775","observed_orcids":["https://orcid.org/0000-0002-5021-8775"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsuzsanna Kahan","raw_affiliation_strings":["University of Szeged, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Szeged, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056811246","display_name":"Herve R. Bonnefoi","orcid":"https://orcid.org/0000-0003-4293-9748","observed_orcids":["https://orcid.org/0000-0003-4293-9748"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Bonnefoi","raw_affiliation_strings":["Institut Bergoni\u00e9 Comprehensive Cancer Centre, Universit\u00e9 de Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Bergoni\u00e9 Comprehensive Cancer Centre, Universit\u00e9 de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210134409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103324664","display_name":"Matthew S. Squires","orcid":"https://orcid.org/0009-0006-2611-7735","observed_orcids":["https://orcid.org/0009-0006-2611-7735"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthew Squires","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419804","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0002-6072-0697","observed_orcids":["https://orcid.org/0000-0002-6072-0697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037790221","display_name":"St\u00e9phanie Deudon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephanie Deudon","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113700678","display_name":"Michael M. Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael M. Shi","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001814176","display_name":"Fabrice Andr\u00e9","orcid":"https://orcid.org/0000-0001-5795-8357","observed_orcids":["https://orcid.org/0000-0001-5795-8357","https://orcid.org/0000-0002-6272-6048"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Andr\u00e9","raw_affiliation_strings":["Institut Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5063676677"],"corresponding_institution_ids":["https://openalex.org/I124601658","https://openalex.org/I4210135416"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":11.6636,"has_fulltext":true,"cited_by_count":114,"citation_normalized_percentile":{"value":0.99070359,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"18","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dovitinib","display_name":"dovitinib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.7269999980926514},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.7960000038146973},{"id":"https://openalex.org/keywords/fgfr-inhibitors","display_name":"FGFR inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9110000133514404},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.890999972820282},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/early-trial-termination","display_name":"early trial termination","score":0.6320000290870667},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.49399998784065247},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.7250000238418579},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.3799999952316284},{"id":"https://openalex.org/keywords/vomiting","display_name":"vomiting","score":0.6190000176429749},{"id":"https://openalex.org/keywords/asthenia","display_name":"asthenia","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.597000002861023},{"id":"https://openalex.org/keywords/visceral-disease","display_name":"visceral disease","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.852292537689209},{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.8473727703094482},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6872435212135315},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.664604902267456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6299989223480225},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5339051485061646},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.47999948263168335},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47644999623298645},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47103267908096313},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42550545930862427},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3326655626296997},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.20014545321464539},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11351525783538818},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077267","descriptor_name":"Fulvestrant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13058-017-0807-8","doi":"https://doi.org/10.1186/s13058-017-0807-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-017-0807-8","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-017-0807-8","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5301372","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5301372","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Res","raw_type":"Text"},{"id":"pmid:28183331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28183331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research : BCR","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:publicatio.bibl.u-szeged.hu:34299","doi":null,"is_oa":true,"landing_page_url":"http://publicatio.bibl.u-szeged.hu/34299/1/s13058-017-0807-8.pdf","pdf_url":"http://publicatio.bibl.u-szeged.hu/34299/1/s13058-017-0807-8.pdf","source":{"id":"https://openalex.org/S4306400675","display_name":"SZTE Publicatio Repozit\u00f3rium (University of Szeged)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I227486990","host_organization_name":"University of Szeged","host_organization_lineage":["https://openalex.org/I227486990"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Foly\u00f3iratcikk"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/572191","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/572191","pdf_url":"https://lirias.kuleuven.be/retrieve/4b639f0c-ce79-4445-abd7-6e62dc034ef8","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Breast Cancer Research, vol. 19 (1), Art.No. ARTN 18","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cris.unibo.it:11585/1003932","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11585/1003932","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dnet:ricscm______::85ad66841d6db41d63dcd347818724f3","doi":null,"is_oa":true,"landing_page_url":"https://repositoriosaludmadrid.es/handle/20.500.12530/40013","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13058-017-0807-8","doi":"https://doi.org/10.1186/s13058-017-0807-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13058-017-0807-8","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-017-0807-8","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G4718744824","display_name":"Statistical Methods for Cancer Clinical Trials","funder_award_id":"P01CA142538","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320310388","display_name":"Novartis Pharmaceuticals Corporation","ror":"https://ror.org/028fhxy95"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2587095588.pdf","grobid_xml":"https://content.openalex.org/works/W2587095588.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W165173872","https://openalex.org/W1464936406","https://openalex.org/W1829077072","https://openalex.org/W1956308309","https://openalex.org/W1966643394","https://openalex.org/W1970714443","https://openalex.org/W1973116775","https://openalex.org/W1980207397","https://openalex.org/W1987936187","https://openalex.org/W1994664175","https://openalex.org/W1994720314","https://openalex.org/W2011911766","https://openalex.org/W2023297465","https://openalex.org/W2028092386","https://openalex.org/W2031131661","https://openalex.org/W2044702943","https://openalex.org/W2045265777","https://openalex.org/W2047047579","https://openalex.org/W2050948792","https://openalex.org/W2052249651","https://openalex.org/W2058212333","https://openalex.org/W2059983371","https://openalex.org/W2066559457","https://openalex.org/W2068633458","https://openalex.org/W2076258532","https://openalex.org/W2089361524","https://openalex.org/W2098320019","https://openalex.org/W2101844536","https://openalex.org/W2106787323","https://openalex.org/W2118155696","https://openalex.org/W2123621576","https://openalex.org/W2127287298","https://openalex.org/W2127518316","https://openalex.org/W2128288739","https://openalex.org/W2137698996","https://openalex.org/W2144304220","https://openalex.org/W2144790402","https://openalex.org/W2146758625","https://openalex.org/W2153766902","https://openalex.org/W2159427817","https://openalex.org/W2160457467","https://openalex.org/W2162424539","https://openalex.org/W2167188058","https://openalex.org/W2168006407","https://openalex.org/W2171244965","https://openalex.org/W2176672352","https://openalex.org/W2230476250","https://openalex.org/W2272263563","https://openalex.org/W2343358448","https://openalex.org/W2402384680","https://openalex.org/W2533683200","https://openalex.org/W2560367415","https://openalex.org/W2900898778","https://openalex.org/W2917837889","https://openalex.org/W2999830304","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W1983382702","https://openalex.org/W2603379995","https://openalex.org/W1986838201","https://openalex.org/W2597553489","https://openalex.org/W2245460722","https://openalex.org/W2560839005","https://openalex.org/W2098320019","https://openalex.org/W6939895665","https://openalex.org/W2590650442","https://openalex.org/W6902529381"],"abstract_inverted_index":{"BACKGROUND:":[0],")":[1],"breast":[2,33,37],"cancer":[3,38],"cases,":[4],"is":[5],"correlated":[6],"with":[7,30,116,218,229,248],"decreased":[8],"overall":[9],"survival":[10,76],"and":[11,54,59,104,194,196,201,264],"resistance":[12],"to":[13,64,83,111],"endocrine":[14],"therapy":[15],"(ET).":[16],"Dovitinib,":[17],"a":[18],"potent":[19],"FGFR":[20,31],"inhibitor,":[21],"has":[22],"demonstrated":[23],"antitumor":[24],"activity":[25,234],"in":[26,133,169,187,227,235,256],"heavily":[27],"pretreated":[28],"patients":[29,88,115,260],"pathway-amplified":[32,151,238,259],"cancer.":[34],"METHODS:":[35],"advanced":[36],"that":[39,251,265],"had":[40],"progressed":[41],"during":[42],"or":[43,69],"after":[44],"prior":[45],"ET.":[46],"Patients":[47],"were":[48,61,92,204],"stratified":[49],"by":[50],"FGF":[51,97,117,150,237,258],"pathway":[52,98,118,273],"amplification":[53,99,274],"presence":[55],"of":[56,96,114,212,223,268,271],"visceral":[57],"disease,":[58],"they":[60],"randomized":[62],"1:1":[63],"receive":[65],"fulvestrant":[66,215,230],"plus":[67,214],"dovitinib":[68,135,171,189,213,269],"placebo.":[70],"The":[71,94,120,209],"primary":[72],"endpoint":[73],"was":[74,100,107,125,161,216,262,282],"progression-free":[75],"(PFS).":[77],"RESULTS:":[78],"From":[79],"15":[80],"May":[81],"2012":[82],"26":[84],"November":[85],"2014,":[86],"97":[87],"from":[89],"36":[90],"centers":[91],"enrolled.":[93],"frequency":[95],"lower":[101],"than":[102,261,284],"anticipated,":[103],"the":[105,134,149,156,170,179,188,219,236,241,257,280],"study":[106],"terminated":[108],"early":[109],"owing":[110],"slow":[112],"accrual":[113],"amplification.":[119],"median":[121,157],"PFS":[122,158,253],"(95%":[123,159],"CI)":[124,160],"5.5":[126,130,166],"(3.8-14.0)":[127],"months":[128,132,164,168],"vs":[129,136,165,172],"(3.5-10.7)":[131],"placebo":[137,173,197],"arms,":[138,174],"respectively":[139,175],"(HR,":[140,176],"0.68;":[141],"did":[142],"not":[143],"meet":[144],"predefined":[145,180],"efficacy":[146],"criteria).":[147,182],"For":[148],"subgroup":[152],"(n":[153],"=":[154],"31),":[155],"10.9":[162],"(3.5-16.5)":[163],"(3.5-16.4)":[167],"0.64;":[177],"met":[178],"superiority":[181],"Frequently":[183],"reported":[184,243],"adverse":[185],"events":[186,254],"(diarrhea,":[190,198],"nausea,":[191,200],"vomiting,":[192],"asthenia,":[193],"headache)":[195],"fatigue,":[199],"asthenia)":[202],"arms":[203],"mostly":[205],"low":[206],"grade.":[207],"CONCLUSIONS:":[208],"safety":[210,221],"profile":[211,222],"consistent":[217],"known":[220],"single-agent":[224],"dovitinib.":[225],"Dovitinib":[226],"combination":[228],"showed":[231],"promising":[232],"clinical":[233],"subgroup.":[239],"However,":[240],"data":[242],"herein":[244],"should":[245],"be":[246,277],"interpreted":[247],"caution,":[249],"given":[250],"fewer":[252],"occurred":[255],"expected":[263],"an":[266],"effect":[267],"regardless":[270],"FGR":[272],"status":[275],"cannot":[276],"excluded,":[278],"because":[279],"population":[281],"smaller":[283],"expected.":[285],"TRIAL":[286],"REGISTRATION:":[287],"ClinicalTrials.gov":[288],"identifier:":[289],"NCT01528345":[290],".":[291],"Registered":[292],"31":[293],"January":[294],"2012.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}
