{"id":"https://openalex.org/W2586956089","doi":"https://doi.org/10.1055/s-2004-831545","title":"Regulation eines NF-\u03baB-inhibierenden Mechanismus w\u00e4hrend der Differenzierung intestinaler Makrophagen (IMAC)","display_name":"Regulation eines NF-\u03baB-inhibierenden Mechanismus w\u00e4hrend der Differenzierung intestinaler Makrophagen (IMAC)","publication_year":2004,"publication_date":"2004-08-18","ids":{"openalex":"https://openalex.org/W2586956089","doi":"https://doi.org/10.1055/s-2004-831545","mag":"2586956089"},"language":"de","primary_location":{"id":"doi:10.1055/s-2004-831545","doi":"https://doi.org/10.1055/s-2004-831545","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-831545","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052757741","display_name":"Katja Schreiter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Schreiter","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065186874","display_name":"Martin Hausmann","orcid":"https://orcid.org/0000-0002-0696-0251","observed_orcids":["https://orcid.org/0000-0002-0696-0251"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Hausmann","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031853123","display_name":"Tanja Sp\u00f6ttl","orcid":"https://orcid.org/0000-0001-8780-0227","observed_orcids":["https://orcid.org/0000-0001-8780-0227"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"TN Sp\u00f6ttl","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051726567","display_name":"Werner Falk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W Falk","raw_affiliation_strings":["Klinik und Poliklinik f\u00fcr Innere Medizin I der Universit\u00e4t Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Innere Medizin I der Universit\u00e4t Regensburg","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079998509","display_name":"Hans H. Herfarth","orcid":"https://orcid.org/0000-0003-4268-823X","observed_orcids":["https://orcid.org/0000-0003-4268-823X"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Herfarth","raw_affiliation_strings":["Klinik und Poliklinik f\u00fcr Innere Medizin I der Universit\u00e4t Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Innere Medizin I der Universit\u00e4t Regensburg","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110836079","display_name":"J\u00fcrgen Sch\u00f6lmerich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Sch\u00f6lmerich","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058012401","display_name":"Gerhard Rogler","orcid":"https://orcid.org/0000-0002-1733-9188","observed_orcids":["https://orcid.org/0000-0002-1733-9188"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Rogler","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I","institution_ids":["https://openalex.org/I3129555431"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"08","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-macrophages","display_name":"intestinal macrophages","score":0.9459999799728394},{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tanks","display_name":"tanks","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/traf2","display_name":"TRAF2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tnf-receptor-2","display_name":"TNF receptor 2","score":0.7009999752044678},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/intestinal-mucosa","display_name":"intestinal mucosa","score":0.718999981880188},{"id":"https://openalex.org/keywords/inflammatory-gene-expression","display_name":"inflammatory gene expression","score":0.5139999985694885},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.6769999861717224},{"id":"https://openalex.org/keywords/tlr5","display_name":"TLR5","score":0.5170000195503235},{"id":"https://openalex.org/keywords/tlr6","display_name":"TLR6","score":0.5099999904632568},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.6010000109672546},{"id":"https://openalex.org/keywords/tlr8","display_name":"TLR8","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C123233396","wikidata":"https://www.wikidata.org/wiki/Q14914361","display_name":"TRAF2","level":4,"score":0.7346669435501099},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.61724454164505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.607598602771759},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5461550354957581},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5215854048728943},{"id":"https://openalex.org/C93880895","wikidata":"https://www.wikidata.org/wiki/Q2579343","display_name":"Tumor necrosis factor receptor","level":3,"score":0.5055267810821533},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.397562175989151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.358273446559906},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31187981367111206},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2256496548652649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.185683012008667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12723898887634277},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09088888764381409}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2004-831545","doi":"https://doi.org/10.1055/s-2004-831545","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-831545","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970466629","https://openalex.org/W2076231872","https://openalex.org/W1991072797","https://openalex.org/W7099213853","https://openalex.org/W2625446942","https://openalex.org/W7101081335","https://openalex.org/W2122440393","https://openalex.org/W2213346651","https://openalex.org/W2117293778","https://openalex.org/W2102376334"],"abstract_inverted_index":{"Einleitung:":[0],"NF-\u03baB":[1,15,36,66,76],"spielt":[2],"eine":[3,137,184,296],"entscheidende":[4],"Rolle":[5],"bei":[6,171,245,253,293],"der":[7,56,93,144,151,186,268,279],"Regulation":[8,216],"von":[9,25,35,81,88,149,188,217,251,256,289],"entz\u00fcndungsassoziierten":[10],"Genen.":[11],"Unter":[12],"anderem":[13],"wird":[14],"durch":[16,83,91,302],"Tumor":[17],"Nekrose":[18],"Faktor":[19],"(TNF)":[20],"und":[21,70,85,117,126,136,161,174],"IL\u20131":[22],"aktiviert.":[23],"Bindung":[24,92],"TNF":[26],"an":[27,61,98],"den":[28,99],"TNF-Rezeptor":[29],"2":[30],"(p75)":[31],"f\u00fchrt":[32],"zur":[33],"Aktivierung":[34,77],"\u00fcber":[37],"TRAF2":[38,49,89,269,298],"(tumor":[39],"necrosis":[40],"factor":[41],"receptor-associated":[42],"factor).":[43],"In":[44],"Abwesenheit":[45,288],"eines":[46],"Liganden":[47],"ist":[48,69],"in":[50,121,145,168,190,198,204,219,227,234,236,243,258,278,291],"einem":[51],"inaktiven":[52,73],"Zustand":[53],"im":[54,195,224],"Zytoplasma":[55],"Zelle":[57],"verteilt":[58],"indem":[59,142],"es":[60],"TANK":[62,82,94,160,189,218,252,290],"(TRAF":[63],"family":[64],"member-associated":[65],"activator)":[67],"gebunden":[68],"so":[71],"einen":[72],"Komplex":[74,105],"bildet.":[75],"erfolgt":[78],"nach":[79],"Phosphorylierung":[80],"IKK-i":[84],"sukzessive":[86],"Freisetzung":[87],"oder":[90],"binding":[95],"kinase":[96],"(TBK)\u20131":[97],"TANK/TRAF2-Komplex":[100],"wodurch":[101],"ein":[102,282],"aktiver":[103],"tern\u00e4rer":[104],"gebildet":[106],"wird.":[107,286],"Methoden:":[108],"CD33":[109],"+":[110],"IMAC":[111,128,152,191,205,220,235,244,259,292],"wurden":[112,140],"mittels":[113,165],"immunomagnetischer":[114],"Beads":[115],"isoliert":[116],"mRNA":[118,143,150],"wurde":[119,164,233],"aus":[120,127,129,153,192,206,221,260],"vitro":[122,146,199,228],"differenzierten":[123,147,200,229],"Makrophagen":[124],"(Mak)":[125],"normaler":[130,193,207,222],"Mukosa":[131,156,170,208,223,263,281],"isoliert.":[132],"Affymetrix\u00a9":[133],"Oligonucleotid-Array":[134],"Analysen":[135],"subtraktive":[138,212],"Hybridisierung":[139,213],"durchgef\u00fchrt":[141],"Mak":[148],"nicht":[154,237,241,261],"entz\u00fcndeter":[155,238,262],"subtrahiert":[157],"wurde.":[158],"Die":[159,180,211,249,287],"TBK\u20131":[162,202,257],"Proteinexpression":[163],"Immunhistochemischer":[166],"F\u00e4rbungen":[167],"intestinaler":[169],"Patienten":[172],"mit":[173],"ohne":[175],"intestinale":[176],"Entz\u00fcndung":[177],"nachgewiesen.":[178],"Ergebnisse:":[179],"Affymetrix":[181],"Analyse":[182],"ergab":[183],"Induktion":[185,250],"Expression":[187],"Schleimhaut":[194,239],"Vergleich":[196,225],"zu":[197,226,265],"Mak.":[201,230],"war":[203],"herunter":[209],"reguliert.":[210],"best\u00e4tigt":[214],"die":[215,303],"Eine":[231],"TANK-Protein-Expression":[232],"nachgewiesen,":[240],"jedoch":[242],"Morbus":[246],"Crohn.":[247],"Schlussfolgerung:":[248],"gleichzeitiger":[254],"Herabregulation":[255],"kann":[264],"einer":[266],"Inhibierung":[267],"vermittelten":[270],"NF-\u03baB-Aktivierung":[271],"f\u00fchren.":[272],"Dies":[273],"tr\u00e4gt":[274],"dazu":[275],"bei,":[276],"dass":[277],"intestinalen":[280],"anerger":[283],"IMAC-Ph\u00e4notyp":[284],"generiert":[285],"MC":[294],"erlaubt":[295],"erh\u00f6hte":[297],"vermittelte":[299],"NF-\u03baB-Aktivierung.":[300],"Unterst\u00fctzt":[301],"DFG":[304],"(SFB":[305],"585)":[306]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2017-02-17T00:00:00"}