{"id":"https://openalex.org/W25869390","doi":null,"title":"[Liraglutide and glimepiride on glycaemic control in type 2 diabetes in the Mexican cohort (LEAD 3)].","display_name":"[Liraglutide and glimepiride on glycaemic control in type 2 diabetes in the Mexican cohort (LEAD 3)].","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W25869390","mag":"25869390","pmid":"https://pubmed.ncbi.nlm.nih.gov/21205505"},"language":"es","primary_location":{"id":"pmid:21205505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21205505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista medica del Instituto Mexicano del Seguro Social","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049691512","display_name":"Pedro Alberto Garc\u00eda-Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-3184-8237","observed_orcids":["https://orcid.org/0000-0002-3184-8237"]},"institutions":[{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Pedro Garc\u00eda-Hern\u00e1ndez","raw_affiliation_strings":["Servicio de Endocrinolog\u00eda, Hospital Universitario de Monterrey Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez, Monterrey, Nuevo Le\u00f3n, M\u00e9xico. pedroalbertogh@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Endocrinolog\u00eda, Hospital Universitario de Monterrey Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez, Monterrey, Nuevo Le\u00f3n, M\u00e9xico. pedroalbertogh@yahoo.com","institution_ids":["https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101839639","display_name":"Mar\u00eda del Rosario Arechavaleta-Granell","orcid":"https://orcid.org/0000-0001-8080-7186","observed_orcids":["https://orcid.org/0000-0001-8080-7186"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mar\u00eda del Rosario Arechavaleta-Granell","raw_affiliation_strings":["Instituto Mexicano del Seguro Social, Centro M\u00e9dico Nacional de Occidente, Guadalajara Jalisco, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Mexicano del Seguro Social, Centro M\u00e9dico Nacional de Occidente, Guadalajara Jalisco, M\u00e9xico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jorge Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130989","display_name":"Novo Nordisk (Mexico)","ror":"https://ror.org/03w48ac58","country_code":"MX","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210130989","https://openalex.org/I4210159963"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jorge Yamamoto","raw_affiliation_strings":["Novo Nordisk Servicios, , M\u00e9xico, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Servicios, , M\u00e9xico, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I4210130989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109094661","display_name":"Ali Falahati","orcid":"https://orcid.org/0009-0001-5836-5593","observed_orcids":["https://orcid.org/0009-0001-5836-5593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali Falahati","raw_affiliation_strings":["Novo Nordisk A/S, , Copenhague, Dinamarca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, , Copenhague, Dinamarca","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089208115","display_name":"Guillermo Gonz\u00e1lez-G\u00e1lvez","orcid":"https://orcid.org/0000-0001-9611-2055","observed_orcids":["https://orcid.org/0000-0001-9611-2055"]},"institutions":[{"id":"https://openalex.org/I4210120508","display_name":"Hospital Civil de Guadalajara","ror":"https://ror.org/02epdjj68","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210120508"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Guillermo Gonz\u00e1lez-G\u00e1lvez","raw_affiliation_strings":["Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Endocrinolog\u00eda, Guadalajara, Jalisco, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Endocrinolog\u00eda, Guadalajara, Jalisco, M\u00e9xico","institution_ids":["https://openalex.org/I4210120508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00483556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"48","issue":"5","first_page":"543","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":1.0},{"id":"https://openalex.org/keywords/glimepiride","display_name":"glimepiride","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9549999833106995},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8799999952316284},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6579999923706055},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.871999979019165},{"id":"https://openalex.org/keywords/mexican-patients","display_name":"Mexican patients","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7927581667900085},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6123379468917847}],"mesh":[{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008800","descriptor_name":"Mexico","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21205505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21205505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista medica del Instituto Mexicano del Seguro Social","raw_type":"English Abstract"},{"id":"pmh:oai:redalyc.org:457745510013","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=457745510013","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista M\u00e9dica del Instituto Mexicano del Seguro Social (M\u00e9xico) Num.5 Vol.48","raw_type":"art\u00edculo cient\u00edfico"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1863279491","https://openalex.org/W1986331352","https://openalex.org/W1998735874","https://openalex.org/W2013851956","https://openalex.org/W2063715420","https://openalex.org/W2073547913","https://openalex.org/W2077681546","https://openalex.org/W2080128749","https://openalex.org/W2081276121","https://openalex.org/W2098459806","https://openalex.org/W2103516789","https://openalex.org/W2106036385","https://openalex.org/W2146901298","https://openalex.org/W2159205789","https://openalex.org/W2337454357"],"related_works":["https://openalex.org/W6983225419","https://openalex.org/W2312778649","https://openalex.org/W3031548469","https://openalex.org/W2098459806","https://openalex.org/W2325198396","https://openalex.org/W1987538170","https://openalex.org/W2071835038","https://openalex.org/W2012425163","https://openalex.org/W1998281835","https://openalex.org/W1928513790"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"the":[3,41],"efficacy":[4],"of":[5,20,96,116,151],"liraglutide":[6,55,78,90,109,138],"monotherapy":[7,10,139],"with":[8,13,76,88,101,108,121,136,155],"glimepiride":[9,64],"in":[11,40,129,133,144,153],"subjects":[12,37,48,135],"DM2":[14],"inadequately":[15],"controlled":[16],"by":[17,71,105],"previous":[18],"treatment":[19],"diet/exercise":[21],"or":[22,58,63],"oral":[23],"antidiabetic":[24],"drug.":[25],"METHODS:":[26],"A":[27],"52-week,":[28],"double-blinded,":[29],"active-controlled,":[30],"parallel-group,":[31],"multi-centre,":[32],"prospective":[33],"trial,":[34],"involving":[35],"746":[36],"was":[38,99,119],"conducted":[39],"USA":[42],"and":[43,74,81,148],"Mexico.":[44],"In":[45],"Mexico,":[46],"171":[47],"were":[49,127],"rando-mised":[50],"(1:1:1)":[51],"to":[52],"once":[53],"daily":[54],"(either":[56],"1.2,":[57],"1.8":[59,79,110],"mg/day":[60,66],"injected":[61],"subcutaneously)":[62],"(8":[65],"orally).":[67],"RESULTS:":[68],"Hb1Ac":[69],"reduced":[70,104],"0.64%,":[72],"1.31%":[73],"0.30%":[75],"glimepiride,":[77],"mg":[80],"1.2":[82],"mg,":[83,111],"respectively.":[84],"Body":[85],"weight":[86,94,146],"decreased":[87],"both":[89],"doses":[91],"while":[92],"a":[93,113],"gain":[95],"0.94":[97],"kg":[98],"observed":[100],"glimepiride.":[102,122,156],"FPG":[103,114],"27.9":[106],"mg/dL":[107,118],"whereas":[112],"increase":[115],"9.54":[117],"shown":[120],"No":[123],"major":[124],"hypoglycaemic":[125],"episodes":[126],"reported":[128],"this":[130],"trial.":[131],"CONCLUSIONS:":[132],"Mexican":[134],"DM2,":[137],"can":[140],"provide":[141],"greater":[142],"reduction":[143],"HbA1c,":[145],"loss":[147],"lower":[149],"risk":[150],"hypoglycaemia":[152],"comparison":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}