{"id":"https://openalex.org/W2586927659","doi":"https://doi.org/10.1007/s00125-017-4210-x","title":"Painting a new picture of personalised medicine for diabetes","display_name":"Painting a new picture of personalised medicine for diabetes","publication_year":2017,"publication_date":"2017-02-07","ids":{"openalex":"https://openalex.org/W2586927659","doi":"https://doi.org/10.1007/s00125-017-4210-x","mag":"2586927659","pmid":"https://pubmed.ncbi.nlm.nih.gov/28175964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518376"},"language":"en","primary_location":{"id":"doi:10.1007/s00125-017-4210-x","doi":"https://doi.org/10.1007/s00125-017-4210-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-017-4210-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-017-4210-x.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00125-017-4210-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064948585","display_name":"Mark I. McCarthy","orcid":"https://orcid.org/0000-0002-4393-0510","observed_orcids":["https://orcid.org/0000-0002-4393-0510"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mark I. McCarthy","raw_affiliation_strings":["Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK. mark.mccarthy@drl.ox.ac.uk","Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. mark.mccarthy@drl.ox.ac.uk","Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. mark.mccarthy@drl.ox.ac.uk","Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK. mark.mccarthy@drl.ox.ac.uk","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210129944"]},{"raw_affiliation_string":"Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. mark.mccarthy@drl.ox.ac.uk","institution_ids":["https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. mark.mccarthy@drl.ox.ac.uk","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210129944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5064948585"],"corresponding_institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210129944","https://openalex.org/I4210147381"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":15.0346,"has_fulltext":true,"cited_by_count":256,"citation_normalized_percentile":{"value":0.99377188,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"60","issue":"5","first_page":"793","last_page":"799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.4731000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.4731000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.14390000700950623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.10209999978542328,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.921999990940094},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.8849999904632568},{"id":"https://openalex.org/keywords/molecular-taxonomy","display_name":"molecular taxonomy","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pathophysiological-mechanisms","display_name":"pathophysiological mechanisms","score":0.7149999737739563},{"id":"https://openalex.org/keywords/diabetes-risk","display_name":"diabetes risk","score":0.6499999761581421},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5080000162124634},{"id":"https://openalex.org/keywords/metabolic-trajectories","display_name":"metabolic trajectories","score":0.746999979019165},{"id":"https://openalex.org/keywords/complex-diseases","display_name":"complex diseases","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C205783811","wikidata":"https://www.wikidata.org/wiki/Q11629","display_name":"Painting","level":2,"score":0.6296565532684326},{"id":"https://openalex.org/C2986265897","wikidata":"https://www.wikidata.org/wiki/Q23852","display_name":"Human physiology","level":2,"score":0.589059054851532},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5206053256988525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5158864259719849},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.2658322751522064},{"id":"https://openalex.org/C52119013","wikidata":"https://www.wikidata.org/wiki/Q50637","display_name":"Art history","level":1,"score":0.2370765507221222},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23706156015396118},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1453709900379181}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00125-017-4210-x","doi":"https://doi.org/10.1007/s00125-017-4210-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-017-4210-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-017-4210-x.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5528156","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6518376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"Text"},{"id":"pmid:28175964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28175964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"Journal Article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:7a52c81d-fba7-433b-98b9-3935ec0fd630","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:7a52c81d-fba7-433b-98b9-3935ec0fd630","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1007/s00125-017-4210-x","doi":"https://doi.org/10.1007/s00125-017-4210-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-017-4210-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-017-4210-x.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2502254555","display_name":"Characterising causal alleles for common disease.","funder_award_id":"098381","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3529949959","display_name":null,"funder_award_id":"115317","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G4426574518","display_name":null,"funder_award_id":"L020149","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4887183744","display_name":"A systems based approach to integrating genetic and longitudinal omics data to support diagnosis and prediction of common chronic disease","funder_award_id":"MR/M004422/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5418810510","display_name":"Integrating genome-scale data to reveal causal mechanisms in type 2 diabetes","funder_award_id":"U01DK105535","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5855140949","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0611-10099","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6216729408","display_name":"Defining the molecular and physiological mechanisms of pancreatic islet dysfunction which lead to type 2 diabetes","funder_award_id":"MR/L020149/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7004411822","display_name":"Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics.","funder_award_id":"090532","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7328074751","display_name":null,"funder_award_id":"115881","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G8370359350","display_name":"A systematic approach to understanding the biology underpinning GWAS hits.","funder_award_id":"106130/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8603611396","display_name":"A systematic approach to understanding the biology underpinning GWAS hits.","funder_award_id":"106130","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320326631","display_name":"Innovative Medicines Initiative","ror":"https://ror.org/019af4n30"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2586927659.pdf","grobid_xml":"https://content.openalex.org/works/W2586927659.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1839682376","https://openalex.org/W2008945055","https://openalex.org/W2020231706","https://openalex.org/W2035253975","https://openalex.org/W2061670942","https://openalex.org/W2103769722","https://openalex.org/W2106305501","https://openalex.org/W2133857188","https://openalex.org/W2141642891","https://openalex.org/W2156696375","https://openalex.org/W2157375578","https://openalex.org/W2175465469","https://openalex.org/W2177538943","https://openalex.org/W2269288506","https://openalex.org/W2405412222","https://openalex.org/W2415293309","https://openalex.org/W2461793432","https://openalex.org/W2487079259","https://openalex.org/W2513408092","https://openalex.org/W2527803868","https://openalex.org/W3030529622","https://openalex.org/W4213337898","https://openalex.org/W4323874344"],"related_works":["https://openalex.org/W4387328489","https://openalex.org/W2596450471","https://openalex.org/W2013489119","https://openalex.org/W3169740884","https://openalex.org/W4390065868","https://openalex.org/W2464564792","https://openalex.org/W2291214354","https://openalex.org/W2800283810","https://openalex.org/W2315329242","https://openalex.org/W2114974487"],"abstract_inverted_index":{"The":[0,41],"current":[1,34],"focus":[2],"on":[3,59,75,109,115],"delivery":[4],"of":[5,33,44,61,78,97,149,154,184],"personalised":[6],"(or":[7],"precision)":[8],"medicine":[9],"reflects":[10],"the":[11,57,122],"expectation":[12],"that":[13,89,113,126,136,146,158],"developments":[14],"in":[15,51,180],"genomics,":[16],"imaging":[17],"and":[18,25,28,35,38,54,86,131,169],"other":[19],"domains":[20],"will":[21,141],"extend":[22],"our":[23,94],"diagnostic":[24],"prognostic":[26],"capabilities,":[27],"enable":[29],"more":[30],"effective":[31],"targeting":[32],"future":[36],"preventative":[37],"therapeutic":[39],"options.":[40],"clinical":[42],"benefits":[43],"this":[45,155],"approach":[46],"are":[47,90],"already":[48],"being":[49],"realised":[50],"rare":[52],"diseases":[53],"cancer":[55],"but":[56],"impact":[58],"management":[60],"complex":[62],"diseases,":[63],"such":[64],"as":[65],"type":[66,98],"2":[67,99],"diabetes,":[68],"remains":[69],"limited.":[70],"This":[71,101,133],"may":[72],"reflect":[73],"reliance":[74],"inappropriate":[76],"models":[77],"disease":[79],"architecture,":[80],"based":[81],"around":[82],"rare,":[83],"high-impact":[84],"genetic":[85],"environmental":[87],"exposures":[88],"poorly":[91],"suited":[92],"to":[93,121,128],"emerging":[95],"understanding":[96],"diabetes.":[100],"review":[102],"proposes":[103],"an":[104,117],"alternative":[105],"'palette'":[106],"model,":[107],"centred":[108],"a":[110,181],"molecular":[111],"taxonomy":[112],"focuses":[114],"positioning":[116],"individual":[118],"with":[119,139],"respect":[120],"major":[123],"pathophysiological":[124],"processes":[125],"contribute":[127],"diabetes":[129,140],"risk":[130],"progression.":[132],"model":[134,156],"anticipates":[135],"many":[137],"individuals":[138,171],"have":[142],"multiple":[143],"parallel":[144],"defects":[145],"affect":[147],"several":[148],"these":[150],"processes.":[151,185],"One":[152],"corollary":[153],"is":[157,176],"research":[159],"efforts":[160],"should,":[161],"at":[162],"least":[163],"initially,":[164],"be":[165],"targeted":[166],"towards":[167],"identifying":[168],"characterising":[170],"whose":[172],"adverse":[173],"metabolic":[174],"trajectory":[175],"dominated":[177],"by":[178],"perturbation":[179],"restricted":[182],"set":[183]},"counts_by_year":[{"year":2026,"cited_by_count":32},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":38},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}