{"id":"https://openalex.org/W2586901155","doi":"https://doi.org/10.1515/fobio-2016-0004","title":"Adipose-derived stem cells: a review of osteogenesis differentiation","display_name":"Adipose-derived stem cells: a review of osteogenesis differentiation","publication_year":2016,"publication_date":"2016-12-07","ids":{"openalex":"https://openalex.org/W2586901155","doi":"https://doi.org/10.1515/fobio-2016-0004","mag":"2586901155"},"language":"en","primary_location":{"id":"doi:10.1515/fobio-2016-0004","doi":"https://doi.org/10.1515/fobio-2016-0004","is_oa":true,"landing_page_url":"https://doi.org/10.1515/fobio-2016-0004","pdf_url":null,"source":{"id":"https://openalex.org/S4210211679","display_name":"Acta Universitatis Lodziensis Folia Biologica et Oecologica","issn_l":"1730-2366","issn":["1730-2366","2083-8484"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus","poland-20"],"host_organization":"https://openalex.org/P4310320290","host_organization_name":"University of Lodz Press","host_organization_lineage":["https://openalex.org/P4310320290","https://openalex.org/P4310317463"],"host_organization_lineage_names":["University of Lodz Press","University of \u0141\u00f3d\u017a"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Universitatis Lodziensis. Folia Biologica et Oecologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1515/fobio-2016-0004","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003393410","display_name":"Aleksandra Skubis-Sikora","orcid":"https://orcid.org/0000-0002-3105-3055","observed_orcids":["https://orcid.org/0000-0002-3105-3055"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aleksandra Skubis","raw_affiliation_strings":["Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087539105","display_name":"Bartosz Sikora","orcid":"https://orcid.org/0000-0001-8268-9654","observed_orcids":["https://orcid.org/0000-0001-8268-9654"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Bartosz Sikora","raw_affiliation_strings":["Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054381667","display_name":"Nikola Zmarz\u0142y","orcid":"https://orcid.org/0000-0002-7833-6167","observed_orcids":["https://orcid.org/0000-0002-7833-6167"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Nikola Zmarz\u0142y","raw_affiliation_strings":["Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088229278","display_name":"Emilia Morawiec","orcid":"https://orcid.org/0000-0002-8360-359X","observed_orcids":["https://orcid.org/0000-0002-8360-359X"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Emilia Wojdas","raw_affiliation_strings":["Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024856950","display_name":"Urszula M Mazurek","orcid":"https://orcid.org/0000-0003-1181-4934","observed_orcids":["https://orcid.org/0000-0003-1181-4934","https://orcid.org/0000-0003-4898-198X"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Urszula Mazurek","raw_affiliation_strings":["Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine","institution_ids":["https://openalex.org/I166182418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166182418"],"apc_list":null,"apc_paid":null,"fwci":0.2467,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47647026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"12","issue":null,"first_page":"38","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":1.0},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.7459999918937683},{"id":"https://openalex.org/keywords/stem-cell-proliferation","display_name":"stem cell proliferation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7995306849479675},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7473900318145752},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.714063286781311},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6619000434875488},{"id":"https://openalex.org/C143441281","wikidata":"https://www.wikidata.org/wiki/Q5133858","display_name":"Clinical uses of mesenchymal stem cells","level":5,"score":0.6607433557510376},{"id":"https://openalex.org/C13685319","wikidata":"https://www.wikidata.org/wiki/Q7607302","display_name":"Stem cell transplantation for articular cartilage repair","level":5,"score":0.5938655138015747},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5597659945487976},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5449754595756531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49354326725006104},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.4794551134109497},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4509453773498535},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08243083953857422},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1515/fobio-2016-0004","doi":"https://doi.org/10.1515/fobio-2016-0004","is_oa":true,"landing_page_url":"https://doi.org/10.1515/fobio-2016-0004","pdf_url":null,"source":{"id":"https://openalex.org/S4210211679","display_name":"Acta Universitatis Lodziensis Folia Biologica et Oecologica","issn_l":"1730-2366","issn":["1730-2366","2083-8484"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus","poland-20"],"host_organization":"https://openalex.org/P4310320290","host_organization_name":"University of Lodz Press","host_organization_lineage":["https://openalex.org/P4310320290","https://openalex.org/P4310317463"],"host_organization_lineage_names":["University of Lodz Press","University of \u0141\u00f3d\u017a"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Universitatis Lodziensis. Folia Biologica et Oecologica","raw_type":"journal-article"},{"id":"pmh:oai:dspace.uni.lodz.pl:11089/20774","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11089/20774","pdf_url":null,"source":{"id":"https://openalex.org/S4306401347","display_name":"University of Lodz Repository (University of \u0141\u00f3d\u017a)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34250744","host_organization_name":"University of \u0141\u00f3d\u017a","host_organization_lineage":["https://openalex.org/I34250744"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1515/fobio-2016-0004","doi":"https://doi.org/10.1515/fobio-2016-0004","is_oa":true,"landing_page_url":"https://doi.org/10.1515/fobio-2016-0004","pdf_url":null,"source":{"id":"https://openalex.org/S4210211679","display_name":"Acta Universitatis Lodziensis Folia Biologica et Oecologica","issn_l":"1730-2366","issn":["1730-2366","2083-8484"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus","poland-20"],"host_organization":"https://openalex.org/P4310320290","host_organization_name":"University of Lodz Press","host_organization_lineage":["https://openalex.org/P4310320290","https://openalex.org/P4310317463"],"host_organization_lineage_names":["University of Lodz Press","University of \u0141\u00f3d\u017a"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Universitatis Lodziensis. Folia Biologica et Oecologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W986924007","https://openalex.org/W1248523452","https://openalex.org/W1922731526","https://openalex.org/W1970924172","https://openalex.org/W1975478366","https://openalex.org/W1978274015","https://openalex.org/W1981736557","https://openalex.org/W1982079577","https://openalex.org/W1984783420","https://openalex.org/W1985903426","https://openalex.org/W1990419270","https://openalex.org/W1992365767","https://openalex.org/W2002307559","https://openalex.org/W2007396170","https://openalex.org/W2020333453","https://openalex.org/W2025371271","https://openalex.org/W2033524865","https://openalex.org/W2034805489","https://openalex.org/W2049621548","https://openalex.org/W2058861612","https://openalex.org/W2061989491","https://openalex.org/W2069645055","https://openalex.org/W2076785899","https://openalex.org/W2079837524","https://openalex.org/W2080378392","https://openalex.org/W2083156208","https://openalex.org/W2096221523","https://openalex.org/W2098526024","https://openalex.org/W2102016724","https://openalex.org/W2107070241","https://openalex.org/W2116726599","https://openalex.org/W2117975263","https://openalex.org/W2123907877","https://openalex.org/W2131624895","https://openalex.org/W2131945662","https://openalex.org/W2138889138","https://openalex.org/W2157480974","https://openalex.org/W2160728753","https://openalex.org/W2161660985","https://openalex.org/W2173497140","https://openalex.org/W2193288696","https://openalex.org/W2257669500","https://openalex.org/W2268783183","https://openalex.org/W2332868292","https://openalex.org/W2376741234","https://openalex.org/W2400503990"],"related_works":["https://openalex.org/W3015018987","https://openalex.org/W2286477901","https://openalex.org/W2884088311","https://openalex.org/W2016682170","https://openalex.org/W3008297018","https://openalex.org/W3201603209","https://openalex.org/W90435474","https://openalex.org/W2352051491","https://openalex.org/W2769795302","https://openalex.org/W2095212309"],"abstract_inverted_index":{"This":[0],"review":[1],"article":[2,19],"provides":[3],"an":[4],"overview":[5],"on":[6,21,110],"adipose-derived":[7],"stem":[8,23,68,114],"cells":[9,24,35,69,147],"(ADSCs)":[10],"for":[11,39,50,153],"implications":[12],"in":[13,31,100,162,163,166],"bone":[14,55,131,144],"tissue":[15,56,59],"regeneration.":[16,57],"Firstly":[17],"this":[18,154],"focuses":[20],"mesenchymal":[22,67],"(MSCs)":[25],"which":[26,157],"are":[27,48,117,123],"object":[28],"of":[29,62,66,84,107,113,129],"interest":[30],"regenerative":[32,119],"medicine.":[33],"Stem":[34,146],"have":[36],"unlimited":[37],"potential":[38],"self-renewal":[40],"and":[41,103,165],"develop":[42],"into":[43,160],"various":[44],"cell":[45],"types.":[46],"They":[47],"used":[49],"many":[51,125],"therapies":[52],"such":[53],"as":[54],"Adipose":[58],"is":[60,94,135],"one":[61],"the":[63],"main":[64],"sources":[65],"(MSCs).":[70],"Regenerative":[71],"medicine":[72],"intends":[73],"to":[74,81,96,137],"differentiate":[75,159],"ADSC":[76],"along":[77],"specific":[78],"lineage":[79],"pathways":[80],"effect":[82],"repair":[83],"damaged":[85],"or":[86,141],"failing":[87],"organs.":[88],"For":[89],"further":[90],"clinical":[91],"applications":[92],"it":[93],"necessary":[95,136],"understand":[97],"mechanisms":[98],"involved":[99],"ADSCs":[101,156],"proliferation":[102],"differentiation.":[104],"Second":[105],"part":[106],"manuscript":[108],"based":[109],"osteogenesis":[111],"differentiation":[112],"cells.":[115],"Bones":[116],"highly":[118],"organs":[120],"but":[121],"there":[122,134],"still":[124],"problems":[126],"with":[127],"therapy":[128],"large":[130],"defects.":[132],"Sometimes":[133],"make":[138],"a":[139,150],"replacement":[140],"expansion":[142],"new":[143],"tissue.":[145],"might":[148],"be":[149],"good":[151],"solution":[152],"especially":[155],"manage":[158],"osteoblast":[161],"vitro":[164],"vivo":[167],"conditions.":[168]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}