{"id":"https://openalex.org/W2586868314","doi":null,"title":"Passive Passage: Investigation of Pore Lining Residues in Fluc type F- Ion Channels","display_name":"Passive Passage: Investigation of Pore Lining Residues in Fluc type F- Ion Channels","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2586868314","mag":"2586868314"},"language":"en","primary_location":{"id":"pmh:oai:bir.brandeis.edu:10192/32309","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10192/32309","pdf_url":null,"source":{"id":"https://openalex.org/S4406922578","display_name":"Brandeis Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Minh Pham","orcid":"https://orcid.org/0000-0003-0234-4790","observed_orcids":["https://orcid.org/0000-0003-0234-4790"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Minh Pham","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0234-4790","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pore-lining-residues","display_name":"pore-lining residues","score":0.7929999828338623},{"id":"https://openalex.org/keywords/polar-residues","display_name":"polar residues","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ion-conduction-pathway","display_name":"ion conduction pathway","score":0.6919999718666077},{"id":"https://openalex.org/keywords/fluoride-selectivity","display_name":"fluoride selectivity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/fluoride-toxicity","display_name":"fluoride toxicity","score":0.4690000116825104},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"mutagenesis","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7558102607727051},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.652522087097168},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.5591304302215576},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.523163914680481},{"id":"https://openalex.org/C45516822","wikidata":"https://www.wikidata.org/wiki/Q6382011","display_name":"KcsA potassium channel","level":4,"score":0.5160143375396729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4675084054470062},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4586617350578308},{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.44394388794898987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15421518683433533},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08211395144462585},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bir.brandeis.edu:10192/32309","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10192/32309","pdf_url":null,"source":{"id":"https://openalex.org/S4406922578","display_name":"Brandeis Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2586868314","doi":null,"is_oa":false,"landing_page_url":"http://bir.brandeis.edu/handle/10192/32309?show=full","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1823822487","https://openalex.org/W1893822674","https://openalex.org/W1970806949","https://openalex.org/W1975715632","https://openalex.org/W2029296469","https://openalex.org/W2030742180","https://openalex.org/W2031664044","https://openalex.org/W2036677716","https://openalex.org/W2052111270","https://openalex.org/W2058592878","https://openalex.org/W2059131094","https://openalex.org/W2078752919","https://openalex.org/W2113054340","https://openalex.org/W2125825163","https://openalex.org/W2132502501","https://openalex.org/W2153761301","https://openalex.org/W2157624463","https://openalex.org/W2160695808","https://openalex.org/W2331349292","https://openalex.org/W2337146234","https://openalex.org/W2404347710","https://openalex.org/W4205623738"],"related_works":["https://openalex.org/W3008488399","https://openalex.org/W1893822674","https://openalex.org/W2467263699","https://openalex.org/W2487933339","https://openalex.org/W2058592878","https://openalex.org/W2757302566","https://openalex.org/W7130609067","https://openalex.org/W2013248014","https://openalex.org/W4248530146","https://openalex.org/W2063678782"],"abstract_inverted_index":{"Microorganisms":[0],"are":[1,104,113,188],"commonly":[2],"exposed":[3],"to":[4,17,47,65,71,83,115,123,168,179,191,195],"fluoride":[5,64],"in":[6,45,89,139,150,161],"acidic":[7],"environments,":[8],"which":[9],"can":[10],"induce":[11],"its":[12],"intracellular":[13],"accumulation,":[14],"and":[15,121,198,216],"lead":[16,167],"the":[18,39,42,49,58,69,90,117,124,133,196],"inhibition":[19],"of":[20,37,51,57,102,106,136,142,147,201,207,222],"essential":[21],"cellular":[22],"processes":[23],"such":[24],"as":[25],"nucleic":[26],"acid":[27],"production.":[28],"However":[29],"some":[30],"unicellular":[31],"organisms":[32],"possess":[33],"fluoride-specific":[34],"exporting":[35],"proteins":[36,79],"either":[38],"CLCF":[40],"or":[41,131],"Fluc":[43,59,103,143],"family":[44,60],"order":[46],"counteract":[48],"influx":[50],"toxic":[52],"fluoride.":[53],"Particularly,":[54],"F-":[55,77,127,162],"channels":[56],"allow":[61],"membrane":[62],"impermeable":[63],"passively":[66],"diffuse":[67],"from":[68],"cell":[70],"sub-toxic":[72],"levels.":[73],"Recently,":[74],"these":[75,99,137],"extremely":[76],"specific":[78],"have":[80],"been":[81],"determined":[82],"adopt":[84],"an":[85],"antiparallel":[86,96],"homodimeric":[87],"assembly":[88],"lipid":[91],"bilayer,":[92],"likely":[93],"forming":[94],"two":[95,140],"pores.":[97],"Interestingly,":[98],"interior":[100],"regions":[101],"comprised":[105],"residues":[107,138,187],"with":[108],"highly":[109],"conserved":[110],"polarity":[111],"that":[112],"predicted":[114],"form":[116],"ion":[118,172],"conduction":[119],"pathway":[120],"contribute":[122],"channel\u2019s":[125],"unusual":[126],"selectivity.":[128],"Mutagenesis":[129],"removing":[130],"modifying":[132],"polar":[134,181,186],"characteristic":[135],"homologues":[141],"revealed":[144],"different":[145],"responses":[146],"channel":[148,173,212],"functionality":[149],"proteoliposome":[151],"efflux":[152,163],"experiments.":[153],"Some":[154],"residue":[155],"mutations":[156],"had":[157],"no":[158],"observable":[159],"changes":[160],"rates,":[164],"while":[165],"others":[166],"dramatic":[169],"effects":[170],"on":[171,219],"function":[174],"even":[175],"when":[176],"mildly":[177],"mutated":[178],"other":[180],"residues.":[182],"The":[183],"more":[184],"sensitive":[185],"thus":[189],"believed":[190],"be":[192],"specifically":[193],"integral":[194],"structural":[197],"functional":[199],"composition":[200],"this":[202],"channel.":[203],"A":[204],"crystal":[205],"structure":[206],"a":[208],"functionally":[209],"inactive":[210],"mutant":[211],"was":[213],"also":[214],"obtained":[215],"provides":[217],"insight":[218],"future":[220],"investigations":[221],"Fluc\u2019s":[223],"pore-lining":[224],"regions.":[225]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}