{"id":"https://openalex.org/W2586744146","doi":"https://doi.org/10.1002/ajh.24674","title":"Transplantation in thalassemia: Revisiting the Pesaro risk factors 25 years later","display_name":"Transplantation in thalassemia: Revisiting the Pesaro risk factors 25 years later","publication_year":2017,"publication_date":"2017-02-09","ids":{"openalex":"https://openalex.org/W2586744146","doi":"https://doi.org/10.1002/ajh.24674","mag":"2586744146","pmid":"https://pubmed.ncbi.nlm.nih.gov/28181283"},"language":"en","primary_location":{"id":"doi:10.1002/ajh.24674","doi":"https://doi.org/10.1002/ajh.24674","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.24674","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.24674","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.24674","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069596141","display_name":"Emanuele Angelucci","orcid":"https://orcid.org/0000-0002-6512-6080","observed_orcids":["https://orcid.org/0000-0002-6512-6080"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Emanuele Angelucci","raw_affiliation_strings":["Hematology, IRCCS Azienda Ospedaliera Universitaria, San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro Genova Italy"],"raw_orcid":"https://orcid.org/0000-0002-6512-6080","affiliations":[{"raw_affiliation_string":"Hematology, IRCCS Azienda Ospedaliera Universitaria, San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro Genova Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011749918","display_name":"Federica Pilo","orcid":"https://orcid.org/0000-0002-3326-0429","observed_orcids":["https://orcid.org/0000-0002-3326-0429"]},"institutions":[{"id":"https://openalex.org/I4210166522","display_name":"Azienda Ospedaliera G. Brotzu","ror":"https://ror.org/05t0c7p82","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210166522"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Pilo","raw_affiliation_strings":["Hematology and Transplant Center, Ospedale Oncologico di Riferimento Regionale \u201cArmando Businco\u201d, Azienda Ospedaliera Brotzu Cagliari Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Transplant Center, Ospedale Oncologico di Riferimento Regionale \u201cArmando Businco\u201d, Azienda Ospedaliera Brotzu Cagliari Italy","institution_ids":["https://openalex.org/I4210166522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077729374","display_name":"Thomas D. Coates","orcid":"https://orcid.org/0000-0001-9878-6029","observed_orcids":["https://orcid.org/0000-0001-9878-6029"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Coates","raw_affiliation_strings":["Hematology, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069596141"],"corresponding_institution_ids":["https://openalex.org/I4210146472"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"92","issue":"5","first_page":"411","last_page":"413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalassemia","display_name":"thalassemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9580000042915344},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.7120000123977661},{"id":"https://openalex.org/keywords/hepatomegaly","display_name":"hepatomegaly","score":0.9120000004768372},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.859000027179718},{"id":"https://openalex.org/keywords/non-transferrin-bound-iron","display_name":"non-transferrin-bound iron","score":0.8379999995231628},{"id":"https://openalex.org/keywords/labile-plasma-iron","display_name":"labile plasma iron","score":0.8709999918937683},{"id":"https://openalex.org/keywords/iron-toxicity","display_name":"iron toxicity","score":0.39899998903274536},{"id":"https://openalex.org/keywords/prognosis-prediction","display_name":"outcome prediction","score":0.453000009059906},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.3490000069141388},{"id":"https://openalex.org/keywords/adult-patients","display_name":"adult patients","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.8415571451187134},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.6945443153381348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6571149826049805},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.5355031490325928},{"id":"https://openalex.org/C2777218474","wikidata":"https://www.wikidata.org/wiki/Q1069061","display_name":"Chelation therapy","level":3,"score":0.5302077531814575},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5177797079086304},{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.503009021282196},{"id":"https://openalex.org/C2777940137","wikidata":"https://www.wikidata.org/wiki/Q3616632","display_name":"Beta thalassemia","level":3,"score":0.4488360285758972},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.44407641887664795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4299622178077698},{"id":"https://openalex.org/C3018783601","wikidata":"https://www.wikidata.org/wiki/Q3144934","display_name":"Hereditary hemochromatosis","level":3,"score":0.4215567111968994},{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.3867324888706207},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3808441758155823},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37548795342445374},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3372293710708618},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33208024501800537}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":false},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049674","descriptor_name":"History, 21st Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064591","descriptor_name":"Allografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ajh.24674","doi":"https://doi.org/10.1002/ajh.24674","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.24674","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.24674","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},{"id":"pmid:28181283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28181283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hematology","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1002/ajh.24674","doi":"https://doi.org/10.1002/ajh.24674","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.24674","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.24674","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2586744146.pdf","grobid_xml":"https://content.openalex.org/works/W2586744146.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W268116559","https://openalex.org/W1962706925","https://openalex.org/W1970096539","https://openalex.org/W1976626122","https://openalex.org/W1986617312","https://openalex.org/W2015457454","https://openalex.org/W2028135932","https://openalex.org/W2038282096","https://openalex.org/W2049619475","https://openalex.org/W2082049631","https://openalex.org/W2097534024","https://openalex.org/W2115215339","https://openalex.org/W2238351347","https://openalex.org/W2310835136","https://openalex.org/W2315168906","https://openalex.org/W2342340077","https://openalex.org/W2466995531","https://openalex.org/W3025200217"],"related_works":["https://openalex.org/W2310835136","https://openalex.org/W7097408161","https://openalex.org/W2062083912","https://openalex.org/W2342340077","https://openalex.org/W3214359270","https://openalex.org/W178234560","https://openalex.org/W4392942543","https://openalex.org/W3083687397","https://openalex.org/W2272906907","https://openalex.org/W4405040678"],"abstract_inverted_index":{"During":[0],"the":[1,37,60,71,91,97,108,166,190,205,246,252,338,349,358,388,394,397,404,412,416,427,473,496,500,506,520,535,547,552,558,569,588,596,602,605,624,655,667,674,677,687,690,715,732,739,744,772,798,837],"last":[2,187,389],"few":[3],"years,":[4],"we":[5,409],"have":[6,764],"witnessed":[7],"extraordinary":[8],"progress":[9,839],"in":[10,19,116,141,148,189,238,265,326,495,532,546,648,673,680,695,721,752,755,825,840],"our":[11,20,777],"knowledge":[12],"of":[13,22,39,62,110,137,179,351,360,419,436,444,448,455,463,485,502,519,554,560,598,612,626,658,676,682,746,779,784,801,804,820],"iron":[14,23,26,41,50,54,123,182,283,292,302,367,374,398,437,466,487,503,512,555,564,594,613,630,683,708,748,780,786,805,841],"pathophysiology,":[15],"as":[16,18,80,195,211,517,757,827],"well":[17,102],"understanding":[21,681,778],"toxicity":[24,33,399],"and":[25,56,59,75,96,144,177,208,224,229,232,234,236,242,263,269,314,329,336,342,348,372,403,446,460,489,505,513,530,541,593,618,660,699,710,770,796,818],"overload.":[27],"This":[28,126,186],"formula":[29,400],"proposes":[30],"that":[31,157,425,652,689,731],"tissue":[32,44,449,464,706,712],"arises":[34],"from":[35,165],"both":[36],"quantity":[38],"toxic":[40,452,486,514,563,629,747,785],"species":[42,46,467,631,709],"(i.e.,":[43,296,369,492],"reactive":[45,465,515,707,802],"=":[47],"non-transferrin":[48],"bound":[49,511],"(NTBI),":[51],"labile":[52],"plasma":[53],"(LPI),":[55],"enhanced":[57],"LPI)2":[58],"duration":[61,178,559,625],"exposure.":[63],"The":[64,221,844],"detrimental":[65],"effects":[66],"are":[67,653,723,829],"further":[68,685],"modulated":[69],"by":[70,76,312,362,836],"individual's":[72],"anti-oxidant":[73],"genetics":[74],"environmental":[77,490],"factors":[78,278,295,363,430,491,662,672,822],"such":[79],"dietary":[81],"antioxidants,":[82],"or":[83,88,290,609],"other":[84,287],"metals":[85],"like":[86,650,663,847],"copper,":[87],"selenium.":[89],"In":[90,600],"late":[92],"eighties,":[93],"Guido":[94,809],"Lucarelli":[95,810],"Pesaro":[98,405,413],"group":[99],"developed":[100],"a":[101,120,483],"recognized":[103,813],"scoring":[104,127,320,380,406],"system":[105,128,321,381],"to":[106,181,258,282,340,366,451,509,534,562,575,628,646,692,703,738,792,848],"predict":[107,324],"outcome":[109,619],"allogeneic":[111],"hematopoietic":[112],"stem":[113],"cell":[114],"transplantation":[115,385,694,763,791,824],"thalassemia,":[117,659],"which":[118],"is":[119,393,423,481,565,573,697,729],"paradigm":[121],"for":[122,216,332,337,387,814,823,853],"overload":[124,293,368,438,614],"diseases.3-6":[125],"stratified":[129],"patients":[130,759],"<16":[131],"years":[132,477,834],"old":[133],"into":[134,635],"three":[135,152,276,428],"categories":[136],"risk":[138,155,277,325,429,821],"factors,":[139,156],"resulting":[140],"statistically":[142,153],"significant":[143,154,766],"clinically":[145],"remarkable":[146],"differences":[147],"outcome.":[149],"There":[150],"were":[151,227,279,431],"is,":[158],"hepatomegaly":[159,347],"(\u22642":[160],"cm":[161,164],"versus":[162,172],">2":[163],"costal":[167],"arch),":[168],"liver":[169,301,373,521],"fibrosis":[170,480],"(absent":[171],"present":[173],"at":[174,217],"any":[175],"degree),":[176],"exposure":[180,450,488,508,627,768],"chelation":[183,456,701,783],"(Table":[184],"1).":[185],"parameter,":[188],"deferoxamine-only":[191],"era,":[192],"was":[193,250,254,621,632],"defined":[194],"life-long":[196,700],"deferoxamine,":[197],"starting":[198],"no":[199,286,581],"later":[200,835],"than":[201],"18":[202],"months":[203],"after":[204],"first":[206],"transfusion":[207,767],"administered":[209],"regularly":[210],"an":[212],"8-hour":[213],"continuous":[214],"infusion":[215],"least":[218],"5":[219],"days/week.":[220],"overall":[222],"survival":[223,226],"thalassemia-free":[225],"94%":[228],"87%,":[230],"84%":[231],"81%,":[233],"50%":[235],"47%":[237,264],"Class":[239,266],"1,":[240,267],"2,":[241,268],"3,":[243,270],"respectively.":[244],"When":[245],"same":[247,733],"conditioning":[248],"regimen":[249],"used,":[251],"difference":[253],"almost":[255],"entirely":[256],"due":[257],"transplant-related":[259,591],"mortality":[260],"(6,":[261],"15,":[262],"respectively;":[271],"P":[272],"<":[273],".0001).":[274],"These":[275],"clearly":[280,457,831],"related":[281,294,365],"overload,":[284,556],"but":[285,441,557],"conventional":[288],"direct":[289,434,608],"indirect":[291,442,610],"age,":[297],"transfusions,":[298],"serum":[299,370,616],"ferritin,":[300],"concentration,":[303],"splenomegaly,":[304],"splenectomy,":[305],"chronic":[306],"hepatitis,":[307],"etc.)":[308],"achieved":[309],"statistical":[310],"significance":[311],"univariate":[313],"multivariate":[315],"analyses.3,":[316],"6":[317],"Moreover,":[318,354,743],"this":[319,379,420,639],"did":[322],"not":[323,432,550,633],"adult":[327],"patients,7":[328],"received":[330],"criticism":[331],"its":[333],"nonquantitative":[334],"nature":[335],"susceptibility":[339],"intraobserver":[341],"interobserver":[343],"variability,":[344],"particularly":[345],"regarding":[346,587],"definition":[350],"adequate":[352],"chelation.":[353],"several":[355,579],"colleagues":[356],"questioned":[357],"absence":[359],"impact":[361],"directly":[364],"ferritin":[371],"concentration).":[375],"Despite":[376],"these":[377],"criticisms,":[378],"has":[382,584],"notably":[383],"influenced":[384],"strategy":[386],"25":[390,476,833],"years.8":[391],"What":[392],"relationship":[395],"between":[396,590,607],"mentioned":[401],"above1":[402],"system?":[407],"If":[408],"closely":[410],"analyze":[411],"score":[414],"under":[415],"magnifying":[417],"glass":[418],"formula,":[421],"it":[422,572,728],"evident":[424],"all":[426,601,753],"quantitative":[433],"markers":[435],"\u201cper":[439],"se\u201d,":[440],"measures":[443],"intensity":[445],"extent":[447,501],"iron.":[453],"Adequacy":[454],"means":[458],"consistent":[459],"sufficient":[461],"suppression":[462],"(NTBI/LPI)":[468],"over":[469],"time,":[470],"based":[471,775],"on":[472,568,718,776,806],"practice":[474],"applied":[475],"ago.":[478],"Liver":[479],"definitely":[482],"marker":[484],"viral":[493],"infections)":[494],"liver.":[497,548],"Hepatomegaly":[498],"reflects":[499],"deposition":[504],"time-averaged":[507],"transferrin":[510,539],"iron9":[516],"loading":[518],"significantly":[522],"increases":[523],"when":[524],"NTBI/LPI":[525,795],"enters":[526],"through":[527,538],"ion":[528],"channels":[529],"transporters":[531],"addition":[533],"regulated":[536],"entry":[537],"receptor-1":[540],"2-mediated":[542],"mechanisms":[543],"normally":[544],"operative":[545],"Thus,":[549],"only":[551,604],"magnitude":[553],"exposition":[561],"important.":[566],"Based":[567],"discussion":[570],"above,":[571],"easy":[574],"understand":[576],"why":[577],"despite":[578],"studies":[580],"definitive":[582],"conclusion":[583],"been":[585],"reached":[586],"relation":[589,640],"mortality/morbidity":[592],"outside":[595,654],"field":[597,657],"thalassemia.11-15":[599],"studies,":[603],"correlation":[606],"estimates":[611],"(mainly":[615],"ferritin)":[617],"parameters":[620],"explored":[622],"while":[623],"taken":[634],"account.":[636],"Of":[637],"course,":[638],"would":[641,846],"be":[642,736,750,788,812],"much":[643],"more":[644],"difficult":[645],"study":[647],"disorders":[649],"leukemia":[651],"homogenous":[656],"where":[661],"neoplastic":[664],"disease":[665],"confound":[666],"outcomes.":[668],"Reinterpreting":[669],"transplant":[670],"predictive":[671],"light":[675],"current":[678],"advances":[679],"homeostasis":[684],"supports":[686],"concept":[688,734],"key":[691],"successful":[693],"thalassemia":[696,722,826],"regular":[698],"therapy":[702,720,741],"consistently":[704],"suppress":[705],"prevent":[711],"damage.":[713],"Because":[714],"ongoing":[716],"trials":[717],"gene":[719,740],"performed":[724],"using":[725],"autologous":[726],"transplantation,":[727],"likely":[730],"could":[735,787],"relevant":[737],"approach.":[742],"role":[745],"should":[749,811],"considered":[751],"transplantations":[754],"general":[756],"most":[758],"who":[760],"undergo":[761],"marrow":[762],"had":[765],"before":[769],"during":[771],"procedure.11-15":[773],"However,":[774],"toxicity,1,":[781],"9":[782],"done":[789],"throughout":[790],"quickly":[793],"reduce":[794],"block":[797],"amplifying":[799],"effect":[800],"forms":[803],"inflammation.18":[807],"Finally,":[808],"his":[815],"clinical":[816],"observations":[817],"establishment":[819],"they":[828],"now":[830],"supported":[832],"huge":[838],"pathophysiology":[842],"understanding.":[843],"authors":[845],"acknowledge":[849],"Martine":[850],"Torres,":[851],"PhD":[852],"her":[854],"editorial":[855],"assistance.":[856]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-17T00:00:00"}