{"id":"https://openalex.org/W2586743601","doi":"https://doi.org/10.1177/0003319789040004098","title":"Heparin and Prostacyclin","display_name":"Heparin and Prostacyclin","publication_year":1989,"publication_date":"1989-04-01","ids":{"openalex":"https://openalex.org/W2586743601","doi":"https://doi.org/10.1177/0003319789040004098","mag":"2586743601","pmid":"https://pubmed.ncbi.nlm.nih.gov/2650580"},"language":"en","primary_location":{"id":"doi:10.1177/0003319789040004098","doi":"https://doi.org/10.1177/0003319789040004098","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0003319789040004098","pdf_url":null,"source":{"id":"https://openalex.org/S153867169","display_name":"Angiology","issn_l":"0003-3197","issn":["0003-3197","1940-1574"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M. Camici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Camici","raw_affiliation_strings":["2nd Medical Clinic, University Hospitals, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Medical Clinic, University Hospitals, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016897129","display_name":"Lucia Evangelisti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Evangelisti","raw_affiliation_strings":["2nd Medical Clinic, University Hospitals, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Medical Clinic, University Hospitals, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210165410"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.2522,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6136729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"4","first_page":"294","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.8259999752044678},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.9980000257492065},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/heparin-dosing","display_name":"heparin dosing","score":0.6919999718666077},{"id":"https://openalex.org/keywords/platelet-poor-plasma","display_name":"platelet-poor plasma","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9557028412818909},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.8059625625610352},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7055697441101074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4330849349498749},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3908050060272217},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.34939485788345337}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000990","descriptor_name":"Antithrombin III","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010314","descriptor_name":"Partial Thromboplastin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1177/0003319789040004098","doi":"https://doi.org/10.1177/0003319789040004098","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0003319789040004098","pdf_url":null,"source":{"id":"https://openalex.org/S153867169","display_name":"Angiology","issn_l":"0003-3197","issn":["0003-3197","1940-1574"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiology","raw_type":"journal-article"},{"id":"pmid:2650580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2650580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angiology","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/13679","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/13679","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W21793809","https://openalex.org/W1519085965","https://openalex.org/W1971759979","https://openalex.org/W1976876483","https://openalex.org/W1978883377","https://openalex.org/W1979397793","https://openalex.org/W1997453827","https://openalex.org/W1997544868","https://openalex.org/W2003915795","https://openalex.org/W2005204433","https://openalex.org/W2009175905","https://openalex.org/W2009906225","https://openalex.org/W2013812505","https://openalex.org/W2017755964","https://openalex.org/W2018859526","https://openalex.org/W2021403302","https://openalex.org/W2029134608","https://openalex.org/W2037594789","https://openalex.org/W2039581574","https://openalex.org/W2044070853","https://openalex.org/W2048438574","https://openalex.org/W2050072921","https://openalex.org/W2051250161","https://openalex.org/W2055650479","https://openalex.org/W2061847666","https://openalex.org/W2062185761","https://openalex.org/W2066189281","https://openalex.org/W2070356976","https://openalex.org/W2077776741","https://openalex.org/W2081380404","https://openalex.org/W2148279379","https://openalex.org/W2153192188","https://openalex.org/W2165731310","https://openalex.org/W2317329910","https://openalex.org/W2337735034","https://openalex.org/W2401724820","https://openalex.org/W2404137321","https://openalex.org/W2411437351","https://openalex.org/W2414749910","https://openalex.org/W2418982540","https://openalex.org/W2427185386","https://openalex.org/W2791281712"],"related_works":["https://openalex.org/W2039581574","https://openalex.org/W2055650479","https://openalex.org/W1987915905","https://openalex.org/W100900256","https://openalex.org/W1995673796","https://openalex.org/W2920997374","https://openalex.org/W1979831792","https://openalex.org/W2945520199","https://openalex.org/W2023883487","https://openalex.org/W1988683880"],"abstract_inverted_index":{"Hemodialysis":[0],"performed":[1],"with":[2,29,105],"prostacyclin":[3,63,76],"(5":[4],"ng/kg/min)":[5],"as":[6],"a":[7,112,118],"substitute":[8,65],"for":[9,66],"heparin":[10,21,26,38,67,116,135],"was":[11],"studied":[12,19],"in":[13,69,114,138,142,145],"10":[14],"patients.":[15],"The":[16,31],"subjects":[17],"were":[18],"during":[20,25],"perfusion":[22,27],"alone":[23],"and":[24,44,54,107],"together":[28],"prostacyclin.":[30,149],"authors":[32],"investigated":[33],"the":[34,72,78,85,88,94,123,146],"effect":[35,80],"of":[36,75,81,87,148,152],"two":[37],"regimens":[39],"(regimen":[40],"I:":[41],"2,000":[42],"U/hr":[43],"regimen":[45],"II:":[46],"500":[47],"U/hr)":[48],"upon":[49],"plasma":[50,144],"antithrombin":[51,95],"level":[52],"(IU/mL)":[53],"activated":[55,89,126],"thromboplastin":[56,91,128],"time":[57,129],"(sec).":[58],"Our":[59],"findings":[60,155],"show:":[61],"(1)":[62],"can":[64],"anticoagulation":[68],"hemodialysis;":[70],"(2)":[71],"concomitant":[73],"administration":[74],"enhances":[77],"anticoagulant":[79],"heparin,":[82],"based":[83],"on":[84],"measurement":[86],"partial":[90,127],"time;":[92],"(3)":[93],"activity":[96],"is":[97,130],"increased":[98],"by":[99,122,134],"both":[100],"treatments":[101],"but":[102],"more":[103,132],"so":[104],"prostacyclin;":[106],"(4)":[108],"platelet":[109],"activation":[110],"plays":[111],"role":[113],"limiting":[115],"anticoagulation,":[117],"conclusion":[119],"partly":[120],"supported":[121],"finding":[124],"that":[125],"somewhat":[131],"prolonged":[133],"when":[136],"measured":[137],"platelet-poor":[139],"rather":[140],"than":[141],"platelet-rich":[143],"presence":[147],"Physiopathologic":[150],"implications":[151],"these":[153],"preliminary":[154],"are":[156],"discussed.":[157]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-17T00:00:00"}