{"id":"https://openalex.org/W2586710089","doi":"https://doi.org/10.1093/ndt/gfw164.11","title":"SP267PITFALLS OF DRUG DEVELOPMENT FOR CHRONIC KIDNEY DISEASE IN MOUSE MODELS","display_name":"SP267PITFALLS OF DRUG DEVELOPMENT FOR CHRONIC KIDNEY DISEASE IN MOUSE MODELS","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2586710089","doi":"https://doi.org/10.1093/ndt/gfw164.11","mag":"2586710089"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfw164.11","doi":"https://doi.org/10.1093/ndt/gfw164.11","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfw164.11","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025069419","display_name":"Anja Thorenz","orcid":"https://orcid.org/0000-0001-8149-0045","observed_orcids":["https://orcid.org/0000-0001-8149-0045"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Thorenz","raw_affiliation_strings":["Medical School Hannover, Nephrology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Nephrology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066875692","display_name":"Song Rong","orcid":"https://orcid.org/0000-0001-9985-1515","observed_orcids":["https://orcid.org/0000-0001-9985-1515"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Song Rong","raw_affiliation_strings":["Medical School Hannover, Nephrology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Nephrology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081380558","display_name":"Rongjun Chen","orcid":"https://orcid.org/0000-0002-8133-5472","observed_orcids":["https://orcid.org/0000-0002-8133-5472"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rongjun Chen","raw_affiliation_strings":["Medical School Hannover, Nephrology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Nephrology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072325586","display_name":"Bennet Hensen","orcid":"https://orcid.org/0000-0001-6966-273X","observed_orcids":["https://orcid.org/0000-0001-6966-273X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bennet Hensen","raw_affiliation_strings":["Medical School Hannover, Radiology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Radiology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113210523","display_name":"Jan Hinrich Braesen","orcid":"https://orcid.org/0000-0002-2863-3067","observed_orcids":["https://orcid.org/0000-0002-2863-3067"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Hinrich Braesen","raw_affiliation_strings":["Medical School Hannover, Pathology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Pathology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041014447","display_name":"Martin Meier","orcid":"https://orcid.org/0000-0001-8642-0409","observed_orcids":["https://orcid.org/0000-0001-8642-0409"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Meier","raw_affiliation_strings":["Medical School Hannover, Central animal facility, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Central animal facility, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110143117","display_name":"Hermann G. Haller","orcid":"https://orcid.org/0000-0002-8361-6446","observed_orcids":["https://orcid.org/0000-0002-8361-6446","https://orcid.org/0009-0000-5740-838X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hermann Haller","raw_affiliation_strings":["Medical School Hannover, Nephrology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Nephrology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048940037","display_name":"Andreas Klos","orcid":"https://orcid.org/0000-0001-8404-8789","observed_orcids":["https://orcid.org/0000-0001-8404-8789","https://orcid.org/0000-0002-4309-0830"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Klos","raw_affiliation_strings":["Medical School Hannover, Microbiology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Microbiology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112223285","display_name":"Katja Hueper","orcid":"https://orcid.org/0000-0002-3195-4400","observed_orcids":["https://orcid.org/0000-0002-3195-4400"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Hueper","raw_affiliation_strings":["Medical School Hannover, Radiology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School Hannover, Radiology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113787654","display_name":"Faikah Gueler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Faikah Gueler","raw_affiliation_strings":["Medical school Hannover, Nephrology, Hannover, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical school Hannover, Nephrology, Hannover, GERMANY","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"suppl_1","first_page":"i176","last_page":"i176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9480000138282776},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7940000295639038},{"id":"https://openalex.org/keywords/unilateral-ureteral-obstruction","display_name":"unilateral ureteral obstruction","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9660000205039978},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.8100000023841858},{"id":"https://openalex.org/keywords/renal-perfusion","display_name":"renal perfusion","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/collagen-type-i-alpha-1","display_name":"collagen type I alpha 1","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9516922831535339},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7727596759796143},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.6616966128349304},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6281940340995789},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44945400953292847},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43948468565940857},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3689260184764862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2886025905609131}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ndt/gfw164.11","doi":"https://doi.org/10.1093/ndt/gfw164.11","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfw164.11","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3164095845","https://openalex.org/W1983456891","https://openalex.org/W7160901110","https://openalex.org/W7162093460","https://openalex.org/W4397048181","https://openalex.org/W2519187256","https://openalex.org/W3215573725","https://openalex.org/W4416867819","https://openalex.org/W3203854463","https://openalex.org/W2137593842"],"abstract_inverted_index":{"Introduction":[0],"and":[1,22,59,121,127,149,162,184,191,196,202],"Aims:":[2],"Phase":[3],"I":[4],"studies":[5,65],"for":[6,28,64,91,153],"the":[7,37,49,80,124,144],"development":[8,93],"of":[9,26,51,66,123,143,204],"new":[10],"therapies":[11],"are":[12,20,32,82,89],"often":[13],"times":[14],"done":[15,148,159,170],"in":[16,75,94,160,189],"mice":[17,103,128,150],"since":[18],"they":[19],"inexpensive":[21],"a":[23,61],"broad":[24],"variety":[25],"antibodies":[27],"subsequent":[29],"phenotype":[30],"analysis":[31],"present.":[33],"For":[34,135],"renal":[35,95,108,138,145,178,185],"fibrosis":[36,109,139,186],"most":[38],"frequently":[39],"used":[40],"model":[41,50],"is":[42],"unilateral":[43,141],"ureter":[44,126],"obstruction":[45],"(UUO).":[46],"Lately,":[47],"also":[48],"ischemia":[52],"induced":[53,118,137],"chronic":[54,67],"kidney":[55,68],"disease":[56,69],"was":[57,78,117,147,169],"characterized":[58],"opened":[60],"further":[62],"opportunity":[63],"(CKD).":[70],"The":[71],"question":[72],"we":[73,98],"addressed":[74],"this":[76],"study":[77],"whether":[79,100],"models":[81,157],"interchangeable":[83],"or":[84,112],"if":[85],"more":[86],"sophisticated":[87],"considerations":[88],"needed":[90],"drug":[92],"fibrosis.":[96],"Therefore,":[97],"tested":[99],"complement":[101],"deficient":[102,164],"(C5aR2)":[104],"showed":[105],"protection":[106],"from":[107],"after":[110,113,133],"UUO":[111,116],"IRI.":[114],"Methods:":[115],"by":[119,171,197],"ligation":[120],"dissection":[122],"left":[125],"were":[129,151,158,187],"sacrificed":[130],"at":[131],"d10":[132],"surgery.":[134],"IRI":[136],"45min":[140],"clamping":[142],"pedicle":[146],"followed":[152],"3":[154],"weeks.":[155],"Both":[156],"WT":[161],"C5aR2":[163],"mice.":[165],"Longitudinal":[166],"follow":[167],"up":[168],"functional":[172],"magnetic":[173],"resonance":[174],"imaging":[175],"to":[176],"measure":[177],"perfusion":[179],"impairment.":[180],"Renal":[181],"morphology,":[182],"inflammation":[183],"investigated":[188],"PAS":[190],"Masson":[192],"trichrome":[193],"stained":[194],"tissue":[195],"immunohistochemistry":[198],"(fibronectin,":[199,207],"sirius":[200],"red)":[201],"qPCR":[203],"pro-fibrotic":[205],"markers":[206],"CTGF":[208],"collagen":[209],"1\u03b11.":[210]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2017-02-17T00:00:00"}
