{"id":"https://openalex.org/W25866948","doi":null,"title":"Comparison of the efficacy and tolerance of a garlic preparation vs. bezafibrate.","display_name":"Comparison of the efficacy and tolerance of a garlic preparation vs. bezafibrate.","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W25866948","mag":"25866948","pmid":"https://pubmed.ncbi.nlm.nih.gov/1288512"},"language":"en","primary_location":{"id":"pmid:1288512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1288512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026851486","display_name":"H Holzgartner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Holzgartner","raw_affiliation_strings":["Arbeits- und Forschungsgemeinschaft f\u00fcr Arzneimittel-Sicherheit e.V., Cologne, Fed. Rep. of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arbeits- und Forschungsgemeinschaft f\u00fcr Arzneimittel-Sicherheit e.V., Cologne, Fed. Rep. of Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"U Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109134411","display_name":"Ulrike K\u00fchn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Kuhn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4763,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.80911583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"12","first_page":"1473","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/garlic","display_name":"garlic","score":0.5519999861717224},{"id":"https://openalex.org/keywords/bezafibrate","display_name":"bezafibrate","score":0.8199999928474426},{"id":"https://openalex.org/keywords/primary-hyperlipoproteinemia","display_name":"primary hyperlipoproteinemia","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.5640000104904175},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8970000147819519},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":1.0},{"id":"https://openalex.org/keywords/alliin","display_name":"alliin","score":0.7080000042915344},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.41100001335144043},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.7329999804496765},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2776362216","wikidata":"https://www.wikidata.org/wiki/Q577387","display_name":"Bezafibrate","level":2,"score":0.9640188813209534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6858097314834595},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6792397499084473},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6521198153495789},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6429762840270996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4312885105609894},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001629","descriptor_name":"Bezafibrate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001629","descriptor_name":"Bezafibrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005737","descriptor_name":"Garlic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006951","descriptor_name":"Hyperlipoproteinemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006952","descriptor_name":"Hyperlipoproteinemia Type III","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006952","descriptor_name":"Hyperlipoproteinemia Type III","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009812","descriptor_name":"Odorants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1288512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1288512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},{"id":"mag:25866948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1288512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2279092062","https://openalex.org/W154534913","https://openalex.org/W2054011238","https://openalex.org/W34356669","https://openalex.org/W2052326997","https://openalex.org/W142828285","https://openalex.org/W2084092709","https://openalex.org/W2155037982","https://openalex.org/W2116765403","https://openalex.org/W1996579035"],"abstract_inverted_index":{"The":[0,36,60,89],"efficacy":[1],"and":[2,29,54,103,109,138,140,195],"tolerance":[3],"of":[4,39,46,57,86,98,110,120,155,172,178,192],"a":[5,13,79,127],"garlic":[6,47,183,193],"preparation":[7],"(Sapec,":[8],"Kwai)":[9],"was":[10,22,148,186],"investigated":[11],"in":[12,24,132,135,143,152,167],"randomized":[14],"double-blind":[15],"study":[16,21,124],"vs.":[17],"bezafibrate.":[18],"This":[19],"multi-centre":[20],"conducted":[23],"5":[25,164],"general":[26],"medical":[27],"practices":[28],"involved":[30],"98":[31,90],"patients":[32,74,165],"with":[33,62],"primary":[34],"hyperlipoproteinaemia.":[35],"daily":[37],"doses":[38],"the":[40,67,84,87,95,118,121,153,176,179,182,190,196,199],"active":[41],"substances":[42],"were":[43,75,161],"900":[44],"mg":[45,56],"powder":[48],"(standardized":[49],"as":[50],"to":[51,77,175],"1.3%":[52],"alliin)":[53],"600":[55],"bezafibrate,":[58],"respectively.":[59],"pre-phase":[61],"placebo":[63],"lasted":[64],"6":[65],"weeks,":[66],"treatment":[68,122,169],"period":[69],"covered":[70],"12":[71],"weeks.":[72],"All":[73],"advised":[76],"observe":[78],"low-fat":[80],"\"step-1":[81],"diet\"":[82],"for":[83,106,114],"duration":[85],"study.":[88],"case":[91],"report":[92],"forms":[93],"allowed":[94],"statistical":[96],"evaluation":[97],"total":[99,133],"cholesterol,":[100,134],"HDL":[101,144],"cholesterol":[102,112,137,200],"triglyceride":[104],"levels":[105],"94":[107],"patients,":[108],"LDL":[111,136],"values":[113],"92":[115],"patients.":[116,180],"In":[117],"course":[119],"both":[123,156,168],"medications":[125],"caused":[126],"statistically":[128],"highly":[129],"significant":[130,150],"reduction":[131],"triglycerides,":[139],"an":[141],"increase":[142],"cholesterol.":[145],"However,":[146],"there":[147,185],"no":[149,187],"difference":[151],"efficacies":[154],"medication":[157],"groups.":[158],"Side":[159],"effects":[160],"mentioned":[162],"by":[163],"each":[166],"groups,":[170],"none":[171],"which":[173],"led":[174],"withdrawal":[177],"Concerning":[181],"preparation,":[184],"correlation":[188],"between":[189],"perception":[191],"odour":[194],"influence":[197],"on":[198],"level.":[201]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}