{"id":"https://openalex.org/W2586694359","doi":"https://doi.org/10.1182/blood.v110.11.2103.2103","title":"Rapid In Vivo Consumption and Ex Vivo Phagocytosis of WASP(\u2212) Platelets.","display_name":"Rapid In Vivo Consumption and Ex Vivo Phagocytosis of WASP(\u2212) Platelets.","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2586694359","doi":"https://doi.org/10.1182/blood.v110.11.2103.2103","mag":"2586694359"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.2103.2103","doi":"https://doi.org/10.1182/blood.v110.11.2103.2103","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.2103.2103","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018431271","display_name":"Amanda Prislovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086422","display_name":"Memphis VA Medical Center","ror":"https://ror.org/000vjzq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086422","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda Prislovsky","raw_affiliation_strings":["Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN, USA","USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I4210086422"]},{"raw_affiliation_string":"USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086501578","display_name":"Falk Nimmerjahn","orcid":"https://orcid.org/0000-0002-5418-316X","observed_orcids":["https://orcid.org/0000-0002-5418-316X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Falk Nimmerjahn","raw_affiliation_strings":["Laboratory for Experimental Immunology and Immunotherapy, Nikolaus-Feibiger-Centre, Erlangen, Germany","USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Experimental Immunology and Immunotherapy, Nikolaus-Feibiger-Centre, Erlangen, Germany","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007474253","display_name":"Jeffrey V. Ravetch","orcid":"https://orcid.org/0000-0003-2024-9041","observed_orcids":["https://orcid.org/0000-0003-2024-9041"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey V. Ravetch","raw_affiliation_strings":["Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY, USA","USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY, USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111929888","display_name":"Carl W. Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carl W. Jackson","raw_affiliation_strings":["St Jude Children\u2019s Research Hospital, Hematology/Oncology, Memphis, TN, USA","USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital, Hematology/Oncology, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002935249","display_name":"Ted S. Strom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210086422","display_name":"Memphis VA Medical Center","ror":"https://ror.org/000vjzq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086422","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ted S. Strom","raw_affiliation_strings":["Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN, USA","Pathology and Laboratory Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA","USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Memphis VA Medical Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I4210086422"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007474253","https://openalex.org/A5018431271","https://openalex.org/A5086501578","https://openalex.org/A5111929888"],"corresponding_institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I4210086422","https://openalex.org/I83399316"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3991435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"11","first_page":"2103","last_page":"2103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wiskott-aldrich-syndrome","display_name":"Wiskott-Aldrich syndrome","score":0.9700000286102295},{"id":"https://openalex.org/keywords/platelet-consumption","display_name":"platelet consumption","score":0.8100000023841858},{"id":"https://openalex.org/keywords/platelet-clearance","display_name":"platelet clearance","score":0.6850000023841858},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/reticulated-platelets","display_name":"reticulated platelets","score":0.8759999871253967},{"id":"https://openalex.org/keywords/platelet-turnover","display_name":"platelet turnover","score":0.7260000109672546},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/platelet-phagocytosis","display_name":"platelet phagocytosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cd47","display_name":"CD47","score":0.6320000290870667},{"id":"https://openalex.org/keywords/integrin-beta3","display_name":"CD61","score":0.8529999852180481},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.8399999737739563},{"id":"https://openalex.org/keywords/antiplatelet-antibodies","display_name":"antiplatelet antibodies","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8907963037490845},{"id":"https://openalex.org/C2776958478","wikidata":"https://www.wikidata.org/wiki/Q14914622","display_name":"Thrombopoiesis","level":5,"score":0.879105806350708},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7636760473251343},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7066581845283508},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5447760820388794},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5139583945274353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49403172731399536},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.47337430715560913},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.459661602973938},{"id":"https://openalex.org/C2778153459","wikidata":"https://www.wikidata.org/wiki/Q953638","display_name":"Wiskott\u2013Aldrich syndrome","level":3,"score":0.4427035450935364},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.39996591210365295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34203222393989563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2862660884857178},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16368043422698975},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.138065904378891},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.07074835896492004},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.2103.2103","doi":"https://doi.org/10.1182/blood.v110.11.2103.2103","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.2103.2103","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087792204","https://openalex.org/W2583497405","https://openalex.org/W1993321728","https://openalex.org/W2144140866","https://openalex.org/W2590589078","https://openalex.org/W2484006480","https://openalex.org/W2979872568","https://openalex.org/W2010949326","https://openalex.org/W1969172568","https://openalex.org/W2103771488"],"abstract_inverted_index":{"Abstract":[0],"Patients":[1],"with":[2,69,110,229,256,295,350],"the":[3,39,148,162,180,189,314,406,409,430],"Wiskott-Aldrich":[4],"Syndrome":[5],"(WAS)":[6],"have":[7,16,23,27,44,420],"thrombocytopenia":[8,428],"and":[9,14,68,83,96,114,143,146,172,210,214,248,362,372,451],"increased":[10,140,205,321,376,447,452],"platelet":[11,18,49,127,158,389,398],"consumption":[12,89,104,120,282],"rates,":[13],"may":[15],"reduced":[17,357],"production":[19,134,159],"rates.":[20],"WASP(\u2212)":[21,42,78,122,196,201,226,259,285,363,439],"mice":[22,43,202],"been":[24],"reported":[25],"to":[26,58,92,98,107,235,309,340,343,356,381,394,455],"only":[28,185],"a":[29,45,116,186,443],"mild":[30],"thrombocytopenia.":[31],"We":[32],"find":[33],"that":[34,87,132,156,177,300,388,408,418],"when":[35,429],"fully":[36],"crossed":[37],"onto":[38],"C57Bl/6J":[40],"background,":[41],">50%":[46],"reduction":[47],"in":[48,65,80,141,147,192,280,287,369,384],"counts.":[50],"Ex":[51],"vivo":[52,101,112,237,281,378],"labeled":[53],"WASP(\u2212)platelets":[54],"are":[55,62,129,139,232,261,276],"consumed":[56],"2":[57],"4-fold":[59],"faster":[60],"than":[61,72,245,267,275,298],"WT":[63,66,81,194,246,268,288,302,424],"platelets":[64,79,209,227,260,269,286,367,382,425,431,440],"mice,":[67,82],"exponential":[70],"rather":[71],"linear":[73],"kinetics.":[74],"Clearance":[75],"rates":[76,105,169],"of":[77,119,121,164,170,179,188,200,207,217,284,301,313,318,323,411,437,446],"vice":[84],"versa,":[85],"indicate":[86,176],"rapid":[88,435],"is":[90,136,153,290,299,306,337],"due":[91,308,339],"factors":[93],"both":[94,360,370],"intrinsic":[95],"extrinsic":[97],"platelets.":[99,125,253,278,303,364],"In":[100],"biotinylation":[102],"demonstrates":[103],"comparable":[106],"those":[108],"seen":[109],"ex":[111,236,377],"labeling,":[113],"shows":[115],"normal":[117],"rate":[118,135,283],"reticulated":[123,173,208],"(immature)":[124],"Reticulated":[126],"counts":[128],"reduced,":[130],"indicating":[131],"their":[133,150],"reduced.":[137],"Megakaryocytes":[138],"spleen":[142],"bone":[144,240],"marrow,":[145],"latter":[149,181],"ploidy":[151],"distribution":[152],"normal,":[154],"suggesting":[155,387],"impaired":[157],"occurs":[160],"at":[161],"level":[163],"thrombopoiesis.":[165],"The":[166,279],"absolute":[167],"turnover":[168,191],"mature":[171],"platelets,":[174,247],"however,":[175],"maturation":[178],"can":[182],"account":[183],"for":[184,359],"fraction":[187,206],"former\u2019s":[190],"either":[193,385],"or":[195,317,326,414],"mice.":[197],"A":[198],"subset":[199,219],"show":[203,374],"an":[204,351],"more":[211,233,265,291],"severe":[212],"thrombocytopenia,":[213],"some":[215],"members":[216],"this":[218],"also":[220,262],"express":[221],"serum":[222],"anti-platelet":[223],"antibodies.":[224],"CMFDA-labeled":[225],"opsonized":[228,366,438],"anti-CD61(IgG1)":[230],"antibody":[231,297,354],"susceptible":[234,250],"phagocytosis":[238,305,336,358,379,436],"by":[239,270,293,332],"marrow":[241],"derived":[242],"macrophages":[243],"(BMDM)":[244],"as":[249,251,330,348],"CD47(\u2212/\u2212)":[252,277,361],"After":[254],"opsonization":[255,294,349],"6A6(IgG2b)":[257],"antibody,":[258],"taken":[263],"up":[264],"rapidly":[266,274],"BMDM,":[271],"but":[272],"less":[273],"recipients":[289],"accelerated":[292],"anti-CD61":[296],"Increased":[304,335],"not":[307,338,392],"(A)":[310],"altered":[311],"levels":[312],"targeted":[315],"antigens":[316],"CD47":[319,373,399],"(B)":[320],"exposure":[322],"phosphatidyl":[324],"serine,":[325],"(C)":[327],"antibody-induced":[328],"activation":[329],"assayed":[331],"CD62P":[333],"expression.":[334],"selective":[341],"sensitivity":[342],"IgG1":[344],"vs":[345],"IgG2b":[346],"antibodies,":[347],"engineered":[352],"6A6(IgG1)":[353],"leads":[355],"Anti-CD61":[365],"deficient":[368,383],"WASP":[371,390],"markedly":[375],"compared":[380],"protein,":[386],"does":[391],"function":[393],"amplify":[395],"signals":[396],"from":[397],"through":[400],"macrophage":[401],"SIRP-alpha.":[402],"These":[403],"results":[404],"raise":[405],"possibility":[407],"binding":[410],"low":[412,415],"affinity":[413],"titer":[416],"antibodies":[417],"might":[419],"no":[421],"effect":[422],"on":[423],"could":[426,441],"cause":[427],"lack":[432],"WASP.":[433],"Alternatively,":[434],"promote":[442],"self-reinforcing":[444],"cycle":[445],"host":[448,456],"antigen":[449],"presentation":[450],"immune":[453],"responses":[454],"antigens.":[457]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2017-02-17T00:00:00"}