{"id":"https://openalex.org/W2586651574","doi":null,"title":"Irreversible Electroporation Therapy for the Treatment of Spontaneous Tumors in Cancer Patients","display_name":"Irreversible Electroporation Therapy for the Treatment of Spontaneous Tumors in Cancer Patients","publication_year":2011,"publication_date":"2011-12-24","ids":{"openalex":"https://openalex.org/W2586651574","mag":"2586651574"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/51741","doi":null,"is_oa":false,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-11092011-145552/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Neal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Robert L. Evans","orcid":"https://orcid.org/0000-0002-1690-9927","observed_orcids":["https://orcid.org/0000-0002-1690-9927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L. Evans","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1690-9927","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10642","display_name":"Atmospheric-Pressure Plasma Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irreversible-electroporation","display_name":"irreversible electroporation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-ablation","display_name":"tumor ablation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/focal-ablation","display_name":"focal ablation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/needle-electrode","display_name":"needle electrode","score":0.578000009059906},{"id":"https://openalex.org/keywords/electric-field-modeling","display_name":"electric field modeling","score":0.6169999837875366},{"id":"https://openalex.org/keywords/heterogeneous-tissue","display_name":"heterogeneous tissue","score":0.6610000133514404},{"id":"https://openalex.org/keywords/treatment-planning","display_name":"treatment planning","score":0.46399998664855957},{"id":"https://openalex.org/keywords/treatment-monitoring","display_name":"treatment monitoring","score":0.3310000002384186},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.5049999952316284},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.39899998903274536},{"id":"https://openalex.org/keywords/minimally-invasive-cancer-therapy","display_name":"minimally invasive cancer therapy","score":0.6150000095367432},{"id":"https://openalex.org/keywords/electrical-impedance-tomography","display_name":"electrical impedance tomography","score":0.6259999871253967},{"id":"https://openalex.org/keywords/ultrasound","display_name":"ultrasound","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.5677458643913269},{"id":"https://openalex.org/C2778716261","wikidata":"https://www.wikidata.org/wiki/Q17164846","display_name":"Irreversible electroporation","level":4,"score":0.5324071049690247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5193625092506409},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.5103492140769958},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4790840744972229},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3771297335624695},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32656732201576233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32038572430610657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20006760954856873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05955922603607178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/51741","doi":null,"is_oa":false,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-11092011-145552/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2586651574","doi":null,"is_oa":false,"landing_page_url":"https://vtechworks.lib.vt.edu/handle/10919/51741","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":193,"referenced_works":["https://openalex.org/W2830937","https://openalex.org/W40015146","https://openalex.org/W41186048","https://openalex.org/W93319412","https://openalex.org/W99479793","https://openalex.org/W152718781","https://openalex.org/W160196378","https://openalex.org/W169771143","https://openalex.org/W566531905","https://openalex.org/W1490324405","https://openalex.org/W1511333159","https://openalex.org/W1521859708","https://openalex.org/W1522712041","https://openalex.org/W1532219419","https://openalex.org/W1543287659","https://openalex.org/W1555481595","https://openalex.org/W1556018645","https://openalex.org/W1605353467","https://openalex.org/W1640053709","https://openalex.org/W1852377452","https://openalex.org/W1856420383","https://openalex.org/W1904722209","https://openalex.org/W1924811449","https://openalex.org/W1936620128","https://openalex.org/W1963551591","https://openalex.org/W1967650453","https://openalex.org/W1968285225","https://openalex.org/W1969097291","https://openalex.org/W1970805100","https://openalex.org/W1972214019","https://openalex.org/W1972891483","https://openalex.org/W1973142530","https://openalex.org/W1974677529","https://openalex.org/W1975793579","https://openalex.org/W1976257328","https://openalex.org/W1976522396","https://openalex.org/W1978542226","https://openalex.org/W1979145688","https://openalex.org/W1979444189","https://openalex.org/W1984371575","https://openalex.org/W1987264887","https://openalex.org/W1990735504","https://openalex.org/W1993711956","https://openalex.org/W1994368688","https://openalex.org/W1994680513","https://openalex.org/W1995583440","https://openalex.org/W1997096826","https://openalex.org/W1997178536","https://openalex.org/W1997940993","https://openalex.org/W1998048632","https://openalex.org/W1999355247","https://openalex.org/W2000144812","https://openalex.org/W2000640611","https://openalex.org/W2002193311","https://openalex.org/W2004120034","https://openalex.org/W2004155851","https://openalex.org/W2004469159","https://openalex.org/W2004754106","https://openalex.org/W2005336374","https://openalex.org/W2006489816","https://openalex.org/W2007345685","https://openalex.org/W2008064731","https://openalex.org/W2008693739","https://openalex.org/W2013377079","https://openalex.org/W2013902422","https://openalex.org/W2013941176","https://openalex.org/W2019068717","https://openalex.org/W2019232209","https://openalex.org/W2019410912","https://openalex.org/W2020786750","https://openalex.org/W2022981781","https://openalex.org/W2023103584","https://openalex.org/W2024422046","https://openalex.org/W2024731442","https://openalex.org/W2026431467","https://openalex.org/W2027039522","https://openalex.org/W2032138177","https://openalex.org/W2032783816","https://openalex.org/W2033348143","https://openalex.org/W2033516066","https://openalex.org/W2034684832","https://openalex.org/W2036257020","https://openalex.org/W2036288764","https://openalex.org/W2036947184","https://openalex.org/W2037342314","https://openalex.org/W2038434543","https://openalex.org/W2039112227","https://openalex.org/W2039134364","https://openalex.org/W2041252154","https://openalex.org/W2041472987","https://openalex.org/W2041655322","https://openalex.org/W2042057570","https://openalex.org/W2042298446","https://openalex.org/W2043729132","https://openalex.org/W2044632997","https://openalex.org/W2047209444","https://openalex.org/W2047231260","https://openalex.org/W2048252534","https://openalex.org/W2051987232","https://openalex.org/W2054337002","https://openalex.org/W2055186346","https://openalex.org/W2055734602","https://openalex.org/W2056104198","https://openalex.org/W2056221094","https://openalex.org/W2057844392","https://openalex.org/W2058680827","https://openalex.org/W2061703524","https://openalex.org/W2065753258","https://openalex.org/W2067114252","https://openalex.org/W2067174641","https://openalex.org/W2067861173","https://openalex.org/W2069041223","https://openalex.org/W2071590462","https://openalex.org/W2071938131","https://openalex.org/W2074834846","https://openalex.org/W2075371851","https://openalex.org/W2075852744","https://openalex.org/W2076027770","https://openalex.org/W2079530087","https://openalex.org/W2080957075","https://openalex.org/W2081687897","https://openalex.org/W2083043482","https://openalex.org/W2085749017","https://openalex.org/W2086449211","https://openalex.org/W2087531972","https://openalex.org/W2088127162","https://openalex.org/W2088454377","https://openalex.org/W2089577633","https://openalex.org/W2089819212","https://openalex.org/W2089885033","https://openalex.org/W2094626068","https://openalex.org/W2098266560","https://openalex.org/W2101084310","https://openalex.org/W2101863964","https://openalex.org/W2103898450","https://openalex.org/W2104881278","https://openalex.org/W2105752309","https://openalex.org/W2108837056","https://openalex.org/W2109397102","https://openalex.org/W2109581113","https://openalex.org/W2111409695","https://openalex.org/W2112143708","https://openalex.org/W2114251279","https://openalex.org/W2114367134","https://openalex.org/W2114518471","https://openalex.org/W2114610817","https://openalex.org/W2115049251","https://openalex.org/W2118417839","https://openalex.org/W2123806589","https://openalex.org/W2124614417","https://openalex.org/W2125308877","https://openalex.org/W2126038274","https://openalex.org/W2126753054","https://openalex.org/W2128951348","https://openalex.org/W2129920443","https://openalex.org/W2130309466","https://openalex.org/W2137813909","https://openalex.org/W2138919554","https://openalex.org/W2140031668","https://openalex.org/W2141109897","https://openalex.org/W2143059818","https://openalex.org/W2144706342","https://openalex.org/W2144962134","https://openalex.org/W2145028145","https://openalex.org/W2145316749","https://openalex.org/W2146362841","https://openalex.org/W2146996882","https://openalex.org/W2150660378","https://openalex.org/W2151014553","https://openalex.org/W2157277459","https://openalex.org/W2158019592","https://openalex.org/W2158370459","https://openalex.org/W2159995158","https://openalex.org/W2160643377","https://openalex.org/W2162071711","https://openalex.org/W2162843292","https://openalex.org/W2166855537","https://openalex.org/W2167670081","https://openalex.org/W2168719196","https://openalex.org/W2170055510","https://openalex.org/W2175210372","https://openalex.org/W2187203158","https://openalex.org/W2316005366","https://openalex.org/W2322376825","https://openalex.org/W2324922778","https://openalex.org/W2327649074","https://openalex.org/W2328333669","https://openalex.org/W2330442656","https://openalex.org/W2331884247","https://openalex.org/W2396873152","https://openalex.org/W2409788302","https://openalex.org/W2517493656","https://openalex.org/W4256390741"],"related_works":["https://openalex.org/W2535695757","https://openalex.org/W2072856982","https://openalex.org/W1494548926","https://openalex.org/W3154069357","https://openalex.org/W6889780823","https://openalex.org/W3032426152","https://openalex.org/W3202664262","https://openalex.org/W4211080646","https://openalex.org/W2602970650","https://openalex.org/W6964762356"],"abstract_inverted_index":{"Irreversible":[0],"electroporation":[1,339],"is":[2,69,162,182,334,527],"a":[3,14,55,82,233,305,321,341,450,512,534,538,559,566],"minimally":[4,155],"invasive":[5,156],"technique":[6,120,133,319],"for":[7,134,272,327,347,366,478,587],"the":[8,33,40,43,48,64,67,72,92,101,175,180,194,246,255,364,372,416,433,443,470,487,496,521,531,553,574,581,591,613,623],"non-thermal":[9,83,130],"destruction":[10],"of":[11,17,42,50,66,202,232,350,400,418,426,436,447,498,533,593,615,625],"cells":[12,225],"in":[13,47,81,113,193,275,296,378,408,421,430,442,490,530,537,565,580,584,600],"targeted":[15,34,348],"volume":[16],"tissue,":[18,352],"using":[19,270,406,449,501],"brief":[20],"electric":[21,37,140,176,256],"pulses,":[22],"(~100":[23],"\u00b5s":[24],"long)":[25],"delivered":[26,144],"through":[27,145],"electrodes":[28],"placed":[29],"into":[30,340,511],"or":[31,218],"around":[32],"region.":[35],"These":[36],"pulses":[38,68,141,257],"destabilize":[39],"integrity":[41],"cell":[44,73],"membrane,":[45],"resulting":[46,395,579],"creation":[49],"nanoscale":[51],"defects":[52],"that":[53,85,311,375,493,541],"increase":[54],"cell\u2019s":[56],"permeability":[57],"to":[58,99,115,124,159,178,187,222,229,242,336,414,458,519,546,549,608],"exchange":[59],"with":[60,174,205,291,353,371,432],"its":[61,111,547],"environment.":[62,568],"When":[63],"energy":[65],"high":[70],"enough,":[71],"cannot":[74],"recover":[75],"from":[76,285,396,495,523],"these":[77,116,286,401,510],"effects":[78,497],"and":[79,106,157,167,196,254,267,277,299,323,361,387,391,411,464,473,508,552,561,573,622],"dies":[80],"manner":[84],"does":[86],"not":[87],"damage":[88],"neighboring":[89],"structures,":[90],"including":[91,137,383,612],"extracellular":[93],"matrix.":[94],"IRE":[95,139,271,292,367,419,499,610],"has":[96,121,226,293],"been":[97,122,227],"shown":[98,228,281],"spare":[100],"major":[102],"vasculature,":[103],"myelin":[104],"sheaths,":[105],"other":[107],"supporting":[108],"tissues,":[109,136],"permitting":[110],"use":[112,427,520],"proximity":[114,548],"vital":[117],"structures.":[118],"This":[119,358],"proposed":[123],"be":[125,143,172,230,243,259,313],"harnessed":[126],"as":[127,209],"an":[128,238,354,616],"advantageous":[129],"focal":[131],"ablation":[132,318],"diseased":[135,351],"tumors.":[138,303,357],"may":[142,171,258],"small":[146,300],"(\u00f8":[147],"\u2248":[148],"1":[149],"mm)":[150],"needle":[151,453],"electrodes,":[152],"making":[153],"treatments":[154],"easy":[158],"apply.":[160],"There":[161],"sub-millimeter":[163],"demarcation":[164],"between":[165],"treated":[166],"unaffected":[168],"cells,":[169],"which":[170,179],"correlated":[173],"field":[177],"tissue":[181,197,393,491,507],"exposed,":[183],"enabling":[184],"numerical":[185,412],"predictions":[186],"facilitate":[188],"treatment":[189,345,435,475,514,532],"planning.":[190],"Immediate":[191],"changes":[192,489],"cellular":[195],"structure":[198],"allow":[199],"real-time":[200],"monitoring":[201],"affected":[203],"volumes":[204],"imaging":[206],"techniques":[207],"such":[208],"computed":[210],"tomography,":[211,217],"magnetic":[212],"resonance":[213],"imaging,":[214],"electrical":[215],"impedance":[216],"ultrasound.":[219],"The":[220,329,398,424,517,556,597],"ability":[221,518],"kill":[223],"tumor":[224,273,389,557],"independent":[231],"functioning":[234],"immune":[235,239,620],"system,":[236],"though":[237],"response":[240,621],"seems":[241],"promoted":[244],"by":[245,251,604],"ablation.":[247],"Treatments":[248],"are":[249],"unaltered":[250],"blood":[252],"flow":[253],"administered":[260],"quickly":[261],"(~":[262],"5":[263],"min).":[264],"Recently,":[265],"safety":[266],"case":[268],"studies":[269,295],"therapy":[274,368,420,500,575],"animal":[276],"human":[278,437],"patients":[279],"have":[280],"promising":[282],"results.":[283],"Apart":[284],"new":[287],"studies,":[288],"previous":[289],"work":[290,331,410,526,598],"involved":[294],"healthy":[297],"tissues":[298],"cutaneous":[301],"experimental":[302,465],"As":[304],"result,":[306],"there":[307],"remain":[308],"significant":[309],"differences":[310],"must":[312],"considered":[314],"when":[315,369],"translating":[316],"this":[317,467,524,595,601],"towards":[320],"successful":[322,434],"reliable":[324],"therapeutic":[325,481,627],"option":[326],"patients.":[328],"dissertation":[330,468,602],"presented":[332,370,599],"here":[333],"designed":[335],"develop":[337],"irreversible":[338],"robust,":[342],"clinically":[343],"viable":[344],"modality":[346],"regions":[349],"emphasis":[355],"on":[356],"includes":[359],"examining":[360,605],"creating":[362],"proving":[363],"efficacy":[365],"many":[373],"complexities":[374],"present":[376],"themselves":[377],"real-world":[379],"clinical":[380,459],"patient":[381,540,582,619],"therapies,":[382],"heterogeneous":[384,422,567],"environments,":[385],"large":[386,535,560],"irregular":[388,562],"geometries,":[390],"dynamic":[392,488],"properties":[394,492],"treatment.":[397],"impact":[399],"factors":[402],"were":[403],"theoretically":[404],"tested":[405,529],"preliminary":[407,462],"vitro":[409],"modeling":[413],"determine":[415],"feasibility":[417,425],"systems.":[423],"was":[428,542,558,571],"validated":[429],"vivo":[431,503],"mammary":[438,444],"carcinomas":[439],"orthotopically":[440],"implanted":[441],"fat":[445],"pad":[446],"mice":[448],"simple,":[451],"single":[452],"electrode":[454],"design":[455],"easily":[456],"translatable":[457],"environments.":[460],"Following":[461],"theoretical":[463],"work,":[466],"considers":[469],"most":[471],"effective":[472],"accurate":[474],"planning":[476,515,570],"strategies":[477],"developing":[479],"optimal":[480],"outcomes.":[482],"It":[483],"also":[484],"experimentally":[485],"characterizes":[486],"result":[494],"ex":[502],"porcine":[504],"renal":[505],"cortical":[506],"incorporates":[509],"revised":[513],"model.":[516],"developments":[522],"earlier":[525],"empirically":[528],"sarcoma":[536],"canine":[539],"surgically":[543],"unresectable":[544],"due":[545],"critical":[550],"arteries":[551],"sciatic":[554],"nerve.":[555],"shape,":[563],"located":[564],"Treatment":[569],"performed":[572],"carried":[576],"out,":[577],"ultimately":[578],"being":[583],"complete":[585],"remission":[586],"14":[588],"months":[589],"at":[590],"time":[592],"composing":[594],"work.":[596],"finishes":[603],"potential":[606],"supplements":[607],"enhance":[609],"therapy,":[611],"presence":[614],"inherent":[617],"tumor-specific":[618],"addition":[624],"adjuvant":[626],"modalities.":[628]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-02-17T00:00:00"}