{"id":"https://openalex.org/W2586598060","doi":"https://doi.org/10.1182/blood.v118.21.2593.2593","title":"Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia","display_name":"Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia","publication_year":2011,"publication_date":"2011-11-18","ids":{"openalex":"https://openalex.org/W2586598060","doi":"https://doi.org/10.1182/blood.v118.21.2593.2593","mag":"2586598060"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v118.21.2593.2593","doi":"https://doi.org/10.1182/blood.v118.21.2593.2593","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v118.21.2593.2593","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113591445","display_name":"Hongbo Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbo Lu","raw_affiliation_strings":["Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079218001","display_name":"Venkata Lokesh Battula","orcid":"https://orcid.org/0000-0001-5415-9058","observed_orcids":["https://orcid.org/0000-0001-5415-9058"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Venkata Lokesh Battula","raw_affiliation_strings":["Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105421410","display_name":"Yuexi Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuexi Shi","raw_affiliation_strings":["Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028049853","display_name":"Richard B. Lock","orcid":"https://orcid.org/0000-0002-3436-9071","observed_orcids":["https://orcid.org/0000-0002-3436-9071"]},"institutions":[{"id":"https://openalex.org/I4210112315","display_name":"Children's Cancer Institute Australia","ror":"https://ror.org/01x784220","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210112315"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard B Lock","raw_affiliation_strings":["Leukemia Biology, Children's Cancer Institute Australia, Randwick, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Biology, Children's Cancer Institute Australia, Randwick, Australia,","institution_ids":["https://openalex.org/I4210112315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089482204","display_name":"Suzanne M. Spong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136455","display_name":"FibroGen (United States)","ror":"https://ror.org/03sxe1905","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136455"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suzanne Spong","raw_affiliation_strings":["FibroGen, Inc., San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroGen, Inc., San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210136455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079262854","display_name":"Michael Andreeff","orcid":"https://orcid.org/0000-0002-1144-1958","observed_orcids":["https://orcid.org/0000-0002-1144-1958"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Andreeff","raw_affiliation_strings":["Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022647201","display_name":"Marina Y Konopleva","orcid":"https://orcid.org/0000-0002-9347-2212","observed_orcids":["https://orcid.org/0000-0002-9347-2212"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Konopleva","raw_affiliation_strings":["Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079218001","https://openalex.org/A5089482204","https://openalex.org/A5105421410"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4210136455"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2767329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"21","first_page":"2593","last_page":"2593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.7670000195503235},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7129999995231628},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.8479999899864197},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9739999771118164},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/src-phosphorylation","display_name":"Src phosphorylation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ribosomal-protein-s6","display_name":"ribosomal protein S6","score":0.7720000147819519},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/building-information-modeling","display_name":"building information modeling","score":0.871999979019165},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9020000100135803},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6389999985694885},{"id":"https://openalex.org/keywords/fibronectin-adhesion","display_name":"fibronectin adhesion","score":0.8019999861717224},{"id":"https://openalex.org/keywords/rs4","display_name":"RS4","score":0.41200000047683716},{"id":"https://openalex.org/keywords/reh-cells","display_name":"REH cells","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.9887145757675171},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.644053041934967},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5598155856132507},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5156790018081665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4505307674407959},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36285191774368286},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2877656817436218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27396160364151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22672411799430847},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07199180126190186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v118.21.2593.2593","doi":"https://doi.org/10.1182/blood.v118.21.2593.2593","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v118.21.2593.2593","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2572524578","https://openalex.org/W2080481766","https://openalex.org/W1991566771","https://openalex.org/W2552626215","https://openalex.org/W2621219464","https://openalex.org/W2273141996","https://openalex.org/W1979270666","https://openalex.org/W1517503216","https://openalex.org/W2524151845","https://openalex.org/W2022338718"],"abstract_inverted_index":{"Abstract":[0,1],"2593":[2],"Connective":[3],"tissue":[4],"growth":[5,124,157,248],"factor":[6],"(CTGF/CCN2)":[7],"is":[8,36,55],"a":[9,278,308],"member":[10],"of":[11,15,40,53,77,99,109,113,121,142,183,197,202,221,223,234,251,271,293],"the":[12,70,148,232,291],"CCN":[13],"family":[14],"proteins":[16],"involved":[17],"in":[18,38,60,79,90,118,126,131,149,214,231,284,300,314],"extracellular":[19],"matrix":[20],"production,":[21],"tumor":[22],"cell":[23,123],"proliferation,":[24],"adhesion,":[25],"migration,":[26],"and":[27,49,73,92,103,128,159,201,209,227,238,249,256],"metastasis.":[28],"Recent":[29],"studies":[30],"have":[31],"shown":[32],"that":[33,50,187,245,262],"CTGF":[34,54,78,89,100,114,137,153,188,246,280,304],"expression":[35,52,222],"elevated":[37],"75%":[39],"acute":[41,315],"lymphoblastic":[42,316],"leukemia":[43,122],"(Br":[44],"J":[45],"Haematol,":[46],"2007;":[47,63],"138(6):740\u20138),":[48],"increased":[51],"associated":[56],"with":[57,219,274,297],"inferior":[58],"outcome":[59],"B-ALL":[61],"(Blood,":[62],"109(7):3080\u20133).":[64],"In":[65,147],"this":[66,301],"study,":[67],"we":[68,83],"characterized":[69],"functional":[71],"role":[72],"downstream":[74,204],"signaling":[75,184,305],"pathways":[76,185],"ALL":[80,94,252,282],"cells.":[81],"First,":[82],"utilized":[84],"lentiviral":[85],"shRNA":[86],"to":[87,134,144,166,311],"knock-down":[88],"RS4;11":[91,127,143,216],"REH":[93],"cells":[95,253],"expressing":[96,281],"high":[97],"levels":[98,233],"mRNA":[101],"(479.3\u00b137.2":[102],"57.3\u00b15.9":[104],"copies":[105,108],"per":[106],"100":[107],"ABL1,":[110],"respectively).":[111],"Silencing":[112],"(CTGF-knockdown,":[115],"CTGF-kd)":[116],"resulted":[117],"significant":[119],"suppression":[120],"(57%":[125],"by":[129],"70%":[130],"REH)":[132],"compared":[133],"control":[135],"vector.":[136],"knockdown":[138,154],"moderately":[139],"reduced":[140],"adhesion":[141],"fibronectin":[145],"(27%\u00b10.1%).":[146],"vitro":[150],"culture":[151],"system,":[152],"significantly":[155,212,267],"enhanced":[156],"inhibition":[158],"apoptosis":[160],"induction":[161],"after":[162],"48":[163],"hour":[164],"exposure":[165],"chemotherapy":[167,299],"agents":[168],"(annexinV(+):":[169],"Vincristine":[170],"25.8\u00b13.5%,":[171],"Vincristine/CTGF-kd":[172],"42.6\u00b12.8%;":[173],"Dexamethasone":[174],"66.3\u00b11.8%,":[175],"Dexamethasone/CTGF-kd":[176],"99.3\u00b10.6%;":[177],"Methotrexate,":[178],"17.4\u00b10.6%,":[179],"Methotrexate/CTGF-kd":[180],"39.5\u00b13.9).":[181],"Analysis":[182],"showed":[186],"down-regulation":[189],"inhibits":[190],"Src":[191,255],"phosphorylation":[192,196],"at":[193,199],"Tyr416.":[194],"Remarkably,":[195],"AKT":[198,224],"Ser473,":[200],"mTOR":[203],"targets":[205,225],"S6":[206],"Ribosomal":[207],"Protein":[208],"4E-BP1":[210],"were":[211,240],"inhibited":[213],"CTGF-knockdown":[215],"cells,":[217],"concomitantly":[218],"upregulation":[220],"Bim":[226],"p27.":[228],"No":[229],"changes":[230],"apoptotic":[235],"regulators":[236],"cIAP1":[237],"Bcl-xL":[239],"found.":[241],"This":[242],"data":[243],"suggest":[244],"regulates":[247],"chemosensitivity":[250],"through":[254],"AKT/mTOR":[257],"signaling.":[258],"We":[259,287],"previously":[260],"reported":[261],"an":[263],"anti-CTGF":[264,295],"monoclonal":[265],"antibody":[266],"extended":[268],"median":[269],"survival":[270],"mice":[272],"implanted":[273],"xenografts":[275],"derived":[276],"from":[277],"primary":[279],"sample":[283],"NOD/SCID":[285],"mice.":[286],"are":[288],"now":[289],"investigating":[290],"effects":[292],"combining":[294],"treatment":[296],"cytotoxic":[298,312],"model.":[302],"Blocking":[303],"may":[306],"represent":[307],"useful":[309],"adjunct":[310],"therapies":[313],"leukemia.":[317],"Disclosures:":[318],"Spong:":[319],"Fibrogen:":[320],"Employment,":[321],"Equity":[322],"Ownership.":[323]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}
