{"id":"https://openalex.org/W2586483101","doi":null,"title":"Irradiation-induced DNA strand breaks in normal hematopoietic cells and in chronic lymphocytic leukemia","display_name":"Irradiation-induced DNA strand breaks in normal hematopoietic cells and in chronic lymphocytic leukemia","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2586483101","mag":"2586483101"},"language":"en","primary_location":{"id":"pmh:oai:trepo.tuni.fi:10024/67004","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67004","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67004/1/951-44-4824-3.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://trepo.tuni.fi/bitstream/10024/67004/1/951-44-4824-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032806997","display_name":"Maarit H Myllyperki\u00f6","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maarit H Myllyperki\u00f6","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032806997"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.31299999356269836,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.9120000004768372},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/normal-hematopoietic-cells","display_name":"normal hematopoietic cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.921999990940094},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6729999780654907},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9150000214576721},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":1.0},{"id":"https://openalex.org/keywords/comet-assay","display_name":"comet assay","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.37299999594688416},{"id":"https://openalex.org/keywords/radiation-induced-dna-damage","display_name":"radiation-induced DNA damage","score":0.46799999475479126},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.4320000112056732},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.40700000524520874},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.8105997443199158},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5362842082977295},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5281293988227844},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5125874876976013},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.45140349864959717},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3879246711730957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38618820905685425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34088772535324097},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31697458028793335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2274978756904602},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.16989636421203613}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:trepo.tuni.fi:10024/67004","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67004","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67004/1/951-44-4824-3.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"pmh:oai:tampub.uta.fi:10024/67004","doi":null,"is_oa":false,"landing_page_url":"http://tampub.uta.fi/handle/10024/67004","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"mag:2586483101","doi":null,"is_oa":false,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67004","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:trepo.tuni.fi:10024/67004","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67004","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67004/1/951-44-4824-3.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326518","display_name":"Tays","ror":"https://ror.org/02hvt5f17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2586483101.pdf","grobid_xml":"https://content.openalex.org/works/W2586483101.grobid-xml"},"referenced_works_count":191,"referenced_works":["https://openalex.org/W1377731","https://openalex.org/W44973038","https://openalex.org/W49922173","https://openalex.org/W87583817","https://openalex.org/W88241752","https://openalex.org/W99640531","https://openalex.org/W110705983","https://openalex.org/W117448714","https://openalex.org/W135851248","https://openalex.org/W140075199","https://openalex.org/W163659664","https://openalex.org/W176189142","https://openalex.org/W180295822","https://openalex.org/W207432979","https://openalex.org/W233347039","https://openalex.org/W254755899","https://openalex.org/W323873274","https://openalex.org/W327514080","https://openalex.org/W625371011","https://openalex.org/W1272522950","https://openalex.org/W1483306411","https://openalex.org/W1483429575","https://openalex.org/W1520554998","https://openalex.org/W1524485065","https://openalex.org/W1552162287","https://openalex.org/W1554627281","https://openalex.org/W1556318295","https://openalex.org/W1560115849","https://openalex.org/W1572492791","https://openalex.org/W1587471612","https://openalex.org/W1588567003","https://openalex.org/W1591166893","https://openalex.org/W1758358249","https://openalex.org/W1789947960","https://openalex.org/W1805451181","https://openalex.org/W1863799659","https://openalex.org/W1876073513","https://openalex.org/W1899220633","https://openalex.org/W1917341586","https://openalex.org/W1963712961","https://openalex.org/W1964921193","https://openalex.org/W1965281971","https://openalex.org/W1969906070","https://openalex.org/W1971109667","https://openalex.org/W1972365114","https://openalex.org/W1974899954","https://openalex.org/W1977263017","https://openalex.org/W1979636924","https://openalex.org/W1980462458","https://openalex.org/W1981082946","https://openalex.org/W1984191455","https://openalex.org/W1986972235","https://openalex.org/W1987925440","https://openalex.org/W1990370246","https://openalex.org/W1991247489","https://openalex.org/W1991455005","https://openalex.org/W1992082799","https://openalex.org/W1994285603","https://openalex.org/W1995920508","https://openalex.org/W1998819200","https://openalex.org/W1999035626","https://openalex.org/W1999735484","https://openalex.org/W2000163871","https://openalex.org/W2001100951","https://openalex.org/W2002957935","https://openalex.org/W2003745314","https://openalex.org/W2004498595","https://openalex.org/W2004794384","https://openalex.org/W2007314634","https://openalex.org/W2007730927","https://openalex.org/W2010594589","https://openalex.org/W2011153759","https://openalex.org/W2012845469","https://openalex.org/W2014571977","https://openalex.org/W2014707536","https://openalex.org/W2015500565","https://openalex.org/W2016302707","https://openalex.org/W2017626786","https://openalex.org/W2018355080","https://openalex.org/W2021241545","https://openalex.org/W2021498593","https://openalex.org/W2022298895","https://openalex.org/W2025548737","https://openalex.org/W2028167976","https://openalex.org/W2028297064","https://openalex.org/W2028326016","https://openalex.org/W2029246663","https://openalex.org/W2029464576","https://openalex.org/W2030538986","https://openalex.org/W2031327241","https://openalex.org/W2032355188","https://openalex.org/W2034562422","https://openalex.org/W2036103078","https://openalex.org/W2036800150","https://openalex.org/W2037852498","https://openalex.org/W2038136941","https://openalex.org/W2038858201","https://openalex.org/W2039474501","https://openalex.org/W2039529164","https://openalex.org/W2040220442","https://openalex.org/W2040904778","https://openalex.org/W2041621304","https://openalex.org/W2041642148","https://openalex.org/W2042813346","https://openalex.org/W2043426639","https://openalex.org/W2045227320","https://openalex.org/W2047531320","https://openalex.org/W2048643069","https://openalex.org/W2049177744","https://openalex.org/W2050783603","https://openalex.org/W2051009364","https://openalex.org/W2052178794","https://openalex.org/W2052810045","https://openalex.org/W2052831715","https://openalex.org/W2056796686","https://openalex.org/W2061728264","https://openalex.org/W2063022334","https://openalex.org/W2064235474","https://openalex.org/W2067205379","https://openalex.org/W2068409711","https://openalex.org/W2072035316","https://openalex.org/W2072458893","https://openalex.org/W2072778949","https://openalex.org/W2074496226","https://openalex.org/W2076180276","https://openalex.org/W2077639080","https://openalex.org/W2077660111","https://openalex.org/W2078386567","https://openalex.org/W2078695215","https://openalex.org/W2078709642","https://openalex.org/W2082603775","https://openalex.org/W2083873600","https://openalex.org/W2083966256","https://openalex.org/W2086632920","https://openalex.org/W2088801588","https://openalex.org/W2092629964","https://openalex.org/W2094853329","https://openalex.org/W2097432692","https://openalex.org/W2099530293","https://openalex.org/W2101472561","https://openalex.org/W2112595430","https://openalex.org/W2114281142","https://openalex.org/W2114539716","https://openalex.org/W2116578026","https://openalex.org/W2118442221","https://openalex.org/W2124106713","https://openalex.org/W2124233093","https://openalex.org/W2124875813","https://openalex.org/W2126614953","https://openalex.org/W2130983726","https://openalex.org/W2134259738","https://openalex.org/W2135851757","https://openalex.org/W2136751661","https://openalex.org/W2137741723","https://openalex.org/W2139210450","https://openalex.org/W2144944910","https://openalex.org/W2156169904","https://openalex.org/W2161528623","https://openalex.org/W2167927325","https://openalex.org/W2168823709","https://openalex.org/W2172916891","https://openalex.org/W2173751778","https://openalex.org/W2207624647","https://openalex.org/W2229539623","https://openalex.org/W2244873192","https://openalex.org/W2257284526","https://openalex.org/W2311232153","https://openalex.org/W2316918699","https://openalex.org/W2329211716","https://openalex.org/W2333408219","https://openalex.org/W2340403458","https://openalex.org/W2341863517","https://openalex.org/W2343398839","https://openalex.org/W2395205108","https://openalex.org/W2399834522","https://openalex.org/W2407514301","https://openalex.org/W2407879537","https://openalex.org/W2408955560","https://openalex.org/W2409547420","https://openalex.org/W2414450679","https://openalex.org/W2426446588","https://openalex.org/W2433260158","https://openalex.org/W2443922537","https://openalex.org/W2469329273","https://openalex.org/W2470124325","https://openalex.org/W2472162196","https://openalex.org/W2475095210","https://openalex.org/W2941515424","https://openalex.org/W2988858604","https://openalex.org/W4301965537","https://openalex.org/W4318598629"],"related_works":["https://openalex.org/W3203963448","https://openalex.org/W3204760332","https://openalex.org/W629276900","https://openalex.org/W1543757523","https://openalex.org/W2288323882","https://openalex.org/W2075376362","https://openalex.org/W2574830374","https://openalex.org/W3086713968","https://openalex.org/W3183182790","https://openalex.org/W7052264254"],"abstract_inverted_index":{"Ionisoiva":[0,7],"ja":[1,13,56,66,91,104,147,152,157,164,169,185],"UV-s\u00e4teily":[2,20,72],"aiheuttavat":[3],"solujen":[4,232],"DNA:han":[5],"vaurioita.":[6,26],"s\u00e4teily":[8],"aiheuttaa":[9,21,31],"monenlaisia":[10],"DNA:n":[11,22,89,119,150,182,212],"em\u00e4s-":[12],"sokerivaurioita,":[14],"mutta":[15],"vi":[16],"katkaista":[17],"DNA-s\u00e4ikeen":[18],"suoraankin.":[19],"kaksoiskierteist\u00e4":[23],"rakennetta":[24],"v\u00e4\u00e4nt\u00e4vi\u00e4":[25],"Korjaamattomina":[27],"n\u00e4m\u00e4":[28],"vauriot":[29,69],"voivat":[30],"mutaatioita":[32],"sek\u00e4":[33,173],"vaikuttaa":[34],"sy\u00f6v\u00e4n":[35],"syntyyn.":[36],"DNA-vaurioiden":[37],"tehokas":[38],"korjaus":[39],"onkin":[40],"ensiarvoisen":[41],"t\u00e4rke\u00e4\u00e4":[42],"eli\u00f6n":[43],"elinkyvyn":[44],"yll\u00e4pit\u00e4miseksi.":[45],"Soluilla":[46],"on":[47,84,115,123],"eri":[48,120],"keinoja":[49],"vaurioiden":[50,204],"korjaamiseen.":[51,140],"T\u00e4rkeimm\u00e4t":[52],"ovat":[53,101],"nuklotidiekskiisiokorjaus":[54],"(NER)":[55],"em\u00e4sekskiisiokorjaus":[57],"(BER).":[58],"Ionisoivan":[59,179],"s\u00e4teilyn":[60,180],"aiheuttamat":[61,68],"DNA-vauriot":[62],"soluissa":[63,168,207],"korjaa":[64,70],"BER":[65],"UV-s\u00e4teilyn":[67,148],"NER.":[71],"ei":[73],"katkaise":[74],"DNA-s\u00e4iett\u00e4":[75],"suoraan,":[76],"vaan":[77],"ketjun":[78,93,154],"katkeaminen":[79],"tapahtuu":[80],"osana":[81],"korjaustapahtumaa.":[82],"Komeettamenetelm\u00e4":[83],"metodi,":[85],"jolla":[86],"voidaan":[87,108],"tutkia":[88,110],"yhden":[90,151],"kahden":[92,153],"katkoksia":[94],"yksitt\u00e4isiss\u00e4":[95],"spesifisesti":[96],"erotelluissa":[97],"soluissa.":[98,178],"Menetelm\u00e4n":[99],"etuja":[100],"nopeus,":[102],"visuaalisuus":[103],"hyv\u00e4":[105],"toistettavuus.":[106],"Komeettamenetelm\u00e4ll\u00e4":[107],"my\u00f6s":[109],"eritt\u00e4in":[111],"pieni\u00e4":[112],"solupopulaatioita.":[113],"Menetelm\u00e4":[114],"oivallinen":[116],"ty\u00f6kalu":[117],"tutkittaessa":[118],"korjausreittej\u00e4.":[121],"T\u00e4m\u00e4":[122],"mahdollista":[124],"silloin,":[125],"kun":[126],"DNA-vaurio":[127],"aiheutetaan":[128],"tunnetusti,":[129],"esimerkiksi":[130],"s\u00e4teilyll\u00e4,":[131],"jolloin":[132],"tiedet\u00e4\u00e4n,":[133],"mit\u00e4":[134],"korjausreitti\u00e4":[135],"solu":[136],"k\u00e4ytt\u00e4\u00e4":[137],"muodostuneen":[138],"vaurion":[139],"T\u00e4m\u00e4n":[141],"tutkimuksen":[142],"tarkoituksena":[143],"oli":[144,187],"kartoittaa":[145],"ionisoivan":[146],"aiheuttamien":[149,181,203],"katkosten":[155],"muodostumista":[156],"korjaantumista":[158],"ihmisen":[159],"normaaleissa":[160],"kypsiss\u00e4":[161],"verisoluissa:":[162],"lymfosyyteiss\u00e4":[163],"granulosyyteiss\u00e4,":[165],"ep\u00e4kypsiss\u00e4":[166],"luuytimen":[167,170,198],"CD34+":[171,194],"kantasoluissa":[172],"kroonisen":[174,250],"lymfaattisen":[175,251],"leukemian":[176,252],"leukeemisissa":[177],"ketjukatkosten":[183],"muodostuminen":[184],"korjaantuminen":[186,213],"yll\u00e4tt\u00e4v\u00e4n":[188],"samankaltainen":[189],"kaikissa":[190],"tutkituissa":[191],"solutyypeiss\u00e4.":[192],"Luuytimen":[193],"kantasolut":[195],"osoittautuivat":[196],"kypsempi\u00e4":[197],"soluja":[199],"tehokkaammiksi":[200],"suuren":[201],"UV-s\u00e4teilyannoksen":[202],"korjaajiksi.":[205],"Leukeemisissa":[206],"todettiin":[208],"normaaleista":[209],"soluista":[210],"poikkeava":[211],"UV-s\u00e4detyksen":[214],"j\u00e4lkeen.":[215],"24":[216],"tunnin":[217],"kuluttua":[218],"s\u00e4detyksest\u00e4":[219],"solut":[220,227],"olivat":[221,228],"muodostaneet":[222],"kaksi":[223],"ryhm\u00e4\u00e4,":[224],"joista":[225],"toisessa":[226],"apoptoottisia.":[229],"N\u00e4iden":[230],"kuolevien":[231],"osuus":[233],"saattaa":[234],"olla":[235],"yksi":[236],"m\u00e4\u00e4r\u00e4\u00e4v\u00e4":[237],"tekij\u00e4":[238],"potilaiden":[239],"s\u00e4deherkkyydess\u00e4.":[240],"On":[241],"mahdollista,":[242],"ett\u00e4":[243],"t\u00e4m\u00e4nkaltainen":[244],"tieto":[245],"auttaa":[246],"tulevaisuudessa":[247],"kehitt\u00e4m\u00e4\u00e4n":[248],"uusia":[249],"hoitomuotoja.":[253]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}
