{"id":"https://openalex.org/W2586462479","doi":"https://doi.org/10.1182/blood.v104.11.5060.5060","title":"Defective Anti-Bacterial Carbohydrate Antibody Production after Unrelated HSC Transplantation.","display_name":"Defective Anti-Bacterial Carbohydrate Antibody Production after Unrelated HSC Transplantation.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2586462479","doi":"https://doi.org/10.1182/blood.v104.11.5060.5060","mag":"2586462479"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.5060.5060","doi":"https://doi.org/10.1182/blood.v104.11.5060.5060","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.5060.5060","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067009658","display_name":"Ami J. Shah","orcid":"https://orcid.org/0000-0001-5700-6188","observed_orcids":["https://orcid.org/0000-0001-5700-6188"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ami J. Shah","raw_affiliation_strings":["Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101995182","display_name":"John E. Wagner","orcid":"https://orcid.org/0000-0003-1996-6262","observed_orcids":["https://orcid.org/0000-0003-1996-6262"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Wagner","raw_affiliation_strings":["Hematology/Oncology, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101459545","display_name":"Neena Kapoor","orcid":"https://orcid.org/0000-0002-3352-9651","observed_orcids":["https://orcid.org/0000-0002-3352-9651"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neena Kapoor","raw_affiliation_strings":["Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Raymond Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raymond Chan","raw_affiliation_strings":["Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046180673","display_name":"Kenneth I. Weinberg","orcid":"https://orcid.org/0000-0003-1922-9131","observed_orcids":["https://orcid.org/0000-0003-1922-9131"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth I. Weinberg","raw_affiliation_strings":["Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045306382","display_name":"Robertson Parkman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robertson Parkman","raw_affiliation_strings":["Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1336910626"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32352789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"11","first_page":"5060","last_page":"5060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.6718999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.6718999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.3052000105381012,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unrelated-donor-bone-marrow-transplantation","display_name":"unrelated donor bone marrow transplantation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/unrelated-cord-blood-transplantation","display_name":"unrelated cord blood transplantation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/thymic-function","display_name":"thymic function","score":0.847000002861023},{"id":"https://openalex.org/keywords/immunoglobulin-deficiency","display_name":"antibody deficiency","score":0.6019999980926514},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.706169068813324},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6398910284042358},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6005281209945679},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5764274001121521},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5305222272872925},{"id":"https://openalex.org/C2777351567","wikidata":"https://www.wikidata.org/wiki/Q908822","display_name":"Toxoid","level":4,"score":0.474410742521286},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.29964911937713623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2184690237045288}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.5060.5060","doi":"https://doi.org/10.1182/blood.v104.11.5060.5060","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.5060.5060","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978267709","https://openalex.org/W2572501531","https://openalex.org/W2101620140","https://openalex.org/W2535140827","https://openalex.org/W7057125868","https://openalex.org/W2333527985","https://openalex.org/W2750737136","https://openalex.org/W3032442863","https://openalex.org/W2041852114","https://openalex.org/W2025076935"],"abstract_inverted_index":{"Abstract":[0],"Protective":[1],"levels":[2,119,155,187,196,219,271],"of":[3,21,29,33,36,63,71,96,129,137,151,156,177,188,197,210,213,220,227,290,295,298,302,331],"anti-bacterial":[4,221,281],"carbohydrate":[5,49,222,240,282],"antibodies":[6,198],"are":[7,25,242,257,285,321],"necessary":[8],"to":[9,43,193,199,216,314,327],"protect":[10],"HSC":[11,23,215,291,304],"transplantation":[12,130],"recipients":[13,70,115,169,212,261,265,273,289,301],"from":[14],"severe":[15,30,332],"infections":[16,31],"with":[17,94,116],"encapsulated":[18],"bacteria.":[19],"Recipients":[20],"unrelated":[22,72,77,180,214,292,303],"transplants":[24,80,293],"at":[26,126,148,174],"increased":[27],"risk":[28],"regardless":[32,294],"their":[34,312],"history":[35,136],"graft":[37],"versus":[38],"host":[39],"disease":[40],"(GVHD).":[41],"Antibodies":[42],"a":[44,135,200,228,235],"naturally":[45],"occurring,":[46],"prototypic":[47],"bacterial":[48,239,333],"antigen,":[50,202],"polyribose":[51],"phosphate":[52],"(PRP),":[53],"present":[54],"in":[55,68,246,259,263,272,279,287],"Hemophilus":[56],"influenza":[57],"type":[58],"b":[59],"and":[60,76,83,98,131,253],"K100":[61],"stains":[62],"E.":[64],"coli,":[65],"were":[66,87,92,120,142,191],"measured":[67],"the":[69,127,149,175,208,211,248,288,296,329],"bone":[73],"marrow":[74],"(UBMT)":[75],"cord":[78],"blood":[79],"(UCBT).":[81],"UBMT":[82,104,264],"UCBT":[84,161,260],"recipients,":[85,105,140,162,181],"who":[86,141,182],"not":[88,133,184,225],"on":[89],"immunosuppressive":[90],"therapy,":[91],"analyzed":[93],"follow-ups":[95],"12":[97],"7":[99,163],"years,":[100],"respectively.":[101],"Of":[102,159],"20":[103],"only":[106],"3":[107,114],"had":[108,153,164],"protective":[109,117,154,165,186,195,218,268,280],"anti-PRP":[110,269],"antibody":[111,118,166,223,230,270,283],"levels.":[112],"All":[113,179],"younger":[121],"than":[122,144,262,275],"1":[123,145],"year":[124,146],"old":[125,147,171],"time":[128,150,176],"did":[132,183],"have":[134,185],"GVHD.":[138],"No":[139],"older":[143,274],"transplantation,":[152],"anti-carbohydrate":[157,189,316],"antibody.":[158],"16":[160],"levels,":[167],"including":[168],"as":[170,172],"53":[173],"UCBT.":[178],"antibodies,":[190],"able":[192],"produce":[194,217,315],"protein":[201],"tetanus":[203],"toxoid,":[204],"after":[205],"immunization.":[206],"Therefore,":[207],"inability":[209],"is":[224,234],"part":[226],"generalized":[229],"deficiency":[231],"state,":[232],"but":[233],"specific":[236],"defect.":[237],"Since":[238],"antigens":[241,245],"T":[243,254],"lymphocyte-dependent":[244],"humans,":[247],"results":[249],"indicate":[250],"that":[251],"thymic":[252],"lymphocyte":[255],"function":[256],"greater":[258],"(p=.008":[266],"for":[267,311],"age":[276],"1).":[277],"Defects":[278],"production":[284],"common":[286],"source":[297],"HSC.":[299],"The":[300],"transplants,":[305],"especially":[306],"UBMT,":[307],"should":[308],"be":[309],"tested":[310],"capacity":[313],"antibody,":[317],"and,":[318],"if":[319],"deficiencies":[320],"detected,":[322],"appropriate":[323],"prophylactic":[324],"measures":[325],"undertaken":[326],"reduce":[328],"likelihood":[330],"infections.":[334]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2017-02-17T00:00:00"}