{"id":"https://openalex.org/W2586448965","doi":"https://doi.org/10.1002/bkcs.11085","title":"Selection of DNA Aptamers Against Botulinum Neurotoxin E for Development of Fluorescent Aptasensor","display_name":"Selection of DNA Aptamers Against Botulinum Neurotoxin E for Development of Fluorescent Aptasensor","publication_year":2017,"publication_date":"2017-02-09","ids":{"openalex":"https://openalex.org/W2586448965","doi":"https://doi.org/10.1002/bkcs.11085","mag":"2586448965"},"language":"en","primary_location":{"id":"doi:10.1002/bkcs.11085","doi":"https://doi.org/10.1002/bkcs.11085","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bkcs.11085","pdf_url":null,"source":{"id":"https://openalex.org/S77209346","display_name":"Bulletin of the Korean Chemical Society","issn_l":"0253-2964","issn":["0253-2964","1229-5949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","kci-registered","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the Korean Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102205493","display_name":"Shuo Ren","orcid":"https://orcid.org/0009-0003-6948-9270","observed_orcids":["https://orcid.org/0009-0003-6948-9270"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Shuo Ren","raw_affiliation_strings":["Department of Biomedical Engineering, Dongguk University, Seoul 100-715, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Dongguk University, Seoul 100-715, Korea","institution_ids":["https://openalex.org/I205490536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102255872","display_name":"Hye-Soo Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye\u2010Soo Shin","raw_affiliation_strings":["Global Research Laboratory (GRL) for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research Laboratory (GRL) for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082985667","display_name":"Vinayakumar Gedi","orcid":"https://orcid.org/0000-0002-7042-0321","observed_orcids":["https://orcid.org/0000-0002-7042-0321"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Vinayakumar Gedi","raw_affiliation_strings":["Global Research Laboratory (GRL) for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research Laboratory (GRL) for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068461927","display_name":"Pooja Dua","orcid":"https://orcid.org/0000-0002-8045-9940","observed_orcids":["https://orcid.org/0000-0002-8045-9940"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Pooja Dua","raw_affiliation_strings":["Global Research Laboratory (GRL) for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research Laboratory (GRL) for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074471138","display_name":"Dong Ki Lee","orcid":"https://orcid.org/0000-0002-0048-9112","observed_orcids":["https://orcid.org/0000-0002-0048-9112","https://orcid.org/0000-0002-3443-5286"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dong\u2010Ki Lee","raw_affiliation_strings":["Global Research Laboratory (GRL) for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research Laboratory (GRL) for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101445770","display_name":"Soyoun Kim","orcid":"https://orcid.org/0000-0002-3824-564X","observed_orcids":["https://orcid.org/0000-0002-3824-564X"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Soyoun Kim","raw_affiliation_strings":["Department of Biomedical Engineering, Dongguk University, Seoul 100-715, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Dongguk University, Seoul 100-715, Korea","institution_ids":["https://openalex.org/I205490536"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074471138","https://openalex.org/A5101445770"],"corresponding_institution_ids":["https://openalex.org/I205490536","https://openalex.org/I848706"],"apc_list":{"value":3470,"currency":"USD","value_usd":3470},"apc_paid":null,"fwci":0.3349,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.53851772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"38","issue":"3","first_page":"324","last_page":"328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-neurotoxin-e","display_name":"botulinum neurotoxin E","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dna-aptamers","display_name":"DNA aptamers","score":0.9610000252723694},{"id":"https://openalex.org/keywords/selex","display_name":"SELEX","score":0.8730000257492065},{"id":"https://openalex.org/keywords/fluorescent-aptasensor","display_name":"fluorescent aptasensor","score":0.9190000295639038},{"id":"https://openalex.org/keywords/graphene-oxide","display_name":"graphene oxide","score":0.703000009059906},{"id":"https://openalex.org/keywords/botulinum-toxin-detection","display_name":"botulinum toxin detection","score":0.734000027179718},{"id":"https://openalex.org/keywords/clostridium-botulinum","display_name":"Clostridium botulinum","score":0.847000002861023},{"id":"https://openalex.org/keywords/bioterrorism-agents","display_name":"bioterrorism agents","score":0.7369999885559082},{"id":"https://openalex.org/keywords/aptamer-binding-affinity","display_name":"aptamer binding affinity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/biolayer-interferometry","display_name":"biolayer interferometry","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9884486198425293},{"id":"https://openalex.org/C122682173","wikidata":"https://www.wikidata.org/wiki/Q907101","display_name":"Systematic evolution of ligands by exponential enrichment","level":4,"score":0.841658353805542},{"id":"https://openalex.org/C2777010668","wikidata":"https://www.wikidata.org/wiki/Q131268","display_name":"Clostridium botulinum","level":3,"score":0.7314929962158203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6312820315361023},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5697649717330933},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5329234600067139},{"id":"https://openalex.org/C2777351567","wikidata":"https://www.wikidata.org/wiki/Q908822","display_name":"Toxoid","level":4,"score":0.45464807748794556},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.44893699884414673},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3777843117713928},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3751579523086548},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3627619743347168},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.32665205001831055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23723703622817993},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2152143120765686},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13885700702667236},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11988255381584167},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0832357108592987},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/bkcs.11085","doi":"https://doi.org/10.1002/bkcs.11085","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bkcs.11085","pdf_url":null,"source":{"id":"https://openalex.org/S77209346","display_name":"Bulletin of the Korean Chemical Society","issn_l":"0253-2964","issn":["0253-2964","1229-5949"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","kci-registered","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the Korean Chemical Society","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322007","display_name":"Ministry of Environment","ror":"https://ror.org/04xmt0833"},{"id":"https://openalex.org/F4320323103","display_name":"Agency for Defense Development","ror":"https://ror.org/05fhe0r85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W16590836","https://openalex.org/W1921158802","https://openalex.org/W1968987000","https://openalex.org/W2001474817","https://openalex.org/W2011093050","https://openalex.org/W2013779288","https://openalex.org/W2015400256","https://openalex.org/W2017060659","https://openalex.org/W2018010004","https://openalex.org/W2035498423","https://openalex.org/W2039418825","https://openalex.org/W2039904359","https://openalex.org/W2061700744","https://openalex.org/W2064566811","https://openalex.org/W2079321730","https://openalex.org/W2082166203","https://openalex.org/W2082734948","https://openalex.org/W2088808595","https://openalex.org/W2089998956","https://openalex.org/W2104788883","https://openalex.org/W2115146730","https://openalex.org/W2116973295","https://openalex.org/W2124395350","https://openalex.org/W2137889830","https://openalex.org/W2141157874","https://openalex.org/W2147786402","https://openalex.org/W2337321132"],"related_works":["https://openalex.org/W4403885831","https://openalex.org/W2011093050","https://openalex.org/W3035965809","https://openalex.org/W2015400256","https://openalex.org/W4411275900","https://openalex.org/W2082166203","https://openalex.org/W7203791563","https://openalex.org/W3048509323","https://openalex.org/W2337321132","https://openalex.org/W2480900211"],"abstract_inverted_index":{"Botulinum":[0],"neurotoxins":[1],"(BoNTs)":[2],"produced":[3],"by":[4],"Clostridium":[5],"botulinum":[6],"are":[7,37],"the":[8,23,40,88,98,117],"deadliest":[9],"toxins":[10],"known":[11],"to":[12,22,53],"mankind":[13],"with":[14,136],"a":[15,29,47,68,113,122,133],"potential":[16],"of":[17,26,115,149],"possible":[18],"bioterrorism":[19],"agents.":[20],"Due":[21],"high\u2010potential":[24],"harm":[25],"these":[27],"toxins,":[28],"sensitive":[30,150],"and":[31,87,131],"real\u2010time":[32],"monitoring":[33],"capable":[34],"detection":[35,125,151],"systems":[36],"required":[38],"for":[39,147],"early":[41],"stage":[42],"detection.":[43],"In":[44,127],"this":[45],"study,":[46],"novel":[48],"sol\u2013gel\u2010based":[49],"SELEX":[50],"was":[51,119],"used":[52,146],"isolate":[54],"single\u2010stranded":[55],"nucleic":[56],"acids":[57],"(ssDNA)":[58],"aptamers":[59,91],"against":[60],"purified":[61],"BoNT":[62],"type":[63],"E":[64],"toxoid":[65],"(BoNTE)":[66],"using":[67,84,94],"chemically":[69],"synthesized":[70],"random":[71],"N40":[72],"ssDNA":[73,134],"library.":[74],"The":[75],"bound":[76],"aptamer":[77,100,118,135],"sequences":[78],"after":[79],"five":[80],"rounds":[81],"were":[82,92],"analyzed":[83],"next\u2010generation":[85],"sequencing":[86],"resulted":[89],"high\u2010frequency":[90],"characterized":[93],"biolayer":[95],"interferometry.":[96],"Among":[97],"tested,":[99],"BT5.6":[101],"showed":[102],"low":[103],"nanomolar":[104],"binding":[105],"affinity":[106,138],"(KD,":[107],"53.3":[108],"nM)":[109],"toward":[110,139],"BoNTE.":[111],"As":[112],"proof":[114],"concept,":[116],"utilized":[120],"in":[121],"graphene":[123],"oxide\u2010based":[124],"platform.":[126],"summary,":[128],"we":[129,142],"screened":[130],"identified":[132],"high":[137],"BoNTE,":[140],"which,":[141],"believe":[143],"can":[144],"be":[145],"development":[148],"systems.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-02-17T00:00:00"}
