{"id":"https://openalex.org/W2586416458","doi":null,"title":"Genomics-Based Analysis of Antibody Response to Sheep Red Blood Cells in Chickens","display_name":"Genomics-Based Analysis of Antibody Response to Sheep Red Blood Cells in Chickens","publication_year":2007,"publication_date":"2007-05-18","ids":{"openalex":"https://openalex.org/W2586416458","mag":"2586416458"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/27914","doi":null,"is_oa":true,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-05292007-123730/","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/111653dc-9e58-4da9-8edb-0a1f09f81c73/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://vtechworks.lib.vt.edu/bitstreams/111653dc-9e58-4da9-8edb-0a1f09f81c73/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109293250","display_name":"Tuoyu Geng","orcid":"https://orcid.org/0000-0001-5619-8181","observed_orcids":["https://orcid.org/0000-0001-5619-8181"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tuoyu Geng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109293250"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sheep-red-blood-cells","display_name":"sheep red blood cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/genetic-control-of-immunity","display_name":"genetic control of immunity","score":0.6800000071525574},{"id":"https://openalex.org/keywords/polygenic-inheritance","display_name":"polygenic inheritance","score":0.6520000100135803},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.7519999742507935},{"id":"https://openalex.org/keywords/divergent-selection","display_name":"divergent selection","score":0.6990000009536743},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.847000002861023},{"id":"https://openalex.org/keywords/sequence-characterized-amplified-region","display_name":"sequence characterized amplified region","score":0.8759999871253967},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.4729999899864197},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.6909999847412109},{"id":"https://openalex.org/keywords/immune-response-genetics","display_name":"immune response genetics","score":0.3840000033378601},{"id":"https://openalex.org/keywords/marker-assisted-selection","display_name":"marker-assisted selection","score":0.5479999780654907},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5445393323898315},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5099083185195923},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.48226314783096313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46444466710090637},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38942477107048035},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3826597034931183},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28537100553512573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19289660453796387},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.18439218401908875}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/27914","doi":null,"is_oa":true,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-05292007-123730/","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/111653dc-9e58-4da9-8edb-0a1f09f81c73/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2586416458","doi":null,"is_oa":false,"landing_page_url":"https://vtechworks.lib.vt.edu/handle/10919/27914","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/27914","doi":null,"is_oa":true,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-05292007-123730/","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/111653dc-9e58-4da9-8edb-0a1f09f81c73/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.6735000014305115,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2586416458.pdf","grobid_xml":"https://content.openalex.org/works/W2586416458.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W2081632","https://openalex.org/W177019528","https://openalex.org/W1501778305","https://openalex.org/W1524948073","https://openalex.org/W1582628935","https://openalex.org/W1583476286","https://openalex.org/W1669012339","https://openalex.org/W1829148295","https://openalex.org/W1847694155","https://openalex.org/W1935910619","https://openalex.org/W1972325113","https://openalex.org/W1973880013","https://openalex.org/W1979979725","https://openalex.org/W1986203187","https://openalex.org/W1986916893","https://openalex.org/W1989259989","https://openalex.org/W1989979293","https://openalex.org/W1992108607","https://openalex.org/W1997276741","https://openalex.org/W1999966048","https://openalex.org/W2007489588","https://openalex.org/W2018716249","https://openalex.org/W2020592248","https://openalex.org/W2022452100","https://openalex.org/W2026349732","https://openalex.org/W2028671182","https://openalex.org/W2032165441","https://openalex.org/W2032923498","https://openalex.org/W2045360275","https://openalex.org/W2045370896","https://openalex.org/W2046875666","https://openalex.org/W2051037450","https://openalex.org/W2051662558","https://openalex.org/W2052901856","https://openalex.org/W2053818267","https://openalex.org/W2054131098","https://openalex.org/W2059484857","https://openalex.org/W2060677532","https://openalex.org/W2062082512","https://openalex.org/W2062276015","https://openalex.org/W2063343975","https://openalex.org/W2066327574","https://openalex.org/W2072926823","https://openalex.org/W2073917725","https://openalex.org/W2074161066","https://openalex.org/W2075413744","https://openalex.org/W2076313382","https://openalex.org/W2077809663","https://openalex.org/W2078225503","https://openalex.org/W2084185832","https://openalex.org/W2094845766","https://openalex.org/W2096995317","https://openalex.org/W2106630193","https://openalex.org/W2106713259","https://openalex.org/W2107504433","https://openalex.org/W2111220263","https://openalex.org/W2111648895","https://openalex.org/W2114587365","https://openalex.org/W2125111830","https://openalex.org/W2127220612","https://openalex.org/W2128312644","https://openalex.org/W2130530904","https://openalex.org/W2133449490","https://openalex.org/W2146838779","https://openalex.org/W2150926065","https://openalex.org/W2152626773","https://openalex.org/W2157750697","https://openalex.org/W2159365979","https://openalex.org/W2162375220","https://openalex.org/W2164075646","https://openalex.org/W2164847431","https://openalex.org/W2165178527","https://openalex.org/W2170240282","https://openalex.org/W2323810580","https://openalex.org/W2328036634","https://openalex.org/W2415360490","https://openalex.org/W7099069770"],"related_works":["https://openalex.org/W2028290120","https://openalex.org/W1844259805","https://openalex.org/W177718138","https://openalex.org/W1990556214","https://openalex.org/W2018716249","https://openalex.org/W2271303405","https://openalex.org/W2510095066","https://openalex.org/W4408572888","https://openalex.org/W2083498751","https://openalex.org/W2008970819"],"abstract_inverted_index":{"Immune":[0],"response":[1,23,31,43,84,142],"provides":[2],"vertebrates":[3],"an":[4,54],"important":[5],"mechanism":[6],"to":[7,11,34,44,60,77,90,100,111,143,211,225,233,258,334],"fight":[8],"pathogens":[9],"and":[10,104,110,155,176,195,238,273,307,348,367],"reduce":[12],"the":[13,18,29,58,113,134,167,185,202,216,235,252,282,286,296,304,324,380],"incidence":[14],"of":[15,21,32,72,120,139,152,161,170,184,205,215,219,228,251,281,303,315,323,342,382],"diseases.":[16],"Defining":[17],"molecular":[19,62],"basis":[20],"antibody":[22,40,386],"may":[24,376],"facilitate":[25],"genetic":[26,137],"improvement":[27],"in":[28,42,57,85,116,166,285,295,328],"immune":[30,67],"animals":[33],"pathogens.":[35],"For":[36],"almost":[37],"4":[38,203],"decades,":[39],"titers":[41,183],"challenge":[45],"by":[46,244],"sheep":[47],"red":[48],"blood":[49],"cells":[50],"(anti-SRBC)":[51],"have":[52,335],"provided":[53],"investigative":[55],"tool":[56],"efforts":[59],"define":[61],"mechanisms":[63],"that":[64,136,363,375,384],"underlie":[65,385],"vertebrate":[66],"response.":[68,130,387],"The":[69,147,180],"overall":[70],"objective":[71],"this":[73,359],"dissertation":[74,360],"research":[75],"was":[76,256],"identify":[78,101],"DNA":[79,102],"markers":[80,103,122],"associated":[81,106,123,290],"with":[82,107,124,191,277,292],"anti-SRBC":[83,129,182,240,293,309,350],"chickens.":[86],"Specific":[87],"objectives":[88,132],"were:":[89],"develop":[91],"a":[92,140,259,313],"resource":[93,148,298],"population":[94,149],"for":[95,98,173,193,197,201,275,379],"QTL":[96],"analysis":[97,302],"anti-SRBC,":[99,109],"genes":[105,331,374,383],"primary":[108],"evaluate":[112],"allelic":[114],"frequencies":[115],"non-selected":[117],"chicken":[118],"populations":[119],"candidate":[121,365],"either":[125],"high":[126,177],"or":[127],"low":[128,174],"These":[131],"tested":[133,274],"hypothesis":[135],"control":[138],"chicken's":[141],"SRBC":[144],"is":[145],"polygenic.":[146],"developed":[150],"consisted":[151],"F1,":[153],"backcross,":[154],"F2":[156,206],"derived":[157],"from":[158,163,209,223,301,346],"reciprocal":[159],"crosses":[160],"birds":[162,351],"parental":[164,186,236,287,305],"lines":[165,187,241,288,310],"28th":[168],"generation":[169],"divergent":[171],"selection":[172],"(L)":[175],"(H)":[178],"anti-SRBC.":[179,278],"mean":[181],"were":[188,242,271,289,319,327],"significantly":[189],"different,":[190],"11.5":[192],"H":[194,237,308,349],"2.6":[196],"L":[198,239,306,347],"(P<0.05).":[199],"That":[200],"groups":[204,218],"progeny":[207,221],"ranged":[208,222],"6.3":[210],"7.5,":[212],"while":[213],"those":[214],"8":[217],"backcross":[220,297],"3.9":[224],"13.3.":[226],"Four":[227],"555":[229],"random":[230],"primers":[231],"used":[232],"screen":[234],"informative":[243],"amplifying":[245],"seven":[246,283],"line-specific":[247,254,317,325],"fragments":[248,255],"(P<0.0025).":[249],"Each":[250],"7":[253],"converted":[257],"sequence":[260],"characterized":[261],"amplified":[262],"region":[263],"(SCAR)":[264],"within":[265],"which":[266],"single":[267],"nucleotide":[268],"polymorphisms":[269],"(SNPs)":[270],"identified":[272,352],"association":[276],"Only":[279],"two":[280],"SCARs":[284,366],"(P<0.05)":[291],"level":[294],"population.":[299],"Additionally,":[300],"using":[311],"microarrays,":[312],"total":[314],"57":[316],"SNPs":[318,326,368],"also":[320],"identified.":[321],"Twenty":[322],"and/or":[329],"near":[330],"previously":[332],"reported":[333],"immunity-related":[336],"function.":[337],"Microarray-based":[338],"gene":[339],"expression":[340],"profiling":[341],"pooled":[343],"RNA":[344],"samples":[345],"three":[353],"differentially":[354,372],"expressed":[355,373],"genes.":[356],"In":[357],"summary,":[358],"describes":[361],"resources":[362],"include":[364],"as":[369,371],"well":[370],"be":[377],"useful":[378],"identification":[381]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}
