{"id":"https://openalex.org/W2586217554","doi":"https://doi.org/10.1016/j.ygeno.2017.01.006","title":"Analysis of steric effects in DamID profiling of transcription factor target genes","display_name":"Analysis of steric effects in DamID profiling of transcription factor target genes","publication_year":2017,"publication_date":"2017-02-08","ids":{"openalex":"https://openalex.org/W2586217554","doi":"https://doi.org/10.1016/j.ygeno.2017.01.006","mag":"2586217554","pmid":"https://pubmed.ncbi.nlm.nih.gov/28189763"},"language":"en","primary_location":{"id":"doi:10.1016/j.ygeno.2017.01.006","doi":"https://doi.org/10.1016/j.ygeno.2017.01.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygeno.2017.01.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S088875431730006X/pdf","source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S088875431730006X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005850694","display_name":"Mirana Ramialison","orcid":"https://orcid.org/0000-0001-6315-4777","observed_orcids":["https://orcid.org/0000-0001-6315-4777"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]},{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mirana Ramialison","raw_affiliation_strings":["Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia; Systems Biology Institute, Australia","Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia","Systems Biology Institute, Australia","Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia; Systems Biology Institute, Australia","institution_ids":["https://openalex.org/I19514445","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Systems Biology Institute, Australia","institution_ids":[]},{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia","institution_ids":["https://openalex.org/I19514445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019822945","display_name":"Ashley J. Waardenberg","orcid":"https://orcid.org/0000-0002-9382-7490","observed_orcids":["https://orcid.org/0000-0002-9382-7490"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]},{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ashley J. Waardenberg","raw_affiliation_strings":["Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; Children's Medical Research Institute, University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia","Children's Medical Research Institute, University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia","Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; Children's Medical Research Institute, University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I146584863","https://openalex.org/I19514445"]},{"raw_affiliation_string":"Children's Medical Research Institute, University of Sydney, 214 Hawkesbury Road, Westmead, NSW 2145, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I146584863"]},{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia","institution_ids":["https://openalex.org/I19514445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021245416","display_name":"Nicole Sch\u00f6nrock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicole Schonrock","raw_affiliation_strings":["Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia","Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia","St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia","institution_ids":["https://openalex.org/I136750679","https://openalex.org/I31746571"]},{"raw_affiliation_string":"Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia","institution_ids":["https://openalex.org/I136750679"]},{"raw_affiliation_string":"St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074497233","display_name":"Tram B. Doan","orcid":"https://orcid.org/0000-0002-4530-6447","observed_orcids":["https://orcid.org/0000-0002-4530-6447"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tram Doan","raw_affiliation_strings":["Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia","institution_ids":["https://openalex.org/I19514445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031730079","display_name":"Dani\u00eblle de Jong","orcid":"https://orcid.org/0000-0003-4003-5593","observed_orcids":["https://orcid.org/0000-0003-4003-5593"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Danielle de Jong","raw_affiliation_strings":["Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia","institution_ids":["https://openalex.org/I19514445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008556225","display_name":"Romaric Bouveret","orcid":"https://orcid.org/0000-0002-3141-5167","observed_orcids":["https://orcid.org/0000-0002-3141-5167"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Romaric Bouveret","raw_affiliation_strings":["Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia. Electronic address: r.bouveret@victorchang.edu.au","St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia","Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3141-5167","affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia. Electronic address: r.bouveret@victorchang.edu.au","institution_ids":["https://openalex.org/I19514445","https://openalex.org/I31746571"]},{"raw_affiliation_string":"St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia","institution_ids":["https://openalex.org/I19514445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061874736","display_name":"Richard Paul Harvey","orcid":"https://orcid.org/0000-0002-9950-9792","observed_orcids":["https://orcid.org/0000-0002-9950-9792"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Richard P. Harvey","raw_affiliation_strings":["Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington 2052, Australia. Electronic address: r.harvey@victorchang.edu.au","School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington 2052, Australia","St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia","Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington 2052, Australia. Electronic address: r.harvey@victorchang.edu.au","institution_ids":["https://openalex.org/I19514445","https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington 2052, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia","institution_ids":["https://openalex.org/I19514445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008556225","https://openalex.org/A5061874736"],"corresponding_institution_ids":["https://openalex.org/I19514445","https://openalex.org/I31746571"],"apc_list":{"value":2980,"currency":"USD","value_usd":2980},"apc_paid":{"value":2980,"currency":"USD","value_usd":2980},"fwci":0.3967,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.54193225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"109","issue":"2","first_page":"75","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/damid","display_name":"DamID","score":0.7820000052452087},{"id":"https://openalex.org/keywords/steric-effects","display_name":"steric effects","score":0.8899999856948853},{"id":"https://openalex.org/keywords/transcriptional-targets","display_name":"transcription factor target genes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/nkx2-5","display_name":"Nkx2.5","score":0.8980000019073486},{"id":"https://openalex.org/keywords/srf","display_name":"SRF","score":0.9919999837875366},{"id":"https://openalex.org/keywords/elk-1","display_name":"Elk-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/elk4","display_name":"ELK4","score":1.0},{"id":"https://openalex.org/keywords/dna-adenine-methyltransferase","display_name":"DNA adenine methyltransferase","score":0.781000018119812},{"id":"https://openalex.org/keywords/homeodomain","display_name":"homeodomain","score":0.5950000286102295},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chromatin-binding","display_name":"chromatin binding","score":0.4620000123977661},{"id":"https://openalex.org/keywords/cardiac-transcription-factors","display_name":"cardiac transcription factors","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.797174334526062},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6740012168884277},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.669498860836029},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.6363487243652344},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5736732482910156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5453592538833618},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5080044865608215},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.46087247133255005},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4575064182281494},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42460909485816956},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39767956733703613},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35254260897636414},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.1391322910785675},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13690775632858276},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.07683864235877991},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072576","descriptor_name":"Homeobox Protein Nkx-2.5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015265","descriptor_name":"Site-Specific DNA-Methyltransferase (Adenine-Specific)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026362","descriptor_name":"Serum Response Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050807","descriptor_name":"ets-Domain Protein Elk-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050808","descriptor_name":"ets-Domain Protein Elk-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ygeno.2017.01.006","doi":"https://doi.org/10.1016/j.ygeno.2017.01.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygeno.2017.01.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S088875431730006X/pdf","source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},{"id":"pmid:28189763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28189763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.jcu.edu.au:55655","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.jcu.edu.au/55655/1/55655_Ramialison_et_al_2017.pdf","pdf_url":"https://researchonline.jcu.edu.au/55655/1/55655_Ramialison_et_al_2017.pdf","source":{"id":"https://openalex.org/S4377196350","display_name":"ResearchOnline - JCU (James Cook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86467917","host_organization_name":"James Cook University","host_organization_lineage":["https://openalex.org/I86467917"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.ygeno.2017.01.006","doi":"https://doi.org/10.1016/j.ygeno.2017.01.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygeno.2017.01.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S088875431730006X/pdf","source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1030457190","display_name":"Gene regulatory networks in heart development","funder_award_id":"DP0988507","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G2448116343","display_name":"Genome-wide analysis of gene regulatory networks in heart development and congenital heart disease","funder_award_id":"1121172","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2742345854","display_name":null,"funder_award_id":"19131","funder_id":"https://openalex.org/F4320307859","funder_display_name":"Atlantic Philanthropies"},{"id":"https://openalex.org/G2990982191","display_name":"Dynamics of the Nuclear Pore Proteins and the Mechanism of Transport","funder_award_id":"1121172","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3152892380","display_name":"Probing the Cardiac Gene Regulatory Network in Development and Congenital Heart Disease","funder_award_id":"1061539","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G4486801105","display_name":"Australia Fellowship","funder_award_id":"573705","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G5612225981","display_name":"Old genes learning new tricks: characterising regulatory changes driving increased heart complexity during vertebrate evolution","funder_award_id":"DP140101067","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G6838078222","display_name":"Molecular Approaches to Cardiac Development, Disease and Regeneration","funder_award_id":"1118576","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7052472536","display_name":"Genetic pathways in heart development and congential heart disease","funder_award_id":"573703","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7349970753","display_name":"Unravelling gene networks in heart development and congenital heart disease","funder_award_id":"1049980","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8093928432","display_name":"Transcriptional control of lineage specification in the developing heart","funder_award_id":"111553","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320307859","display_name":"Atlantic Philanthropies","ror":"https://ror.org/03ca35056"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2586217554.pdf","grobid_xml":"https://content.openalex.org/works/W2586217554.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W45534775","https://openalex.org/W610887637","https://openalex.org/W1506160581","https://openalex.org/W1788080342","https://openalex.org/W1927621349","https://openalex.org/W1964733653","https://openalex.org/W1967656072","https://openalex.org/W1976871677","https://openalex.org/W1979353384","https://openalex.org/W1988393300","https://openalex.org/W1994446230","https://openalex.org/W2033800157","https://openalex.org/W2033871452","https://openalex.org/W2036145288","https://openalex.org/W2060399360","https://openalex.org/W2069368388","https://openalex.org/W2090880234","https://openalex.org/W2116467413","https://openalex.org/W2116634113","https://openalex.org/W2119805681","https://openalex.org/W2121036654","https://openalex.org/W2123490534","https://openalex.org/W2129061533","https://openalex.org/W2129593538","https://openalex.org/W2129816618","https://openalex.org/W2136430672","https://openalex.org/W2141222206","https://openalex.org/W2145010689","https://openalex.org/W2145906336","https://openalex.org/W2151570111","https://openalex.org/W2155583879","https://openalex.org/W2168390964","https://openalex.org/W2524206329","https://openalex.org/W2744357375","https://openalex.org/W4210347168"],"related_works":["https://openalex.org/W2785823495","https://openalex.org/W2272753924","https://openalex.org/W1573323739","https://openalex.org/W2951536505","https://openalex.org/W2528062088","https://openalex.org/W2287383975","https://openalex.org/W6945689200","https://openalex.org/W4210440526","https://openalex.org/W4386530763","https://openalex.org/W7018308376"],"abstract_inverted_index":{"DNA":[0,11,22,40],"adenine":[1,23],"methyltransferase":[2,24],"identification":[3],"(DamID)":[4],"is":[5,90,134],"an":[6],"enzymatic":[7],"technology":[8],"for":[9,72],"detecting":[10],"regions":[12,41],"targeted":[13],"by":[14,43,62],"chromatin-associated":[15],"proteins.":[16],"Proteins":[17],"are":[18],"fused":[19],"to":[20,38,136],"bacterial":[21],"(Dam)":[25],"and":[26,50,52,56,67,78,144],"expressed":[27],"in":[28,84,142],"cultured":[29],"cells":[30],"or":[31],"whole":[32],"organisms.":[33],"Here,":[34],"we":[35],"used":[36],"DamID":[37,89],"detect":[39],"bound":[42,61],"the":[44,94,102,105,119,140,145],"cardiac-restricted":[45],"transcription":[46],"factors":[47],"(TFs)":[48],"NKX2-5":[49,77,116],"SRF,":[51],"ubiquitously-expressed":[53],"co-factors":[54],"ELK1":[55],"ELK4.":[57],"We":[58],"compared":[59],"targets":[60],"these":[63],"TFs":[64],"as":[65],"N-":[66],"C-terminal":[68],"fusions":[69,99],"with":[70],"Dam,":[71],"both":[73],"wild":[74],"type":[75],"(WT)":[76],"mutant":[79,117],"proteins":[80],"mimicking":[81],"those":[82],"found":[83],"congenital":[85],"heart":[86],"disease.":[87],"Overall,":[88],"highly":[91],"robust:":[92],"while":[93],"orientation":[95,146],"of":[96,104,131,147],"WT":[97],"Dam":[98,148],"can":[100],"affect":[101],"size":[103],"target":[106,127],"sets,":[107],"their":[108],"signatures":[109],"remained":[110],"largely":[111],"reproducible.":[112],"Furthermore,":[113],"a":[114],"severe":[115],"lacking":[118],"homeodomain":[120],"showed":[121],"strong":[122],"steric":[123,132],"effects":[124],"negatively":[125],"impacting":[126],"discovery.":[128],"The":[129],"extent":[130],"effect":[133],"likely":[135],"be":[137],"dependent":[138],"on":[139],"protein":[141],"question":[143],"fusion.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2017-02-17T00:00:00"}