{"id":"https://openalex.org/W258614243","doi":null,"title":"Acrolein as a novel therapeutic target for spinal cord injury induced neuropathic pain","display_name":"Acrolein as a novel therapeutic target for spinal cord injury induced neuropathic pain","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W258614243","mag":"258614243"},"language":"en","primary_location":{"id":"pmh:oai:docs.lib.purdue.edu:dissertations-15954","doi":null,"is_oa":false,"landing_page_url":"https://docs.lib.purdue.edu/dissertations/AAI3688545","pdf_url":null,"source":{"id":"https://openalex.org/S4377196310","display_name":"Purdue e-Pubs (Purdue University System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801333002","host_organization_name":"Purdue University System","host_organization_lineage":["https://openalex.org/I2801333002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations Available from ProQuest","raw_type":"text"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067817905","display_name":"Jonghyuck Park","orcid":"https://orcid.org/0000-0003-2040-0063","observed_orcids":["https://orcid.org/0000-0003-2040-0063"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonghyuck Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2040-0063","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067817905"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acrolein","display_name":"acrolein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/trpa1","display_name":"TRPA1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7009999752044678},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.9049999713897705},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hydralazine","display_name":"hydralazine","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.8725118637084961},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6553603410720825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6466639637947083},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.48780015110969543},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44464224576950073},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10255536437034607}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:docs.lib.purdue.edu:dissertations-15954","doi":null,"is_oa":false,"landing_page_url":"https://docs.lib.purdue.edu/dissertations/AAI3688545","pdf_url":null,"source":{"id":"https://openalex.org/S4377196310","display_name":"Purdue e-Pubs (Purdue University System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801333002","host_organization_name":"Purdue University System","host_organization_lineage":["https://openalex.org/I2801333002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations Available from ProQuest","raw_type":"text"},{"id":"pmh:oai:docs.lib.purdue.edu:open_access_dissertations-1467","doi":null,"is_oa":false,"landing_page_url":"https://docs.lib.purdue.edu/open_access_dissertations/342","pdf_url":null,"source":{"id":"https://openalex.org/S4377196310","display_name":"Purdue e-Pubs (Purdue University System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801333002","host_organization_name":"Purdue University System","host_organization_lineage":["https://openalex.org/I2801333002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Dissertations","raw_type":"text"},{"id":"mag:258614243","doi":null,"is_oa":false,"landing_page_url":"https://docs.lib.purdue.edu/cgi/viewcontent.cgi?article=1467&context=open_access_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050646124","https://openalex.org/W2806239239","https://openalex.org/W1829280981","https://openalex.org/W2617768567","https://openalex.org/W2323281653","https://openalex.org/W2969244040","https://openalex.org/W2069433716","https://openalex.org/W2189092746","https://openalex.org/W4413998166","https://openalex.org/W1549621074"],"abstract_inverted_index":{"Despite":[0],"years":[1],"of":[2,19,53,60,94,142,161,173,183,189,218],"research,":[3],"post-spinal":[4],"cord":[5],"injury":[6],"(SCI)":[7],"chronic":[8],"neuropathic":[9,33],"pain":[10,34,106,132],"remains":[11],"refractory":[12],"to":[13,32,130,177,192,213,220],"treatment":[14,102],"and":[15,28,51,66,70,98,159,215],"drastically":[16],"impairs":[17],"quality":[18],"life":[20],"for":[21],"SCI":[22,207],"victims":[23],"beyond":[24],"paralysis.":[25],"Although":[26],"inflammation":[27],"free":[29],"radicals":[30],"contribute":[31],"in":[35,126,180,204],"SCI,":[36],"the":[37,73,92,181,205],"mechanism":[38],"is":[39,81,112,151],"not":[40],"completely":[41],"clear.":[42],"We":[43],"have":[44,77,137],"recently":[45],"demonstrated":[46],"that":[47,79,116,150],"acrolein,":[48,184],"a":[49,57,113,139,147,169],"product":[50],"catalyst":[52],"lipid":[54],"peroxidation,":[55],"induces":[56],"vicious":[58],"cycle":[59],"oxidative":[61,68],"stress,":[62],"amplifying":[63],"its":[64],"effects":[65],"perpetuating":[67],"stress":[69],"inflammation.":[71],"In":[72,134,196],"current":[74,178],"study,":[75],"we":[76,136,167],"confirmed":[78],"acrolein":[80,111,157,193,198,221],"elevated":[82],"significantly":[83],"at":[84],"least":[85],"two":[86],"weeks":[87],"post-SCI":[88],"which":[89],"coincides":[90],"with":[91,109],"emergence":[93],"hyperalgesia":[95,208],"(mechanical,":[96],"cold":[97],"thermal).":[99],"Furthermore,":[100],"anti-acrolein":[101],"hydalazine":[103],"can":[104],"reverse":[105],"behavior.":[107],"Consistent":[108],"this,":[110],"known":[114,153],"ligand":[115],"directly":[117],"excites":[118],"transient":[119],"receptor":[120,124],"potential":[121],"ankyrin":[122],"1":[123],"(TRPA1)":[125],"DRG":[127,174,190,219],"nociceptive":[128],"neurons":[129,176],"transmit":[131],"sensation.":[133],"addition,":[135],"observed":[138,168],"significant":[140],"increase":[141],"monocyte":[143],"chemoattractant":[144],"protein-1":[145],"(MCP1),":[146],"pro-inflammatory":[148],"chemokine":[149],"also":[152],"be":[154],"increased":[155],"upon":[156],"stimulation":[158,179],"capable":[160],"sensitizing":[162],"TRPA1":[163,214],"following":[164],"SCI.":[165,195],"Similarly,":[166],"heightened":[170],"excitatory":[171],"response":[172],"sensory":[175],"presence":[182],"indicating":[185],"an":[186,201],"enhanced":[187,216],"sensitivity":[188,217],"cells":[191],"post":[194,206],"summary,":[197],"may":[199],"play":[200],"important":[202],"role":[203],"through":[209],"greater":[210],"direct":[211],"binding":[212],"via":[222],"MCP1-mediated":[223],"pathway":[224]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}