{"id":"https://openalex.org/W2585707848","doi":null,"title":"Cortical Parvalbumin Interneuron Epigenetic Modulation by DNA Methyltransferase","display_name":"Cortical Parvalbumin Interneuron Epigenetic Modulation by DNA Methyltransferase","publication_year":2014,"publication_date":"2014-02-04","ids":{"openalex":"https://openalex.org/W2585707848","mag":"2585707848"},"language":"en","primary_location":{"id":"pmh:oai:bir.brandeis.edu:10192/26310","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10192/26310","pdf_url":null,"source":{"id":"https://openalex.org/S4406922578","display_name":"Brandeis Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064129992","display_name":"Alexander W. Cristofaro","orcid":"https://orcid.org/0000-0001-7905-9264","observed_orcids":["https://orcid.org/0000-0001-7905-9264"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexander Cristofaro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7905-9264","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064129992"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.13500000536441803,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parvalbumin-positive-interneurons","display_name":"parvalbumin interneurons","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.5540000200271606},{"id":"https://openalex.org/keywords/inhibitory-interneurons","display_name":"inhibitory interneurons","score":0.7459999918937683},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.5370000004768372},{"id":"https://openalex.org/keywords/postsynaptic-inhibition","display_name":"postsynaptic inhibition","score":0.6700000166893005},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.6480000019073486},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C141547260","wikidata":"https://www.wikidata.org/wiki/Q2720322","display_name":"Parvalbumin","level":2,"score":0.8770354390144348},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.8324835300445557},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7730298042297363},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6373035311698914},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.5645979046821594},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5134397745132446},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5132062435150146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4706360995769501},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.39409416913986206},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3794664144515991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3396894335746765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3277580440044403},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25896987318992615},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.21439683437347412},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1583232581615448},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09718304872512817},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.059800148010253906}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bir.brandeis.edu:10192/26310","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10192/26310","pdf_url":null,"source":{"id":"https://openalex.org/S4406922578","display_name":"Brandeis Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2585707848","doi":null,"is_oa":false,"landing_page_url":"https://bir.brandeis.edu/handle/10192/26310","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1006291621","https://openalex.org/W1799723421","https://openalex.org/W1921961511","https://openalex.org/W1969370432","https://openalex.org/W1973869717","https://openalex.org/W1977772936","https://openalex.org/W1984708728","https://openalex.org/W1988950593","https://openalex.org/W1990888945","https://openalex.org/W1991169840","https://openalex.org/W1995453535","https://openalex.org/W1998408088","https://openalex.org/W1999574084","https://openalex.org/W2005344589","https://openalex.org/W2007023571","https://openalex.org/W2019651776","https://openalex.org/W2033162367","https://openalex.org/W2041848975","https://openalex.org/W2044745906","https://openalex.org/W2060446375","https://openalex.org/W2086657106","https://openalex.org/W2091414779","https://openalex.org/W2093289593","https://openalex.org/W2103017472","https://openalex.org/W2105665255","https://openalex.org/W2117131162","https://openalex.org/W2124049725","https://openalex.org/W2124097252","https://openalex.org/W2131797361","https://openalex.org/W2138639794","https://openalex.org/W2141458291","https://openalex.org/W2149561999","https://openalex.org/W2151152058","https://openalex.org/W2153900602","https://openalex.org/W2154431984","https://openalex.org/W2912329939"],"related_works":["https://openalex.org/W2789399743","https://openalex.org/W7116953632","https://openalex.org/W7220958211","https://openalex.org/W2809316166","https://openalex.org/W3011275958","https://openalex.org/W3130271997","https://openalex.org/W4281291643","https://openalex.org/W2062872787","https://openalex.org/W7133712800","https://openalex.org/W6925355192"],"abstract_inverted_index":{"The":[0,167],"mammalian":[1],"brain":[2],"differentiates":[3],"itself":[4],"from":[5,137,189],"its":[6],"evolutionary":[7],"predecessors":[8],"by":[9,50,72,107,205],"the":[10,41,101,152,198,211],"trait":[11],"of":[12,23,31,53,74,100,109,119,124,141,147,155,160,171,201,213],"a":[13,51,60,67,93,110,116,125,138,156,177],"large":[14],"and":[15,25,46,88,185],"complex":[16],"cortical":[17],"network.":[18],"Cortical":[19],"circuitry":[20],"is":[21,208],"composed":[22],"excitatory":[24,182],"inhibitory":[26,120,144,218],"neurons":[27,49],"having":[28],"many":[29],"subsets":[30],"integrative":[32],"firing":[33,36],"properties.":[34],"These":[35],"properties":[37],"are":[38,105],"regulated":[39],"at":[40],"epigenetic":[42],"level":[43],"during":[44],"development":[45],"post-replication":[47],"in":[48,70,97,115,181,210,216,220],"class":[52,118,140],"DNA":[54,71],"methyltransferase":[55],"(DNMT)":[56],"proteins":[57,76],"that":[58],"target":[59],"dinucleotide":[61],"sequence":[62],"CpG.":[63],"Methylation":[64],"can":[65,173],"confer":[66],"heterochromatic":[68],"state":[69],"recruitment":[73],"methyl-binding":[75],"such":[77],"as":[78],"MBD-1-MBD-4":[79],"(Hendrich":[80],"et":[81,85,130],"al":[82,86,131],"1998;":[83],"Boyes":[84],"1991)":[87],"HDACs.":[89],"We":[90],"have":[91],"used":[92],"transgenic":[94],"mouse":[95],"model":[96],"which":[98,163],"combinations":[99],"two":[102],"early-development":[103],"DNMTs":[104],"ablated":[106],"use":[108,123],"conditional":[111],"knockout":[112],"allele":[113],"driven":[114],"specific":[117],"neurons.":[121,145],"By":[122],"manual":[126],"cell-sorting":[127],"technique":[128],"(Hempel":[129],"2007)":[132],"we":[133,196],"collected":[134],"RNA":[135],"profiles":[136],"distinct":[139],"parvalbumin":[142],"positive":[143],"Results":[146],"RNA-Sequencing":[148],"brought":[149],"to":[150,176],"attention":[151],"differential":[153],"expression":[154],"previously":[157,178],"classified":[158],"family":[159],"genes,":[161],"\u03b1-takusan,":[162],"regulate":[164],"synaptic":[165],"activity.":[166],"broad":[168],"down":[169,199],"regulation":[170,200],"\u03b1-takusan":[172,203],"be":[174],"related":[175],"found":[179],"reduction":[180,212],"post-synaptic":[183],"amplitude":[184],"frequency":[186],"data":[187],"obtained":[188],"prior":[190],"electrophysiological":[191],"experiments.":[192],"From":[193],"these":[194],"findings":[195],"believe":[197],"certain":[202],"genes":[204],"DNMT":[206],"activity":[207],"causal":[209],"postsynaptic":[214],"excitation":[215],"parvalbumin-positive":[217],"interneurons":[219],"L5":[221],"motor":[222],"cortex.":[223]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-02-10T00:00:00"}
