{"id":"https://openalex.org/W2585640055","doi":"https://doi.org/10.1182/blood.v116.21.1026.1026","title":"Transient Responses to Notch and Tlx1/Hox11 Inhibition In T-Cell Acute Lymphoblastic Leukemia/Lymphoma.","display_name":"Transient Responses to Notch and Tlx1/Hox11 Inhibition In T-Cell Acute Lymphoblastic Leukemia/Lymphoma.","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2585640055","doi":"https://doi.org/10.1182/blood.v116.21.1026.1026","mag":"2585640055"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.1026.1026","doi":"https://doi.org/10.1182/blood.v116.21.1026.1026","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.1026.1026","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035510520","display_name":"Erica A. Lehotzky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica A. Lehotzky","raw_affiliation_strings":["Medicine/Heme-Onc, University of Michigan, Ann Arbor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine/Heme-Onc, University of Michigan, Ann Arbor,","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039019694","display_name":"Mark Y. Chiang","orcid":"https://orcid.org/0000-0003-2099-0956","observed_orcids":["https://orcid.org/0000-0003-2099-0956"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Y. Chiang","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39243996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"21","first_page":"1026","last_page":"1026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tlx1","display_name":"TLX1","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hox11","display_name":"HOX11","score":0.9679999947547913},{"id":"https://openalex.org/keywords/notch1-signaling","display_name":"Notch1 signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ccr7","display_name":"CCR7","score":0.7720000147819519},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8949999809265137},{"id":"https://openalex.org/keywords/notch1-mutation","display_name":"NOTCH1 mutation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/leukemia-progression","display_name":"leukemia progression","score":0.6399999856948853},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6337414979934692},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5119589567184448},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.49745920300483704},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.46414175629615784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46377816796302795},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4206588864326477},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.41972020268440247},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.410258024930954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40733802318573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3551473915576935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.316109836101532},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23257607221603394},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.22351306676864624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17454612255096436}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.1026.1026","doi":"https://doi.org/10.1182/blood.v116.21.1026.1026","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.1026.1026","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050014257","https://openalex.org/W1990949341","https://openalex.org/W2000763528","https://openalex.org/W2409888422","https://openalex.org/W2152682783","https://openalex.org/W2020684972","https://openalex.org/W2340237593","https://openalex.org/W3030597314","https://openalex.org/W1490833013","https://openalex.org/W1572148375"],"abstract_inverted_index":{"Abstract":[0,1],"1026":[2],"Despite":[3],"numerous":[4],"advances":[5],"in":[6,123,137,149,177,194,201],"the":[7,27,55,59,101,113,119,124,138,145,214,249,303],"past":[8],"few":[9],"decades,":[10],"treatment":[11,304],"of":[12,42,48,58,79,85,94,105,112,118,129,153,182,198,220,234,284,305,311],"acute":[13],"lymphoblastic":[14],"leukemia/lymphoma":[15],"(ALL)":[16],"remains":[17],"a":[18,64,75,281],"common":[19],"and":[20,50,140,164,222,266,271,276,290],"considerable":[21],"challenge.":[22],"Further":[23],"efforts":[24],"to":[25,35,109,273,287,313],"define":[26],"molecular":[28],"lesions":[29],"that":[30,143,239],"drive":[31],"ALL":[32,44],"are":[33,98,252],"needed":[34],"improve":[36],"clinical":[37],"management.":[38],"The":[39,96,260],"Hox":[40,60,71],"subfamily":[41],"T-cell":[43,106],"(T-ALL)":[45],"represents":[46],"30\u201340%":[47],"pediatric":[49],"adult":[51],"cases.":[52],"TLX1/HOX11":[53],"is":[54],"prototypical":[56],"member":[57],"group.":[61],"To":[62],"generate":[63],"resource":[65],"for":[66,70,298,302],"developing":[67],"targeted":[68],"therapies":[69],"T-ALLs,":[72],"we":[73],"developed":[74],"doxycycline-regulated":[76],"mouse":[77],"model":[78],"Tlx1-initiated":[80],"T-ALL.":[81,306],"Dysregulated":[82],"thymic":[83],"expression":[84,184,200,219,233],"Tlx1":[86,183,199,211,240,258,289],"induces":[87],"T-ALL":[88,285],"after":[89],"\u223c5-7":[90],"months":[91],"with":[92,156,231],"penetrance":[93],"15\u201360%.":[95],"lymphoblasts":[97],"arrested":[99],"at":[100],"early":[102],"CD4+/CD8+/CD24hi":[103],"stage":[104],"development,":[107],"similar":[108],"human":[110,150],"T-ALLs":[111],"TLX1":[114],"subtype.":[115],"Spontaneous":[116],"activation":[117],"Notch1":[120,146],"oncogene":[121],"occurred":[122],"tumors.":[125],"In":[126,179],"about":[127],"two-thirds":[128],"samples,":[130],"Notch":[131,154,167,270,291],"was":[132],"activated":[133],"through":[134],"acquired":[135],"mutations":[136,147],"heterodimerization":[139],"PEST":[141],"domains":[142],"resemble":[144],"found":[148],"patients.":[151],"Inhibition":[152],"signaling":[155],"g-secretase":[157],"inhibitors":[158],"completely":[159],"abrogated":[160],"cell":[161,191],"line":[162,192],"growth":[163,193,275],"induced":[165],"apoptosis.":[166],"inhibition":[168],"also":[169],"transiently":[170,204],"delayed":[171,205],"leukemia":[172,206,246,250,261],"progression":[173,207],"by":[174,208],"\u223c17":[175],"days":[176],"vivo.":[178],"contrast,":[180],"suppression":[181,197,212],"had":[185,213],"more":[186],"moderate":[187],"inhibitory":[188,216],"effects":[189,217,227],"on":[190,218,256],"vitro.":[195],"However,":[196],"transgenic":[202],"mice":[203],"\u223c11":[209],"days.":[210],"strongest":[215],"CCR7":[221],"lymph":[223],"node":[224],"size.":[225],"These":[226,236],"were":[228],"fully":[229,254],"reversed":[230],"ectopic":[232],"Tlx1.":[235],"data":[237],"show":[238],"can":[241],"convert":[242],"normal":[243],"thymocytes":[244],"into":[245],"cells,":[247],"but":[248],"cells":[251,262,286],"not":[253],"dependent":[255],"continued":[257],"expression.":[259],"recruit":[263],"secondary":[264],"factors":[265],"pathways":[267,301],"such":[268],"as":[269],"c-Myc":[272],"sustain":[274],"survival.":[277],"Our":[278,293],"study":[279,294],"highlights":[280],"strong":[282],"resiliency":[283],"both":[288],"inhibition.":[292],"has":[295],"important":[296],"implications":[297],"targeting":[299],"these":[300],"Disclosures:":[307],"No":[308],"relevant":[309],"conflicts":[310],"interest":[312],"declare.":[314]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
