{"id":"https://openalex.org/W2585008239","doi":"https://doi.org/10.1016/j.jsxm.2016.12.070","title":"056 Dyslipidemia But Not Hyperglycemia Appears as the Main Factor Damaging Muscle Derived Stem Cells and their Tissue Repair Capacity by Long-term Exposure to a Type 2 Diabetic Milieu","display_name":"056 Dyslipidemia But Not Hyperglycemia Appears as the Main Factor Damaging Muscle Derived Stem Cells and their Tissue Repair Capacity by Long-term Exposure to a Type 2 Diabetic Milieu","publication_year":2017,"publication_date":"2017-02-01","ids":{"openalex":"https://openalex.org/W2585008239","doi":"https://doi.org/10.1016/j.jsxm.2016.12.070","mag":"2585008239"},"language":"en","primary_location":{"id":"doi:10.1016/j.jsxm.2016.12.070","doi":"https://doi.org/10.1016/j.jsxm.2016.12.070","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jsxm.2016.12.070","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020835540","display_name":"Maryam Masouminia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Masouminia","raw_affiliation_strings":["LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042189383","display_name":"Dolores A Vernet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Vernet","raw_affiliation_strings":["LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110471460","display_name":"Jia-Ruei Tsao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Tsao","raw_affiliation_strings":["Charles R Drew University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles R Drew University","institution_ids":["https://openalex.org/I52710748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111787739","display_name":"R. Gelfand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Gelfand","raw_affiliation_strings":["LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059395115","display_name":"Leila Loni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Loni","raw_affiliation_strings":["LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112401258","display_name":"Ruben D. Salas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Salas","raw_affiliation_strings":["LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Castro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Castro","raw_affiliation_strings":["LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015960665","display_name":"James Aboagye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Aboagye","raw_affiliation_strings":["LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112129547","display_name":"Jacob Rajfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Rajfer","raw_affiliation_strings":["UCLA School of Medicine \u00a0","USA; LABioMed at Harbor-UCLA Medical Center \u00a0","LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA School of Medicine \u00a0","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"USA; LABioMed at Harbor-UCLA Medical Center \u00a0","institution_ids":["https://openalex.org/I4210165985"]},{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034784511","display_name":"N\u00e9stor F. Gonz\u00e1lez-Cadavid","orcid":"https://orcid.org/0000-0003-3181-2944","observed_orcids":["https://orcid.org/0000-0003-3181-2944"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.F. Gonzalez-Cadavid","raw_affiliation_strings":["UCLA School of Medicine \u00a0","USA; LABioMed at Harbor-UCLA Medical Center \u00a0","LABioMed at Harbor-UCLA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA School of Medicine \u00a0","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"USA; LABioMed at Harbor-UCLA Medical Center \u00a0","institution_ids":["https://openalex.org/I4210165985"]},{"raw_affiliation_string":"LABioMed at Harbor-UCLA Medical Center","institution_ids":["https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"Supplement_2","first_page":"e28","last_page":"e28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-derived-stem-cells","display_name":"muscle-derived stem cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":1.0},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.734000027179718},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.640999972820282},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.8980000019073486},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":0.6639999747276306},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5440000295639038},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6610000133514404},{"id":"https://openalex.org/keywords/autograft","display_name":"autograft","score":0.6050000190734863},{"id":"https://openalex.org/keywords/zucker-rats","display_name":"Zucker rats","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7101978063583374},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.702117919921875},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5270949602127075},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5109044909477234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4932684302330017},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44681692123413086},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4462434947490692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1312921643257141},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.05677974224090576}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jsxm.2016.12.070","doi":"https://doi.org/10.1016/j.jsxm.2016.12.070","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jsxm.2016.12.070","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2902928227","https://openalex.org/W3042656667","https://openalex.org/W2968116521","https://openalex.org/W2929095341","https://openalex.org/W2563218086","https://openalex.org/W2141271735","https://openalex.org/W7118546937","https://openalex.org/W2041386692","https://openalex.org/W7213507596","https://openalex.org/W4415476051"],"abstract_inverted_index":{"The":[0],"impairment":[1],"of":[2,7,15,97],"the":[3,18,63,95],"tissue":[4,14],"repair":[5,75],"capacity":[6],"stem":[8,39,127],"cells":[9,40,122,128],"by":[10,207,215],"exposure":[11],"in":[12,108,114,157],"their":[13,28,80,110],"origin":[16],"to":[17,83,101,116,155,183,189,197],"type":[19],"2":[20],"diabetes":[21],"(T2D)":[22],"milieu":[23],"has":[24],"clinical":[25],"relevance":[26],"for":[27,171,219,242],"use":[29],"as":[30,60,170],"autografts.":[31],"We":[32],"have":[33,106],"previously":[34],"shown":[35],"that":[36],"muscle":[37,121],"derived":[38],"(MDSC)":[41],"from":[42,65,139,147],"aged":[43],"obese":[44],"Zucker":[45,150],"(OZ)":[46],"rats":[47,67,141,151],"with":[48,55,62,68,137,142],"long-term":[49],"late":[50,143],"T2D":[51,70,144],"(L-MDSC)":[52],"were":[53,133,168,205,240],"imprinted":[54],"a":[56,73],"fibrotic/inflammatory":[57],"transcriptional":[58],"signature":[59],"compared":[61],"MDSC":[64,103],"OZ":[66,140],"early":[69],"(E-MDSC),":[71],"and":[72,88,99,124,164,202,212,230,235,244],"poor":[74],"efficacy":[76],"when":[77],"implanted":[78],"into":[79],"corpora":[81],"cavernosa":[82],"correct":[84],"erectile":[85],"dysfunction":[86],"(ED)":[87],"its":[89],"underlying":[90],"corporal":[91,119],"histopathology.":[92],"To":[93],"ascertain":[94],"contributions":[96],"dyslipidemia":[98],"hyperglycemia":[100],"this":[102],"damage,":[104],"we":[105],"studied":[107],"vitro":[109],"effects":[111],"on":[112],"E-MDSC,":[113],"comparison":[115],"similarly":[117],"exposed":[118],"smooth":[120],"(CSMC)":[123],"induced":[125],"pluripotent":[126],"(iPS).":[129],"For":[130,192],"dyslipidemia,":[131],"E-MDSC":[132],"incubated":[134,169],"(5":[135],"days)":[136],"serum":[138],"(L-OZ)":[145],"versus":[146],"non-diabetic":[148],"lean":[149],"(ND-LZ),":[152],"at":[153],"0.1":[154],"5%":[156],"DMEM-5.8":[158],"mM":[159],"glucose-10%":[160],"FCS.":[161],"Rat":[162],"CSMC,":[163],"mouse":[165],"fibroblast":[166],"iPS,":[167],"E-MDSC.":[172],"Other":[173],"ED-MDSC":[174],"received":[175],"free":[176],"fatty":[177],"acid":[178],"(FFA)":[179],"(sodium":[180],"palmitate,":[181],"1":[182],"8":[184],"mM),":[185],"or":[186],"cholesterol":[187],"(10":[188],"400":[190],"mg/dl).":[191],"hyperglycemia,":[193],"glucose":[194],"was":[195],"5.8":[196],"25":[198],"mM.":[199],"Morphological":[200],"changes":[201],"fat":[203],"infiltration":[204],"detected":[206],"Oil":[208],"red":[209],"O":[210],"staining,":[211],"protein":[213],"expression":[214],"quantitative":[216],"western":[217],"blots":[218],"lipid":[220],"metabolism":[221],"(CBP\u03b1),":[222],"apoptosis":[223],"(caspase":[224],"3,":[225],"Bax/Bcl2),":[226],"proliferation":[227],"(PCNA),":[228],"SMC":[229],"myofibroblast":[231],"generation":[232],"(calponin,":[233],"ASMA);":[234],"fibrosis":[236],"(myostatin).":[237],"L-OZ/ND-LZ":[238],"incubations":[239],"used":[241],"RT/PCR":[243],"DNA":[245],"microarrays.":[246]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-02-10T00:00:00"}
