{"id":"https://openalex.org/W2584955680","doi":"https://doi.org/10.1002/anie.201611181","title":"One\u2010Pot N\u2010Deprotection and Catalytic Intramolecular Asymmetric Reductive Amination for the Synthesis of Tetrahydroisoquinolines","display_name":"One\u2010Pot N\u2010Deprotection and Catalytic Intramolecular Asymmetric Reductive Amination for the Synthesis of Tetrahydroisoquinolines","publication_year":2017,"publication_date":"2017-01-31","ids":{"openalex":"https://openalex.org/W2584955680","doi":"https://doi.org/10.1002/anie.201611181","mag":"2584955680","pmid":"https://pubmed.ncbi.nlm.nih.gov/28140506"},"language":"en","primary_location":{"id":"doi:10.1002/anie.201611181","doi":"https://doi.org/10.1002/anie.201611181","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.201611181","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070695078","display_name":"Huan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Zhou","raw_affiliation_strings":["Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390949","display_name":"Yuan Liu","orcid":"https://orcid.org/0000-0003-3973-4207","observed_orcids":["https://orcid.org/0000-0003-3973-4207"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Liu","raw_affiliation_strings":["Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080321431","display_name":"Suhua Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suhua Yang","raw_affiliation_strings":["Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066038963","display_name":"Le Zhou","orcid":"https://orcid.org/0000-0001-9043-6657","observed_orcids":["https://orcid.org/0000-0001-9043-6657","https://orcid.org/0009-0005-9764-3604"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Zhou","raw_affiliation_strings":["Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045793387","display_name":"Mingxin Chang","orcid":"https://orcid.org/0000-0002-5407-3403","observed_orcids":["https://orcid.org/0000-0002-5407-3403"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingxin Chang","raw_affiliation_strings":["Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering Northwest A&amp;F University  22 Xinong Road, Yangling Shaanxi 712100 PR China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi, 712100 PR China","institution_ids":["https://openalex.org/I89652312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045793387"],"corresponding_institution_ids":["https://openalex.org/I89652312"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":3.2467,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.92543315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"56","issue":"10","first_page":"2725","last_page":"2729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahydroisoquinolines","display_name":"tetrahydroisoquinolines","score":0.968999981880188},{"id":"https://openalex.org/keywords/n-deprotection","display_name":"N-deprotection","score":0.7670000195503235},{"id":"https://openalex.org/keywords/n-boc-deprotection","display_name":"N-Boc deprotection","score":0.8960000276565552},{"id":"https://openalex.org/keywords/intramolecular-reductive-amination","display_name":"intramolecular reductive amination","score":0.8899999856948853},{"id":"https://openalex.org/keywords/asymmetric-catalysis","display_name":"asymmetric catalysis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/iridium-complexes","display_name":"iridium complexes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/imine-reduction","display_name":"imine reduction","score":0.5920000076293945},{"id":"https://openalex.org/keywords/titanium-isopropoxide","display_name":"titanium isopropoxide","score":0.9110000133514404},{"id":"https://openalex.org/keywords/p-toluenesulfonic-acid","display_name":"p-toluenesulfonic acid","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pharmaceutical-intermediates","display_name":"pharmaceutical intermediates","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2776406546","wikidata":"https://www.wikidata.org/wiki/Q411677","display_name":"Tetrahydroisoquinoline","level":2,"score":0.8942528963088989},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8075759410858154},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.8005833029747009},{"id":"https://openalex.org/C2779938440","wikidata":"https://www.wikidata.org/wiki/Q549876","display_name":"Reductive amination","level":3,"score":0.7460007667541504},{"id":"https://openalex.org/C198503264","wikidata":"https://www.wikidata.org/wiki/Q471635","display_name":"Amination","level":3,"score":0.7298371195793152},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.7004021406173706},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6212844252586365},{"id":"https://openalex.org/C2776573223","wikidata":"https://www.wikidata.org/wiki/Q408057","display_name":"Imine","level":3,"score":0.5818182826042175},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5590149760246277},{"id":"https://openalex.org/C528581852","wikidata":"https://www.wikidata.org/wiki/Q877","display_name":"Iridium","level":3,"score":0.488576740026474},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.4401947557926178},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.41275322437286377},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3953528106212616}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/anie.201611181","doi":"https://doi.org/10.1002/anie.201611181","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.201611181","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:28140506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28140506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.7400000095367432}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W180105277","https://openalex.org/W1963973539","https://openalex.org/W1982640631","https://openalex.org/W1982744128","https://openalex.org/W2003267640","https://openalex.org/W2007316523","https://openalex.org/W2009884940","https://openalex.org/W2029864078","https://openalex.org/W2030879400","https://openalex.org/W2033556576","https://openalex.org/W2034882227","https://openalex.org/W2048994453","https://openalex.org/W2052333428","https://openalex.org/W2053967820","https://openalex.org/W2058841148","https://openalex.org/W2058952352","https://openalex.org/W2066325934","https://openalex.org/W2067468868","https://openalex.org/W2071482843","https://openalex.org/W2074996645","https://openalex.org/W2096869977","https://openalex.org/W2098587085","https://openalex.org/W2108749125","https://openalex.org/W2112804131","https://openalex.org/W2114301477","https://openalex.org/W2130506287","https://openalex.org/W2147842186","https://openalex.org/W2159259582","https://openalex.org/W2175158825","https://openalex.org/W2238889153","https://openalex.org/W2277980090","https://openalex.org/W2300247830","https://openalex.org/W2318497333","https://openalex.org/W2318946250","https://openalex.org/W2327365624","https://openalex.org/W2328521607","https://openalex.org/W2415131470","https://openalex.org/W2426986579","https://openalex.org/W2498284321","https://openalex.org/W2521585712","https://openalex.org/W2526216986","https://openalex.org/W2950775447","https://openalex.org/W2951131385","https://openalex.org/W3146727813","https://openalex.org/W4231306806","https://openalex.org/W4235097364","https://openalex.org/W4236463097","https://openalex.org/W4240257122","https://openalex.org/W4241622264","https://openalex.org/W4254749619"],"related_works":["https://openalex.org/W2039238670","https://openalex.org/W4252438383","https://openalex.org/W2953210966","https://openalex.org/W2467159142","https://openalex.org/W2461702754","https://openalex.org/W2062618910","https://openalex.org/W2759190239","https://openalex.org/W2950616381","https://openalex.org/W1972617814","https://openalex.org/W2048333659"],"abstract_inverted_index":{"A":[0],"one-pot":[1],"N-Boc":[2],"deprotection":[3],"and":[4,54],"catalytic":[5],"intramolecular":[6],"reductive":[7],"amination":[8],"protocol":[9],"for":[10],"the":[11,58,61,65,72],"preparation":[12],"of":[13,60],"enantiomerically":[14],"pure":[15],"tetrahydroisoquinoline":[16,66],"alkaloids":[17],"is":[18],"described.":[19],"The":[20],"iodine-bridged":[21],"dimeric":[22],"iridium":[23],"complexes":[24],"displayed":[25],"superb":[26],"stereoselectivity":[27],"to":[28,64,71],"give":[29],"tetrahydroisoquinolines,":[30],"including":[31],"several":[32],"key":[33],"pharmaceutical":[34],"drug":[35],"intermediates,":[36],"in":[37,49],"excellent":[38],"yields":[39],"under":[40],"mild":[41],"reaction":[42],"conditions.":[43],"Three":[44],"additives":[45],"played":[46],"important":[47],"roles":[48],"this":[50],"reaction:":[51],"Titanium(IV)":[52],"isopropoxide":[53],"molecular":[55],"iodine":[56],"accelerated":[57],"transformation":[59],"intermediate":[62],"imine":[63],"product;":[67],"p-toluenesulfonic":[68],"acid":[69],"contributed":[70],"stereocontrol.":[73]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
