{"id":"https://openalex.org/W2584899538","doi":"https://doi.org/10.57709/9415244","title":"Effect of Ketamine on Social Avoidance in Socially Defeated Male and Female Syrian Hamsters","display_name":"Effect of Ketamine on Social Avoidance in Socially Defeated Male and Female Syrian Hamsters","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2584899538","doi":"https://doi.org/10.57709/9415244","mag":"2584899538"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.gsu.edu:biology_theses-1079","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.gsu.edu/biology_theses/75","pdf_url":"https://scholarworks.gsu.edu/biology_theses/75","source":{"id":"https://openalex.org/S4406922693","display_name":"Digital Archive @ GSU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.gsu.edu/biology_theses/75","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068432499","display_name":"Guzman Bambaren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Guzman Bambaren, Alejandro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068432499"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":1.0},{"id":"https://openalex.org/keywords/social-avoidance","display_name":"social avoidance","score":0.9269999861717224},{"id":"https://openalex.org/keywords/social-defeat","display_name":"social defeat","score":0.8349999785423279},{"id":"https://openalex.org/keywords/social-stress","display_name":"social stress","score":0.9580000042915344},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.6850000023841858},{"id":"https://openalex.org/keywords/rapid-acting-antidepressants","display_name":"rapid-acting antidepressants","score":0.7440000176429749},{"id":"https://openalex.org/keywords/syrian-hamster","display_name":"golden hamster","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C2910480608","wikidata":"https://www.wikidata.org/wiki/Q204175","display_name":"Syrian hamsters","level":3,"score":0.5428788661956787},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.4069637060165405},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3915286362171173},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.36863985657691956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31691694259643555},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1347368061542511}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:scholarworks.gsu.edu:biology_theses-1079","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.gsu.edu/biology_theses/75","pdf_url":"https://scholarworks.gsu.edu/biology_theses/75","source":{"id":"https://openalex.org/S4406922693","display_name":"Digital Archive @ GSU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Theses","raw_type":"text"},{"id":"pmh:oai:scholarworks.gsu.edu:20.500.14694/2326","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14694/2326","pdf_url":null,"source":{"id":"https://openalex.org/S4306400481","display_name":"Counseling And Psychological Services Dissertations (Georgia State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181565077","host_organization_name":"Georgia State University","host_organization_lineage":["https://openalex.org/I181565077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2584899538","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.gsu.edu/biology_theses/75/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.57709/9415244","doi":"https://doi.org/10.57709/9415244","is_oa":true,"landing_page_url":"https://doi.org/10.57709/9415244","pdf_url":null,"source":{"id":"https://openalex.org/S7407051460","display_name":"Georgia State University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:scholarworks.gsu.edu:biology_theses-1079","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.gsu.edu/biology_theses/75","pdf_url":"https://scholarworks.gsu.edu/biology_theses/75","source":{"id":"https://openalex.org/S4406922693","display_name":"Digital Archive @ GSU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Theses","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2584899538.pdf","grobid_xml":"https://content.openalex.org/works/W2584899538.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1516186123","https://openalex.org/W1633497115","https://openalex.org/W1969227419","https://openalex.org/W1970627396","https://openalex.org/W1974139348","https://openalex.org/W1977435319","https://openalex.org/W1988428530","https://openalex.org/W1992601778","https://openalex.org/W1994568212","https://openalex.org/W1996515322","https://openalex.org/W2000183519","https://openalex.org/W2003693093","https://openalex.org/W2007816528","https://openalex.org/W2011074775","https://openalex.org/W2013309206","https://openalex.org/W2017868252","https://openalex.org/W2026730082","https://openalex.org/W2052830386","https://openalex.org/W2054931962","https://openalex.org/W2057919764","https://openalex.org/W2062102986","https://openalex.org/W2074796005","https://openalex.org/W2091808479","https://openalex.org/W2094166526","https://openalex.org/W2095286567","https://openalex.org/W2105571318","https://openalex.org/W2108040321","https://openalex.org/W2157670485","https://openalex.org/W2157974953","https://openalex.org/W2164078216","https://openalex.org/W2165973903","https://openalex.org/W2175484872","https://openalex.org/W2224337684"],"related_works":["https://openalex.org/W1421194570","https://openalex.org/W3141966150","https://openalex.org/W2965993357","https://openalex.org/W2430291071","https://openalex.org/W2278438056","https://openalex.org/W2996418077","https://openalex.org/W6991159076","https://openalex.org/W2701832183","https://openalex.org/W2610998570","https://openalex.org/W3179003031"],"abstract_inverted_index":{"Social":[0,102],"stress":[1,69],"can":[2,140],"cause":[3],"or":[4],"exacerbate":[5],"neuropsychiatric":[6],"illnesses":[7],"such":[8],"as":[9],"depression.":[10],"Unfortunately,":[11],"currently":[12],"available":[13],"treatments":[14],"for":[15,120],"these":[16],"disorders":[17],"are":[18,24],"slow":[19],"to":[20,55,143,147],"take":[21],"effect":[22],"and":[23,44,93,118],"often":[25],"ineffective.":[26],"One":[27],"promising":[28],"novel":[29],"treatment":[30],"option":[31],"is":[32],"the":[33,122],"anesthetic":[34],"ketamine,":[35],"which":[36],"may":[37],"have":[38,50,98],"rapid-acting":[39],"antidepressant":[40],"effects":[41],"in":[42,70,91],"humans":[43],"rodents.":[45],"These":[46,135],"rodent":[47,65],"studies,":[48],"however,":[49],"primarily":[51],"used":[52],"artificial":[53],"stressors":[54],"produce":[56],"depression-like":[57],"responses.":[58],"Our":[59],"lab":[60],"uses":[61],"an":[62],"ethologically":[63],"relevant":[64],"model":[66],"of":[67,80,88],"social":[68,83,100,148],"Syrian":[71,95],"hamsters.":[72],"We":[73],"tested":[74,105,119],"whether":[75],"a":[76,85],"single,":[77],"intraperitoneal":[78],"dose":[79],"ketamine":[81,109,139],"reduces":[82],"avoidance,":[84],"common":[86],"symptom":[87],"mental":[89],"disorders,":[90],"male":[92],"female":[94],"hamsters":[96],"that":[97,138],"experienced":[99],"stress.":[101,149],"avoidance":[103,121,127],"was":[104],"one":[106,128],"day":[107,129],"after":[108],"injection.":[110],"Eight":[111],"days":[112,133],"later,":[113],"subjects":[114],"were":[115],"defeated":[116],"again,":[117],"following":[123],"day.":[124],"Ketamine":[125],"reduced":[126],"but":[130],"not":[131],"nine":[132],"post-injection.":[134],"data":[136],"suggest":[137],"act":[141],"rapidly":[142],"prevent":[144],"depressive-like":[145],"responses":[146]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-02-10T00:00:00"}