{"id":"https://openalex.org/W2584841492","doi":"https://doi.org/10.1080/1744666x.2017.1292133","title":"Clinical use of adjuvants in allergen-immunotherapy","display_name":"Clinical use of adjuvants in allergen-immunotherapy","publication_year":2017,"publication_date":"2017-02-04","ids":{"openalex":"https://openalex.org/W2584841492","doi":"https://doi.org/10.1080/1744666x.2017.1292133","mag":"2584841492","pmid":"https://pubmed.ncbi.nlm.nih.gov/28162007"},"language":"en","primary_location":{"id":"doi:10.1080/1744666x.2017.1292133","doi":"https://doi.org/10.1080/1744666x.2017.1292133","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1744666x.2017.1292133","pdf_url":null,"source":{"id":"https://openalex.org/S170220373","display_name":"Expert Review of Clinical Immunology","issn_l":"1744-666X","issn":["1744-666X","1744-8409"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50657","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038444881","display_name":"Ludger Klimek","orcid":"https://orcid.org/0000-0002-2455-0192","observed_orcids":["https://orcid.org/0000-0002-2455-0192"]},"institutions":[{"id":"https://openalex.org/I4210119608","display_name":"Zentrum f\u00fcr Rhinologie und Allergologie","ror":"https://ror.org/01wwsba50","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210119608"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ludger Klimek","raw_affiliation_strings":["Center for Rhinology and Allergology, Wiesbaden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rhinology and Allergology, Wiesbaden, Germany","institution_ids":["https://openalex.org/I4210119608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086064578","display_name":"Carsten B. Schmidt\u2010Weber","orcid":"https://orcid.org/0000-0002-3203-8084","observed_orcids":["https://orcid.org/0000-0002-3203-8084"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten B. Schmidt-Weber","raw_affiliation_strings":["Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038522274","display_name":"Matthias F. Kramer","orcid":"https://orcid.org/0000-0002-3740-4733","observed_orcids":["https://orcid.org/0000-0002-3740-4733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias F. Kramer","raw_affiliation_strings":["Bencard Allergie GmbH, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bencard Allergie GmbH, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036529789","display_name":"Murray A. Skinner","orcid":"https://orcid.org/0009-0008-4935-4316","observed_orcids":["https://orcid.org/0009-0008-4935-4316"]},"institutions":[{"id":"https://openalex.org/I4210151077","display_name":"Allergy Therapeutics (United Kingdom)","ror":"https://ror.org/04vgd1s66","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151077"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Murray A. Skinner","raw_affiliation_strings":["Allergy Therapeutics Ltd, Worthing, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy Therapeutics Ltd, Worthing, UK","institution_ids":["https://openalex.org/I4210151077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059395871","display_name":"Matthew D. Heath","orcid":"https://orcid.org/0000-0002-6095-4098","observed_orcids":["https://orcid.org/0000-0002-6095-4098","https://orcid.org/0000-0001-5991-3435"]},"institutions":[{"id":"https://openalex.org/I4210151077","display_name":"Allergy Therapeutics (United Kingdom)","ror":"https://ror.org/04vgd1s66","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151077"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew D. Heath","raw_affiliation_strings":["Allergy Therapeutics Ltd, Worthing, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy Therapeutics Ltd, Worthing, UK","institution_ids":["https://openalex.org/I4210151077"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038444881"],"corresponding_institution_ids":["https://openalex.org/I4210119608"],"apc_list":null,"apc_paid":null,"fwci":1.2698,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.75949367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"13","issue":"6","first_page":"599","last_page":"610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.9229999780654907},{"id":"https://openalex.org/keywords/allergen-extracts","display_name":"allergen extracts","score":0.7689999938011169},{"id":"https://openalex.org/keywords/vaccine-delivery-systems","display_name":"vaccine delivery systems","score":0.7720000147819519},{"id":"https://openalex.org/keywords/allergy-treatment","display_name":"allergy treatment","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8047192096710205},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.7722295522689819},{"id":"https://openalex.org/C2779787640","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Allergen immunotherapy","level":4,"score":0.5799785256385803},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5721770524978638},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4505201578140259},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.41882458329200745},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36342185735702515},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36151444911956787},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.34864556789398193},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19989290833473206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07533296942710876}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1080/1744666x.2017.1292133","doi":"https://doi.org/10.1080/1744666x.2017.1292133","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1744666x.2017.1292133","pdf_url":null,"source":{"id":"https://openalex.org/S170220373","display_name":"Expert Review of Clinical Immunology","issn_l":"1744-666X","issn":["1744-666X","1744-8409"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:28162007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28162007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of clinical immunology","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1453518","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1453518","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:50657","doi":null,"is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50657","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Expert Rev. Clin. Immunol. 13, 599-610 (2017)","raw_type":null},{"id":"pmh:oai:push-zb.helmholtz-munich.de:50657","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=50657","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Expert Rev. Clin. Immunol. 13, 599-610 (2017)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:50657","doi":null,"is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50657","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Expert Rev. Clin. Immunol. 13, 599-610 (2017)","raw_type":null},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317248","display_name":"Allergy Therapeutics","ror":"https://ror.org/04vgd1s66"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W13460663","https://openalex.org/W45195219","https://openalex.org/W1149419008","https://openalex.org/W1217568736","https://openalex.org/W1421474020","https://openalex.org/W1541731964","https://openalex.org/W1556933267","https://openalex.org/W1573590923","https://openalex.org/W1907513513","https://openalex.org/W1917501444","https://openalex.org/W1931521005","https://openalex.org/W1964354442","https://openalex.org/W1968658765","https://openalex.org/W1970274313","https://openalex.org/W1973659113","https://openalex.org/W1973766914","https://openalex.org/W1978846537","https://openalex.org/W1979991507","https://openalex.org/W1982584872","https://openalex.org/W1990702493","https://openalex.org/W1990953521","https://openalex.org/W1991701295","https://openalex.org/W1993406411","https://openalex.org/W1993775186","https://openalex.org/W1995173766","https://openalex.org/W1997120806","https://openalex.org/W1999347737","https://openalex.org/W2000431016","https://openalex.org/W2002636234","https://openalex.org/W2005788144","https://openalex.org/W2007622060","https://openalex.org/W2011959957","https://openalex.org/W2013887826","https://openalex.org/W2017933691","https://openalex.org/W2018309112","https://openalex.org/W2026070855","https://openalex.org/W2029373703","https://openalex.org/W2033759527","https://openalex.org/W2034197799","https://openalex.org/W2035319060","https://openalex.org/W2035790540","https://openalex.org/W2040804066","https://openalex.org/W2042045439","https://openalex.org/W2044507989","https://openalex.org/W2046337461","https://openalex.org/W2046574729","https://openalex.org/W2046941690","https://openalex.org/W2050131389","https://openalex.org/W2050740641","https://openalex.org/W2054123856","https://openalex.org/W2055796980","https://openalex.org/W2056489903","https://openalex.org/W2057868114","https://openalex.org/W2059512105","https://openalex.org/W2062033298","https://openalex.org/W2062913649","https://openalex.org/W2065252029","https://openalex.org/W2066063987","https://openalex.org/W2066892212","https://openalex.org/W2069098256","https://openalex.org/W2072535088","https://openalex.org/W2073539122","https://openalex.org/W2082941861","https://openalex.org/W2086135773","https://openalex.org/W2088465681","https://openalex.org/W2092778039","https://openalex.org/W2096678687","https://openalex.org/W2105667065","https://openalex.org/W2107074680","https://openalex.org/W2107801478","https://openalex.org/W2109660290","https://openalex.org/W2110395890","https://openalex.org/W2115850341","https://openalex.org/W2117243106","https://openalex.org/W2117631259","https://openalex.org/W2131523916","https://openalex.org/W2132851798","https://openalex.org/W2137880001","https://openalex.org/W2141549572","https://openalex.org/W2149292297","https://openalex.org/W2151181789","https://openalex.org/W2153307110","https://openalex.org/W2155645788","https://openalex.org/W2156269164","https://openalex.org/W2166556848","https://openalex.org/W2170319274","https://openalex.org/W2170382285","https://openalex.org/W2177496755","https://openalex.org/W2178698647","https://openalex.org/W2201520634","https://openalex.org/W2215564680","https://openalex.org/W2338589974","https://openalex.org/W2398389006","https://openalex.org/W2410501542","https://openalex.org/W2513947093","https://openalex.org/W2515370071","https://openalex.org/W2517802114","https://openalex.org/W2620850347","https://openalex.org/W4292199690"],"related_works":["https://openalex.org/W4412664579","https://openalex.org/W7160083713","https://openalex.org/W4392108566","https://openalex.org/W6959342181","https://openalex.org/W4400780590","https://openalex.org/W2942422312","https://openalex.org/W2035319060","https://openalex.org/W2178698647","https://openalex.org/W4312783322","https://openalex.org/W3136063583"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Allergen-specific":[1],"Immunotherapy":[2],"(AIT)":[3],"is":[4,126],"the":[5,12,52,66,115,137,140,160,170],"only":[6],"available":[7],"treatment":[8,112],"aimed":[9],"to":[10,50,76,102,165],"tackle":[11],"underlying":[13],"causes":[14],"of":[15,20,25,57,69,91,105,110,117,121,130,143,148,172,182],"allergy.":[16],"The":[17,89,119],"active":[18,97],"components":[19,181],"subcutaneous":[21],"vaccines":[22],"traditionally":[23],"consist":[24],"natural":[26],"or":[27],"modified":[28],"allergen":[29],"extracts":[30],"which":[31],"can":[32],"be":[33],"combined":[34],"with":[35,96],"adjuvant":[36],"platforms.":[37],"In":[38,61],"recent":[39],"years":[40],"new":[41],"targets":[42],"have":[43],"been":[44,100],"further":[45],"developed":[46],"in":[47,85,94,159],"an":[48],"attempt":[49],"raise":[51],"safety":[53],"and":[54,71,81,113,152,176],"efficacy":[55,109],"profile":[56],"AIT.":[58,86],"Areas":[59],"covered:":[60],"this":[62],"review,":[63],"we":[64],"discuss":[65],"desirable":[67],"attributes":[68],"adjuvants":[70,175],"delivery":[72,177],"systems":[73,178],"from":[74,163],"empiricism":[75],"rational":[77],"design,":[78],"for":[79,124],"current":[80],"future":[82],"clinical":[83,108,166],"applications":[84],"Expert":[87],"commentary:":[88],"introduction":[90],"novel":[92],"adjuvants,":[93,155],"combination":[95],"targets,":[98],"has":[99,156],"demonstrated":[101],"reduce":[103,114],"symptoms":[104],"AIT,":[106],"increase":[107],"allergy":[111],"number":[116],"doses.":[118],"evolution":[120,158],"vaccine":[122],"development":[123,167],"AIT":[125,184],"entering":[127],"a":[128],"phase":[129],"scientific":[131],"progress":[132],"that":[133],"challenges":[134],"dogmas.":[135],"Over":[136],"past":[138,161],"century":[139],"traditional":[141],"concept":[142],"immunotherapy,":[144],"entailing":[145],"long-course":[146],"administration":[147],"native":[149],"extract":[150],"preparations":[151],"first":[153],"generation":[154,174],"seen":[157],"decade":[162],"proof-of-concept":[164],"pipelines":[168],"encompassing":[169],"advent":[171],"second":[173],"forming":[179],"essential":[180],"modern":[183],"development.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-02-10T00:00:00"}