{"id":"https://openalex.org/W2584634744","doi":null,"title":"Regulation of TRPV5 channels by Calmodulin","display_name":"Regulation of TRPV5 channels by Calmodulin","publication_year":2016,"publication_date":"2016-06-30","ids":{"openalex":"https://openalex.org/W2584634744","mag":"2584634744"},"language":"en","primary_location":{"id":"pmh:oai:lra.le.ac.uk:2381/37958","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/37958","pdf_url":"http://hdl.handle.net/2381/37958","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2381/37958","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036019162","display_name":"Fedir M. Bokhovchuk","orcid":"https://orcid.org/0000-0001-7319-3091","observed_orcids":["https://orcid.org/0000-0001-7319-3091"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fedir Bokhovchuk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7319-3091","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036019162"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpv5","display_name":"TRPV5","score":0.8859999775886536},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/calcium-channel-inactivation","display_name":"calcium channel inactivation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/calcium-sensing","display_name":"calcium sensing","score":0.4000000059604645},{"id":"https://openalex.org/keywords/c-terminal-binding-site","display_name":"C-terminal binding site","score":0.6510000228881836},{"id":"https://openalex.org/keywords/channel-regulation","display_name":"channel regulation","score":0.40799999237060547},{"id":"https://openalex.org/keywords/membrane-phospholipids","display_name":"membrane phospholipids","score":0.7360000014305115},{"id":"https://openalex.org/keywords/calcium-reabsorption","display_name":"calcium reabsorption","score":0.7039999961853027},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.5189999938011169},{"id":"https://openalex.org/keywords/nmr-structure-determination","display_name":"NMR structure determination","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.7023733854293823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21167561411857605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10667964816093445},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:lra.le.ac.uk:2381/37958","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/37958","pdf_url":"http://hdl.handle.net/2381/37958","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:figshare.com:article/10178948","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Regulation_of_TRPV5_channels_by_Calmodulin/10178948","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2584634744","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.692491","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lra.le.ac.uk:2381/37958","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/37958","pdf_url":"http://hdl.handle.net/2381/37958","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2584634744.pdf","grobid_xml":"https://content.openalex.org/works/W2584634744.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2131904845"],"related_works":["https://openalex.org/W2794637478","https://openalex.org/W7096979341","https://openalex.org/W4312137126","https://openalex.org/W2102314273","https://openalex.org/W2137958695","https://openalex.org/W2105324254","https://openalex.org/W2789817861","https://openalex.org/W4404637913","https://openalex.org/W2138710896","https://openalex.org/W2805039112"],"abstract_inverted_index":{"The":[0,24,157,196],"epithelial":[1],"selective":[2],"Ca\u00b2\u207a":[3,30,166],"channel":[4,10],"transient":[5],"receptor":[6],"potential":[7],"vanilloid":[8],"5":[9],"(TRPV5)":[11],"constitutes":[12],"the":[13,22,52,60,66,83,93,101,104,110,118,121,137,145,149,171,182,185,200,208],"apical":[14],"entry":[15],"gate":[16],"for":[17,100,203],"active":[18],"Ca2+":[19],"reabsorption":[20],"in":[21,59,82,142,168],"kidney.":[23],"activity":[25],"of":[26,63,69,76,103,112,117,134,148,159,189,207],"TRPV5":[27,84,122,172,190,210],"and,":[28],"therefore,":[29],"influx,":[31],"is":[32,56,98],"tightly":[33],"regulated":[34],"by":[35,40,90,178],"various":[36],"hormonal":[37],"stimuli":[38],"mediated":[39],"interactions":[41],"with":[42,131,170],"numerous":[43],"intracellular":[44],"binding":[45,96],"partners.":[46],"Previously,":[47],"it":[48,87],"was":[49,80,88,174,194],"shown":[50,89],"that":[51,92],"Ca\u00b2\u207a-sensor":[53],"Calmodulin":[54],"(CaM)":[55],"directly":[57],"involved":[58],"Ca\u00b2\u207a-induced":[61],"inactivation":[62,102],"TRPV5;":[64],"however,":[65],"structural":[67,115],"basis":[68,202],"this":[70],"mechanism":[71],"remained":[72],"unclear.":[73],"A":[74],"series":[75],"putative":[77],"CaM-binding":[78],"sites":[79],"identified":[81],"monomer":[85],"and":[86,114,124,144,152,191],"electrophysiology":[91],"C-terminal":[94,187],"distal":[95],"site":[97],"essential":[99],"channel.":[105],"This":[106],"thesis":[107],"reports":[108],"on":[109],"investigation":[111],"molecular":[113],"aspects":[116],"interaction":[119,183],"between":[120,184],"C-terminus":[123],"CaM.":[125],"Using":[126],"high-resolution":[127],"NMR":[128,179],"spectroscopy":[129],"together":[130],"a":[132,160,164,204],"set":[133],"complimentary":[135],"methods,":[136],"CaM:TRPV5":[138],"complexes":[139],"were":[140,155],"studied":[141],"detail":[143],"distinct":[146],"roles":[147],"CaM":[150,161],"N-":[151],"C-":[153],"domains":[154],"demonstrated.":[156],"structure":[158],"mutant,":[162],"mimicking":[163],"low":[165],"state,":[167],"complex":[169],"peptide":[173],"determined":[175],"de":[176],"novo":[177],"spectroscopy.":[180],"Also,":[181],"proximal":[186],"region":[188],"membrane":[192],"phospholipids":[193],"studied.":[195],"combined":[197],"data":[198],"provide":[199],"mechanistic":[201],"new":[205],"model":[206],"Ca\u00b2\u207a/CaM-dependent":[209],"inactivation.":[211]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-02-10T00:00:00"}