{"id":"https://openalex.org/W2584619006","doi":"https://doi.org/10.1182/blood.v106.11.3294.3294","title":"AF1q Is a Novel Poor Prognostic Marker for Adult Acute Myelogenous Leukemia (AML) Patients with Normal Cytogenetics.","display_name":"AF1q Is a Novel Poor Prognostic Marker for Adult Acute Myelogenous Leukemia (AML) Patients with Normal Cytogenetics.","publication_year":2005,"publication_date":"2005-11-16","ids":{"openalex":"https://openalex.org/W2584619006","doi":"https://doi.org/10.1182/blood.v106.11.3294.3294","mag":"2584619006"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v106.11.3294.3294","doi":"https://doi.org/10.1182/blood.v106.11.3294.3294","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.3294.3294","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079022291","display_name":"Crawford John Strunk","orcid":"https://orcid.org/0000-0003-1954-2929","observed_orcids":["https://orcid.org/0000-0003-1954-2929"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crawford J. Strunk","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079124367","display_name":"Uwe Platzbecker","orcid":"https://orcid.org/0000-0003-1863-3239","observed_orcids":["https://orcid.org/0000-0003-1863-3239"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Platzbecker","raw_affiliation_strings":["Department of Medicine I, University Hospital Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, University Hospital Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006122560","display_name":"Christian Thiede","orcid":"https://orcid.org/0000-0003-1241-2048","observed_orcids":["https://orcid.org/0000-0003-1241-2048"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Thiede","raw_affiliation_strings":["Department of Medicine I, University Hospital Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, University Hospital Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018356664","display_name":"Markus Andreas Schaich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Andreas Schaich","raw_affiliation_strings":["Department of Medicine I, University Hospital Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, University Hospital Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048469868","display_name":"Thomas Illmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Illmer","raw_affiliation_strings":["Department of Medicine I, University Hospital Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, University Hospital Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015125792","display_name":"Zizhen Kang","orcid":"https://orcid.org/0000-0001-5621-8912","observed_orcids":["https://orcid.org/0000-0001-5621-8912"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zizhen Kang","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075270450","display_name":"Patrick S. Leahy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Leahy","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chunbiao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunbiao Li","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047351829","display_name":"Sunee Reiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunee Reiner","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113618728","display_name":"Mary J. Laughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary J. Laughlin","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042915360","display_name":"Hillard Michael Lazarus","orcid":"https://orcid.org/0000-0002-1159-5607","observed_orcids":["https://orcid.org/0000-0002-1159-5607"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hillard M. Lazarus","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004390044","display_name":"Kevin D. Bunting","orcid":"https://orcid.org/0000-0001-8822-1892","observed_orcids":["https://orcid.org/0000-0001-8822-1892"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin D. Bunting","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019470085","display_name":"Stanton L. Gerson","orcid":"https://orcid.org/0000-0003-3106-2549","observed_orcids":["https://orcid.org/0000-0003-3106-2549"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanton L. Gerson","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017002895","display_name":"Gerhard Ehninger","orcid":"https://orcid.org/0000-0003-0056-0422","observed_orcids":["https://orcid.org/0000-0003-0056-0422"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Ehninger","raw_affiliation_strings":["Department of Medicine I, University Hospital Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, University Hospital Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112478994","display_name":"William W. Tse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William W. Tse","raw_affiliation_strings":["Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I4390039247"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.388,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.67707323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"11","first_page":"3294","last_page":"3294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normal-cytogenetics","display_name":"normal cytogenetics","score":0.9350000023841858},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.9089999794960022},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9089999794960022},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5789999961853027},{"id":"https://openalex.org/keywords/post-remission-therapy","display_name":"post-remission therapy","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7469593286514282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6362937092781067},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.6357656717300415},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5808183550834656},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5520152449607849},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.4926922917366028},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.4577758014202118},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3834126591682434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3262827396392822},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.11924275755882263},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11914852261543274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11103746294975281},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v106.11.3294.3294","doi":"https://doi.org/10.1182/blood.v106.11.3294.3294","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.3294.3294","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073493897","https://openalex.org/W2079292861","https://openalex.org/W3031268528","https://openalex.org/W2607107082","https://openalex.org/W2559774336","https://openalex.org/W2549733812","https://openalex.org/W2980250031","https://openalex.org/W4315866091","https://openalex.org/W2817153975","https://openalex.org/W2584950149"],"abstract_inverted_index":{"Abstract":[0],"Adult":[1],"AML":[2,12,87,116,124,156,165,197,343,377],"with":[3,91,126,173,206,254,264,280,345,363,378],"normal":[4,153,346],"cytogenetics":[5,347],"accounts":[6],"for":[7,108,339,376],"45\u201355%":[8],"of":[9,60,66,162,196,213,257],"de":[10],"novo":[11],"patients,":[13],"who":[14],"usually":[15],"are":[16,41,356],"categorized":[17],"as":[18,70,367,369,371],"intermediate-risk":[19],"but":[20],"have":[21],"wide":[22],"5-yr":[23],"overall":[24],"survival":[25,112],"(OS)":[26],"rates":[27,240],"between":[28],"24\u201342%.":[29],"The":[30,75],"optimal":[31],"post-remission":[32],"treatment":[33],"strategies,":[34],"especially":[35],"hematopoietic":[36],"stem":[37],"cell":[38],"transplantation":[39],"(HSCT),":[40],"yet":[42],"to":[43,204,209,232,278,320],"be":[44,54,333],"defined.":[45],"Recent":[46],"molecular":[47,336],"studies":[48,355],"suggested":[49],"that":[50,100,120,218,328],"clinical":[51],"outcome":[52],"may":[53,332,351],"predicted":[55],"by":[56,145,178],"presence":[57,256],"or":[58,62],"absence":[59],"mutation":[61,261],"changes":[63],"in":[64,85,114,123,137,151,314,365],"expression":[65,103,129,144,202,222,235,250,267,283,323,331],"specific":[67],"genes":[68],"such":[69],"FMS-like":[71],"tyrosine":[72],"3":[73,292],"(FLT3).":[74],"AF1q":[76,102,128,143,201,221,234,249,266,282,317,330,360],"gene,":[77],"an":[78,86,105,258,300],"MLL":[79],"fusion":[80],"partner,":[81],"originally":[82],"was":[83,251],"identified":[84],"patient\u2019s":[88],"leukemic":[89],"cells":[90],"t(1;":[92],"11)":[93],"(q21;":[94],"q23)":[95],"abnormalities.":[96],"We":[97],"previously":[98],"found":[99],"high":[101,127,246,265,316,329],"is":[104,361],"independent":[106],"poor-prognosticator":[107],"OS":[109,226,274,302],"and":[110,185,228,275,311,348],"disease-free":[111],"(DFS)":[113],"pediatric":[115],"patients.":[117],"Data":[118],"indicated":[119],"allogeneic":[121,184,269,349],"HSCT":[122,190,270,298,350],"patients":[125,157,182,187,198,344],"might":[130],"improve":[131,352],"survival.":[132],"To":[133],"test":[134],"this":[135],"hypothesis":[136],"adults,":[138],"we":[139],"studied":[140],"leukemia":[141],"marrow":[142],"real-time":[146],"polymerase":[147],"chain":[148],"reaction":[149],"(Q-PCR)":[150],"290":[152],"cytogenetic":[154],"adult":[155,342],"treated":[158],"within":[159],"a":[160,272,334,372],"trial":[161],"the":[163,214,219,255,315,321],"German":[164],"Study":[166],"Initiative":[167],"Leukemia":[168],"(DSIL).":[169],"Patients":[170,263],"were":[171],"induced":[172],"two":[174],"cytarabine-based":[175],"cycles":[176],"followed":[177],"consolidation":[179],"therapy.":[180],"Forty-eight":[181],"received":[183,188],"58":[186],"autologous":[189,297],"after":[191,241],"initial":[192],"induction.":[193],"Over":[194],"95%":[195],"had":[199,271],"elevated":[200],"compared":[203,231,277,319],"control":[205],"highest":[207,220],"up":[208],"409-fold.":[210],"Quartile":[211],"analysis":[212],"study":[215],"population":[216],"showed":[217,299],"trended":[223],"toward":[224],"worse":[225],"(p=0.09)":[227,313],"DFS":[229,276,312],"(p=0.1)":[230],"low":[233,281,322],"despite":[236],"similar":[237,273],"complete":[238],"remission":[239],"induction":[242],"(low":[243],"66%":[244],"vs.":[245,306],"69%).":[247],"High":[248],"significantly":[252],"associated":[253],"FLT3":[259,364,379],"ITD":[260],"(p=0.013).":[262],"given":[268],"pts":[279],"(62%":[284],"&":[285,289],"56%":[286],"vs":[287],"64%":[288],"62%":[290],"at":[291],"yr,":[293],"respectively).":[294],"In":[295],"fact,":[296],"inferior":[301],"(median":[303],"25":[304],"mo":[305],"median":[307],"not":[308],"reached,":[309],"p=0.04)":[310],"group":[318],"group.":[324],"These":[325],"data":[326],"suggest":[327],"useful":[335],"prognostic":[337],"marker":[338],"poor":[340],"prognosis":[341],"OS.":[353],"Further":[354],"focusing":[357],"on":[358],"whether":[359],"interactive":[362],"leukemogenesis":[366],"well":[368],"serving":[370],"simultaneous":[373],"therapeutic":[374],"target":[375],"mutation.":[380]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-02-10T00:00:00"}