{"id":"https://openalex.org/W2584401577","doi":"https://doi.org/10.1152/ajprenal.00497.2016","title":"Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis","display_name":"Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis","publication_year":2017,"publication_date":"2017-02-02","ids":{"openalex":"https://openalex.org/W2584401577","doi":"https://doi.org/10.1152/ajprenal.00497.2016","mag":"2584401577","pmid":"https://pubmed.ncbi.nlm.nih.gov/28148531","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5451553"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00497.2016","doi":"https://doi.org/10.1152/ajprenal.00497.2016","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00497.2016","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5451553","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005045243","display_name":"K. Melissa Hallow","orcid":"https://orcid.org/0000-0002-8156-2245","observed_orcids":["https://orcid.org/0000-0002-8156-2245"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Melissa Hallow","raw_affiliation_strings":["College of Engineering and College of Public Health, Department of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia;"],"raw_orcid":"https://orcid.org/0000-0002-8156-2245","affiliations":[{"raw_affiliation_string":"College of Engineering and College of Public Health, Department of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia;","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046762498","display_name":"Yeshitila Gebremichael","orcid":"https://orcid.org/0000-0002-4790-7975","observed_orcids":["https://orcid.org/0000-0002-4790-7975"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeshitila Gebremichael","raw_affiliation_strings":["College of Engineering and College of Public Health, Department of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering and College of Public Health, Department of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia;","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050618782","display_name":"Gabriel Helmlinger","orcid":"https://orcid.org/0000-0003-4925-2463","observed_orcids":["https://orcid.org/0000-0003-4925-2463"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Helmlinger","raw_affiliation_strings":["Astrazeneca Pharmaceuticals, Waltham, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astrazeneca Pharmaceuticals, Waltham, Massachusetts;","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085734264","display_name":"Volker Vallon","orcid":"https://orcid.org/0000-0002-9211-2063","observed_orcids":["https://orcid.org/0000-0002-9211-2063"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volker Vallon","raw_affiliation_strings":["Division of Nephrology and Hypertension, Departments of Medicine and Pharmacology, University of California San Diego, La Jolla, California; and","Veterans Affairs San Diego Healthcare System, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Departments of Medicine and Pharmacology, University of California San Diego, La Jolla, California; and","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Affairs San Diego Healthcare System, San Diego, California","institution_ids":["https://openalex.org/I4210099595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005045243"],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":null,"apc_paid":null,"fwci":10.1119,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.98916329,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"312","issue":"5","first_page":"F819","last_page":"F835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerular-hyperfiltration","display_name":"glomerular hyperfiltration","score":0.8799999952316284},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/proximal-tubule-sodium-reabsorption","display_name":"proximal tubule sodium reabsorption","score":0.9309999942779541},{"id":"https://openalex.org/keywords/tubuloglomerular-feedback","display_name":"tubuloglomerular feedback","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glomerular-hypertension","display_name":"glomerular hypertension","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pressure-natriuresis","display_name":"pressure natriuresis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sodium-balance","display_name":"sodium balance","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C7643261","wikidata":"https://www.wikidata.org/wiki/Q3742013","display_name":"Tubuloglomerular feedback","level":3,"score":0.8932855129241943},{"id":"https://openalex.org/C2776179406","wikidata":"https://www.wikidata.org/wiki/Q25326546","display_name":"Glomerular hyperfiltration","level":4,"score":0.8700888156890869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6923694610595703},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6567689776420593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5177411437034607},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5158252120018005},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.5091044306755066},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4672173261642456},{"id":"https://openalex.org/C57476199","wikidata":"https://www.wikidata.org/wiki/Q7312501","display_name":"Renal sodium reabsorption","level":4,"score":0.4638851284980774},{"id":"https://openalex.org/C174459258","wikidata":"https://www.wikidata.org/wiki/Q6980232","display_name":"Natriuresis","level":3,"score":0.4627174735069275},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.37753239274024963},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.3462187349796295}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006977","descriptor_name":"Hypertension, Renal","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006977","descriptor_name":"Hypertension, Renal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006977","descriptor_name":"Hypertension, Renal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009318","descriptor_name":"Natriuresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065608","descriptor_name":"Renal Reabsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajprenal.00497.2016","doi":"https://doi.org/10.1152/ajprenal.00497.2016","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00497.2016","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4845281","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5451553","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5451553","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5451553","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"},{"id":"pmid:28148531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28148531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4845281","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5451553","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G695802478","display_name":"UAB-UCSD O'Brien Center for Acute Kidney Injury Research","funder_award_id":"P30DK079337","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8418906495","display_name":"Glomerular and Tubular Function in the Diabetic Kidney","funder_award_id":"R01DK056248","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W137228593","https://openalex.org/W146953779","https://openalex.org/W1521707732","https://openalex.org/W1540594287","https://openalex.org/W1606165384","https://openalex.org/W1964733961","https://openalex.org/W1965843452","https://openalex.org/W1966187721","https://openalex.org/W1972051392","https://openalex.org/W1975508939","https://openalex.org/W1980041972","https://openalex.org/W1981967789","https://openalex.org/W1983909116","https://openalex.org/W1988692632","https://openalex.org/W1990025047","https://openalex.org/W1991631709","https://openalex.org/W1993375259","https://openalex.org/W1995996138","https://openalex.org/W2004582643","https://openalex.org/W2014339920","https://openalex.org/W2026285168","https://openalex.org/W2027213678","https://openalex.org/W2027545319","https://openalex.org/W2028930894","https://openalex.org/W2029704515","https://openalex.org/W2033212729","https://openalex.org/W2039190712","https://openalex.org/W2042443829","https://openalex.org/W2058906411","https://openalex.org/W2063732928","https://openalex.org/W2077120585","https://openalex.org/W2080568056","https://openalex.org/W2080620995","https://openalex.org/W2080650843","https://openalex.org/W2091031177","https://openalex.org/W2093992125","https://openalex.org/W2106537990","https://openalex.org/W2112710337","https://openalex.org/W2113285066","https://openalex.org/W2117890587","https://openalex.org/W2121585481","https://openalex.org/W2124502714","https://openalex.org/W2125375423","https://openalex.org/W2128814368","https://openalex.org/W2139137948","https://openalex.org/W2139321392","https://openalex.org/W2140070979","https://openalex.org/W2144823962","https://openalex.org/W2146264128","https://openalex.org/W2149544137","https://openalex.org/W2150192337","https://openalex.org/W2150280691","https://openalex.org/W2151299194","https://openalex.org/W2151920020","https://openalex.org/W2153899855","https://openalex.org/W2155190577","https://openalex.org/W2156329045","https://openalex.org/W2164080605","https://openalex.org/W2167583779","https://openalex.org/W2176863242","https://openalex.org/W2180605142","https://openalex.org/W2213965463","https://openalex.org/W2215556956","https://openalex.org/W2238341693","https://openalex.org/W2269785741","https://openalex.org/W2338246966","https://openalex.org/W2341168086","https://openalex.org/W2342752724","https://openalex.org/W2409568467","https://openalex.org/W2411534003","https://openalex.org/W2424539745","https://openalex.org/W2426210392","https://openalex.org/W4299867190","https://openalex.org/W4322699964"],"related_works":["https://openalex.org/W4389034384","https://openalex.org/W2288644520","https://openalex.org/W3009930262","https://openalex.org/W2089026665","https://openalex.org/W2164080605","https://openalex.org/W1672921524","https://openalex.org/W2115385271","https://openalex.org/W1981418790","https://openalex.org/W4390183530","https://openalex.org/W2265163395"],"abstract_inverted_index":{"Glomerular":[0],"hypertension":[1,178,227],"and":[2,11,41,48,69,109,156,179,209,228,242],"hyperfiltration":[3,22,80,105,180,229,241],"in":[4,32,36,91,111,133,136,151,161,176,230],"early":[5],"diabetes":[6],"are":[7,116],"associated":[8],"with":[9],"development":[10],"progression":[12],"of":[13,20,50,61,78,89,147,159,171,190,205,212,214,225,239],"diabetic":[14,21,232,240],"kidney":[15,64],"disease.":[16],"The":[17,82,164],"tubular":[18,149,162,217],"hypothesis":[19],"proposes":[23],"that":[24,85,98,167,201],"it":[25],"is":[26,99],"initiated":[27],"by":[28,103,107],"a":[29,58,95,187],"primary":[30,87,191,206],"increase":[31],"sodium":[33],"(Na)":[34],"reabsorption":[35,135],"the":[37,42,62,72,76,79,86,92,104,131,145,157,174,198,203,210,215,223,231,236,247],"proximal":[38,248],"tubule":[39],"(PT)":[40],"resulting":[43],"tubuloglomerular":[44],"feedback":[45],"(TGF)":[46],"response":[47,137],"lowering":[49],"Bowman":[51],"space":[52],"pressure":[53],"(PBow).":[54],"Here":[55],"we":[56,195],"utilized":[57],"mathematical":[59],"model":[60,83],"human":[63],"to":[65,118,138,153,182,219],"investigate":[66],"over":[67],"acute":[68],"chronic":[70],"timescales":[71],"mechanisms":[73],"responsible":[74],"for":[75,197],"magnitude":[77],"response.":[81],"implicates":[84],"hyperreabsorption":[88,208],"Na":[90,96,120,134,184],"PT":[93,192,207],"produces":[94],"imbalance":[97],"only":[100],"partially":[101],"restored":[102],"induced":[106],"TGF":[108],"changes":[110],"PBow.":[112],"Thus":[113],"secondary":[114,169],"adaptations":[115],"needed":[117,181],"restore":[119,183],"balance.":[121],"This":[122],"may":[123],"include":[124],"neurohumoral":[125],"transport":[126,172],"regulation":[127],"and/or":[128],"pressure-natriuresis":[129],"(i.e.,":[130],"decrease":[132],"increased":[139],"renal":[140],"perfusion":[141],"pressure).":[142],"We":[143],"explored":[144],"role":[146],"each":[148],"segment":[150],"contributing":[152],"this":[154],"compensation":[155],"consequences":[158],"impairment":[160,213],"compensation.":[163],"simulations":[165],"indicate":[166],"impaired":[168],"downregulation":[170],"potentiated":[173],"rise":[175],"glomerular":[177,226],"balance":[185],"at":[186],"given":[188],"level":[189,224],"hyperreabsorption.":[193],"Therefore,":[194],"propose":[196],"first":[199],"time":[200],"both":[202],"extent":[204],"degree":[211],"distal":[216],"responsiveness":[218],"regulatory":[220],"signals":[221],"determine":[222],"kidney,":[233],"thereby":[234],"extending":[235],"tubule-centric":[237],"concept":[238],"potential":[243],"therapeutic":[244],"approaches":[245],"beyond":[246],"tubule.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-10T00:00:00"}
