{"id":"https://openalex.org/W25841796","doi":null,"title":"PERFIL ONTOGEN\u00c9TICO DA CAPTA\u00c7\u00c3O BASAL DE GLUTAMATO EM FATIAS DE ESTRUTURAS CEREBRAIS DE RATOS E AVALIA\u00c7\u00c3O DE SUA SENSIBILIDADE \u00c0 GUANOSINA","display_name":"PERFIL ONTOGEN\u00c9TICO DA CAPTA\u00c7\u00c3O BASAL DE GLUTAMATO EM FATIAS DE ESTRUTURAS CEREBRAIS DE RATOS E AVALIA\u00c7\u00c3O DE SUA SENSIBILIDADE \u00c0 GUANOSINA","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W25841796","mag":"25841796"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3201637","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/5289","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059636215","display_name":"Ana Paula Thomazi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ana Paula Thomazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059636215"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.16369999945163727,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ontogeny","display_name":"ontogeny","score":0.8289999961853027},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8539999723434448},{"id":"https://openalex.org/keywords/guanosine","display_name":"guanosine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":1.0},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9750000238418579},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.6340000033378601},{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.984000027179718},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sodium-dependent-transport","display_name":"sodium-dependent transport","score":0.6140000224113464},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.36800000071525574},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6620000004768372},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6510000228881836},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.6510000228881836},{"id":"https://openalex.org/keywords/brain-slices","display_name":"brain slices","score":0.36000001430511475},{"id":"https://openalex.org/keywords/in-vitro-uptake","display_name":"in vitro uptake","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3825734257698059},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.33325228095054626}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:3201637","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/5289","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5289","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:lume.ufrgs.br:10183/5289","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5289","pdf_url":null,"source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o"},{"id":"mag:25841796","doi":null,"is_oa":false,"landing_page_url":"https://www.lume.ufrgs.br/bitstream/handle/10183/5289/000423952.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3201637","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/5289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":124,"referenced_works":["https://openalex.org/W267012506","https://openalex.org/W1439525013","https://openalex.org/W1490043608","https://openalex.org/W1490951507","https://openalex.org/W1512720139","https://openalex.org/W1528744681","https://openalex.org/W1603110302","https://openalex.org/W1605408170","https://openalex.org/W1629378997","https://openalex.org/W1900227502","https://openalex.org/W1900368273","https://openalex.org/W1944942244","https://openalex.org/W1963487339","https://openalex.org/W1965591468","https://openalex.org/W1965902234","https://openalex.org/W1969400861","https://openalex.org/W1970217675","https://openalex.org/W1972737184","https://openalex.org/W1973169178","https://openalex.org/W1976289522","https://openalex.org/W1976400860","https://openalex.org/W1976754780","https://openalex.org/W1979512287","https://openalex.org/W1980420429","https://openalex.org/W1983130749","https://openalex.org/W1983197885","https://openalex.org/W1983353615","https://openalex.org/W1983836947","https://openalex.org/W1985231669","https://openalex.org/W1987329304","https://openalex.org/W1988467687","https://openalex.org/W1988657739","https://openalex.org/W1991391149","https://openalex.org/W1991542726","https://openalex.org/W1991701465","https://openalex.org/W1993463589","https://openalex.org/W1998510465","https://openalex.org/W2000703659","https://openalex.org/W2001293242","https://openalex.org/W2003272712","https://openalex.org/W2003410399","https://openalex.org/W2009190178","https://openalex.org/W2009812273","https://openalex.org/W2016575029","https://openalex.org/W2017002693","https://openalex.org/W2019690187","https://openalex.org/W2019742983","https://openalex.org/W2020705596","https://openalex.org/W2022788380","https://openalex.org/W2023811880","https://openalex.org/W2024945446","https://openalex.org/W2026368095","https://openalex.org/W2027129098","https://openalex.org/W2030352252","https://openalex.org/W2031315226","https://openalex.org/W2031893017","https://openalex.org/W2032879739","https://openalex.org/W2035371282","https://openalex.org/W2035750459","https://openalex.org/W2036903429","https://openalex.org/W2037414045","https://openalex.org/W2038469239","https://openalex.org/W2038826547","https://openalex.org/W2039248264","https://openalex.org/W2043166209","https://openalex.org/W2043686726","https://openalex.org/W2045035156","https://openalex.org/W2047085703","https://openalex.org/W2049384506","https://openalex.org/W2050634340","https://openalex.org/W2051506807","https://openalex.org/W2051554010","https://openalex.org/W2053268711","https://openalex.org/W2054452512","https://openalex.org/W2055698215","https://openalex.org/W2057100505","https://openalex.org/W2058948754","https://openalex.org/W2059415866","https://openalex.org/W2068055544","https://openalex.org/W2072078981","https://openalex.org/W2073830624","https://openalex.org/W2074683128","https://openalex.org/W2074919593","https://openalex.org/W2079580249","https://openalex.org/W2082220840","https://openalex.org/W2083327396","https://openalex.org/W2084001480","https://openalex.org/W2084258351","https://openalex.org/W2087268155","https://openalex.org/W2089202206","https://openalex.org/W2089745167","https://openalex.org/W2092358916","https://openalex.org/W2092939335","https://openalex.org/W2093187114","https://openalex.org/W2094164373","https://openalex.org/W2094673798","https://openalex.org/W2096675020","https://openalex.org/W2102131116","https://openalex.org/W2103926307","https://openalex.org/W2105331328","https://openalex.org/W2116447221","https://openalex.org/W2119888580","https://openalex.org/W2121156887","https://openalex.org/W2126033464","https://openalex.org/W2128744963","https://openalex.org/W2131408584","https://openalex.org/W2133067333","https://openalex.org/W2138733394","https://openalex.org/W2142097068","https://openalex.org/W2144918294","https://openalex.org/W2149406855","https://openalex.org/W2150929583","https://openalex.org/W2152732725","https://openalex.org/W2153116158","https://openalex.org/W2153315387","https://openalex.org/W2153450997","https://openalex.org/W2157853053","https://openalex.org/W2158402600","https://openalex.org/W2168367599","https://openalex.org/W2246678623","https://openalex.org/W2315842096","https://openalex.org/W2323399887","https://openalex.org/W2412188999","https://openalex.org/W2428447800"],"related_works":["https://openalex.org/W2017692155","https://openalex.org/W7042275089","https://openalex.org/W2233550203","https://openalex.org/W2249391468","https://openalex.org/W2231459758","https://openalex.org/W7120698816","https://openalex.org/W7065463519","https://openalex.org/W1931953074","https://openalex.org/W2224679915","https://openalex.org/W7009593589"],"abstract_inverted_index":{"O":[0,216],"glutamato,":[1,72],"quando":[2],"em":[3,105,175,185,195,210,237,253,258,271,278],"altas":[4],"concentra\u00e7\u00f5es":[5],"na":[6,208],"fenda":[7],"sin\u00e1ptica,":[8],"\u00e9":[9,54],"excitot\u00f3xico,":[10],"podendo":[11],"levar":[12],"\u00e0":[13,17,161],"morte":[14],"celular":[15],"devido":[16],"hiper-estimula\u00e7\u00e3o":[18],"de":[19,47,50,57,60,62,66,71,86,90,95,124,135,140,157,163,171,234,239,241,243,250,293,303],"seus":[20,51],"receptores.":[21],"Seu":[22],"efeito":[23,217],"neurot\u00f3xico":[24],"tem":[25],"sido":[26],"relacionado":[27],"a":[28,84,155,169,228,231,274],"v\u00e1rias":[29],"doen\u00e7as":[30],"agudas":[31],"e":[32,41,74,97,109,131,138,145,149,187,199,205,223,260,273],"cr\u00f4nicas":[33],"do":[34],"SNC,":[35],"tais":[36],"como":[37,287],"isquemia,":[38],"epilepsia,":[39],"Alzheimer":[40],"Parkinson.":[42],"A":[43,246],"manuten\u00e7\u00e3o":[44],"dos":[45],"n\u00edveis":[46,52],"glutamato":[48,87,125,158,172,235,251],"abaixo":[49],"excitot\u00f3xicos":[53],"realizada":[55],"atrav\u00e9s":[56],"um":[58,119,202,291],"mecanismo":[59,292],"transporte":[61],"alta":[63],"afinidade":[64],"dependente":[65],"s\u00f3dio.":[67],"Os":[68],"principais":[69],"transportadores":[70],"GLAST":[73],"GLT-1,":[75],"est\u00e3o":[76],"presentes":[77],"nos":[78],"astr\u00f3citos.":[79],"Alguns":[80],"estudos":[81,101],"demonstram":[82],"que":[83,227,269,296],"capta\u00e7\u00e3o":[85,123,156,170,209,232,249],"parece":[88,220,289],"variar":[89],"acordo":[91],"com":[92,142,255],"o":[93,129,301],"per\u00edodo":[94],"desenvolvimento":[96,130],"envelhecimento;":[98],"entretanto,":[99],"poucos":[100],"avaliam":[102],"este":[103],"par\u00e2metro":[104,277],"animais":[106,176,254],"imaturos,":[107],"maduros":[108],"velhos":[110,182,213,281],"utilizando":[111],"uma":[112],"\u00fanica":[113],"metodologia.":[114],"Neste":[115],"trabalho,":[116],"n\u00f3s":[117],"tra\u00e7amos":[118],"perfil":[120],"ontogen\u00e9tico":[121],"da":[122,218,248],"in":[126],"vitro,":[127],"durante":[128,300],"envelhecimento,":[132],"usando":[133],"fatias":[134,238],"estriado,":[136],"hipocampo":[137,188,200,261],"c\u00f3rtex":[139,240],"ratos":[141,181,190,211,242,279],"10,":[143],"21":[144],"60":[146],"dias,":[147],"15":[148,256],"26":[150],"meses.":[151],"Tamb\u00e9m":[152],"analisamos":[153],"se":[154],"era":[159],"sens\u00edvel":[160],"presen\u00e7a":[162],"guanosina.":[164],"Em":[165,197],"todas":[166],"as":[167],"estruturas":[168],"foi":[173],"maior":[174],"jovens":[177,192],"decaindo":[178],"ent\u00e3o,":[179],"at\u00e9":[180],"(15":[183],"meses)":[184],"estriado":[186,198,259],"ou":[189],"adultos":[191],"(60":[193],"dias)":[194],"c\u00f3rtex.":[196],"observamos":[201],"aumento":[203],"parcial":[204,286],"total,":[206,288],"respectivamente,":[207],"muito":[212,280],"(26":[214,282],"meses).":[215],"guanosina":[219],"ser":[221,290],"idade":[222],"estrutura":[224],"dependentes,":[225],"visto":[226],"mesma":[229],"aumentou":[230],"basal":[233],"somente":[236],"10":[244],"dias.":[245],"diminui\u00e7\u00e3o":[247],"observada":[252],"meses":[257],"pode":[262,297],"estar":[263,298],"relacionada":[264],"\u00e0s":[265],"diversas":[266],"desordens":[267],"neurodegenerativas":[268],"ocorrem":[270],"idosos,":[272],"recupera\u00e7\u00e3o":[275],"deste":[276],"II":[283],"meses),":[284],"tanto":[285],"adapta\u00e7\u00e3o":[294],"compensat\u00f3rio":[295],"ocorrendo":[299],"processo":[302],"envelhecimento.":[304]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}