{"id":"https://openalex.org/W2583976468","doi":"https://doi.org/10.1002/iid3.147","title":"POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease","display_name":"POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease","publication_year":2017,"publication_date":"2017-02-02","ids":{"openalex":"https://openalex.org/W2583976468","doi":"https://doi.org/10.1002/iid3.147","mag":"2583976468","pmid":"https://pubmed.ncbi.nlm.nih.gov/28474501","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5418136"},"language":"en","primary_location":{"id":"doi:10.1002/iid3.147","doi":"https://doi.org/10.1002/iid3.147","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iid3.147","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.147","source":{"id":"https://openalex.org/S2764380340","display_name":"Immunity Inflammation and Disease","issn_l":"2050-4527","issn":["2050-4527"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, Inflammation and Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.147","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010505503","display_name":"Becky J. Buelow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Becky J. Buelow","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060117787","display_name":"Michelle M. Rohlfing","orcid":"https://orcid.org/0009-0007-8354-8811","observed_orcids":["https://orcid.org/0009-0007-8354-8811"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Rohlfing","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087253711","display_name":"Fran\u00e7oise Jung","orcid":"https://orcid.org/0009-0002-2731-0327","observed_orcids":["https://orcid.org/0009-0002-2731-0327","https://orcid.org/0000-0003-2791-2934"]},"institutions":[{"id":"https://openalex.org/I4210155218","display_name":"Polyphor (Switzerland)","ror":"https://ror.org/056010s74","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210155218"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Jung","raw_affiliation_strings":["Polyphor Ltd, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polyphor Ltd, Allschwil, Switzerland","institution_ids":["https://openalex.org/I4210155218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108466464","display_name":"Garry J. Douglas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155218","display_name":"Polyphor (Switzerland)","ror":"https://ror.org/056010s74","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210155218"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Garry J. Douglas","raw_affiliation_strings":["Polyphor Ltd, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polyphor Ltd, Allschwil, Switzerland","institution_ids":["https://openalex.org/I4210155218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043556111","display_name":"Mitchell H. Grayson","orcid":"https://orcid.org/0000-0002-4673-2122","observed_orcids":["https://orcid.org/0000-0002-4673-2122"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mitchell H. Grayson","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043556111"],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":0.4114,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.65258498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"2","first_page":"98","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5569999814033508},{"id":"https://openalex.org/keywords/sendai-virus","display_name":"Sendai virus","score":0.746999979019165},{"id":"https://openalex.org/keywords/ccl28","display_name":"CCL28","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ccr10","display_name":"CCR10","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ccr3","display_name":"CCR3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mucous-metaplasia","display_name":"mucous cell metaplasia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/innate-immune-cells","display_name":"innate immune cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.8050000071525574},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cytokine-inhibition","display_name":"cytokine inhibition","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6510699987411499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6136960983276367},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5618544220924377},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010253","descriptor_name":"Respirovirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010253","descriptor_name":"Respirovirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010253","descriptor_name":"Respirovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D029082","descriptor_name":"Sendai virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054447","descriptor_name":"Receptors, CCR10","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054447","descriptor_name":"Receptors, CCR10","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/iid3.147","doi":"https://doi.org/10.1002/iid3.147","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iid3.147","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.147","source":{"id":"https://openalex.org/S2764380340","display_name":"Immunity Inflammation and Disease","issn_l":"2050-4527","issn":["2050-4527"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, Inflammation and Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4268850","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5418136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5418136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5418136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immun Inflamm Dis","raw_type":"Text"},{"id":"pmid:28474501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28474501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, inflammation and disease","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/iid3.147","doi":"https://doi.org/10.1002/iid3.147","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iid3.147","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iid3.147","source":{"id":"https://openalex.org/S2764380340","display_name":"Immunity Inflammation and Disease","issn_l":"2050-4527","issn":["2050-4527"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity, Inflammation and Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312687","display_name":"Children\u2019s Hospital of Wisconsin Research Institute","ror":"https://ror.org/058g1h315"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2583976468.pdf","grobid_xml":"https://content.openalex.org/works/W2583976468.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1485872830","https://openalex.org/W1969134585","https://openalex.org/W1971573104","https://openalex.org/W1997200613","https://openalex.org/W1998846885","https://openalex.org/W2035230720","https://openalex.org/W2055431368","https://openalex.org/W2091327712","https://openalex.org/W2096760010","https://openalex.org/W2101350279","https://openalex.org/W2102621382","https://openalex.org/W2105489252","https://openalex.org/W2115252063","https://openalex.org/W2117502709","https://openalex.org/W2130614990","https://openalex.org/W2136722399","https://openalex.org/W2143014879","https://openalex.org/W2159473787","https://openalex.org/W2160970931","https://openalex.org/W2164513774","https://openalex.org/W2165539495","https://openalex.org/W2168438381","https://openalex.org/W2170734040","https://openalex.org/W2262728865","https://openalex.org/W4236661077"],"related_works":["https://openalex.org/W2314001821","https://openalex.org/W2168438381","https://openalex.org/W1812124934","https://openalex.org/W1998726603","https://openalex.org/W3212829648","https://openalex.org/W3008992704","https://openalex.org/W1978225416","https://openalex.org/W2035230720","https://openalex.org/W3001128936","https://openalex.org/W2783404392"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Asthma":[1],"is":[2,91,261,276],"major":[3],"health":[4],"burden":[5],"throughout":[6],"the":[7,23,41,69,74,101,131,265,272],"world,":[8],"and":[9,64,87,172,179,193,212,278],"there":[10],"are":[11,85],"no":[12],"therapies":[13],"that":[14,60],"have":[15,47],"been":[16,36],"shown":[17],"to":[18,21,38,72,113,191,238,241,263],"be":[19,239],"able":[20],"prevent":[22,100,264],"development":[24,75,102,132,208,266],"of":[25,43,51,68,76,96,103,109,123,133,209,221,250,267,274],"disease.":[26,79,106,136,270],"A":[27],"severe":[28,53,257],"respiratory":[29,54,258],"paramyxoviral":[30,55,259],"infection":[31,56,260],"early":[32,66,228],"in":[33,230,244],"life":[34],"has":[35],"demonstrated":[37],"greatly":[39],"increase":[40],"risk":[42],"developing":[44],"asthma.":[45],"We":[46],"a":[48,52,118,242],"mouse":[49],"model":[50],"(Sendai":[57],"virus,":[58],"SeV)":[59],"mimics":[61],"human":[62],"disease,":[63],"requires":[65,279],"expression":[67],"cytokine":[70],"CCL28":[71,84,251],"drive":[73],"post-viral":[77,104,134,222,268],"airway":[78,105,135,189,210,223,269],"The":[80,107,219],"known":[81,93],"receptors":[82,98],"for":[83],"CCR3":[86],"CCR10.":[88],"However,":[89,271],"it":[90],"not":[92,236],"if":[94,115],"blockade":[95],"these":[97],"will":[99,126],"objective":[108],"this":[110],"study":[111],"was":[112,197,225],"determine":[114],"treatment":[116],"with":[117,142,201,227],"protein":[119],"epitope":[120],"mimetic":[121],"antagonist":[122],"CCR10,":[124],"POL7085,":[125],"provide":[127],"sufficient":[128,262],"protection":[129],"against":[130],"METHODS:":[137],"C57BL6":[138],"mice":[139,154],"were":[140,155,183],"inoculated":[141],"SeV":[143,217],"or":[144,160,162,204,246,252],"UV":[145],"inactivated":[146],"SeV.":[147],"From":[148],"day":[149,165,186],"3-19":[150],"post":[151],"inoculation":[152],"(PI),":[153],"subcutaneously":[156],"administered":[157],"daily":[158],"POL7085":[159,205],"saline,":[161],"every":[163],"other":[164],"anti-CCL28":[166,203],"mAb.":[167],"On":[168],"days":[169],"8,":[170],"10,":[171],"12":[173],"PI":[174,188],"bronchoalveolar":[175],"cytokines,":[176],"serum":[177],"IgE,":[178],"lung":[180],"cellular":[181],"constituents":[182],"measured.":[184,198],"At":[185],"21":[187],"hyper-reactivity":[190,211],"methacholine":[192],"mucous":[194,213],"cell":[195,214],"metaplasia":[196,215],"RESULTS:":[199],"Treatment":[200],"either":[202],"significantly":[206],"reduced":[207],"following":[216],"infection.":[218],"prevention":[220],"disease":[224],"associated":[226],"reductions":[229],"innate":[231],"immune":[232],"cells,":[233],"but":[234],"did":[235],"appear":[237],"due":[240],"reduction":[243],"IL-13":[245],"IgE.":[247],"CONCLUSIONS:":[248],"Blockade":[249],"CCR10":[253],"during":[254],"an":[255],"acute":[256],"mechanism":[273],"action":[275],"unclear":[277],"further":[280],"exploration.":[281]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-10T00:00:00"}
