{"id":"https://openalex.org/W2583889977","doi":"https://doi.org/10.1182/blood.v126.23.664.664","title":"Distinct Bone Marrow Blood Vessels Differentially Regulate Normal and Malignant Hematopoietic Stem and Progenitor Cells","display_name":"Distinct Bone Marrow Blood Vessels Differentially Regulate Normal and Malignant Hematopoietic Stem and Progenitor Cells","publication_year":2015,"publication_date":"2015-12-03","ids":{"openalex":"https://openalex.org/W2583889977","doi":"https://doi.org/10.1182/blood.v126.23.664.664","mag":"2583889977"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v126.23.664.664","doi":"https://doi.org/10.1182/blood.v126.23.664.664","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.664.664","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023531123","display_name":"Tomer Itkin","orcid":"https://orcid.org/0000-0002-9950-0149","observed_orcids":["https://orcid.org/0000-0002-9950-0149"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Tomer Itkin","raw_affiliation_strings":["Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027215308","display_name":"Shiri Gur\u2010Cohen","orcid":"https://orcid.org/0000-0002-6372-2284","observed_orcids":["https://orcid.org/0000-0002-6372-2284"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Shiri Gur Cohen","raw_affiliation_strings":["Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061391818","display_name":"Joel A. Spencer","orcid":"https://orcid.org/0000-0002-4013-8763","observed_orcids":["https://orcid.org/0000-0002-4013-8763"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel A. Spencer","raw_affiliation_strings":["Massachusetts General Hospital, Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078152563","display_name":"Amir Schajnovitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amir Schajnovitz","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030022776","display_name":"Saravana Kumar Ramasamy","orcid":"https://orcid.org/0000-0003-2658-2945","observed_orcids":["https://orcid.org/0000-0003-2658-2945","https://orcid.org/0000-0001-6462-4988"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Saravana K. Ramasamy","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Munster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Munster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059424809","display_name":"Anjali P. Kusumbe","orcid":"https://orcid.org/0000-0002-1911-5495","observed_orcids":["https://orcid.org/0000-0002-1911-5495"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anjali P. Kusumbe","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Munster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Munster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024125174","display_name":"Yookyung Jung","orcid":"https://orcid.org/0000-0003-2790-6016","observed_orcids":["https://orcid.org/0000-0003-2790-6016"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yookyung Jung","raw_affiliation_strings":["Massachusetts General Hospital, Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024496971","display_name":"Guy Ledergor","orcid":"https://orcid.org/0000-0003-0443-6066","observed_orcids":["https://orcid.org/0000-0003-0443-6066"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Guy Ledergor","raw_affiliation_strings":["Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070222392","display_name":"Idan Milo","orcid":"https://orcid.org/0000-0002-2459-3061","observed_orcids":["https://orcid.org/0000-0002-2459-3061"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Idan Milo","raw_affiliation_strings":["Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087628189","display_name":"Michael Gustave Poulos","orcid":"https://orcid.org/0000-0002-7622-9966","observed_orcids":["https://orcid.org/0000-0002-7622-9966"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Gustave Poulos","raw_affiliation_strings":["Ansary Stem Cell Institute/Genetic Medicine, Weill Cornell Medical College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ansary Stem Cell Institute/Genetic Medicine, Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Garcia Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Maria Garcia Fernandez","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041354072","display_name":"Alexander Kalinkovich","orcid":"https://orcid.org/0000-0002-5980-3903","observed_orcids":["https://orcid.org/0000-0002-5980-3903"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alexander Kalinkovich","raw_affiliation_strings":["Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048078874","display_name":"Aya Ludin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Aya Ludin","raw_affiliation_strings":["Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080730322","display_name":"\u00d3rit Kollet","orcid":"https://orcid.org/0000-0002-4912-4579","observed_orcids":["https://orcid.org/0000-0002-4912-4579"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Orit Kollet","raw_affiliation_strings":["Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075140332","display_name":"Guy Shakhar","orcid":"https://orcid.org/0000-0002-0610-6995","observed_orcids":["https://orcid.org/0000-0002-0610-6995"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Guy Shakhar","raw_affiliation_strings":["The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006520748","display_name":"Sim\u00f3n M\u00e9ndez\u2010Ferrer","orcid":"https://orcid.org/0000-0002-9805-9988","observed_orcids":["https://orcid.org/0000-0002-9805-9988"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Simon Mendez-Ferrer","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain","Stem Cell Institute and Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]},{"raw_affiliation_string":"Stem Cell Institute and Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044954737","display_name":"Jason M. Butler","orcid":"https://orcid.org/0000-0002-8630-9038","observed_orcids":["https://orcid.org/0000-0002-8630-9038","https://orcid.org/0000-0001-6671-3159"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason M. Butler","raw_affiliation_strings":["Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090799132","display_name":"Shahin Rafii","orcid":"https://orcid.org/0000-0001-5605-1067","observed_orcids":["https://orcid.org/0000-0001-5605-1067"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahin Rafii","raw_affiliation_strings":["Department of Medicine, Weill Cornell Medical College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055656957","display_name":"Ralf H. Adams","orcid":"https://orcid.org/0000-0003-3031-7677","observed_orcids":["https://orcid.org/0000-0003-3031-7677"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ralf H. Adams","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Munster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Munster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083648953","display_name":"David T. Scadden","orcid":"https://orcid.org/0000-0001-9821-7133","observed_orcids":["https://orcid.org/0000-0001-9821-7133"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Scadden","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA","Harvard Stem Cell Institute, Cambridge, MA","Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054061274","display_name":"Charles P. Lin","orcid":"https://orcid.org/0000-0002-7450-627X","observed_orcids":["https://orcid.org/0000-0002-7450-627X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles P. Lin","raw_affiliation_strings":["Massachusetts General Hospital, Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052979776","display_name":"Tsvee Lapidot","orcid":"https://orcid.org/0000-0001-9844-6454","observed_orcids":["https://orcid.org/0000-0001-9844-6454"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tsvee Lapidot","raw_affiliation_strings":["Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5023531123","https://openalex.org/A5024125174","https://openalex.org/A5024496971","https://openalex.org/A5027215308","https://openalex.org/A5030022776","https://openalex.org/A5048078874","https://openalex.org/A5054061274","https://openalex.org/A5055656957","https://openalex.org/A5059424809","https://openalex.org/A5061391818","https://openalex.org/A5070222392","https://openalex.org/A5075140332","https://openalex.org/A5078152563","https://openalex.org/A5087628189"],"corresponding_institution_ids":["https://openalex.org/I2809107791","https://openalex.org/I4210087915","https://openalex.org/I4210152666","https://openalex.org/I4387153466","https://openalex.org/I53964585"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.3443548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"126","issue":"23","first_page":"664","last_page":"664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.7429999709129333},{"id":"https://openalex.org/keywords/bone-marrow-sinusoids","display_name":"bone marrow sinusoids","score":0.578000009059906},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.6759999990463257},{"id":"https://openalex.org/keywords/endothelial-barrier-integrity","display_name":"endothelial barrier integrity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.843999981880188},{"id":"https://openalex.org/keywords/cxcl12-cxcr4-signaling","display_name":"CXCL12/CXCR4 signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/pericytes","display_name":"pericytes","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hspc-mobilization","display_name":"HSPC mobilization","score":0.8199999928474426},{"id":"https://openalex.org/keywords/amd3100","display_name":"AMD3100","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7311601638793945},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7147857546806335},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6956359148025513},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6760493516921997},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6465192437171936},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5894479751586914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5102078914642334},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.48155477643013},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.43249428272247314},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37869715690612793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3207510709762573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.17549005150794983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11403045058250427},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v126.23.664.664","doi":"https://doi.org/10.1182/blood.v126.23.664.664","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.664.664","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2339406441","https://openalex.org/W4410740886","https://openalex.org/W2792293270","https://openalex.org/W2553379936","https://openalex.org/W1591912379","https://openalex.org/W2098751291","https://openalex.org/W2060930865","https://openalex.org/W4231705930","https://openalex.org/W2501690217","https://openalex.org/W3210934787"],"abstract_inverted_index":{"Abstract":[0],"Bone":[1],"marrow":[2],"(BM)":[3],"endothelial":[4,317,329,427],"cells":[5,256,315,371,395,405],"(BMECs)":[6],"form":[7],"a":[8,80,171,251,359,413],"network":[9],"of":[10,55,157,180,254,336,419],"blood":[11,185],"vessels":[12],"(BVs)":[13],"that":[14,137,225,307,403],"regulate":[15,70],"both":[16],"leukocyte":[17,85,230,445],"trafficking":[18,86,232,347,446],"and":[19,22,40,62,75,84,91,118,133,154,159,197,228,274,313,348,356,415,424],"hematopoietic":[20],"stem":[21,74,125,312],"progenitor":[23,76,314],"cell":[24,77],"(HSPC)":[25],"maintenance.":[26],"However,":[27],"it":[28],"is":[29],"not":[30,270],"clear":[31],"how":[32],"BMECs":[33],"balance":[34],"between":[35],"these":[36,42,303],"dual":[37],"regulatory":[38],"roles":[39],"if":[41],"events":[43],"occur":[44,87],"at":[45,88,235],"the":[46,52,114,151,209,236,243,388],"same":[47,201],"vascular":[48],"site.":[49],"We":[50,401],"define":[51],"BM":[53,73,102,181,248,292,311,353,374,381,407,421,436,449],"architecture":[54],"functionally":[56],"distinct":[57,99,435],"BVs,":[58],"their":[59,188,258,345,352],"spatial":[60],"localization":[61],"association":[63],"with":[64,98,217,283,302,322,368,412,438,452],"specific":[65,96,279,330],"stromal":[66,128,422],"precursors,":[67],"which":[68],"cooperatively":[69],"HSPC":[71,264,298,324,448],"fate.":[72],"maintenance":[78,357,450],"in":[79,165,170,208,257,280,296,342,358],"metabolically":[81,360],"non-active":[82,361],"state":[83],"separate":[89],"sites":[90,451],"are":[92],"differentially":[93],"regulated":[94],"by":[95,110,124,192,387],"BVs":[97,140,272,437],"permeability":[100,146,273,376],"properties.":[101],"arteries":[103],"were":[104,121,168],"found":[105,169,306],"to":[106,147,183,242,380,398,409],"be":[107],"mostly":[108],"encircled":[109],"aSMA+":[111],"pericytes":[112],"whereas":[113],"ensuing":[115],"small-diameter":[116],"endosteal":[117,138,244],"trabecular":[119],"arterioles":[120],"predominantly":[122],"surrounded":[123],"cell-niche":[126],"supporting":[127],"precursor":[129],"cells.":[130],"Live":[131,222],"imaging":[132,223],"flow":[134,143],"analysis":[135],"revealed":[136],"arteriole":[139],"exhibited":[141,191,372],"high":[142,155],"rate,":[144],"low":[145,173],"external":[148],"plasma":[149],"from":[150],"peripheral":[152,184],"blood,":[153],"levels":[156,341],"adhesion-":[158],"tight-junction":[160],"molecules.":[161],"Primitive":[162],"HSPCs":[163,182,207,212],"located":[164,240],"peri-arteriole":[166],"regions":[167],"non-activated,":[172],"reactive":[174],"oxygen":[175],"species":[176],"(ROS)":[177],"state.":[178,362],"Exposure":[179],"plasma,":[186],"enhanced":[187,193,214,297,320],"metabolic":[189],"activity,":[190],"intracellular":[194],"ROS":[195,340],"levels,":[196],"glucose":[198],"uptake.":[199],"The":[200],"was":[202,319],"also":[203],"evident":[204],"for":[205],"circulating":[206],"blood.":[210],"Plasma-exposed":[211],"displayed":[213,396],"motility":[215],"alongside":[216],"reduced":[218,323,373],"long-term":[219],"repopulation":[220],"potential.":[221],"showed":[224],"all":[226],"immature":[227],"mature":[229],"bi-directional":[231,325,346],"occurred":[233],"exclusively":[234],"more":[237],"permeable":[238],"sinusoids,":[239],"downstream":[241],"arterioles.":[245],"Of":[246,363],"note,":[247,364],"sinusoids":[249],"contained":[250],"higher":[252],"prevalence":[253],"ROShigh":[255],"microenvironment,":[259],"including":[260],"HSPCs.":[261],"Rapid":[262],"AMD3100-induced":[263],"mobilization":[265],"preferentially":[266],"affected":[267],"sinusoidal":[268],"but":[269],"arterial":[271],"CXCL12":[275],"chemokine":[276],"release.":[277],"Endothelial":[278],"vivo":[281],"interference":[282],"CXCL12-CXCR4":[284],"interactions,":[285],"via":[286,384],"conditional":[287,328],"CXCR4":[288],"genetic":[289,332],"deletion,":[290],"hampered":[291],"barrier":[293,337,375,440],"integrity":[294,318,338],"resulting":[295],"egress.":[299],"In":[300,429],"line":[301],"results":[304],"we":[305],"during":[308],"conditions":[309],"favoring":[310],"expansion,":[316],"along":[321],"trafficking.":[326],"Conversely,":[327],"induced":[331],"or":[333,447],"pharmacologic":[334],"disruption":[335],"augmented":[339],"HSPCs,":[343],"enhancing":[344],"differentiation":[349],"while":[350],"reducing":[351],"pool":[354],"size":[355],"humanized":[365],"mice":[366],"engrafted":[367],"pre-B":[369,393],"ALL":[370,394],"most":[377],"probably":[378],"due":[379],"endothelium":[382,408],"modification":[383],"FGF-2":[385],"secretion":[386],"leukemic":[389],"clone.":[390],"Interestingly,":[391],"human":[392],"hypersensitivity":[397],"plasmatic":[399],"exposure.":[400],"hypothesize":[402],"malignant":[404],"modify":[406],"provide":[410],"themselves":[411],"supportive":[414],"protective":[416],"microenvironment":[417],"composed":[418],"undifferentiated":[420],"progenitors":[423],"tightly":[425],"sealed":[426],"barrier.":[428],"conclusion,":[430],"our":[431],"study":[432],"identifies":[433],"anatomically":[434],"different":[439],"functions":[441],"serving":[442],"as":[443],"systemic":[444],"clinical":[453],"therapeutic":[454],"relevance.":[455],"Disclosures":[456],"Rafii:":[457],"Angiocrine":[458],"Bioscience:":[459],"Consultancy,":[460],"Equity":[461],"Ownership.":[462]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-10T00:00:00"}