{"id":"https://openalex.org/W25838336","doi":null,"title":"Epidemiology of acquired aplastic anaemia in Pakistan.","display_name":"Epidemiology of acquired aplastic anaemia in Pakistan.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W25838336","mag":"25838336","pmid":"https://pubmed.ncbi.nlm.nih.gov/22830160"},"language":"en","primary_location":{"id":"pmid:22830160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22830160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College, Abbottabad : JAMC","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103792352","display_name":"Ayesha Ehsan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267158","display_name":"FMH College of Medicine & Dentistry","ror":"https://ror.org/01egxa393","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405267158"]},{"id":"https://openalex.org/I4405267646","display_name":"Fatima Memorial Hospital","ror":"https://ror.org/03qhs4066","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405267646"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ayesha Ehsan","raw_affiliation_strings":["Department of Haematology, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan. ayeshaehsan@live.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan. ayeshaehsan@live.com","institution_ids":["https://openalex.org/I4405267158","https://openalex.org/I4405267646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008491963","display_name":"Shahida Amjad Riaz Shah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahida Amjad Riaz Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078815796","display_name":"Tayyaba Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tayyaba Ibrahim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.00265297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"1","first_page":"102","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acquired-aplastic-anemia","display_name":"acquired aplastic anemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epidemiology","display_name":"epidemiology","score":0.8970000147819519},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.921999990940094},{"id":"https://openalex.org/keywords/bone-marrow-cellularity","display_name":"bone marrow cellularity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/pakistani-patients","display_name":"Pakistani patients","score":0.6129999756813049},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.4410000145435333},{"id":"https://openalex.org/keywords/age-distribution","display_name":"age distribution","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9561306834220886},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.8081059455871582},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5372867584228516},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5339760780334473},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5160312652587891},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.48465853929519653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48311638832092285},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4362155497074127},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.366649329662323},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010154","descriptor_name":"Pakistan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017677","descriptor_name":"Age Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22830160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22830160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College, Abbottabad : JAMC","raw_type":"Journal Article"},{"id":"mag:25838336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22830160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1601769732","https://openalex.org/W1833218325","https://openalex.org/W1964493140","https://openalex.org/W1965759235","https://openalex.org/W1971721633","https://openalex.org/W1975937341","https://openalex.org/W1976578467","https://openalex.org/W1987620712","https://openalex.org/W1987647235","https://openalex.org/W1993803161","https://openalex.org/W1994015489","https://openalex.org/W1999405579","https://openalex.org/W2004008756","https://openalex.org/W2020447725","https://openalex.org/W2021446613","https://openalex.org/W2033498694","https://openalex.org/W2037294869","https://openalex.org/W2048977247","https://openalex.org/W2049222157","https://openalex.org/W2050236294","https://openalex.org/W2052285621","https://openalex.org/W2058920799","https://openalex.org/W2065719993","https://openalex.org/W2068854215","https://openalex.org/W2084411309","https://openalex.org/W2109005423","https://openalex.org/W2110736031","https://openalex.org/W2111861407","https://openalex.org/W2120092157","https://openalex.org/W2123852666","https://openalex.org/W2133948127","https://openalex.org/W2135314999","https://openalex.org/W2136506501","https://openalex.org/W2144292818","https://openalex.org/W2144589917","https://openalex.org/W2149296107","https://openalex.org/W2152191498","https://openalex.org/W2154870469","https://openalex.org/W2161114756","https://openalex.org/W2161328469","https://openalex.org/W2171302398","https://openalex.org/W2182187828","https://openalex.org/W2208931577","https://openalex.org/W2306614089","https://openalex.org/W2339255799","https://openalex.org/W2413921586","https://openalex.org/W2437427522","https://openalex.org/W4210975502","https://openalex.org/W4245666729","https://openalex.org/W4293242440"],"related_works":["https://openalex.org/W2437427522","https://openalex.org/W4323844908","https://openalex.org/W7217855047","https://openalex.org/W7204472109","https://openalex.org/W4389247687","https://openalex.org/W2413921586","https://openalex.org/W6930512483","https://openalex.org/W3184183700","https://openalex.org/W2083257257","https://openalex.org/W1936926353"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acquired":[1,202],"aplastic":[2,35,70,121,182,196],"anaemia":[3,36,71,183,197,204],"is":[4,205],"a":[5,15,38,46,143,206,227,237],"rare":[6],"disease":[7,207],"which":[8],"results":[9],"in":[10,37,74,163,170,250],"morbidity":[11],"and":[12,30,92,104,108,127,167,215],"mortality":[13],"at":[14,50,226,233],"young":[16],"age.":[17],"This":[18,44],"study":[19,48,76],"was":[20,45,83,97,137,153,158],"carried":[21],"out":[22],"to":[23,63,150,195],"determine":[24],"the":[25,75,100,105,115,135,177,189,212,216,253],"clinical":[26,107,220],"presentation,":[27],"haematological":[28,109],"parameters":[29,110],"association":[31,192,242],"factors":[32,193,243],"of":[33,40,68,102,119,134,145,173,176,188,208,244,252],"acquired":[34,69,120],"cohort":[39,96],"Pakistani":[41],"patients.":[42,174,254],"METHODS:":[43],"cross-sectional":[47],"conducted":[49],"Haematology":[51],"Department,":[52],"Shaikh":[53],"Zayed":[54],"Hospital,":[55],"Lahore":[56],"over":[57],"7":[58],"years":[59,141],"from":[60],"June":[61],"2000":[62],"July":[64],"2007.":[65],"Eighty-two":[66],"patients":[67,118,136],"were":[72,111,125,130,179,222],"enrolled":[73,117],"by":[77,85],"non-probability":[78],"purposive":[79],"sampling.":[80],"Their":[81],"diagnosis":[82],"confirmed":[84],"complete":[86],"blood":[87],"count,":[88],"bone":[89],"marrow":[90,156],"aspirate":[91],"trephine":[93],"biopsy.":[94],"The":[95,148],"classified":[98],"on":[99],"basis":[101],"severity":[103],"epidemiological,":[106],"analysed.":[112],"RESULTS:":[113],"Of":[114],"82":[116],"anaemia,":[122],"49":[123],"(59.8%)":[124],"males":[126],"33":[128],"(40.2%)":[129],"females.":[131],"Mean":[132],"age":[133,229],"27.93":[138],"+/-":[139],"18.7":[140],"with":[142,236],"range":[144],"1-80":[146],"years.":[147],"male":[149],"female":[151],"ratio":[152],"1.48:1.":[154],"Bone":[155],"cellularity":[157],"less":[159],"than":[160],"25":[161],"%":[162],"31":[164],"(38.0%)":[165],"cases":[166,178,190],"between":[168],"25-30%":[169],"51":[171],"(62%)":[172],"Most":[175],"clinically":[180],"severe":[181,219],"(68%).":[184],"In":[185,211],"62":[186],"(76%)":[187],"no":[191],"predisposing":[194],"could":[198,247],"be":[199,248],"identified.":[200],"CONCLUSION:":[201],"Aplastic":[203,245],"all":[209,234],"ages.":[210],"second":[213],"decade":[214],"elderly":[217],"predominantly":[218],"stages":[221],"seen.":[223],"Males":[224],"presented":[225,232],"younger":[228],"while":[230],"females":[231],"ages":[235],"somewhat":[238],"similar":[239],"incidence.":[240],"No":[241],"Anaemia":[246],"identified":[249],"majority":[251]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}