{"id":"https://openalex.org/W258366235","doi":null,"title":"Herpetic keratitis in experimental vitamin A deficiency.","display_name":"Herpetic keratitis in experimental vitamin A deficiency.","publication_year":1987,"publication_date":"1987-02-01","ids":{"openalex":"https://openalex.org/W258366235","mag":"258366235","pmid":"https://pubmed.ncbi.nlm.nih.gov/8591902"},"language":"en","primary_location":{"id":"pmid:8591902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8591902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113554663","display_name":"Diane L. Hatchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Hatchell","raw_affiliation_strings":["Department of Ophthalmology, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W J O'Brien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W J O'Brien","raw_affiliation_strings":["\u2020Department of Ophthalmology, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Ophthalmology, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109954847","display_name":"Jerry Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Taylor","raw_affiliation_strings":["\u2020Department of Ophthalmology, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Ophthalmology, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001851059","display_name":"Robert A. Hyndiuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Hyndiuk","raw_affiliation_strings":["\u2020Department of Ophthalmology, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Ophthalmology, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":0.7757,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71683724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"2","first_page":"238","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.41499999165534973,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-keratitis","display_name":"herpes simplex keratitis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/vitamin-a-deficiency","display_name":"vitamin A deficiency","score":0.9120000004768372},{"id":"https://openalex.org/keywords/xerophthalmia","display_name":"xerophthalmia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/corneal-lesions","display_name":"corneal lesions","score":0.8009999990463257},{"id":"https://openalex.org/keywords/keratomalacia","display_name":"keratomalacia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.7789999842643738},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5559999942779541},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2777373371","wikidata":"https://www.wikidata.org/wiki/Q1054713","display_name":"Xerophthalmia","level":5,"score":0.8505903482437134},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7578160762786865},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.7525056004524231},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.7187702059745789},{"id":"https://openalex.org/C2778129702","wikidata":"https://www.wikidata.org/wiki/Q2655893","display_name":"Vitamin A deficiency","level":4,"score":0.6828367114067078},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.6520564556121826},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5422564148902893},{"id":"https://openalex.org/C2910275740","wikidata":"https://www.wikidata.org/wiki/Q1628473","display_name":"Corneal ulceration","level":3,"score":0.48984310030937195},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.47078150510787964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4441887438297272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4262063801288605},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3525935411453247},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.34404605627059937},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.256639301776886},{"id":"https://openalex.org/C2779573558","wikidata":"https://www.wikidata.org/wiki/Q424976","display_name":"Retinol","level":3,"score":0.24978342652320862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16726872324943542},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1341184377670288},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.04968780279159546}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014802","descriptor_name":"Vitamin A Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014802","descriptor_name":"Vitamin A Deficiency","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014985","descriptor_name":"Xerophthalmia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8591902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8591902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:258366235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8591902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W144086402","https://openalex.org/W195454896","https://openalex.org/W1571511369","https://openalex.org/W1579312268","https://openalex.org/W1987967570","https://openalex.org/W2013044288","https://openalex.org/W2037168677","https://openalex.org/W2093531507"],"related_works":["https://openalex.org/W1579312268","https://openalex.org/W2037168677","https://openalex.org/W2135002491","https://openalex.org/W1507051264","https://openalex.org/W93531516","https://openalex.org/W1993219565","https://openalex.org/W2135632171","https://openalex.org/W195454896","https://openalex.org/W2021770981","https://openalex.org/W1858443815"],"abstract_inverted_index":{"Herpes":[0],"simplex":[1,80],"virus":[2,55,81,116],"type":[3],"I":[4],"(KOS)":[5],"was":[6,57,105,117],"instilled":[7],"onto":[8],"the":[9,32,44,54,70,73,91,94,101,109,122,128,133,149],"eyes":[10],"of":[11,31,46,69,72,93,119],"rabbits":[12,77],"with":[13,78],"experimentally":[14],"induced":[15],"xerophthalmia":[16],"(vitamin":[17],"A":[18,26,62,75,96,135,143],"deficient)":[19],"and":[20,41,124],"control":[21],"animals":[22,64,98],"fed":[23],"a":[24],"vitamin":[25,61,74,95,134,142],"supplemented":[27],"diet.":[28],"The":[29,86],"severity":[30],"herpes":[33,79],"virus-induced":[34],"corneal":[35,47,102,130],"disease,":[36],"assessed":[37],"by":[38,42,52],"biomicroscopic":[39],"examination":[40],"counting":[43],"number":[45],"lesions":[48,88,131],"as":[49,51],"well":[50],"determining":[53],"titers,":[56],"significantly":[58],"less":[59,106],"in":[60,66,100,121,127,132],"deficient":[63,76,97,136],"than":[65,108],"controls.":[67],"Infection":[68],"corneas":[71,92],"did":[82],"not":[83,147],"precipitate":[84],"keratomalacia.":[85],"few":[87],"present":[89],"on":[90],"were":[99],"periphery,":[103],"which":[104],"keratinized":[107],"central":[110],"cornea.":[111],"Electron":[112],"microscopy":[113],"suggested":[114],"that":[115,141],"capable":[118],"replicating":[120],"basal":[123],"wing":[125],"cells":[126],"peripheral":[129],"animals.":[137],"These":[138],"studies":[139],"indicate":[140],"deficiency":[144],"alone":[145],"may":[146],"predispose":[148],"host":[150],"to":[151],"more":[152],"severe":[153],"ocular":[154],"herpesvirus":[155],"infections.":[156]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
