{"id":"https://openalex.org/W2583633443","doi":null,"title":"Long noncoding RNA MHENCR promotes melanoma progression via regulating miR-425/489-mediated PI3K-Akt pathway.","display_name":"Long noncoding RNA MHENCR promotes melanoma progression via regulating miR-425/489-mediated PI3K-Akt pathway.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2583633443","mag":"2583633443","pmid":"https://pubmed.ncbi.nlm.nih.gov/28123636","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5250706"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5250706","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5250706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5250706","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100701681","display_name":"Xiangjun Chen","orcid":"https://orcid.org/0000-0003-1972-0828","observed_orcids":["https://orcid.org/0000-0003-1972-0828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangjun Chen","raw_affiliation_strings":["Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101486873","display_name":"Hao Dong","orcid":"https://orcid.org/0000-0001-8472-752X","observed_orcids":["https://orcid.org/0000-0001-8472-752X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Dong","raw_affiliation_strings":["Department of General Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sha Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sha Liu","raw_affiliation_strings":["Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343333","display_name":"Li Yu","orcid":"https://orcid.org/0000-0002-1930-2987","observed_orcids":["https://orcid.org/0000-0002-1930-2987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Yu","raw_affiliation_strings":["Intensive Care Unit, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100993674","display_name":"Dexiong Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dexiong Yan","raw_affiliation_strings":["Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xingwei Yao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingwei Yao","raw_affiliation_strings":["Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019734570","display_name":"Weijing Sun","orcid":"https://orcid.org/0000-0001-6549-9605","observed_orcids":["https://orcid.org/0000-0001-6549-9605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weijing Sun","raw_affiliation_strings":["Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110729901","display_name":"Dezhi Han","orcid":"https://orcid.org/0009-0001-9110-3405","observed_orcids":["https://orcid.org/0009-0001-9110-3405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dezhi Han","raw_affiliation_strings":["Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101528886","display_name":"Guozhen Gao","orcid":"https://orcid.org/0000-0002-5354-8227","observed_orcids":["https://orcid.org/0000-0002-5354-8227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guozhen Gao","raw_affiliation_strings":["Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6999,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.94709515,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"90","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.824999988079071},{"id":"https://openalex.org/keywords/mir-425","display_name":"miR-425","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mir-489","display_name":"miR-489","score":1.0},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8960000276565552},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9020000100135803},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8713780641555786},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.787055492401123},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7765764594078064},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.7393599152565002},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7143504023551941},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6784478425979614},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.67137610912323},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6668272018432617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4799642562866211},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4564206600189209},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.44718751311302185},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44527772068977356},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3943159878253937},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34953469038009644},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29733186960220337},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21441048383712769},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19130614399909973},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06185159087181091}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5250706","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5250706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:28123636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28123636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2583633443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28123636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5250706","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5250706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W191165418","https://openalex.org/W1493359429","https://openalex.org/W1515130864","https://openalex.org/W1752844690","https://openalex.org/W1803649964","https://openalex.org/W1957438118","https://openalex.org/W1970907985","https://openalex.org/W2025270110","https://openalex.org/W2032183472","https://openalex.org/W2046387002","https://openalex.org/W2047455573","https://openalex.org/W2068517905","https://openalex.org/W2087377443","https://openalex.org/W2091161969","https://openalex.org/W2100614336","https://openalex.org/W2102585212","https://openalex.org/W2111832790","https://openalex.org/W2117391818","https://openalex.org/W2123479813","https://openalex.org/W2132691262","https://openalex.org/W2136938899","https://openalex.org/W2139055829","https://openalex.org/W2145917258","https://openalex.org/W2145931730","https://openalex.org/W2152606604","https://openalex.org/W2158792391","https://openalex.org/W2169544896","https://openalex.org/W2170552969","https://openalex.org/W2261992653","https://openalex.org/W2268266875","https://openalex.org/W2281777435","https://openalex.org/W2310326730","https://openalex.org/W2311921258","https://openalex.org/W2335954491","https://openalex.org/W2359598110","https://openalex.org/W2397632165","https://openalex.org/W2401641277","https://openalex.org/W2410938778","https://openalex.org/W2411021664","https://openalex.org/W2436603111","https://openalex.org/W2469390778","https://openalex.org/W2474911543","https://openalex.org/W2485326967","https://openalex.org/W2491982852","https://openalex.org/W2493373689","https://openalex.org/W2521783887","https://openalex.org/W2917837889","https://openalex.org/W4229975881","https://openalex.org/W4244068819"],"related_works":["https://openalex.org/W3134905336","https://openalex.org/W3137882024","https://openalex.org/W3031230382","https://openalex.org/W3108983026","https://openalex.org/W4307425027","https://openalex.org/W4322748216","https://openalex.org/W3022270841","https://openalex.org/W4389340082","https://openalex.org/W2025270110","https://openalex.org/W2892745211"],"abstract_inverted_index":{"functional":[0],"experiments":[1],"further":[2],"confirmed":[3],"the":[4],"pro-growth":[5],"and":[6,28],"pro-metastasis":[7],"roles":[8],"of":[9],"MHENCR.":[10],"Collectively,":[11],"our":[12],"findings":[13],"revealed":[14],"that":[15],"MHENCR":[16],"functions":[17],"as":[18],"an":[19],"oncogene":[20],"in":[21],"melanoma":[22],"via":[23],"activating":[24],"miR-425/489-mediated":[25],"PI3K-Akt":[26],"pathway,":[27],"may":[29],"be":[30],"a":[31],"therapeutic":[32],"target":[33],"for":[34],"melanoma.":[35]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-10T00:00:00"}