{"id":"https://openalex.org/W2583533255","doi":"https://doi.org/10.1093/neuonc/nov218.10","title":"IMCT-10A PHASE I DOSE ESCALATION STUDY TO TEST THE SAFETY OF INTRATUMORAL ADOPTIVE IMMUNE THERAPY WITH AlloCTL IN RECURRENT GLIOMA PATIENTS","display_name":"IMCT-10A PHASE I DOSE ESCALATION STUDY TO TEST THE SAFETY OF INTRATUMORAL ADOPTIVE IMMUNE THERAPY WITH AlloCTL IN RECURRENT GLIOMA PATIENTS","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2583533255","doi":"https://doi.org/10.1093/neuonc/nov218.10","mag":"2583533255"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/nov218.10","doi":"https://doi.org/10.1093/neuonc/nov218.10","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nov218.10","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4638906","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063562007","display_name":"Michelle J. Hickey","orcid":"https://orcid.org/0000-0002-4007-1570","observed_orcids":["https://orcid.org/0000-0002-4007-1570"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Hickey","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106037413","display_name":"Horacio Soto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Horacio Soto","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067885167","display_name":"Janet M. Treger","orcid":"https://orcid.org/0009-0008-5854-7814","observed_orcids":["https://orcid.org/0009-0008-5854-7814"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Treger","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083605239","display_name":"Kate L. Erickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate Erickson","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079188247","display_name":"Colin C. Malone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin Malone","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103066215","display_name":"Edward L. Ha","orcid":"https://orcid.org/0000-0002-0061-3830","observed_orcids":["https://orcid.org/0000-0002-0061-3830"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Ha","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emma Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Young","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010449744","display_name":"Robert Michael Prins","orcid":"https://orcid.org/0000-0002-6282-6583","observed_orcids":["https://orcid.org/0000-0002-6282-6583"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Prins","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA","Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079316205","display_name":"Linda M. Liau","orcid":"https://orcid.org/0000-0002-4053-0052","observed_orcids":["https://orcid.org/0000-0002-4053-0052"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Liau","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108422549","display_name":"Carol A. Kruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Kruse","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.28803663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"17","issue":"suppl 5","first_page":"v109.3","last_page":"v109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.8050000071525574},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/recombinant-interleukin-2","display_name":"recombinant interleukin-2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hla-mismatched-donors","display_name":"HLA-mismatched donors","score":0.7900000214576721},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.574999988079071},{"id":"https://openalex.org/keywords/th1-th2-cytokines","display_name":"Th1/Th2 cytokines","score":0.8650000095367432},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7300000190734863},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5590000152587891},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7810613512992859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6104312539100647},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44632527232170105},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44327327609062195},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2587241530418396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24268034100532532}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/nov218.10","doi":"https://doi.org/10.1093/neuonc/nov218.10","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nov218.10","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4638906","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4638906","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4638906","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4638906","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070201923","https://openalex.org/W192010208","https://openalex.org/W1975282675","https://openalex.org/W93771434","https://openalex.org/W2416705646","https://openalex.org/W2028277512","https://openalex.org/W2017029567","https://openalex.org/W2046846890","https://openalex.org/W3216571263","https://openalex.org/W2050968146"],"abstract_inverted_index":{"In":[0,142],"a":[1,88,101,126,194],"Phase":[2],"1":[3],"dose":[4,169,186,195],"escalation":[5],"study":[6,251,283],"we":[7],"evaluated":[8],"the":[9,31,51,56,84,214,238,245,250,286],"safety,":[10],"feasibility,":[11],"toxicity,":[12],"and":[13,23,86,96,158,172,189,205,267,279],"survival":[14,243],"of":[15,34,58,90,93,103,117,134,145,153,160,216,247],"patients":[16,35,80,233,259],"treated":[17,82],"with":[18,36,147],"allogeneic":[19],"cytotoxic":[20],"T":[21,136],"lymphocytes":[22],"recombinant":[24],"IL-2":[25],"(alloCTL,":[26],"rIL-2)":[27],"infusion":[28,275],"administered":[29],"to":[30,129,176,218],"resection":[32],"cavity":[33],"recurrent":[37],"glioma":[38],"(WHO":[39],"grade":[40],"III":[41],"or":[42],"IV).":[43],"AlloCTL":[44],"are":[45,260],"generated":[46],"when":[47],"gamma-irradiated":[48],"lymphoblasts":[49,149],"from":[50,65,123,237,244],"brain":[52],"tumor":[53],"patient":[54,120,148,192],"stimulate":[55],"proliferation":[57,157],"peripheral":[59],"blood":[60],"mononuclear":[61],"cells":[62,137],"(PBMC)":[63],"isolated":[64],"an":[66],"HLA-disparate":[67],"healthy":[68],"donor":[69],"in":[70,231,235],"ex":[71],"vivo":[72],"culture":[73],"via":[74],"one-way":[75],"mixed":[76],"lymphocyte":[77],"reaction.":[78],"Nine":[79],"were":[81,98,111,164,173,182,211],"on":[83,285],"protocol":[85],"received":[87],"range":[89],"0.5-5":[91],"cycles":[92],"therapy.":[94],"Patients":[95],"donors":[97],"mismatched":[99],"at":[100,112,125,166,185,263],"minimum":[102],"2":[104,188],"HLA":[105],"A,":[106],"B,":[107],"DR":[108],"loci.":[109],"Infusates":[110],"least":[113],"30%":[114],"CD3+.":[115],"Cytotoxicity":[116],"alloCTL":[118,146,274],"against":[119],"PBMC":[121],"ranged":[122],"21.0-84.4%":[124],"30:1":[127],"effector":[128],"target":[130],"ratio.":[131],"The":[132,270],"ratio":[133],"CD4/CD8":[135],"averaged":[138],"1.12":[139],"(range":[140],"0.14-2.95).":[141],"vitro":[143],"restimulation":[144],"allowed":[150],"for":[151],"quantitation":[152],"immune":[154],"cell":[155],"subset":[156],"production":[159],"IFN-\u03b3.":[161],"Adverse":[162],"events":[163,181],"noted":[165,183],"all":[167],"three":[168],"levels":[170,187],"tested,":[171],"primarily":[174],"limited":[175],"Grade":[177,179,200],"1-2.":[178],"3-4":[180],"only":[184],"3.":[190],"One":[191],"experienced":[193],"limiting":[196],"toxicity":[197],"characterized":[198],"by":[199],"3":[201],"fatigue,":[202],"arthralgia,":[203],"headache,":[204],"non-infectious":[206],"meningitis.":[207],"Patient":[208],"serum":[209],"samples":[210],"collected":[212],"during":[213],"course":[215],"therapy":[217],"determine":[219],"Th1/Th2":[220],"cytokine":[221],"profiles":[222],"using":[223],"Luminex":[224],"multiplex":[225],"analysis.":[226],"Tumor":[227],"progression":[228],"was":[229,252],"evident":[230],"8/9":[232],"resulting":[234],"removal":[236],"clinical":[239,287],"trial.":[240],"Median":[241],"overall":[242],"time":[246],"inclusion":[248],"into":[249],"8.8":[253],"months":[254],"(range-":[255],"3.6-35.7":[256],"months).":[257],"Two":[258],"still":[261],"alive":[262],"greater":[264],"than":[265],"35.7":[266],"16.4":[268],"months.":[269],"results":[271],"suggest":[272],"that":[273],"is":[276],"safe,":[277],"feasible,":[278],"may":[280],"warrant":[281],"further":[282],"based":[284],"results.":[288]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-10T00:00:00"}