{"id":"https://openalex.org/W2583435338","doi":"https://doi.org/10.1080/10717544.2016.1236848","title":"Contribution of both olfactory and systemic pathways for brain targeting of nimodipine-loaded lipo-pluronics micelles: in vitro characterization and in vivo biodistribution study after intranasal and intravenous delivery","display_name":"Contribution of both olfactory and systemic pathways for brain targeting of nimodipine-loaded lipo-pluronics micelles: in vitro characterization and in vivo biodistribution study after intranasal and intravenous delivery","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2583435338","doi":"https://doi.org/10.1080/10717544.2016.1236848","mag":"2583435338","pmid":"https://pubmed.ncbi.nlm.nih.gov/28156162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8241048"},"language":"en","primary_location":{"id":"doi:10.1080/10717544.2016.1236848","doi":"https://doi.org/10.1080/10717544.2016.1236848","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10717544.2016.1236848","pdf_url":null,"source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/10717544.2016.1236848","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020266793","display_name":"Hassan Medhat Rashed","orcid":"https://orcid.org/0000-0003-0325-6434","observed_orcids":["https://orcid.org/0000-0003-0325-6434"]},"institutions":[{"id":"https://openalex.org/I3089115","display_name":"Egyptian Atomic Energy Authority","ror":"https://ror.org/04hd0yz67","country_code":"EG","type":"government","lineage":["https://openalex.org/I3089115"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hassan M. Rashed","raw_affiliation_strings":["Department of Labeled Compounds, Hot Labs. Center, Egyptian Atomic Energy Authority, Cairo, Egypt and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Labeled Compounds, Hot Labs. Center, Egyptian Atomic Energy Authority, Cairo, Egypt and","institution_ids":["https://openalex.org/I3089115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016063678","display_name":"Rehab Nabil Shamma","orcid":"https://orcid.org/0000-0002-7635-6842","observed_orcids":["https://orcid.org/0000-0002-7635-6842"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Rehab N. Shamma","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072936682","display_name":"Emad B. Basalious","orcid":"https://orcid.org/0000-0002-0594-7119","observed_orcids":["https://orcid.org/0000-0002-0594-7119"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Emad B. Basalious","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016063678"],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":{"value":2335,"currency":"GBP","value_usd":2864},"apc_paid":{"value":2335,"currency":"GBP","value_usd":2864},"fwci":4.0895,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.95095836,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"181","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.4009000062942505,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nimodipine","display_name":"nimodipine","score":1.0},{"id":"https://openalex.org/keywords/99mtc-radiolabeling","display_name":"99mTc radiolabeling","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.8849999904632568},{"id":"https://openalex.org/keywords/intravenous-drug-delivery","display_name":"intravenous drug delivery","score":0.8529999852180481},{"id":"https://openalex.org/keywords/brain-targeting","display_name":"brain targeting","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8429999947547913},{"id":"https://openalex.org/keywords/drug-solubility-enhancement","display_name":"drug solubility enhancement","score":0.6949999928474426},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7950000166893005},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.48100000619888306},{"id":"https://openalex.org/keywords/cardiovascular-side-effects","display_name":"cardiovascular side effects","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.7429489493370056},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7420799732208252},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7156960964202881},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7013049125671387},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.674818754196167},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6511614322662354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5473537445068359},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5453194975852966},{"id":"https://openalex.org/C2777294900","wikidata":"https://www.wikidata.org/wiki/Q421429","display_name":"Nimodipine","level":3,"score":0.520514190196991},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4711317718029022},{"id":"https://openalex.org/C2776093070","wikidata":"https://www.wikidata.org/wiki/Q621636","display_name":"Route of administration","level":2,"score":0.4504658579826355},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.44592535495758057},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.4408209025859833},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26044660806655884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10766980051994324},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.08767423033714294},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.07585200667381287},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009553","descriptor_name":"Nimodipine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009553","descriptor_name":"Nimodipine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009553","descriptor_name":"Nimodipine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009553","descriptor_name":"Nimodipine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011060","descriptor_name":"Poloxalene","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011060","descriptor_name":"Poloxalene","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D020442","descriptor_name":"Poloxamer","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020442","descriptor_name":"Poloxamer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/10717544.2016.1236848","doi":"https://doi.org/10.1080/10717544.2016.1236848","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10717544.2016.1236848","pdf_url":null,"source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8241048","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8241048","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Deliv","raw_type":"Text"},{"id":"pmid:28156162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28156162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug delivery","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:153cdb4190b34d4689d942d52de13b96","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/153cdb4190b34d4689d942d52de13b96","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Delivery, Vol 24, Iss 1, Pp 181-187 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/10717544.2016.1236848","doi":"https://doi.org/10.1080/10717544.2016.1236848","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10717544.2016.1236848","pdf_url":null,"source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W331225987","https://openalex.org/W419513368","https://openalex.org/W1064663426","https://openalex.org/W1881526180","https://openalex.org/W1963832082","https://openalex.org/W1965443653","https://openalex.org/W1966109927","https://openalex.org/W1970555464","https://openalex.org/W1974386861","https://openalex.org/W1982447975","https://openalex.org/W1988541357","https://openalex.org/W1988652094","https://openalex.org/W1989544403","https://openalex.org/W1992262594","https://openalex.org/W2023724749","https://openalex.org/W2024122170","https://openalex.org/W2024363028","https://openalex.org/W2039685150","https://openalex.org/W2051149202","https://openalex.org/W2051462004","https://openalex.org/W2054428277","https://openalex.org/W2075202733","https://openalex.org/W2085395753","https://openalex.org/W2085439787","https://openalex.org/W2087875520","https://openalex.org/W2094761664","https://openalex.org/W2094943913","https://openalex.org/W2114179943","https://openalex.org/W2130627178","https://openalex.org/W2157006832","https://openalex.org/W2200275392","https://openalex.org/W2289349361","https://openalex.org/W2344698737","https://openalex.org/W2571918371","https://openalex.org/W4293240757"],"related_works":["https://openalex.org/W3037748468","https://openalex.org/W2091322268","https://openalex.org/W1064663426","https://openalex.org/W2146620589","https://openalex.org/W2010193744","https://openalex.org/W2124299870","https://openalex.org/W2420189111","https://openalex.org/W3049710539","https://openalex.org/W2353677968","https://openalex.org/W3180373357"],"abstract_inverted_index":{"Nimodipine":[0],"(NM)":[1],"is":[2,35,141],"the":[3,60,80,91,115,120,146,154,157,188,199,219,224],"only":[4],"FDA-approved":[5],"drug":[6,213,216],"for":[7,187],"treating":[8],"subarachnoid":[9],"hemorrhage":[10],"induced":[11],"vasospasm.":[12],"NM":[13,63,105,197],"has":[14],"poor":[15],"oral":[16],"bioavailability":[17],"(5\u201313%)":[18],"due":[19],"to":[20,36,42,59,144,198,206,230],"its":[21,44,47,51],"low":[22],"aqueous":[23],"solubility,":[24,214],"and":[25,41,55,99,109,159,218,233],"extensive":[26],"first":[27],"pass":[28],"metabolism.":[29],"The":[30,85,193,209],"objective":[31],"of":[32,53,90,122,126,137,164,179,190,196,223,236],"this":[33],"study":[34],"develop":[37],"radiolabeled":[38,65],"NM-loaded":[39,93,225],"LPM":[40,94,129,166,226],"test":[43],"ability":[45],"prolong":[46],"circulation":[48,221],"time,":[49],"reduce":[50],"frequency":[52],"administration":[54,125,136,163,178,203],"eventually":[56],"target":[57],"it":[58],"brain":[61,100,160,200],"tissue.":[62],"was":[64,102,204],"with":[66,104,133,174],"99mTc":[67],"by":[68],"direct":[69],"labeling":[70],"method":[71],"using":[72],"sodium":[73],"dithionite.":[74],"Different":[75],"reaction":[76],"conditions":[77],"that":[78,114,134,153,175],"affect":[79],"radiolabeling":[81],"yield":[82],"were":[83,130,167],"studied.":[84],"in":[86,96,119,156,212],"vivo":[87],"pharmacokinetic":[88],"behavior":[89],"optimum":[92],"formulation":[95],"blood,":[97,158],"heart,":[98],"tissue":[101],"compared":[103,132,173],"solution,":[106,139],"after":[107,201],"intravenous":[108,162,177],"intranasal":[110,202],"administration.":[111],"Results":[112,150],"show":[113,152],"radioactivity":[116],"percentage":[117],"(%ID/g)":[118],"heart":[121],"mice":[123],"following":[124,135,161,176],"99mTc-NM":[127,138,180],"loaded":[128],"lower":[131],"which":[140],"greatly":[142,185],"beneficial":[143,186],"minimize":[145],"cardiovascular":[147],"side":[148],"effects.":[149],"also":[151],"%ID/g":[155],"99mTc-NM-loaded":[165],"higher":[168],"at":[169],"all":[170],"sampling":[171],"intervals":[172],"solution.":[181],"This":[182],"would":[183],"be":[184,207,228],"treatment":[189],"neurovascular":[191],"diseases.":[192],"drug-targeting":[194],"efficiency":[195],"calculated":[205],"1872.82%.":[208],"significant":[210],"increase":[211],"enhanced":[215],"absorption":[217],"long":[220],"time":[222],"could":[227],"promising":[229],"improve":[231],"nasal":[232],"parenteral":[234],"delivery":[235],"NM.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-02-10T00:00:00"}