{"id":"https://openalex.org/W2583413931","doi":"https://doi.org/10.1182/blood.v124.21.2503.2503","title":"Characterization of Tcra and Tcrb Repertoires in Acute Myeloid Leukemia Patients before and after Combined Haploidentical and Umbilical Cord Blood Transplant","display_name":"Characterization of Tcra and Tcrb Repertoires in Acute Myeloid Leukemia Patients before and after Combined Haploidentical and Umbilical Cord Blood Transplant","publication_year":2014,"publication_date":"2014-12-06","ids":{"openalex":"https://openalex.org/W2583413931","doi":"https://doi.org/10.1182/blood.v124.21.2503.2503","mag":"2583413931"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v124.21.2503.2503","doi":"https://doi.org/10.1182/blood.v124.21.2503.2503","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.2503.2503","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003617778","display_name":"Houda Alachkar","orcid":"https://orcid.org/0000-0001-5567-5521","observed_orcids":["https://orcid.org/0000-0001-5567-5521"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Houda Alachkar","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032218449","display_name":"Poh\u2010Yin Yew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Poh-Yin Yew","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017811121","display_name":"Rui Yamaguch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Rui Yamaguch","raw_affiliation_strings":["The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014080480","display_name":"Kazuma Kiyotani","orcid":"https://orcid.org/0000-0002-9236-9061","observed_orcids":["https://orcid.org/0000-0002-9236-9061"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kazuma Kiyotani","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444842","display_name":"Hongtao Liu","orcid":"https://orcid.org/0000-0002-3190-7807","observed_orcids":["https://orcid.org/0000-0002-3190-7807"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongtao Liu","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057523501","display_name":"Andrew S. Artz","orcid":"https://orcid.org/0000-0003-0803-9607","observed_orcids":["https://orcid.org/0000-0003-0803-9607"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew S. Artz","raw_affiliation_strings":["University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010645663","display_name":"Amittha Wickrema","orcid":"https://orcid.org/0000-0003-4035-3014","observed_orcids":["https://orcid.org/0000-0003-4035-3014"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amittha Wickrema","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044134864","display_name":"Koen van Besien","orcid":"https://orcid.org/0000-0002-8164-6211","observed_orcids":["https://orcid.org/0000-0002-8164-6211"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koen van Besien","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089893290","display_name":"Michael Russell Bishop","orcid":"https://orcid.org/0000-0002-3979-9273","observed_orcids":["https://orcid.org/0000-0002-3979-9273"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R Bishop","raw_affiliation_strings":["University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088167618","display_name":"Satoru Miyano","orcid":"https://orcid.org/0000-0002-1753-6616","observed_orcids":["https://orcid.org/0000-0002-1753-6616"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoru Miyano","raw_affiliation_strings":["Institute of Medical Science, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Science, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005939966","display_name":"Wendy Stock","orcid":"https://orcid.org/0000-0002-8349-9200","observed_orcids":["https://orcid.org/0000-0002-8349-9200"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Stock","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101940701","display_name":"Yusuke Nakamura","orcid":"https://orcid.org/0009-0009-8461-749X","observed_orcids":["https://orcid.org/0009-0009-8461-749X","https://orcid.org/0000-0003-2956-382X","https://orcid.org/0000-0002-2310-0587","https://orcid.org/0000-0003-4425-4216","https://orcid.org/0009-0004-6320-7030"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yusuke Nakamura","raw_affiliation_strings":["The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003617778","https://openalex.org/A5014080480","https://openalex.org/A5017811121","https://openalex.org/A5032218449","https://openalex.org/A5088167618","https://openalex.org/A5089893290","https://openalex.org/A5101940701"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865","https://openalex.org/I4405286826","https://openalex.org/I74801974"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36293521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"21","first_page":"2503","last_page":"2503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tcr-beta","display_name":"TCR beta","score":1.0},{"id":"https://openalex.org/keywords/cord-blood-transplantation","display_name":"cord blood transplantation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/graft-versus-leukemia-effect","display_name":"graft-versus-leukemia effect","score":0.8679999709129333},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.8830000162124634},{"id":"https://openalex.org/keywords/t-cell-kinetics","display_name":"T cell kinetics","score":0.7289999723434448},{"id":"https://openalex.org/keywords/t-cell-diversity","display_name":"T cell diversity","score":0.4699999988079071},{"id":"https://openalex.org/keywords/high-risk-aml","display_name":"high-risk AML","score":0.7139999866485596},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.875},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.703000009059906},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.7078399658203125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.641165018081665},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5626855492591858},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.539397656917572},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5234917402267456},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4893626570701599},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4652830958366394},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4643360376358032},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4572652280330658},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.45363977551460266},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4398326277732849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2944198250770569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19660255312919617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v124.21.2503.2503","doi":"https://doi.org/10.1182/blood.v124.21.2503.2503","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.2503.2503","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099575031","https://openalex.org/W4389247000","https://openalex.org/W1495246841","https://openalex.org/W2130533960","https://openalex.org/W2598506494","https://openalex.org/W4413274416","https://openalex.org/W2329210926","https://openalex.org/W2570597207","https://openalex.org/W7167720112","https://openalex.org/W2987646358"],"abstract_inverted_index":{"Abstract":[0],"Rationale:":[1],"Allogeneic":[2],"hematopoietic":[3,62,73,97],"stem":[4,63],"cell":[5,135],"transplantation":[6,226],"(HSCT)":[7],"remains":[8],"the":[9,26,42,72,122,152,172,185,208,228,236,251,320,336,348,379,411,419,424,450,524,539,544,616,634,641],"most":[10],"effective":[11,59],"therapy":[12],"for":[13,372,561],"patients":[14,46,80,214,438,503,621],"with":[15,47,127,216,262,322,423,465,476,504,550,559,563,582,667],"acute":[16],"myeloid":[17],"leukemia":[18],"(AML).":[19],"The":[20,130,232,255,278],"graft-versus-leukemia":[21],"effect":[22],"(GVL),":[23],"mediated":[24],"by":[25,338,359],"engrafted":[27],"T":[28,134,138],"lymphocytes":[29,139],"targeting":[30],"leukemic":[31],"cells,":[32,587],"is":[33,111],"thought":[34],"to":[35,94,195,303,346,417,500,613,650,683],"play":[36],"an":[37,56,161],"important":[38],"role":[39],"in":[40,65,78,137,160,212,268,275,344,387,429,454,502,580,598,619,643],"affecting":[41],"overall":[43,280],"outcome":[44],"of":[45,61,116,133,142,167,174,224,230,235,253,266,362,364,374,421,426,474,513,534,546,548,552,573,636,681],"AML.":[48],"Umbilical":[49],"cord":[50,91,100,117,264,427,440,444,451,478,506,515],"blood":[51,92,101,118,299,431,452,455,600],"(UCB)":[52],"has":[53],"emerged":[54],"as":[55],"alternative":[57],"and":[58,75,90,120,145,155,165,170,200,244,271,281,287,304,312,329,350,353,366,376,402,443,462,492,532,584,604,638,640,670],"source":[60],"cells":[64,119,301,428,479,516,537,555,566],"high":[66],"risk":[67],"patients.":[68],"We":[69,206,334,470,542],"previously":[70],"reported":[71],"reconstitution":[74,115],"clinical":[76,128,222,671],"outcomes":[77],"45":[79],"undergoing":[81],"haplo-cord":[82,203,225,316,460,484,623],"transplant,":[83],"a":[84,177,221,330,340,511,610,628,651],"novel":[85,611],"approach":[86,612,626],"which":[87],"combines":[88],"haploidentical":[89],"grafts":[93],"avoid":[95],"delayed":[96],"recovery":[98],"after":[99],"transplant":[102,317,394,461,485],"(Liu":[103],"H,et":[104],"al.":[105],"Blood.":[106],"2011;118(24):6438-45).":[107],"However,":[108],"very":[109],"little":[110],"known":[112],"about":[113],"immune":[114,124],"whether":[121,660],"emerging":[123,209],"repertoire":[125,211,618],"correlates":[126],"outcome.":[129,672],"great":[131],"majority":[132],"receptors":[136],"are":[140],"heterodimers":[141],"alpha":[143],"(TCRA)":[144],"beta":[146],"(TCRB)":[147],"subunits.":[148],"Somatic":[149],"recombination":[150],"combining":[151],"VJ":[153,349],"(alpha)":[154],"VDJ":[156,351],"(beta)":[157],"segments":[158],"results":[159],"astronomical":[162],"functional":[163],"diversity":[164,201,420,466,527,545,572],"complexity":[166],"TCR":[168,617,662],"receptors,":[169],"makes":[171],"characterization":[173],"their":[175],"functions":[176],"tremendously":[178],"complex":[179],"process.":[180],"To":[181],"obtain":[182],"insights":[183],"into":[184,439],"T-cell":[186,198,210],"repertoire,":[187],"we":[188,436,522,590,608],"have":[189,409],"utilized":[190],"next-generation":[191],"sequencing":[192],"(NGS)":[193],"technology":[194],"comprehensively":[196],"characterize":[197,615],"kinetics":[199,635],"following":[202],"transplantation.":[204],"Methods:":[205],"evaluated":[207],"10":[213],"(pts)":[215],"high-risk":[217],"AML":[218,620],"enrolled":[219],"on":[220,399,449,456,467,480,496,517,529,538,567,601,659],"trial":[223],"at":[227,250,305,396,432],"University":[229],"Chicago.":[231],"median":[233,256,279],"age":[234],"pts":[237,246,270,475,509,549,581],"was":[238,259,292,357,370,575],"57":[239],"years":[240],"old":[241],"(range:":[242],"26-67)":[243],"3":[245,269],"had":[247],"active":[248],"disease":[249,282],"time":[252,307,434],"transplant.":[254,624],"UCB":[257],"dose":[258],"1.6x107":[260],"TNC/kg":[261],"HLA":[263],"matching":[265],"4/6":[267],"5/6":[272],"or":[273],"6/6":[274],"7":[276],"pts.":[277],"free":[283],"survival":[284],"were":[285,318,486,556,596],"2.4":[286],"2.2":[288],"years,":[289],"respectively.":[290,588],"cDNA":[291],"generated":[293],"from":[294,297,391],"mRNA":[295],"isolated":[296],"peripheral":[298],"mononuclear":[300],"prior":[302],"sequential":[306],"points":[308],"30,":[309],"100,":[310,569],"180":[311],"365":[313,403],"days":[314,400,602],"post":[315,459,483],"sequenced":[319],"samples":[321,389],"Ion":[323],"Personal":[324],"Genome":[325],"Machine":[326],"(PGM)":[327],"Sequencer":[328],"400-bp":[331],"reading":[332],"kit.":[333],"analyzed":[335],"sequences":[337,361],"applying":[339],"recently":[341],"developed":[342],"algorithm":[343],"order":[345,416],"determine":[347],"combinations":[352],"CDR3":[354,644],"sequences.":[355],"Chimerism":[356],"determined":[358],"microsatellite":[360],"DNA":[363],"donor":[365],"recipient":[367,599],"cells.":[368,507],"Diversity":[369],"calculated":[371,528],"each":[373],"TCRA":[375,574,637],"TCRB":[377,547,639],"using":[378],"inverse":[380],"Simpson\u2019s":[381],"index.":[382],"Results:":[383],"Several":[384],"clones":[385,408,594,663],"found":[386,471,591],"pre-treatment":[388],"obtained":[390],"recipients":[392],"before":[393],"persisted":[395],"low":[397],"frequency":[398],"100":[401,498,519,531,603],"post-transplant":[404],"suggesting":[405],"that":[406,472,595,632],"these":[407],"evaded":[410],"immuno-suppressive":[412],"conditioning":[413],"regimens.":[414],"In":[415,606],"correlate":[418],"TCRs":[422,473,501],"percentage":[425,453,533],"patients\u2019":[430],"different":[433],"points,":[435],"dichotomized":[437],"present":[441],"(>5%)":[442],"absent":[445],"(\u22645%)":[446],"groups,":[447],"based":[448],"day":[457,468,481,497,518,530,568],"30":[458,482],"correlated":[463,666],"it":[464],"100.":[469],">5%":[477],"significantly":[487],"more":[488],"diverse":[489],"(TCRA;":[490],"P=0.008)":[491],"(TCRB;":[493],"P=0.01)":[494],"(Fig.1)":[495],"compared":[499,558],"<5%":[505],"Four":[508],"achieved":[510],"chimersim":[512],">90%":[514],"post-transplant.":[520],"Therefore,":[521],"examined":[523],"correlation":[525],"between":[526],"persisting":[535],"haplo-identical":[536,554,565],"same":[540],"day.":[541],"found,,":[543],"persistence":[551],">10%":[553,583],"15.05":[557],"72.95":[560],"those":[562],"<10%":[564,585],"(P=0.002);":[570],"similarly,":[571],"17":[576],"vs":[577],"101.6":[578],"(P=0.001)":[579],"haplo":[586],"Furthermore,":[589],"several":[592],"recurring":[593],"enriched":[597],"365.":[605],"conclusion,":[607],"report":[609],"specifically":[614],"receiving":[622],"Our":[625],"provides":[627],"valuable":[629],"comprehensive":[630],"analysis":[631],"defines":[633],"changes":[642],"diversity.":[645],"This":[646],"approach,":[647],"when":[648],"applied":[649],"larger":[652],"patient":[653],"cohort":[654],"may":[655],"provide":[656],"useful":[657],"information":[658],"specific":[661],"can":[664],"be":[665],"infectious":[668],"complications":[669],"Figure":[673,675],"1":[674],"1.":[676],"Disclosures":[677],"No":[678],"relevant":[679],"conflicts":[680],"interest":[682],"declare.":[684]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-02-10T00:00:00"}
