{"id":"https://openalex.org/W2583401467","doi":"https://doi.org/10.1371/journal.pone.0171418","title":"Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes","display_name":"Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes","publication_year":2017,"publication_date":"2017-02-02","ids":{"openalex":"https://openalex.org/W2583401467","doi":"https://doi.org/10.1371/journal.pone.0171418","mag":"2583401467","pmid":"https://pubmed.ncbi.nlm.nih.gov/28152040","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5289606"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0171418","doi":"https://doi.org/10.1371/journal.pone.0171418","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0171418","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171418&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171418&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102970379","display_name":"Ana Jovi\u010di\u0107","orcid":"https://orcid.org/0000-0002-7210-1404","observed_orcids":["https://orcid.org/0000-0002-7210-1404"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana Jovi\u010di\u0107","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7210-1404","affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087989608","display_name":"Aaron D. Gitler","orcid":"https://orcid.org/0000-0001-8603-1526","observed_orcids":["https://orcid.org/0000-0001-8603-1526"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron D. Gitler","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, CA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102970379"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.6044,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.94360633,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"12","issue":"2","first_page":"e0171418","last_page":"e0171418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9729999899864197},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sod1-g93a","display_name":"SOD1 G93A","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4959999918937683},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.6650000214576721},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9593342542648315},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.752178430557251},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7332091927528381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.720751941204071},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6367185115814209},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.635043203830719},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.5984130501747131},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2196839153766632},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2111298143863678},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.20470312237739563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1778915822505951},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07013094425201416}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0171418","doi":"https://doi.org/10.1371/journal.pone.0171418","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0171418","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171418&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4172257","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5289606","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5289606","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5289606","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:28152040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28152040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:b498be4814df4987afb9e38662381425","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b498be4814df4987afb9e38662381425","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 12, Iss 2, p e0171418 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4614106","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Distinct_repertoires_of_microRNAs_present_in_mouse_astrocytes_compared_to_astrocyte-secreted_exosomes/4614106","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0171418","doi":"https://doi.org/10.1371/journal.pone.0171418","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0171418","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171418&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1151727234","display_name":"Ataxin-2 as a genetic risk factor for ALS: New insights into neurodegeneration","funder_award_id":"R01NS073660","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1180711700","display_name":"Defining the mechanisms of dipeptide repeat protein toxicity in C9orf72 ALS/FTD","funder_award_id":"R01NS093865","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5605574100","display_name":"Molecular Basis of TDP-43 Proteinopathies: Disease Models and Mechanisms","funder_award_id":"R01NS065317","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2583401467.pdf","grobid_xml":"https://content.openalex.org/works/W2583401467.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1231309555","https://openalex.org/W1584433563","https://openalex.org/W1744683414","https://openalex.org/W1877686344","https://openalex.org/W1938236935","https://openalex.org/W1981820123","https://openalex.org/W1985820334","https://openalex.org/W1986321004","https://openalex.org/W2014946489","https://openalex.org/W2020613231","https://openalex.org/W2055313665","https://openalex.org/W2059355164","https://openalex.org/W2065980876","https://openalex.org/W2066058435","https://openalex.org/W2067013656","https://openalex.org/W2068147651","https://openalex.org/W2086612059","https://openalex.org/W2099671775","https://openalex.org/W2106039274","https://openalex.org/W2107660300","https://openalex.org/W2111560326","https://openalex.org/W2119043140","https://openalex.org/W2124756133","https://openalex.org/W2126576871","https://openalex.org/W2128674168","https://openalex.org/W2135582046","https://openalex.org/W2146546145","https://openalex.org/W2148337676","https://openalex.org/W2148611607","https://openalex.org/W2149930662","https://openalex.org/W2153562609","https://openalex.org/W2156482156","https://openalex.org/W2169465106","https://openalex.org/W2205666820","https://openalex.org/W2948665150","https://openalex.org/W4230882199","https://openalex.org/W4250013468"],"related_works":["https://openalex.org/W4386271725","https://openalex.org/W2804248929","https://openalex.org/W3173966511","https://openalex.org/W2511346649","https://openalex.org/W3045915338","https://openalex.org/W2615003101","https://openalex.org/W3194129089","https://openalex.org/W6981681336","https://openalex.org/W3176444764","https://openalex.org/W7039825537"],"abstract_inverted_index":{"BACKGROUND:":[0],"Astrocytes":[1,164],"are":[2,27,41,58,140,176],"the":[3,9,104,114,124,185,215,222],"most":[4],"abundant":[5],"cell":[6],"type":[7],"in":[8,32,76,94,123,151,157,174,182,214,226],"central":[10],"nervous":[11],"system":[12],"(CNS)":[13],"and":[14,23,102,112,126,137,170],"secrete":[15,165],"various":[16],"factors":[17],"that":[18,39,116,131,147],"regulate":[19],"neuron":[20],"development,":[21],"function":[22],"connectivity.":[24],"microRNAs":[25],"(miRNAs)":[26],"small":[28],"regulatory":[29],"RNAs":[30],"involved":[31],"posttranslational":[33],"gene":[34],"regulation.":[35],"Recent":[36],"findings":[37],"showed":[38],"miRNAs":[40,57,107,167,180,193],"exchanged":[42],"between":[43],"cells":[44,125],"via":[45,72,168],"nanovesicles":[46],"called":[47],"exosomes.":[48,199],"In":[49,143],"this":[50,218],"study,":[51],"we":[52,119,145,205],"sought":[53],"to":[54,190,212],"define":[55],"which":[56],"contained":[59,173],"within":[60],"exosomes":[61,73,115,139,169,175,228],"secreted":[62,127],"by":[63,232],"astrocytes.":[64],"We":[65,129],"also":[66],"explored":[67],"whether":[68],"astroglial":[69],"miRNA":[70,121,132,149,171,202,223],"secretion":[71],"is":[74,153,229],"perturbed":[75,156,231],"a":[77,85,91,158,188,210],"mouse":[78,110,159],"model":[79,160],"of":[80,106,135,161,187,217,234],"amyotrophic":[81],"lateral":[82],"sclerosis":[83],"(ALS),":[84],"neurodegenerative":[86],"disease":[87,96],"where":[88],"astrocytes":[89,111,117,136,152],"play":[90],"crucial":[92],"role":[93],"driving":[95],"progression.":[97],"METHODOLOGY/PRINCIPAL":[98],"FINDINGS:":[99],"By":[100],"isolating":[101],"profiling":[103,203],"expression":[105,122,133,150,224,233],"from":[108,113,179,198],"primary":[109],"secrete,":[118],"compared":[120],"vesicles.":[128],"established":[130],"profiles":[134],"their":[138],"vastly":[141],"different.":[142],"addition,":[144],"determined":[146],"exosomal":[148,201],"not":[154,230],"significantly":[155],"ALS.":[162],"CONCLUSIONS:":[163],"numerous":[166],"species":[172],"considerably":[177],"different":[178],"detectable":[181],"astrocytes,":[183],"suggesting":[184],"existence":[186],"mechanism":[189],"select":[191],"certain":[192],"for":[194],"inclusion":[195],"or":[196],"exclusion":[197],"The":[200],"dataset":[204],"have":[206],"generated":[207],"will":[208],"provide":[209],"resource":[211],"aid":[213],"investigation":[216],"selection":[219],"mechanism.":[220],"Finally,":[221],"profile":[225],"astrocyte-secreted":[227],"mutant":[235],"SOD1-G93A.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-02-10T00:00:00"}