{"id":"https://openalex.org/W2583331728","doi":"https://doi.org/10.1111/ajt.14217","title":"A Tale of Two Pathways: Renewing the Promise of Anti-CD40L Blockade","display_name":"A Tale of Two Pathways: Renewing the Promise of Anti-CD40L Blockade","publication_year":2017,"publication_date":"2017-01-31","ids":{"openalex":"https://openalex.org/W2583331728","doi":"https://doi.org/10.1111/ajt.14217","mag":"2583331728","pmid":"https://pubmed.ncbi.nlm.nih.gov/28141921"},"language":"en","primary_location":{"id":"doi:10.1111/ajt.14217","doi":"https://doi.org/10.1111/ajt.14217","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.14217","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/ajt.14217","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069651723","display_name":"Angus W. Thomson","orcid":"https://orcid.org/0000-0001-6731-8871","observed_orcids":["https://orcid.org/0000-0001-6731-8871"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A.W. Thomson","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA","Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052576326","display_name":"Mohamed B. Ezzelarab","orcid":"https://orcid.org/0000-0002-3919-5250","observed_orcids":["https://orcid.org/0000-0002-3919-5250"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.B. Ezzelarab","raw_affiliation_strings":["Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069651723"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"1156","last_page":"1157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd154","display_name":"CD154","score":0.8130000233650208},{"id":"https://openalex.org/keywords/kidney-allograft-rejection","display_name":"renal allograft rejection","score":0.8410000205039978},{"id":"https://openalex.org/keywords/costimulation-blockade","display_name":"costimulation blockade","score":0.7390000224113464},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.8140000104904175},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.878000020980835},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.902999997138977},{"id":"https://openalex.org/keywords/t-cell-costimulation","display_name":"T cell costimulation","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8915177583694458},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.7407181859016418},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12677663564682007},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08310550451278687}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/ajt.14217","doi":"https://doi.org/10.1111/ajt.14217","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.14217","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},{"id":"pmid:28141921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28141921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1111/ajt.14217","doi":"https://doi.org/10.1111/ajt.14217","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.14217","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3044782860","display_name":"Alemtuzumab and Regulatory T Cells for Heart Transplant Tolerance in Monkeys","funder_award_id":"U01AI091197","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1959883458","https://openalex.org/W2054083392","https://openalex.org/W2059791530","https://openalex.org/W2074054466","https://openalex.org/W2118061894","https://openalex.org/W2139529220","https://openalex.org/W2317185835","https://openalex.org/W2576472127"],"related_works":["https://openalex.org/W2576472127","https://openalex.org/W4253263500","https://openalex.org/W1518371662","https://openalex.org/W4394958466","https://openalex.org/W2059791530","https://openalex.org/W7213979658","https://openalex.org/W4405967528","https://openalex.org/W2169724450","https://openalex.org/W4225725030","https://openalex.org/W2025631961"],"abstract_inverted_index":{"A":[0],"new":[1],"Fc-silent":[2],"anti-human":[3],"CD154":[4],"domain":[5],"antibody":[6],"synergizes":[7],"with":[8,29],"conventional":[9],"immunosuppressants":[10],"to":[11],"control":[12],"renal":[13],"transplant":[14],"rejection":[15],"in":[16,33],"nonhuman":[17],"primates":[18],"without":[19],"evidence":[20],"of":[21,26],"thromboembolism,":[22],"raising":[23],"the":[24,34,37],"prospect":[25],"its":[27],"combination":[28],"approved":[30],"costimulation-blocking":[31],"agents":[32],"clinic.":[35],"See":[36],"article":[38],"from":[39],"Kim":[40],"et":[41],"al":[42],"on":[43],"page":[44],"1182.":[45]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-10T00:00:00"}