{"id":"https://openalex.org/W2583066825","doi":"https://doi.org/10.1111/evo.13190","title":"Parallel emergence of negative epistasis across experimental lineages","display_name":"Parallel emergence of negative epistasis across experimental lineages","publication_year":2017,"publication_date":"2017-01-27","ids":{"openalex":"https://openalex.org/W2583066825","doi":"https://doi.org/10.1111/evo.13190","mag":"2583066825","pmid":"https://pubmed.ncbi.nlm.nih.gov/28128449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5382110"},"language":"en","primary_location":{"id":"doi:10.1111/evo.13190","doi":"https://doi.org/10.1111/evo.13190","is_oa":false,"landing_page_url":"https://doi.org/10.1111/evo.13190","pdf_url":null,"source":{"id":"https://openalex.org/S87560609","display_name":"Evolution","issn_l":"0014-3820","issn":["0014-3820","1558-5646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5382110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069697770","display_name":"Peter C. Zee","orcid":"https://orcid.org/0000-0003-2594-9602","observed_orcids":["https://orcid.org/0000-0003-2594-9602"]},"institutions":[{"id":"https://openalex.org/I157638225","display_name":"California State University, Northridge","ror":"https://ror.org/005f5hv41","country_code":"US","type":"education","lineage":["https://openalex.org/I157638225"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter C. Zee","raw_affiliation_strings":["Department of Biology; California State University; Northridge California","Department of Biology; Indiana University; Bloomington Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology; California State University; Northridge California","institution_ids":["https://openalex.org/I157638225"]},{"raw_affiliation_string":"Department of Biology; Indiana University; Bloomington Indiana","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076629790","display_name":"Gregory J. Velicer","orcid":"https://orcid.org/0000-0001-8721-1502","observed_orcids":["https://orcid.org/0000-0001-8721-1502"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Gregory J. Velicer","raw_affiliation_strings":["Department of Biology; Indiana University; Bloomington Indiana","Department of Environmental Systems Sciences; ETH Z\u00fcrich; Z\u00fcrich Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology; Indiana University; Bloomington Indiana","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"Department of Environmental Systems Sciences; ETH Z\u00fcrich; Z\u00fcrich Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069697770"],"corresponding_institution_ids":["https://openalex.org/I157638225","https://openalex.org/I4210119109","https://openalex.org/I592451"],"apc_list":{"value":3214,"currency":"USD","value_usd":3214},"apc_paid":null,"fwci":0.3621,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59707874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"71","issue":"4","first_page":"1088","last_page":"1095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12090","display_name":"Language and cultural evolution","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3316","display_name":"Cultural Studies"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/negative-epistasis","display_name":"negative epistasis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/myxococcus-xanthus","display_name":"Myxococcus xanthus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pila","display_name":"Pila","score":0.7310000061988831},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.7910000085830688},{"id":"https://openalex.org/keywords/parallel-evolution","display_name":"parallel evolution","score":0.6890000104904175},{"id":"https://openalex.org/keywords/adaptive-mutations","display_name":"adaptive mutation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/social-bacteria","display_name":"social bacteria","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9462409019470215},{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.9179426431655884},{"id":"https://openalex.org/C164017216","wikidata":"https://www.wikidata.org/wiki/Q1549094","display_name":"Swarming (honey bee)","level":2,"score":0.8956484198570251},{"id":"https://openalex.org/C2777120639","wikidata":"https://www.wikidata.org/wiki/Q142803","display_name":"Myxococcus xanthus","level":4,"score":0.6479583382606506},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.644526481628418},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.5613723993301392},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5456020832061768},{"id":"https://openalex.org/C2554327","wikidata":"https://www.wikidata.org/wiki/Q2698599","display_name":"Coalescent theory","level":4,"score":0.5331709980964661},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.500565767288208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34350883960723877},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2511279582977295},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.2484857439994812},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.11610764265060425}],"mesh":[{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016941","descriptor_name":"Myxococcus xanthus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016941","descriptor_name":"Myxococcus xanthus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/evo.13190","doi":"https://doi.org/10.1111/evo.13190","is_oa":false,"landing_page_url":"https://doi.org/10.1111/evo.13190","pdf_url":null,"source":{"id":"https://openalex.org/S87560609","display_name":"Evolution","issn_l":"0014-3820","issn":["0014-3820","1558-5646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution","raw_type":"journal-article"},{"id":"pmid:28128449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28128449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution; international journal of organic evolution","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5382110","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5382110","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Evolution","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5382110","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5382110","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Evolution","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4287630350","display_name":"Comprehensive analysis of evolutionary mutations in a highly social bacterium","funder_award_id":"R01GM079690","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G458230864","display_name":"Genetics Cellular and Molecular Sciences Training Grant","funder_award_id":"T32GM007757","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1493396640","https://openalex.org/W1512993758","https://openalex.org/W1523427112","https://openalex.org/W1565578508","https://openalex.org/W1919835235","https://openalex.org/W1934694257","https://openalex.org/W1946805217","https://openalex.org/W1967902778","https://openalex.org/W1979905261","https://openalex.org/W1984547053","https://openalex.org/W2003685996","https://openalex.org/W2012457691","https://openalex.org/W2016666153","https://openalex.org/W2019140963","https://openalex.org/W2027013694","https://openalex.org/W2031581341","https://openalex.org/W2039227019","https://openalex.org/W2046793790","https://openalex.org/W2054099099","https://openalex.org/W2072718843","https://openalex.org/W2073171022","https://openalex.org/W2081083195","https://openalex.org/W2095830907","https://openalex.org/W2102795115","https://openalex.org/W2110146147","https://openalex.org/W2112945902","https://openalex.org/W2119596924","https://openalex.org/W2119846908","https://openalex.org/W2123035125","https://openalex.org/W2128738569","https://openalex.org/W2134460102","https://openalex.org/W2139486575","https://openalex.org/W2141869844","https://openalex.org/W2143736398","https://openalex.org/W2148801861","https://openalex.org/W2149409778","https://openalex.org/W2152749315","https://openalex.org/W2156477417","https://openalex.org/W2161149122","https://openalex.org/W2161653752","https://openalex.org/W2164622275","https://openalex.org/W2521409077","https://openalex.org/W2582743722","https://openalex.org/W2767892805","https://openalex.org/W4246887724","https://openalex.org/W4249178293"],"related_works":["https://openalex.org/W2582285164","https://openalex.org/W2164622275","https://openalex.org/W6892239033","https://openalex.org/W2535121891","https://openalex.org/W2590088107","https://openalex.org/W1967902778","https://openalex.org/W6967395051","https://openalex.org/W1995152803","https://openalex.org/W6929509511","https://openalex.org/W1922461730"],"abstract_inverted_index":{"Epistatic":[0],"interactions":[1,28,218],"can":[2],"greatly":[3,75],"impact":[4],"evolutionary":[5],"phenomena,":[6],"particularly":[7],"the":[8,22,30,51,62,82,100,131,139,144,164,173,189,223],"process":[9],"of":[10,26,54,65,111,120,167,175,210],"adaptation.":[11],"Here,":[12],"we":[13,103,115,184],"leverage":[14],"four":[15,101,180],"parallel":[16,106],"experimentally":[17],"evolved":[18,70,86,141],"lineages":[19,69,85,107,142,161],"to":[20,155,197],"study":[21],"emergence":[23,174],"and":[24,126,146,222],"trajectories":[25],"epistatic":[27,157],"in":[29,90,130,138],"social":[31,36,225],"bacterium":[32],"Myxococcus":[33],"xanthus.":[34],"A":[35],"gene":[37],"(pilA)":[38],"necessary":[39],"for":[40,59,74],"effective":[41],"group":[42],"swarming":[43,77,149],"on":[44,78],"soft":[45,79],"agar":[46],"had":[47],"been":[48],"deleted":[49],"from":[50,163],"common":[52,156],"ancestor":[53],"these":[55],"lineages.":[56,182],"During":[57],"selection":[58],"competitiveness":[60],"at":[61],"leading":[63],"edge":[64],"growing":[66],"colonies,":[67],"two":[68,84,140],"qualitatively":[71],"novel":[72],"mechanisms":[73],"increased":[76],"agar,":[80],"whereas":[81],"other":[83],"relatively":[87],"small":[88],"increases":[89],"swarming.":[91],"By":[92],"reintroducing":[93],"pilA":[94,127,211],"into":[95],"different":[96],"genetic":[97],"backgrounds":[98],"along":[99],"lineages,":[102],"tested":[104,116],"whether":[105,117],"showed":[108],"similar":[109],"patterns":[110],"epistasis.":[112],"In":[113],"particular,":[114],"a":[118,201],"pattern":[119],"negative":[121,176,191],"epistasis":[122,177,192],"between":[123,219],"accumulating":[124,220],"mutations":[125,221],"previously":[128],"found":[129,136],"fastest":[132,145],"lineage":[133],"would":[134],"be":[135],"only":[137],"with":[143],"most":[147],"striking":[148],"phenotypes,":[150],"or":[151],"rather":[152,214],"was":[153],"due":[154,195],"structure":[158],"across":[159,178],"all":[160,179],"arising":[162],"generic":[165],"fixation":[166],"adaptive":[168],"mutations.":[169],"Our":[170],"analysis":[171],"reveals":[172],"independent":[181],"Further,":[183],"present":[185],"results":[186],"showing":[187],"that":[188,205],"observed":[190],"is":[193],"not":[194],"exclusively":[196],"evolving":[198],"populations":[199],"approaching":[200],"maximum":[202],"phenotypic":[203],"value":[204],"inherently":[206],"limits":[207],"positive":[208],"effects":[209],"reintroduction,":[212],"but":[213],"involves":[215],"direct":[216],"antagonistic":[217],"reintroduced":[224],"gene.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-03T00:00:00"}
