{"id":"https://openalex.org/W2582877239","doi":null,"title":"Alterations in Tgf-\u03b2 Signaling Mediate the Biologic Behaviour of Osteosarcoma Cell Lines","display_name":"Alterations in Tgf-\u03b2 Signaling Mediate the Biologic Behaviour of Osteosarcoma Cell Lines","publication_year":2010,"publication_date":"2010-12-31","ids":{"openalex":"https://openalex.org/W2582877239","mag":"2582877239"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/25551","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/25551","pdf_url":"https://utoronto.scholaris.ca/bitstreams/aba3ff40-0cae-4066-b3a4-3ff8e9fde98c/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/aba3ff40-0cae-4066-b3a4-3ff8e9fde98c/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084911287","display_name":"Benjamin M. Deheshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Benjamin Deheshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084911287"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9010000228881836},{"id":"https://openalex.org/keywords/taz","display_name":"TAZ","score":0.9729999899864197},{"id":"https://openalex.org/keywords/smad-phosphorylation","display_name":"Smad phosphorylation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumour-suppressor","display_name":"tumour suppressor","score":0.7960000038146973},{"id":"https://openalex.org/keywords/bone-tumors","display_name":"bone tumors","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8168383836746216},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.7304911613464355},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6593130826950073},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6218560338020325},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5887332558631897},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5530633330345154},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.5339390635490417},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5335125923156738},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5060667395591736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4624953269958496},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2985772490501404},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2577701807022095},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07991409301757812}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/25551","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/25551","pdf_url":"https://utoronto.scholaris.ca/bitstreams/aba3ff40-0cae-4066-b3a4-3ff8e9fde98c/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/25551","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/25551","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2582877239","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/25551?mode=full","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/25551","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/25551","pdf_url":"https://utoronto.scholaris.ca/bitstreams/aba3ff40-0cae-4066-b3a4-3ff8e9fde98c/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2582877239.pdf","grobid_xml":"https://content.openalex.org/works/W2582877239.grobid-xml"},"referenced_works_count":158,"referenced_works":["https://openalex.org/W157700276","https://openalex.org/W1138153862","https://openalex.org/W1494055834","https://openalex.org/W1513040830","https://openalex.org/W1517364118","https://openalex.org/W1517977083","https://openalex.org/W1531523780","https://openalex.org/W1540456704","https://openalex.org/W1565561072","https://openalex.org/W1571221413","https://openalex.org/W1574854999","https://openalex.org/W1604721396","https://openalex.org/W1660095449","https://openalex.org/W1663371441","https://openalex.org/W1832014025","https://openalex.org/W1880979783","https://openalex.org/W1895211074","https://openalex.org/W1906211198","https://openalex.org/W1907841101","https://openalex.org/W1966260349","https://openalex.org/W1968997237","https://openalex.org/W1970109558","https://openalex.org/W1973800266","https://openalex.org/W1974045120","https://openalex.org/W1974651173","https://openalex.org/W1975244118","https://openalex.org/W1976990850","https://openalex.org/W1978160288","https://openalex.org/W1978785485","https://openalex.org/W1978954099","https://openalex.org/W1982498121","https://openalex.org/W1983628734","https://openalex.org/W1984282087","https://openalex.org/W1985400766","https://openalex.org/W1988942273","https://openalex.org/W1989365021","https://openalex.org/W1990467912","https://openalex.org/W1992409084","https://openalex.org/W1994738588","https://openalex.org/W1994798295","https://openalex.org/W1996405087","https://openalex.org/W1996454218","https://openalex.org/W1997296963","https://openalex.org/W1998132110","https://openalex.org/W2000307461","https://openalex.org/W2003907692","https://openalex.org/W2004102023","https://openalex.org/W2004774286","https://openalex.org/W2005201208","https://openalex.org/W2006260464","https://openalex.org/W2006276830","https://openalex.org/W2007963495","https://openalex.org/W2009629707","https://openalex.org/W2013012202","https://openalex.org/W2014875647","https://openalex.org/W2016094576","https://openalex.org/W2017201371","https://openalex.org/W2018867485","https://openalex.org/W2018978380","https://openalex.org/W2019110548","https://openalex.org/W2021263701","https://openalex.org/W2022896763","https://openalex.org/W2024184251","https://openalex.org/W2026644829","https://openalex.org/W2028919524","https://openalex.org/W2029930661","https://openalex.org/W2030659648","https://openalex.org/W2031556612","https://openalex.org/W2035653659","https://openalex.org/W2039550311","https://openalex.org/W2040365986","https://openalex.org/W2042839797","https://openalex.org/W2044440492","https://openalex.org/W2045023599","https://openalex.org/W2046045619","https://openalex.org/W2046425054","https://openalex.org/W2046780997","https://openalex.org/W2046879173","https://openalex.org/W2047025215","https://openalex.org/W2050389860","https://openalex.org/W2051300777","https://openalex.org/W2061507256","https://openalex.org/W2063282481","https://openalex.org/W2064794660","https://openalex.org/W2067656705","https://openalex.org/W2068132469","https://openalex.org/W2069533174","https://openalex.org/W2069911905","https://openalex.org/W2070210483","https://openalex.org/W2071679256","https://openalex.org/W2071697240","https://openalex.org/W2077046161","https://openalex.org/W2077326574","https://openalex.org/W2081490489","https://openalex.org/W2082466352","https://openalex.org/W2084734843","https://openalex.org/W2084940194","https://openalex.org/W2085197940","https://openalex.org/W2086692663","https://openalex.org/W2087404852","https://openalex.org/W2093531115","https://openalex.org/W2094579915","https://openalex.org/W2095708380","https://openalex.org/W2096590212","https://openalex.org/W2096662041","https://openalex.org/W2097829282","https://openalex.org/W2100522747","https://openalex.org/W2101538557","https://openalex.org/W2113989947","https://openalex.org/W2116217777","https://openalex.org/W2116517031","https://openalex.org/W2116867733","https://openalex.org/W2118671972","https://openalex.org/W2120724429","https://openalex.org/W2122184612","https://openalex.org/W2122269150","https://openalex.org/W2123511906","https://openalex.org/W2125256208","https://openalex.org/W2131155074","https://openalex.org/W2138852914","https://openalex.org/W2139401320","https://openalex.org/W2140986588","https://openalex.org/W2141788705","https://openalex.org/W2145667489","https://openalex.org/W2146191765","https://openalex.org/W2147754310","https://openalex.org/W2147865927","https://openalex.org/W2148583445","https://openalex.org/W2149373223","https://openalex.org/W2150301699","https://openalex.org/W2153526687","https://openalex.org/W2155851278","https://openalex.org/W2156422948","https://openalex.org/W2156460034","https://openalex.org/W2158950529","https://openalex.org/W2159310898","https://openalex.org/W2159594827","https://openalex.org/W2159808336","https://openalex.org/W2161377790","https://openalex.org/W2162577349","https://openalex.org/W2164013013","https://openalex.org/W2164034599","https://openalex.org/W2164427788","https://openalex.org/W2166644606","https://openalex.org/W2167160417","https://openalex.org/W2169110374","https://openalex.org/W2170446218","https://openalex.org/W2171454878","https://openalex.org/W2172177304","https://openalex.org/W2172206677","https://openalex.org/W2188583399","https://openalex.org/W2213413145","https://openalex.org/W2289925455","https://openalex.org/W2317179801","https://openalex.org/W2326367330","https://openalex.org/W2407607321","https://openalex.org/W2408591805","https://openalex.org/W2463427090"],"related_works":["https://openalex.org/W2107396458","https://openalex.org/W4388487165","https://openalex.org/W2809927278","https://openalex.org/W2089439379","https://openalex.org/W2548446844","https://openalex.org/W2534257550","https://openalex.org/W3014333000","https://openalex.org/W1991072611","https://openalex.org/W2111422801","https://openalex.org/W2236739945"],"abstract_inverted_index":{"Osteosarcoma":[0],"is":[1,14],"a":[2,31,84,108,143,147],"mesenchymal":[3],"tumour":[4,109,144],"of":[5,51],"bone":[6],"common":[7],"among":[8],"children":[9],"and":[10,57,62,73,79,105,127],"young":[11],"adults.":[12],"Prognosis":[13],"poor":[15],"if":[16],"metastases":[17],"are":[18,46],"present":[19],"at":[20],"diagnosis.":[21],"The":[22],"transforming":[23],"growth":[24],"factor":[25],"beta":[26],"(TGF-\u03b2)":[27],"signaling":[28,44,126],"pathway":[29,45],"plays":[30],"complex":[32],"dual":[33],"role":[34],"in":[35,41,48,67,87,134,146],"cancer.":[36],"We":[37],"hypothesized":[38],"that":[39],"alterations":[40],"the":[42,49,68,88,118],"TGF-\u03b2":[43,77,102,120,125,140],"important":[47],"tumorigenesis":[50],"osteosarcoma":[52,70,135],"cell":[53,71,90,136],"lines.":[54],"Smad":[55],"phosphorylation":[56],"nuclear":[58],"localization,":[59],"Smad4":[60],"expression,":[61],"TAZ":[63,80,128],"expression":[64,81],"were":[65,115],"determined":[66],"HOS":[69],"line":[72],"tumorigenic":[74,85,132],"derivatives.":[75],"Basal":[76],"activity":[78],"correlated":[82],"with":[83,130],"phenotype":[86],"KHOS":[89,113],"lines":[91],"as":[92,107,142],"measured":[93],"by":[94],"Anchorage":[95],"Independent":[96],"Growth":[97],"(AIG).":[98],"In":[99,122],"comparison,":[100],"exogenous":[101,139],"suppressed":[103],"AIG":[104],"acted":[106,141],"suppressor,":[110],"while":[111],"Smad4-deficient":[112],"cells":[114],"resistant":[116],"to":[117],"inhibitory":[119],"effect.":[121],"conclusion,":[123],"basal":[124],"correlate":[129],"increased":[131],"potential":[133],"lines,":[137],"whereas":[138],"suppressor":[145],"Smad4-dependent":[148],"manner.":[149]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-02-03T00:00:00"}
