{"id":"https://openalex.org/W2582866269","doi":"https://doi.org/10.1182/blood.v104.11.525.525","title":"MLL Rearranged Infant Acute Lymphoblastic Leukemia Is Characterized by Silencing of the Putative Tumor Suppressor Gene FHIT.","display_name":"MLL Rearranged Infant Acute Lymphoblastic Leukemia Is Characterized by Silencing of the Putative Tumor Suppressor Gene FHIT.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2582866269","doi":"https://doi.org/10.1182/blood.v104.11.525.525","mag":"2582866269"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.525.525","doi":"https://doi.org/10.1182/blood.v104.11.525.525","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.525.525","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002362786","display_name":"Ronald W. Stam","orcid":"https://orcid.org/0000-0003-4986-1656","observed_orcids":["https://orcid.org/0000-0003-4986-1656"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Ronald W. Stam","raw_affiliation_strings":["Pediatric Oncology/Hematology, Erasmus MC/Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology/Hematology, Erasmus MC/Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035786690","display_name":"Monique L. den Boer","orcid":"https://orcid.org/0000-0002-5795-2921","observed_orcids":["https://orcid.org/0000-0002-5795-2921"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monique L. Den Boer","raw_affiliation_strings":["Pediatric Oncology/Hematology, Erasmus MC/Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology/Hematology, Erasmus MC/Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063439907","display_name":"Monique Passier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Monique Passier","raw_affiliation_strings":["Pediatric Oncology/Hematology, Erasmus MC/Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology/Hematology, Erasmus MC/Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082614208","display_name":"Stephen E. Sallan","orcid":"https://orcid.org/0000-0002-1064-8981","observed_orcids":["https://orcid.org/0000-0002-1064-8981"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen E. Sallan","raw_affiliation_strings":["Harvard Medical School, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012956545","display_name":"Scott A. Armstrong","orcid":"https://orcid.org/0000-0002-9099-4728","observed_orcids":["https://orcid.org/0000-0002-9099-4728"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott A. Armstrong","raw_affiliation_strings":["Harvard Medical School, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007326278","display_name":"Pieters Pieters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pieters Pieters","raw_affiliation_strings":["Pediatric Oncology/Hematology, Erasmus MC/Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology/Hematology, Erasmus MC/Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002362786","https://openalex.org/A5012956545","https://openalex.org/A5063439907"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210142620"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.3693007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"104","issue":"11","first_page":"525","last_page":"525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.871999979019165},{"id":"https://openalex.org/keywords/infant-acute-lymphoblastic-leukemia","display_name":"infant acute lymphoblastic leukemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fhit","display_name":"FHIT","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-suppressor-gene-silencing","display_name":"tumor suppressor gene silencing","score":0.8399999737739563},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8270000219345093},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2780646079","wikidata":"https://www.wikidata.org/wiki/Q17928393","display_name":"FHIT","level":5,"score":0.993403971195221},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6680492162704468},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6121987104415894},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.6097134351730347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5980616211891174},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.49431657791137695},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4918558597564697},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.4891500771045685},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43146276473999023},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.43140265345573425},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3897012174129486},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38357028365135193},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26158323884010315},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2454584240913391},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.19224682450294495},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.12605631351470947}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.525.525","doi":"https://doi.org/10.1182/blood.v104.11.525.525","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.525.525","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985964461","https://openalex.org/W1966942042","https://openalex.org/W2076313396","https://openalex.org/W2023044006","https://openalex.org/W7098258913","https://openalex.org/W2587033040","https://openalex.org/W2745630081","https://openalex.org/W2145641334","https://openalex.org/W2556358445","https://openalex.org/W2100905170"],"abstract_inverted_index":{"Abstract":[0],"MLL":[1,65,74,100,115,130,152,155,198,231,258,270],"gene":[2,131,259],"rearranged":[3,132,271],"acute":[4,13],"lymphoblastic":[5,14],"leukemia":[6,15,255],"(MLL)":[7],"is":[8,35,51,75,96,190,273],"an":[9],"aggressive":[10],"type":[11,294],"of":[12,30,39,43,79,194,217,239,247,289,295],"(ALL)":[16],"with":[17,108,236],"a":[18,237],"relatively":[19],"poor":[20],"response":[21],"to":[22,47,105,126,139,166,261,284],"treatment,":[23],"predominantly":[24],"occurring":[25],"in":[26,37,99,129,192,202,221,292],"infants":[27,141],"(<1":[28],"years":[29],"age).":[31],"Since":[32],"conventional":[33,109],"chemotherapy":[34],"failing":[36],">50%":[38],"these":[40],"patients,":[41],"identification":[42],"novel":[44],"therapeutic":[45],"targets":[46],"direct":[48],"therapy":[49],"against":[50],"demanded.":[52],"For":[53],"this,":[54],"understanding":[55],"this":[56,293],"disease":[57],"and":[58,61,142,171,224,242],"finding":[59],"biological":[60,287],"molecular":[62],"features":[63],"characterizing":[64],"may":[66],"be":[67,127,251],"crucial.":[68],"Here":[69],"we":[70,121],"report":[71],"that":[72,93,185,269],"infant":[73,133,167,197,223],"characterized":[76,274],"by":[77,253,275],"silencing":[78,291],"the":[80,151,186,195,215,262,286],"putative":[81],"tumor":[82],"suppressor":[83],"fragile":[84],"histidine":[85],"triad":[86],"(FHIT)":[87],"gene.":[88,153],"Gene":[89],"expression":[90,95,125,249],"profiling":[91],"showed":[92],"FHIT":[94,123,163,187,205,210,218,248,276,290],"significantly":[97,158],"reduced":[98,204],"patients":[101,106,156,169,177,227],"(n=20)":[102],"as":[103,137,207,209],"compared":[104,138,165],"diagnosed":[107],"ALL":[110,134,168,176,226,272],"(n=24)":[111],"bearing":[112,257],"germ":[113,229],"line":[114,230],"genes.":[116],"Using":[117],"quantitative":[118],"real-time":[119],"PCR":[120,181],"confirmed":[122],"mRNA":[124,164,206],"low":[128],"(infant":[135],"MLL)":[136],"both":[140,222],"older":[143],"children":[144],"(non-infants)":[145],"not":[146],"carrying":[147,228],"chromosomal":[148],"abnormalities":[149],"involving":[150],"Infant":[154],"(n=35)":[157],"(p<0.001)":[159],"expressed":[160],"~15-fold":[161],"less":[162,173],"(n=8)":[170],"11-fold":[172],"than":[174],"non-infant":[175,225],"(n=22).":[178],"Methylation":[179],"specific":[180],"(MSP)":[182],"analysis":[183],"demonstrated":[184],"promoter":[188,219,277],"region":[189],"hypermethylated":[191],"all":[193],"36":[196],"cases":[199],"tested,":[200],"resulting":[201],"strongly":[203],"well":[208],"protein":[211],"expression.":[212],"In":[213],"contrast,":[214],"incidence":[216],"methylation":[220],"genes":[232],"was":[233],"markedly":[234],"lower,":[235],"frequency":[238],"63%":[240],"(5/8)":[241],"56%":[243],"(24/43)":[244],"respectively.":[245],"Suppression":[246],"could":[250],"reversed":[252],"exposing":[254],"cells":[256],"rearrangements":[260],"demethylating":[263],"drug":[264],"5\u2032-aza-2\u2032-deoxycytidine.":[265],"These":[266],"findings":[267],"imply":[268],"hypermethylation.":[278],"Currently":[279],"experiments":[280],"are":[281],"being":[282],"conducted":[283],"determine":[285],"significance":[288],"cancer.":[296]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-02-03T00:00:00"}
