{"id":"https://openalex.org/W2582615201","doi":"https://doi.org/10.1371/journal.pone.0170626","title":"\u03b3H2Ax Expression as a Potential Biomarker Differentiating between Low and High Grade Cervical Squamous Intraepithelial Lesions (SIL) and High Risk HPV Related SIL","display_name":"\u03b3H2Ax Expression as a Potential Biomarker Differentiating between Low and High Grade Cervical Squamous Intraepithelial Lesions (SIL) and High Risk HPV Related SIL","publication_year":2017,"publication_date":"2017-01-24","ids":{"openalex":"https://openalex.org/W2582615201","doi":"https://doi.org/10.1371/journal.pone.0170626","mag":"2582615201","pmid":"https://pubmed.ncbi.nlm.nih.gov/28118377","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5261776"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0170626","doi":"https://doi.org/10.1371/journal.pone.0170626","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0170626","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170626&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170626&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023803145","display_name":"Konstantinos Leventakos","orcid":"https://orcid.org/0000-0001-9784-8603","observed_orcids":["https://orcid.org/0000-0001-9784-8603"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Leventakos","raw_affiliation_strings":["2nd Department of Pathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","4th Department of Internal Medicine, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Pathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019379026","display_name":"Sotirios Tsiodras","orcid":"https://orcid.org/0000-0002-0463-4321","observed_orcids":["https://orcid.org/0000-0002-0463-4321"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Sotirios Tsiodras","raw_affiliation_strings":["4th Department of Internal Medicine, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0002-0463-4321","affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085723076","display_name":"Theodoros Kelesidis","orcid":"https://orcid.org/0000-0002-8463-3811","observed_orcids":["https://orcid.org/0000-0002-8463-3811"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Theodore Kelesidis","raw_affiliation_strings":["4th Department of Internal Medicine, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037400755","display_name":"Maria Alexandra Kefala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Kefala","raw_affiliation_strings":["2nd Department of Pathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Pathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010861386","display_name":"Christine Kottaridi","orcid":"https://orcid.org/0000-0003-0979-3871","observed_orcids":["https://orcid.org/0000-0003-0979-3871"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christine Kottaridi","raw_affiliation_strings":["Department of Cytopathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytopathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042804433","display_name":"Aris Spathis","orcid":"https://orcid.org/0000-0001-8867-3661","observed_orcids":["https://orcid.org/0000-0001-8867-3661"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Aris Spathis","raw_affiliation_strings":["Department of Cytopathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytopathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024643811","display_name":"Alina\u2010Roxani Gouloumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alina-Roxani Gouloumi","raw_affiliation_strings":["2nd Department of Pathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Pathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006724063","display_name":"Abraham Pouliakis","orcid":"https://orcid.org/0000-0002-0074-3619","observed_orcids":["https://orcid.org/0000-0002-0074-3619"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Abraham Pouliakis","raw_affiliation_strings":["Department of Cytopathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytopathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112774295","display_name":"Asimakis Pappas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Asimakis Pappas","raw_affiliation_strings":["3rd Department of Obstetrics and Gynecology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Obstetrics and Gynecology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004386299","display_name":"Vasileios D. Sioulas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasileios Sioulas","raw_affiliation_strings":["3rd Department of Obstetrics and Gynecology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Obstetrics and Gynecology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090455931","display_name":"Charalambos Chrelias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Charalambos Chrelias","raw_affiliation_strings":["3rd Department of Obstetrics and Gynecology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Obstetrics and Gynecology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041155369","display_name":"Petros Karakitsos","orcid":"https://orcid.org/0000-0002-2957-6850","observed_orcids":["https://orcid.org/0000-0002-2957-6850"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Petros Karakitsos","raw_affiliation_strings":["Department of Cytopathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytopathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102729972","display_name":"Ioannis G Panayiotides","orcid":"https://orcid.org/0000-0002-6394-117X","observed_orcids":["https://orcid.org/0000-0002-6394-117X","https://orcid.org/0009-0005-5942-9631"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Panayiotides","raw_affiliation_strings":["2nd Department of Pathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Pathology, University Hospital \"Attikon\", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019379026"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.2141,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54966381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"1","first_page":"e0170626","last_page":"e0170626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cervical-squamous-intraepithelial-lesions","display_name":"cervical squamous intraepithelial lesions","score":0.8550000190734863},{"id":"https://openalex.org/keywords/high-risk-hpv","display_name":"high-risk HPV","score":0.746999979019165},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8410000205039978},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cervical-squamous-cell-carcinoma","display_name":"cervical squamous cell carcinoma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cervical-adenocarcinoma","display_name":"cervical adenocarcinoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/histological-grading","display_name":"histological grading","score":0.75}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5728294253349304},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5026910305023193},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.49795031547546387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45591530203819275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4195733964443207},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.383428692817688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35818707942962646},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3410297930240631},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32872384786605835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061809","descriptor_name":"Human Papillomavirus DNA Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065310","descriptor_name":"Squamous Intraepithelial Lesions of the Cervix","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D065310","descriptor_name":"Squamous Intraepithelial Lesions of the Cervix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065310","descriptor_name":"Squamous Intraepithelial Lesions of the Cervix","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0170626","doi":"https://doi.org/10.1371/journal.pone.0170626","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0170626","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170626&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4171655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5261776","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5261776","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5261776","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:28118377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28118377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1gw6k4cd","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1gw6k4cd","pdf_url":"https://escholarship.org/content/qt1gw6k4cd/qt1gw6k4cd.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE, vol 12, iss 1","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bdac346ec3a040889fcb6ddf3da234a4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bdac346ec3a040889fcb6ddf3da234a4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 12, Iss 1, p e0170626 (2017)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt1gw6k4cd","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1gw6k4cd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS one, vol 12, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0170626","doi":"https://doi.org/10.1371/journal.pone.0170626","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0170626","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170626&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3276713972","display_name":"UCLA Clinical and Translational Science Institute","funder_award_id":"UL1TR000124","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4059818670","display_name":"Oxidized HDL in the intersection of HIV, immune activation and atherosclerosis","funder_award_id":"K08AI108272","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2582615201.pdf","grobid_xml":"https://content.openalex.org/works/W2582615201.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W99705021","https://openalex.org/W110294243","https://openalex.org/W1602311424","https://openalex.org/W1845837508","https://openalex.org/W1892123683","https://openalex.org/W1973874596","https://openalex.org/W1974875034","https://openalex.org/W1976065177","https://openalex.org/W1985775217","https://openalex.org/W1997836635","https://openalex.org/W2000145678","https://openalex.org/W2005326726","https://openalex.org/W2007749864","https://openalex.org/W2016440796","https://openalex.org/W2027630134","https://openalex.org/W2039143648","https://openalex.org/W2045429308","https://openalex.org/W2075679064","https://openalex.org/W2079466993","https://openalex.org/W2083960841","https://openalex.org/W2090741584","https://openalex.org/W2094469725","https://openalex.org/W2096136751","https://openalex.org/W2110817748","https://openalex.org/W2128252882","https://openalex.org/W2128723092","https://openalex.org/W2141003030","https://openalex.org/W2148172964","https://openalex.org/W2151411596","https://openalex.org/W2152745581","https://openalex.org/W2343812278","https://openalex.org/W2415895890","https://openalex.org/W4238328529","https://openalex.org/W4251548431"],"related_works":["https://openalex.org/W3030679648","https://openalex.org/W2029182878","https://openalex.org/W2954355144","https://openalex.org/W4408460581","https://openalex.org/W4406069499","https://openalex.org/W2932433665","https://openalex.org/W2133452414","https://openalex.org/W2517945562","https://openalex.org/W3037480640","https://openalex.org/W2410510888"],"abstract_inverted_index":{"BACKGROUND:":[0],"\u03b3H2AX":[1,102,124,157,175],"is":[2],"a":[3,135,143,148,163,179],"protein":[4],"biomarker":[5,181],"for":[6,23],"double-stranded":[7],"DNA":[8],"breakage;":[9],"its":[10],"expression":[11,103,125,158],"was":[12,25,114,126],"studied":[13],"in":[14,27,51,104,160,172],"cervical":[15,32,73],"squamous":[16,65,112],"intraepithelial":[17],"lesions":[18],"and":[19,34,71,101,107,122,155,171,185],"carcinomas.":[20],"METHODS:":[21],"Immunostaining":[22],"phospho-\u03b3H2AX":[24],"performed":[26],"sections":[28],"from":[29,39,129],"histologically":[30],"confirmed":[31],"SIL":[33,57,62],"carcinomas,":[35],"as":[36,38,43,178,187,189],"well":[37,188],"normal":[40,130],"cervices":[41,131],"used":[42],"controls.":[44],"In":[45],"total,":[46],"275":[47],"cases":[48],"were":[49],"included":[50],"the":[52,111],"study:":[53],"112":[54],"low":[55,86,136],"grade":[56,61],"(LGSIL),":[58],"99":[59],"high":[60,83,96,144,164,193],"(HGSIL),":[63],"24":[64],"cell":[66],"carcinoma":[67],"(SCC),":[68],"12":[69],"adenocarcinoma":[70],"28":[72],"specimens":[74],"with":[75],"no":[76],"essential":[77],"lesions.":[78],"Correlation":[79],"of":[80,110,119],"histological":[81],"grading,":[82],"risk":[84,87,97,137,145,165,194],"vs.":[85,92],"HPV":[88,98,138,195],"virus":[89,146,166],"presence,":[90],"activated":[91,169,198],"non-activated":[93,149],"status":[94],"(by":[95],"mRNA":[99],"expression)":[100],"both":[105,120,153],"basal":[106,121,154],"surface":[108,123,156],"segments":[109],"epithelium":[113],"performed.":[115],"RESULTS:":[116],"Gradual":[117],"increase":[118],"noted":[127],"up":[128],"to":[132,140],"LGSIL":[133,141,161,184,191],"harboring":[134,142,162,192],"type,":[139],"at":[147,167,196],"state":[150,170],"(p<0.05).":[151],"Thereafter,":[152],"dropped":[159],"an":[168,197],"HGSIL.":[173],"CONCLUSIONS:":[174],"could":[176],"serve":[177],"potential":[180],"discriminating":[182],"between":[183,190],"HGSIL,":[186],"state.":[199]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-03T00:00:00"}