{"id":"https://openalex.org/W2582335517","doi":"https://doi.org/10.1371/journal.ppat.1006063","title":"The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis","display_name":"The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis","publication_year":2017,"publication_date":"2017-01-23","ids":{"openalex":"https://openalex.org/W2582335517","doi":"https://doi.org/10.1371/journal.ppat.1006063","mag":"2582335517","pmid":"https://pubmed.ncbi.nlm.nih.gov/28114397","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5256885"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1006063","doi":"https://doi.org/10.1371/journal.ppat.1006063","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006063","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006063&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006063&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012543772","display_name":"Cordula Boehm","orcid":"https://orcid.org/0000-0002-1746-2450","observed_orcids":["https://orcid.org/0000-0002-1746-2450"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210126499","display_name":"Wellcome Centre for Anti-Infectives Research","ror":"https://ror.org/02e6k9z27","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210126499","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cordula M. Boehm","raw_affiliation_strings":["Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210126499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034302212","display_name":"Samson O. Obado","orcid":"https://orcid.org/0000-0003-3161-0218","observed_orcids":["https://orcid.org/0000-0003-3161-0218"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samson Obado","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, NY, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028176631","display_name":"Catarina Gadelha","orcid":"https://orcid.org/0000-0001-5016-3682","observed_orcids":["https://orcid.org/0000-0001-5016-3682"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catarina Gadelha","raw_affiliation_strings":["School of Life Sciences, University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080027077","display_name":"Alexandra Kaupisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexandra Kaupisch","raw_affiliation_strings":["Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078833055","display_name":"Paul T. Manna","orcid":"https://orcid.org/0000-0002-2260-2075","observed_orcids":["https://orcid.org/0000-0002-2260-2075"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210126499","display_name":"Wellcome Centre for Anti-Infectives Research","ror":"https://ror.org/02e6k9z27","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210126499","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul T. Manna","raw_affiliation_strings":["Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210126499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082410541","display_name":"Gwyn W. Gould","orcid":"https://orcid.org/0000-0001-6571-2875","observed_orcids":["https://orcid.org/0000-0001-6571-2875"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gwyn W. Gould","raw_affiliation_strings":["Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037467809","display_name":"Mary Munson","orcid":"https://orcid.org/0000-0003-2297-8053","observed_orcids":["https://orcid.org/0000-0003-2297-8053"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Munson","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2297-8053","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, United States of America","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084513610","display_name":"Brian T. Chait","orcid":"https://orcid.org/0000-0003-3524-557X","observed_orcids":["https://orcid.org/0000-0003-3524-557X"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian T. Chait","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, NY, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3524-557X","affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, NY, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065548847","display_name":"Michael P. Rout","orcid":"https://orcid.org/0000-0003-2010-706X","observed_orcids":["https://orcid.org/0000-0003-2010-706X"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Rout","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, NY, United States of America","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061440312","display_name":"Mark C. Field","orcid":"https://orcid.org/0000-0002-4866-2885","observed_orcids":["https://orcid.org/0000-0002-4866-2885"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210126499","display_name":"Wellcome Centre for Anti-Infectives Research","ror":"https://ror.org/02e6k9z27","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210126499","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mark C. Field","raw_affiliation_strings":["Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210126499"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5061440312"],"corresponding_institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210126499"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":2201,"currency":"EUR","value_usd":2373},"fwci":2.4738,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.88040232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"e1006063","last_page":"e1006063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.3091000020503998,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exocyst-complex","display_name":"exocyst complex","score":0.9279999732971191},{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.9660000205039978},{"id":"https://openalex.org/keywords/african-trypanosomes","display_name":"African trypanosomes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/sec15","display_name":"Sec15","score":0.9980000257492065},{"id":"https://openalex.org/keywords/membrane-trafficking","display_name":"membrane trafficking","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cell-surface-proteome","display_name":"cell surface proteome","score":0.8820000290870667},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.7239999771118164},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"antigenic variation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/protein-complex-composition","display_name":"protein complex composition","score":0.640999972820282},{"id":"https://openalex.org/keywords/conserved-function","display_name":"conserved function","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2778448323","wikidata":"https://www.wikidata.org/wiki/Q5420527","display_name":"Exocyst","level":4,"score":0.9108888506889343},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.8110489845275879},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8042668104171753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6629948616027832},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6118510961532593},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.5160791277885437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27036410570144653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19235840439796448},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08311709761619568}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.ppat.1006063","doi":"https://doi.org/10.1371/journal.ppat.1006063","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006063","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006063&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4155391","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5256885","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5256885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5256885","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:28114397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28114397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/f26362bd-9338-4ddf-a2a6-8731bcca067b","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/f26362bd-9338-4ddf-a2a6-8731bcca067b","pdf_url":"https://discovery.dundee.ac.uk/ws/files/11768839/journal.ppat.1006063.pdf","source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Boehm, C M, Obado, S, Gadelha, C, Kaupisch, A, Manna, P T, Gould, G W, Munson, M, Chait, B T, Rout, M P & Field, M C 2017, 'The Trypanosome Exocyst : A Conserved Structure Revealing a New Role in Endocytosis', PLoS Pathogens, vol. 13, no. 1, e1006063, pp. 1-25. https://doi.org/10.1371/journal.ppat.1006063","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:strathprints.strath.ac.uk:70105","doi":null,"is_oa":true,"landing_page_url":"https://strathprints.strath.ac.uk/view/author/1266222.html>","pdf_url":"https://strathprints.strath.ac.uk/70105/1/Boehm_etal_PLOS_Pathogens_2017_The_trypanosome_exocyst_a_conserved_structure_revealing_a_new_role_in_endocytosis.pdf","source":{"id":"https://openalex.org/S4306402226","display_name":"Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181647926","host_organization_name":"University of Strathclyde","host_organization_lineage":["https://openalex.org/I181647926"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:eprints.gla.ac.uk:135176","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/view/author/2127.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Articles"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:1119958","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/1119958","pdf_url":"https://nottingham-repository.worktribe.com/file/1119958/1/The%20Trypanosome%20Exocyst%3A%20A%20Conserved%20Structure%20Revealing%20a%20New%20Role%20in%20Endocytosis","source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-4064","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/3059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Articles","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2b9e911be4934c5db25bf5b35a8444c0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2b9e911be4934c5db25bf5b35a8444c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 13, Iss 1, p e1006063 (2017)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4579807","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Trypanosome_Exocyst_A_Conserved_Structure_Revealing_a_New_Role_in_Endocytosis/4579807","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1006063","doi":"https://doi.org/10.1371/journal.ppat.1006063","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006063","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006063&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1500146413","display_name":null,"funder_award_id":"G0900255","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1535106529","display_name":"New Tools for Exploring the Dynamic Interactome (Renewal)","funder_award_id":"U54GM103511","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1676414123","display_name":"Structure and Function of the Exocyst Complex","funder_award_id":"R01GM068803","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1837491031","display_name":"Unveiling the protein landscape of the African trypanosome cell surface and chasing down potential targets for therapeutic intervention","funder_award_id":"MR/N01037X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2101603458","display_name":"Structure, function and evolution of the trypanosome nuclear envelope .","funder_award_id":"082813","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2194509495","display_name":"The development of tools for proteomic analysis in trypanosomes","funder_award_id":"R21AI096069","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3161751711","display_name":"National Center for Dynamic Interactome Research","funder_award_id":"P41GM109824","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3876036040","display_name":null,"funder_award_id":"C25017/A9006","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3905333210","display_name":"Nucleocytoplasmic transport: a target for cellular control","funder_award_id":"U01GM098256","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5269724110","display_name":null,"funder_award_id":"13082","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5922882383","display_name":null,"funder_award_id":"082813","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8929396910","display_name":"National Resource for Mass Spectrom of Biological Macromolecules","funder_award_id":"P41GM103314","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000032136","display_name":null,"funder_award_id":"GM109824","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2582335517.pdf","grobid_xml":"https://content.openalex.org/works/W2582335517.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W15433333","https://openalex.org/W70041852","https://openalex.org/W1508614407","https://openalex.org/W1519266993","https://openalex.org/W1560516060","https://openalex.org/W1605499235","https://openalex.org/W1831824393","https://openalex.org/W1833509159","https://openalex.org/W1943574736","https://openalex.org/W1963573377","https://openalex.org/W1963617455","https://openalex.org/W1965029080","https://openalex.org/W1967352127","https://openalex.org/W1967510219","https://openalex.org/W1967869559","https://openalex.org/W1970341475","https://openalex.org/W1971203075","https://openalex.org/W1974854527","https://openalex.org/W1976776701","https://openalex.org/W1983686919","https://openalex.org/W1984633201","https://openalex.org/W1986180217","https://openalex.org/W1986867603","https://openalex.org/W1988166340","https://openalex.org/W1999495588","https://openalex.org/W1999628208","https://openalex.org/W2005001091","https://openalex.org/W2008429193","https://openalex.org/W2010234198","https://openalex.org/W2015256188","https://openalex.org/W2016891916","https://openalex.org/W2017250842","https://openalex.org/W2018774226","https://openalex.org/W2025277548","https://openalex.org/W2028974051","https://openalex.org/W2029667773","https://openalex.org/W2045373716","https://openalex.org/W2048250978","https://openalex.org/W2055043387","https://openalex.org/W2059775037","https://openalex.org/W2067401012","https://openalex.org/W2068040322","https://openalex.org/W2073658281","https://openalex.org/W2074323186","https://openalex.org/W2076970936","https://openalex.org/W2080752012","https://openalex.org/W2087058910","https://openalex.org/W2087860032","https://openalex.org/W2094201044","https://openalex.org/W2097634535","https://openalex.org/W2101011089","https://openalex.org/W2101956881","https://openalex.org/W2102285200","https://openalex.org/W2102904980","https://openalex.org/W2103425146","https://openalex.org/W2106077567","https://openalex.org/W2106364887","https://openalex.org/W2106457287","https://openalex.org/W2106882534","https://openalex.org/W2110247160","https://openalex.org/W2114282435","https://openalex.org/W2114800213","https://openalex.org/W2121458226","https://openalex.org/W2123139638","https://openalex.org/W2123214587","https://openalex.org/W2124241990","https://openalex.org/W2127815120","https://openalex.org/W2128367551","https://openalex.org/W2134626310","https://openalex.org/W2135318540","https://openalex.org/W2139307727","https://openalex.org/W2141816565","https://openalex.org/W2144502929","https://openalex.org/W2149367157","https://openalex.org/W2152770371","https://openalex.org/W2155573766","https://openalex.org/W2155669342","https://openalex.org/W2156180150","https://openalex.org/W2162905305","https://openalex.org/W2167916132","https://openalex.org/W2170761272","https://openalex.org/W2171151038","https://openalex.org/W2224298134","https://openalex.org/W2237583164","https://openalex.org/W2259019046","https://openalex.org/W2282748127","https://openalex.org/W2333242766","https://openalex.org/W2346179324","https://openalex.org/W2509209284","https://openalex.org/W3217420325"],"related_works":["https://openalex.org/W7214035459","https://openalex.org/W2028839824","https://openalex.org/W2989749060","https://openalex.org/W2590309117","https://openalex.org/W1605499235","https://openalex.org/W1586396057","https://openalex.org/W3191440186","https://openalex.org/W2028972581","https://openalex.org/W4220903071","https://openalex.org/W2036388292"],"abstract_inverted_index":{"Membrane":[0],"transport":[1,15],"is":[2,22,77,170],"an":[3,35,132],"essential":[4,94],"component":[5],"of":[6,63,107,157],"pathogenesis":[7],"for":[8],"most":[9],"infectious":[10],"organisms.":[11],"In":[12,31],"African":[13],"trypanosomes,":[14,149],"to":[16,25],"and":[17,28,33,71,98,109,113,119,127,155,189],"from":[18],"the":[19,61,64,74,88,137,166,179,192],"plasma":[20],"membrane":[21],"closely":[23],"coupled":[24],"immune":[26],"evasion":[27],"antigenic":[29],"variation.":[30],"mammals":[32],"fungi":[34],"octameric":[36],"exocyst":[37,67,146,181],"complex":[38,76],"mediates":[39],"late":[40],"steps":[41],"in":[42,105,125,135,148,161,168],"exocytosis,":[43],"but":[44],"comparative":[45],"genomics":[46],"suggested":[47],"that":[48,73,165,191],"trypanosomes":[49],"retain":[50],"only":[51],"six":[52],"canonical":[53,82],"subunits,":[54],"implying":[55],"mechanistic":[56],"divergence.":[57],"We":[58,175],"directly":[59],"determined":[60],"composition":[62],"Trypanosoma":[65],"brucei":[66],"by":[68],"affinity":[69],"isolation":[70],"demonstrate":[72],"parasite":[75],"nonameric,":[78],"retaining":[79],"all":[80],"eight":[81],"subunits":[83],"(albeit":[84],"highly":[85],"divergent":[86],"at":[87],"sequence":[89],"level)":[90],"plus":[91],"a":[92,122],"novel":[93,183],"subunit,":[95],"Exo99.":[96],"Exo99":[97,120],"Sec15":[99,118],"knockdowns":[100],"have":[101,121],"remarkably":[102],"similar":[103],"phenotypes":[104],"terms":[106],"viability":[108],"impact":[110],"on":[111],"morphology":[112],"trafficking":[114],"pathways.":[115],"Significantly,":[116],"both":[117],"clear":[123],"function":[124],"endocytosis,":[126,153],"global":[128],"proteomic":[129],"analysis":[130],"indicates":[131],"important":[133],"role":[134,167],"maintaining":[136],"surface":[138,158],"proteome.":[139],"Taken":[140],"together":[141],"these":[142],"data":[143],"indicate":[144],"additional":[145],"functions":[147],"which":[150],"likely":[151],"include":[152],"recycling":[154],"control":[156],"composition.":[159],"Knockdowns":[160],"HeLa":[162],"cells":[163],"suggest":[164,190],"endocytosis":[169],"shared":[171],"with":[172],"metazoan":[173],"cells.":[174],"conclude":[176],"that,":[177],"whilst":[178],"trypanosome":[180],"has":[182],"components,":[184],"overall":[185],"functionality":[186],"appears":[187],"conserved,":[188],"unique":[193],"subunit":[194],"may":[195],"provide":[196],"therapeutic":[197],"opportunities.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2017-02-03T00:00:00"}