{"id":"https://openalex.org/W2581960813","doi":"https://doi.org/10.1089/cbr.2016.2133","title":"PARP-1 Expression Quantified by [ 18 F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy","display_name":"PARP-1 Expression Quantified by [ 18 F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy","publication_year":2017,"publication_date":"2017-01-24","ids":{"openalex":"https://openalex.org/W2581960813","doi":"https://doi.org/10.1089/cbr.2016.2133","mag":"2581960813","pmid":"https://pubmed.ncbi.nlm.nih.gov/28118040","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5312613"},"language":"en","primary_location":{"id":"doi:10.1089/cbr.2016.2133","doi":"https://doi.org/10.1089/cbr.2016.2133","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cbr.2016.2133","pdf_url":null,"source":{"id":"https://openalex.org/S87235987","display_name":"Cancer Biotherapy and Radiopharmaceuticals","issn_l":"1084-9785","issn":["1084-9785","1557-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biotherapy and Radiopharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5312613","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023421343","display_name":"Samuel Sander Effron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Sander Effron","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071268972","display_name":"Mehran Makvandi","orcid":"https://orcid.org/0000-0002-6315-4942","observed_orcids":["https://orcid.org/0000-0002-6315-4942"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mehran Makvandi","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034744116","display_name":"Lilie L. Lin","orcid":"https://orcid.org/0000-0001-7681-8966","observed_orcids":["https://orcid.org/0000-0001-7681-8966"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lilie Lin","raw_affiliation_strings":["Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102379498","display_name":"Kuiying Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuiying Xu","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101593193","display_name":"Shihong Li","orcid":"https://orcid.org/0000-0003-4047-2988","observed_orcids":["https://orcid.org/0000-0003-4047-2988"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shihong Li","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074164630","display_name":"Hsiaoju S. Lee","orcid":"https://orcid.org/0000-0001-9082-8618","observed_orcids":["https://orcid.org/0000-0001-9082-8618"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsiaoju Lee","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082627212","display_name":"Catherine Hou","orcid":"https://orcid.org/0000-0001-8905-8492","observed_orcids":["https://orcid.org/0000-0001-8905-8492"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Hou","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074054064","display_name":"Daniel A. Pryma","orcid":"https://orcid.org/0000-0001-8978-4419","observed_orcids":["https://orcid.org/0000-0001-8978-4419"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Pryma","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113559475","display_name":"Cameron J. Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron Koch","raw_affiliation_strings":["Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013971949","display_name":"Robert H. Mach","orcid":"https://orcid.org/0000-0002-7645-2869","observed_orcids":["https://orcid.org/0000-0002-7645-2869"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Mach","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071268972"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.3264,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.81581171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"32","issue":"1","first_page":"9","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/radioactive-tracers","display_name":"radioactive tracers","score":0.628000020980835},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.6470000147819519},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8920000195503235},{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.7950000166893005},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8840000033378601},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.800000011920929},{"id":"https://openalex.org/keywords/parp-activity","display_name":"PARP activity","score":0.5699999928474426},{"id":"https://openalex.org/keywords/skov-3-cells","display_name":"SKOV3 cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5661356449127197},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.5254760384559631},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.484942227602005},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4532932937145233},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3995979130268097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3755950927734375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35624411702156067},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35103553533554077},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3344295918941498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2569112181663513},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1543155014514923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14689737558364868},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054316","descriptor_name":"Biomarkers, Pharmacological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1089/cbr.2016.2133","doi":"https://doi.org/10.1089/cbr.2016.2133","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cbr.2016.2133","pdf_url":null,"source":{"id":"https://openalex.org/S87235987","display_name":"Cancer Biotherapy and Radiopharmaceuticals","issn_l":"1084-9785","issn":["1084-9785","1557-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biotherapy and Radiopharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5312613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5312613","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biother Radiopharm","raw_type":"Text"},{"id":"pmid:28118040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28118040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biotherapy & radiopharmaceuticals","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5312613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5312613","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biother Radiopharm","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5996449649","display_name":"MULTI-DISCIPLINARY RESEARCH AND TRAINING PROGRAM IN BREAST CANCER MOLECULAR IMAGING AND TARGETED RADIOCHEMISTRY","funder_award_id":"DESC0012476","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G9000886278","display_name":"Physician Scientist Training in Clinical Oncology","funder_award_id":"K12CA076931","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891339","display_name":"Summer Undergraduate Program to Educate Radiation Scientists (SUPERS)","funder_award_id":"R25CA140116","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320317053","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1484931598","https://openalex.org/W1842469464","https://openalex.org/W1928092242","https://openalex.org/W1970211011","https://openalex.org/W1982023838","https://openalex.org/W1983383818","https://openalex.org/W1992397774","https://openalex.org/W2009007206","https://openalex.org/W2018543951","https://openalex.org/W2023519288","https://openalex.org/W2036180332","https://openalex.org/W2039986464","https://openalex.org/W2073031381","https://openalex.org/W2098737737","https://openalex.org/W2105007834","https://openalex.org/W2109772731","https://openalex.org/W2112241575","https://openalex.org/W2120801412","https://openalex.org/W2134902059","https://openalex.org/W2137755195","https://openalex.org/W2149668095","https://openalex.org/W2157899948","https://openalex.org/W2163294504","https://openalex.org/W2192508404","https://openalex.org/W2235405584","https://openalex.org/W2338647065","https://openalex.org/W2416684375","https://openalex.org/W4294309286"],"related_works":["https://openalex.org/W4399529110","https://openalex.org/W2338647065","https://openalex.org/W4396591672","https://openalex.org/W2521122556","https://openalex.org/W2395092607","https://openalex.org/W2304888756","https://openalex.org/W4295817678","https://openalex.org/W3153017023","https://openalex.org/W2416684375","https://openalex.org/W4408878124"],"abstract_inverted_index":{"Introduction:":[0],"Poly":[1],"(ADP-ribose)":[2],"polymerase":[3],"1":[4],"(PARP-1)":[5],"is":[6,15],"the":[7,26,37,44,52,65,96,167,212,231,270],"major":[8],"target":[9],"of":[10,29,40,59,69,170,176,194,233,272],"clinical":[11,38],"PARP":[12,30,41,60,73,134,140,196,235,249,273],"inhibitors":[13,31,42,135,274],"and":[14,64,81,85,106,121,139,163,183,221,247],"a":[16,57,195,206,218,234],"potential":[17],"predictive":[18],"biomarker":[19],"for":[20,131],"response":[21,153,271],"to":[22,25,43,77,126,143,151,154,159,165,185,238,269],"therapy.":[23,79],"Due":[24],"limited":[27],"success":[28],"as":[32,56,252],"monotherapy,":[33],"investigators":[34],"have":[35],"shifted":[36],"role":[39],"adjuvant":[45,76,142,237],"setting.":[46],"In":[47,257],"this":[48,258],"study,":[49],"we":[50,260],"evaluate":[51],"radiotracer":[53,97],"[18F]FluorThanatrace":[54],"([18F]FTT)":[55],"marker":[58],"expression":[61,71,112,180,264],"in":[62,72,92,128,181,201,211,243,267,275,280],"vitro":[63,93,129,182,268],"associated":[66],"biological":[67],"implications":[68],"PARP-1":[70,110,178,263],"inhibitor":[74,141,197,236],"treatment":[75,155],"radiation":[78,137,199,239,278],"Materials":[80],"Methods:":[82],"SNU-251":[83,213],"(BRCA1-mutant)":[84],"SKOV3":[86],"(BRCA1-WT)":[87],"cell":[88,203,214,245],"lines":[89,246],"were":[90,102,107,124],"evaluated":[91],"by":[94,114,156,254],"using":[95,157],"[18F]FTT.":[98],"Pharmacological":[99],"binding":[100],"assays":[101,123],"performed":[103],"at":[104,190],"baseline":[105],"correlated":[108],"with":[109,277],"protein":[111,117,147,179,188,227],"measured":[113,253],"Western":[115,145,186,225],"blot":[116,146,187,226],"analysis.":[118],"Cell":[119],"viability":[120],"clonogenic":[122],"used":[125,150],"characterize":[127],"cytotoxicity":[130],"treatments,":[132],"including:":[133],"alone,":[136,138],"radiation.":[144],"analysis":[148,189,228],"was":[149,174,209],"assess":[152],"\u03b3H2AX":[158],"measure":[160,166],"DNA":[161,241],"damage":[162,242],"PAR":[164],"catalytic":[168],"inhibition":[169],"PARP.":[171],"Results:":[172],"[18F]FTT":[173],"capable":[175],"measuring":[177],"corresponded":[184],"baseline.":[191],"The":[192],"addition":[193,232],"enhanced":[198],"effects":[200],"both":[202,244],"lines;":[204],"however,":[205],"greater":[207],"synergy":[208],"observed":[210],"line":[215],"that":[216,230,262],"expresses":[217],"BRCA1":[219],"mutation":[220],"homologous":[222],"recombination":[223],"deficiency.":[224],"showed":[229],"increases":[240],"reduces":[248],"enzymatic":[250],"activity":[251],"PAR.":[255],"Conclusions:":[256],"work,":[259],"found":[261],"positively":[265],"corresponds":[266],"combination":[276],"therapy":[279],"ovarian":[281],"cancer.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-03T00:00:00"}
