{"id":"https://openalex.org/W2581735925","doi":"https://doi.org/10.3389/fendo.2017.00008","title":"Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease","display_name":"Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease","publication_year":2017,"publication_date":"2017-01-26","ids":{"openalex":"https://openalex.org/W2581735925","doi":"https://doi.org/10.3389/fendo.2017.00008","mag":"2581735925","pmid":"https://pubmed.ncbi.nlm.nih.gov/28184213","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5266688"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2017.00008","doi":"https://doi.org/10.3389/fendo.2017.00008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2017.00008","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2017.00008/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2017.00008/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081025063","display_name":"Garrett Heinrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett Heinrich","raw_affiliation_strings":["Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Heritage College of Osteopathic Medicine, Diabetes Institute, Ohio University, Athens, OH, USA","Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA","Heritage College of Osteopathic Medicine, Diabetes Institute, Ohio University, Athens, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Heritage College of Osteopathic Medicine, Diabetes Institute, Ohio University, Athens, OH, USA","institution_ids":["https://openalex.org/I4210106879"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA","institution_ids":["https://openalex.org/I4210106879"]},{"raw_affiliation_string":"Heritage College of Osteopathic Medicine, Diabetes Institute, Ohio University, Athens, OH, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044541588","display_name":"Hilda E. Ghadieh","orcid":"https://orcid.org/0000-0002-7983-2090","observed_orcids":["https://orcid.org/0000-0002-7983-2090"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hilda E. Ghadieh","raw_affiliation_strings":["Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079013457","display_name":"Simona S. Ghanem","orcid":"https://orcid.org/0000-0003-4164-6353","observed_orcids":["https://orcid.org/0000-0003-4164-6353"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simona S. Ghanem","raw_affiliation_strings":["Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072233343","display_name":"Harrison T. Muturi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harrison T. Muturi","raw_affiliation_strings":["Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108415929","display_name":"Khadijeh Rezaei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khadijeh Rezaei","raw_affiliation_strings":["Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091563773","display_name":"Qusai Y. Al\u2013Share","orcid":"https://orcid.org/0000-0002-2306-6198","observed_orcids":["https://orcid.org/0000-0002-2306-6198"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qusai Y. Al-Share","raw_affiliation_strings":["Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050970407","display_name":"Thomas A. Bowman","orcid":"https://orcid.org/0000-0002-9591-7561","observed_orcids":["https://orcid.org/0000-0002-9591-7561"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Bowman","raw_affiliation_strings":["Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes and Endocrine Research (CeDER), College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Deqiang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deqiang Zhang","raw_affiliation_strings":["Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031952528","display_name":"Robert S. Garofalo","orcid":"https://orcid.org/0000-0002-2639-4496","observed_orcids":["https://orcid.org/0000-0002-2639-4496"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Garofalo","raw_affiliation_strings":["Yale Cancer Center, Office of Research Affairs, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cancer Center, Office of Research Affairs, New Haven, CT, USA","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100761396","display_name":"Lei Yin","orcid":"https://orcid.org/0000-0001-9237-9350","observed_orcids":["https://orcid.org/0000-0001-9237-9350"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Yin","raw_affiliation_strings":["Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088611335","display_name":"Sonia Michael Najjar","orcid":"https://orcid.org/0000-0001-6209-8902","observed_orcids":["https://orcid.org/0000-0001-6209-8902"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sonia M. Najjar","raw_affiliation_strings":["Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Heritage College of Osteopathic Medicine, Diabetes Institute, Ohio University, Athens, OH, USA","Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA","Heritage College of Osteopathic Medicine, Diabetes Institute, Ohio University, Athens, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Heritage College of Osteopathic Medicine, Diabetes Institute, Ohio University, Athens, OH, USA","institution_ids":["https://openalex.org/I4210106879"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA","institution_ids":["https://openalex.org/I4210106879"]},{"raw_affiliation_string":"Heritage College of Osteopathic Medicine, Diabetes Institute, Ohio University, Athens, OH, USA","institution_ids":["https://openalex.org/I4210106879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5088611335"],"corresponding_institution_ids":["https://openalex.org/I4210106879"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.6135,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.56039198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"8","issue":null,"first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceacam1","display_name":"CEACAM1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/visceral-obesity","display_name":"visceral obesity","score":0.972000002861023},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/insulin-clearance","display_name":"insulin clearance","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.949999988079071},{"id":"https://openalex.org/keywords/dietary-fat","display_name":"dietary fat","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8618677854537964},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.7925131916999817},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7746453285217285},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7001274824142456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6474034190177917},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5450087785720825},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5413105487823486},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4704168140888214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.467888742685318},{"id":"https://openalex.org/C2777368190","wikidata":"https://www.wikidata.org/wiki/Q477390","display_name":"Hyperinsulinism","level":4,"score":0.4266502857208252},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3740631639957428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3737025856971741},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3389/fendo.2017.00008","doi":"https://doi.org/10.3389/fendo.2017.00008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2017.00008","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2017.00008/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5266688","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5266688","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:28184213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28184213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2017.00008","doi":"https://doi.org/10.3389/fendo.2017.00008","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2017.00008","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2017.00008/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1228145051","display_name":"Insulin resistance in the pathogenesis of NASH","funder_award_id":"R01DK083850","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2445081079","display_name":"CEACAM and Insulin Action","funder_award_id":"R01DK054254","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3130140181","display_name":"CEACAM1: A link between metabolic and cardiovascular diseases","funder_award_id":"R01HL112248","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000067650","display_name":null,"funder_award_id":"K99/R00-DK077449","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000187641","display_name":null,"funder_award_id":"DK077449","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000905293","display_name":"Significance and mechanisms of hepatic ChREBP\u03b1 induction via post-translational modifications in diet-induced NASH","funder_award_id":"R01DK099593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2581735925.pdf","grobid_xml":"https://content.openalex.org/works/W2581735925.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1523155649","https://openalex.org/W1585751449","https://openalex.org/W1849756119","https://openalex.org/W1964031474","https://openalex.org/W1972561828","https://openalex.org/W1976197029","https://openalex.org/W1986002692","https://openalex.org/W1991688216","https://openalex.org/W2000157287","https://openalex.org/W2000514316","https://openalex.org/W2001086424","https://openalex.org/W2001186943","https://openalex.org/W2002335068","https://openalex.org/W2002888717","https://openalex.org/W2019973807","https://openalex.org/W2025578932","https://openalex.org/W2031123770","https://openalex.org/W2031533316","https://openalex.org/W2035816889","https://openalex.org/W2039487569","https://openalex.org/W2044482587","https://openalex.org/W2050802133","https://openalex.org/W2063330822","https://openalex.org/W2065612971","https://openalex.org/W2068173054","https://openalex.org/W2068506660","https://openalex.org/W2069090380","https://openalex.org/W2070559169","https://openalex.org/W2071896162","https://openalex.org/W2072282118","https://openalex.org/W2074913439","https://openalex.org/W2075740571","https://openalex.org/W2084920838","https://openalex.org/W2091479034","https://openalex.org/W2091730131","https://openalex.org/W2095612977","https://openalex.org/W2096291955","https://openalex.org/W2106071911","https://openalex.org/W2106931189","https://openalex.org/W2108210081","https://openalex.org/W2118688891","https://openalex.org/W2119516783","https://openalex.org/W2127515541","https://openalex.org/W2127629859","https://openalex.org/W2128288295","https://openalex.org/W2130001481","https://openalex.org/W2130310006","https://openalex.org/W2131463221","https://openalex.org/W2132083187","https://openalex.org/W2132899896","https://openalex.org/W2133560683","https://openalex.org/W2133576417","https://openalex.org/W2136769963","https://openalex.org/W2138081409","https://openalex.org/W2145774144","https://openalex.org/W2146544786","https://openalex.org/W2149358180","https://openalex.org/W2155754561","https://openalex.org/W2158477352","https://openalex.org/W2160068303","https://openalex.org/W2162403539","https://openalex.org/W2163329855","https://openalex.org/W2170311057","https://openalex.org/W2212750191","https://openalex.org/W2318181715","https://openalex.org/W2325767759","https://openalex.org/W2405221408","https://openalex.org/W2418805933","https://openalex.org/W2523752832","https://openalex.org/W2532614692","https://openalex.org/W2539219422","https://openalex.org/W4252021281","https://openalex.org/W4253418569"],"related_works":["https://openalex.org/W2539219422","https://openalex.org/W2084920838","https://openalex.org/W2212750191","https://openalex.org/W1572610571","https://openalex.org/W2597733146","https://openalex.org/W2068173054","https://openalex.org/W3081722189","https://openalex.org/W3164203202","https://openalex.org/W1849756119","https://openalex.org/W4402889348"],"abstract_inverted_index":{"The":[0,83],"pathogenesis":[1],"of":[2,16,39,51,53,64,78,85,93,98,104,119,122],"human":[3],"non-alcoholic":[4],"fatty":[5,67],"liver":[6],"disease":[7],"(NAFLD)":[8],"remains":[9],"unclear,":[10],"in":[11,13,34,125],"particular":[12],"the":[14,27,40,49,54,76,101,109,116,120],"context":[15],"its":[17],"relationship":[18],"to":[19,74,112],"insulin":[20,45,65,79,87],"resistance":[21],"and":[22,80,90,100,127],"visceral":[23,91,128],"obesity.":[24,129],"Work":[25],"on":[26,66],"Carcinoembryonic":[28],"antigen-related":[29],"cell":[30],"adhesion":[31],"molecule1":[32],"(CEACAM1)":[33],"mice":[35,94],"has":[36],"resolved":[37],"some":[38],"related":[41],"questions.":[42],"CEACAM1":[43,73,106,124],"promotes":[44],"clearance":[46],"by":[47],"enhancing":[48],"rate":[50],"uptake":[52],"insulin-receptor":[55],"complex.":[56],"It":[57],"also":[58],"mediates":[59],"a":[60],"negative":[61],"acute":[62],"effect":[63,103],"acid":[68],"synthase":[69],"activity.":[70],"This":[71],"positions":[72],"coordinate":[75],"regulation":[77],"lipid":[81],"metabolism.":[82],"phenotype":[84],"hyperinsulinemia,":[86],"resistance,":[88],"hepatosteatosis":[89],"obesity":[92],"with":[95],"genetic":[96],"mutations":[97],"Ceacam1":[99],"protective":[102],"hepatic":[105,123],"gain-of-function":[107],"against":[108],"metabolic":[110],"response":[111],"dietary":[113],"fat":[114],"bolster":[115],"significant":[117],"role":[118],"loss":[121],"NAFLD":[126]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-03T00:00:00"}