{"id":"https://openalex.org/W2581569010","doi":null,"title":"The genetics of resistance to lufenuron in Drosophila melanogaster","display_name":"The genetics of resistance to lufenuron in Drosophila melanogaster","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2581569010","mag":"2581569010"},"language":"en","primary_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/38921","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/38921","pdf_url":"http://hdl.handle.net/11343/38921","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11343/38921","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057050347","display_name":"Michael R. Bogwitz","orcid":"https://orcid.org/0000-0002-3293-9157","observed_orcids":["https://orcid.org/0000-0002-3293-9157"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Bogwitz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3293-9157","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057050347"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lufenuron","display_name":"lufenuron","score":0.8690000176429749},{"id":"https://openalex.org/keywords/insecticide-resistance","display_name":"insecticide resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9670000076293945},{"id":"https://openalex.org/keywords/insect-growth-regulators","display_name":"insect growth regulators","score":0.9309999942779541},{"id":"https://openalex.org/keywords/metabolic-detoxification","display_name":"metabolic detoxification","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cyp6g1","display_name":"Cyp6g1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transposon-insertion","display_name":"transposon insertion","score":0.7829999923706055},{"id":"https://openalex.org/keywords/p-element","display_name":"P element","score":0.7459999918937683},{"id":"https://openalex.org/keywords/target-site-resistance","display_name":"target-site resistance","score":0.6190000176429749},{"id":"https://openalex.org/keywords/wild-populations","display_name":"natural populations","score":0.3840000033378601},{"id":"https://openalex.org/keywords/transgene-overexpression","display_name":"transgenic overexpression","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.8472927808761597},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6604692935943604},{"id":"https://openalex.org/C2777097416","wikidata":"https://www.wikidata.org/wiki/Q412933","display_name":"Lufenuron","level":3,"score":0.6598365902900696},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.5411021709442139},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5277705192565918},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.4730481505393982},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.43577301502227783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1345292031764984},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09035882353782654},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/38921","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/38921","pdf_url":"http://hdl.handle.net/11343/38921","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},{"id":"mag:2581569010","doi":null,"is_oa":false,"landing_page_url":"https://minerva-access.unimelb.edu.au/bitstream/11343/38921/1/66118_00000874_01_THESIS_FINAL_%28MERGED%29.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/38921","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/38921","pdf_url":"http://hdl.handle.net/11343/38921","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PhD thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.4359000027179718,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2581569010.pdf","grobid_xml":"https://content.openalex.org/works/W2581569010.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W115671964","https://openalex.org/W900130271","https://openalex.org/W1484005446","https://openalex.org/W1572955611","https://openalex.org/W1573481764","https://openalex.org/W1584188206","https://openalex.org/W1763705033","https://openalex.org/W1965091879","https://openalex.org/W1965354374","https://openalex.org/W1983997390","https://openalex.org/W1984600357","https://openalex.org/W1988163318","https://openalex.org/W1988183681","https://openalex.org/W1989337298","https://openalex.org/W1990874048","https://openalex.org/W1993598455","https://openalex.org/W1996524127","https://openalex.org/W1999090697","https://openalex.org/W2001351593","https://openalex.org/W2006998778","https://openalex.org/W2011394183","https://openalex.org/W2017877170","https://openalex.org/W2024039709","https://openalex.org/W2026472543","https://openalex.org/W2036046606","https://openalex.org/W2036926224","https://openalex.org/W2037280340","https://openalex.org/W2038375851","https://openalex.org/W2042490073","https://openalex.org/W2043013497","https://openalex.org/W2045201641","https://openalex.org/W2045762442","https://openalex.org/W2046499123","https://openalex.org/W2048319750","https://openalex.org/W2050895883","https://openalex.org/W2053139374","https://openalex.org/W2060255019","https://openalex.org/W2062318487","https://openalex.org/W2076422513","https://openalex.org/W2082283842","https://openalex.org/W2082793243","https://openalex.org/W2085914513","https://openalex.org/W2087662072","https://openalex.org/W2088814430","https://openalex.org/W2096379342","https://openalex.org/W2097080919","https://openalex.org/W2099260418","https://openalex.org/W2105672275","https://openalex.org/W2106425356","https://openalex.org/W2110643873","https://openalex.org/W2111572642","https://openalex.org/W2114629114","https://openalex.org/W2115479021","https://openalex.org/W2117936709","https://openalex.org/W2122774081","https://openalex.org/W2127059331","https://openalex.org/W2144450260","https://openalex.org/W2146329352","https://openalex.org/W2160361404","https://openalex.org/W2161725875","https://openalex.org/W2185816512","https://openalex.org/W2317709380","https://openalex.org/W2327816994","https://openalex.org/W2328672349","https://openalex.org/W2333432428","https://openalex.org/W2396355899","https://openalex.org/W2413245974","https://openalex.org/W3215671880","https://openalex.org/W4248806305"],"related_works":["https://openalex.org/W6948735520","https://openalex.org/W6967969868","https://openalex.org/W3033003621","https://openalex.org/W2899820932","https://openalex.org/W6948564273","https://openalex.org/W222859218","https://openalex.org/W4377819110","https://openalex.org/W6892527151","https://openalex.org/W822931816","https://openalex.org/W6892468525"],"abstract_inverted_index":{"The":[0],"rise":[1],"of":[2,28,34,92,136,139,150,188,204,276,319,325,332,343,347],"large":[3],"scale":[4],"agriculture":[5],"in":[6,38,109,121,130,157,170,185,220,231,238,266,284],"the":[7,12,31,90,102,122,134,177,200,252,289,303,317,320,330,345],"20":[8],"th":[9],"century":[10],"created":[11],"need":[13,321],"for":[14,48,53,61,322],"effective":[15],"strategies":[16],"to":[17,96,119,153,175,192,195,228,241,287,297,337],"control":[18],"insect":[19,40,103,338],"pests.Treatment":[20],"with":[21,115],"chemical":[22],"insecticides":[23,114],"has":[24,36,127,147],"been":[25,64,128],"a":[26,43,97,259,267,341],"weapon":[27],"choice,":[29],"but":[30,51],"inevitable":[32],"evolution":[33],"resistance":[35,62,75,155,194,240],"followed":[37],"many":[39],"species.Resistance":[41],"represents":[42],"major":[44,59],"challenge,":[45],"not":[46],"only":[47],"agricultural":[49],"production,":[50],"also":[52,282],"environmental":[54],"preservation":[55],"and":[56,66,71,84,202,249,295,306,328],"human":[57],"health.Two":[58],"options":[60],"have":[63],"identified,":[65,248],"these":[67,80,277],"are":[68],"target-site":[69],"based":[70],"metabolic-based":[72],"resistance.Much":[73],"insecticide":[74,87,326],"research":[76],"focuses":[77],"on":[78,312],"identifying":[79],"mechanisms":[81,156,163,335],"through":[82,199],"genetic":[83],"molecular":[85],"analysis.The":[86],"lufenuron":[88,120,140,290],"is":[89,279],"focus":[91],"this":[93,151,189,232],"study.It":[94],"belongs":[95],"novel":[98],"insecticidal":[99],"group":[100],"called":[101],"growth":[104],"regulators,":[105],"which":[106],"were":[107,164,293],"introduced":[108],"1970s":[110],"as":[111,197,251,308,340],"highly":[112],"selective":[113],"low":[116],"vertebrate":[117],"toxicity.Resistance":[118],"nonpest":[123],"species":[124],"Drosophila":[125],"melanogaster":[126],"observed":[129],"field":[131,137,218],"populations,":[132],"despite":[133],"lack":[135],"usage":[138],"(Wilson":[141],"&":[142],"Cain,":[143],"1997;O'Keefe,":[144],"1997).This":[145],"study":[146,315],"taken":[148],"advantage":[149],"phenomenon":[152],"investigate":[154],"natural":[158,273],"populations.At":[159],"least":[160],"two":[161],"detoxification":[162,178,223,334],"identified.A":[165],"resistant":[166],"isofemale":[167,214],"strain":[168,215,268],"isolated":[169,216],"Victoria,":[171],"Australia":[172],"was":[173,210,226,247,264,281],"used":[174,283],"identify":[176,288],"gene,":[179,224],"Cyp12a4,":[180],"that":[181],"may":[182],"be":[183,229],"involved":[184],"resistance.Tissue-specific":[186],"overexpression":[187,253],"gene":[190],"appears":[191],"confer":[193],"lufenuron,":[196],"confirmed":[198],"generation":[201],"screening":[203,234],"transgenic":[205],"overexpressing":[206],"strains.A":[207],"second":[208],"mechanism":[209,305,311],"identified":[211,265],"from":[212,217,270],"an":[213,285,298],"populations":[219],"Coloardo,":[221],"USA.Another":[222],"Cyp6g1,":[225],"found":[227],"overexpressed":[230],"strain.Transgenic":[233],"confirms":[235],"its":[236],"involvement":[237],"conferring":[239,254],"lufenuron.A":[242],"partial":[243,260],"transposon":[244],"insertion":[245],"(Accord)":[246],"implicated":[250],"mutation.An":[255],"alternate":[256],"allele":[257],"containing":[258],"P-element":[261],"within":[262],"Accord":[263],"collected":[269],"Australian":[271],"(Queensland)":[272],"populations.The":[274],"frequency":[275],"alleles":[278],"high.Mutagenesis":[280],"attempt":[286],"target.17":[291],"mutants":[292],"isolated,":[294],"due":[296],"experimental":[299],"bias,":[300],"all":[301],"carried":[302],"Cyp6g1":[304],"another":[307,313],"yet":[309],"unidentified":[310],"chromosome.This":[314],"highlights":[316],"importance":[318],"better":[323],"understanding":[324],"resistance,":[327],"particularly,":[329],"arsenal":[331],"metabolic":[333],"available":[336],"pests,":[339],"method":[342],"prolonging":[344],"effectiveness":[346],"insecticides.":[348]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-02-03T00:00:00"}
