{"id":"https://openalex.org/W2581544247","doi":null,"title":"Skeletal Muscle Function Deficits in the Elderly: Current Perspectives on Resistance Training.","display_name":"Skeletal Muscle Function Deficits in the Elderly: Current Perspectives on Resistance Training.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2581544247","mag":"2581544247","pmid":"https://pubmed.ncbi.nlm.nih.gov/28191501","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5303008"},"language":"en","primary_location":{"id":"pmid:28191501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28191501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nature and science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5303008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068444469","display_name":"Evan V. Papa","orcid":"https://orcid.org/0000-0002-5013-3018","observed_orcids":["https://orcid.org/0000-0002-5013-3018"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan V Papa","raw_affiliation_strings":["Department of Physical Therapy, University of North Texas Health Science Center, Fort Worth, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, University of North Texas Health Science Center, Fort Worth, Texas, USA","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102369459","display_name":"Xiaoyang Dong","orcid":"https://orcid.org/0000-0002-8572-6737","observed_orcids":["https://orcid.org/0000-0002-8572-6737"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]},{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaoyang Dong","raw_affiliation_strings":["Department of Physical Therapy, University of North Texas Health Science Center, Fort Worth, Texas, USA; Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanchang University; Nanchang, Jiangxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, University of North Texas Health Science Center, Fort Worth, Texas, USA; Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanchang University; Nanchang, Jiangxi Province, China","institution_ids":["https://openalex.org/I165139151","https://openalex.org/I4210164024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100533464","display_name":"Mahdi Hassan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahdi Hassan","raw_affiliation_strings":["Department of Physical Therapy, University of North Texas Health Science Center, Fort Worth, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, University of North Texas Health Science Center, Fort Worth, Texas, USA","institution_ids":["https://openalex.org/I165139151"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3532,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.94499344,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.8560000061988831},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6370000243186951},{"id":"https://openalex.org/keywords/skeletal-muscle-function","display_name":"skeletal muscle function","score":0.8289999961853027},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"muscle weakness","score":0.8880000114440918},{"id":"https://openalex.org/keywords/muscle-loss","display_name":"muscle mass loss","score":0.671999990940094},{"id":"https://openalex.org/keywords/myosin-heavy-chain-isoforms","display_name":"myosin heavy chain isoforms","score":0.8289999961853027},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/muscle-fiber-size","display_name":"muscle fiber size","score":0.8619999885559082},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.6949999928474426},{"id":"https://openalex.org/keywords/disability","display_name":"disability","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.9036199450492859},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.8265151381492615},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.664607048034668},{"id":"https://openalex.org/C3019424981","wikidata":"https://www.wikidata.org/wiki/Q12834857","display_name":"Resistance training","level":2,"score":0.6141666769981384},{"id":"https://openalex.org/C2780247198","wikidata":"https://www.wikidata.org/wiki/Q633403","display_name":"Weakness","level":2,"score":0.5924462080001831},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.5245119333267212},{"id":"https://openalex.org/C2992343062","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle mass","level":2,"score":0.5081074237823486},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.45757102966308594},{"id":"https://openalex.org/C3017897630","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Muscle fibre","level":3,"score":0.4507383108139038},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4425807595252991},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4242955148220062},{"id":"https://openalex.org/C123550912","wikidata":"https://www.wikidata.org/wiki/Q12834857","display_name":"Strength training","level":2,"score":0.41272199153900146},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3239481449127197},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3158365488052368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2896553575992584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27624088525772095},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17566066980361938},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09463974833488464}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:28191501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28191501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nature and science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5303008","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5303008","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Nat Sci","raw_type":"Text"},{"id":"mag:2581544247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28191501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5303008","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5303008","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Nat Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1566882731","display_name":"UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)","funder_award_id":"UL1TR001105","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6495077073","display_name":"UT Southwestern Center for Translational Medicine (UL1/KL2/TL1","funder_award_id":"KL2TR001103","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1580812738","https://openalex.org/W1870980090","https://openalex.org/W1874819978","https://openalex.org/W1939669216","https://openalex.org/W1941728630","https://openalex.org/W1965927192","https://openalex.org/W1973183524","https://openalex.org/W1977748552","https://openalex.org/W1987014525","https://openalex.org/W1995086479","https://openalex.org/W2007741499","https://openalex.org/W2037295316","https://openalex.org/W2048798480","https://openalex.org/W2055778805","https://openalex.org/W2062368765","https://openalex.org/W2063690006","https://openalex.org/W2072399660","https://openalex.org/W2075566081","https://openalex.org/W2092463408","https://openalex.org/W2099629110","https://openalex.org/W2102902846","https://openalex.org/W2113612408","https://openalex.org/W2115150337","https://openalex.org/W2117270168","https://openalex.org/W2121504990","https://openalex.org/W2128837181","https://openalex.org/W2128918644","https://openalex.org/W2128980203","https://openalex.org/W2137687978","https://openalex.org/W2137904740","https://openalex.org/W2148356899","https://openalex.org/W2149067097","https://openalex.org/W2149183722","https://openalex.org/W2153679724","https://openalex.org/W2156422508","https://openalex.org/W2158539135","https://openalex.org/W2162983983","https://openalex.org/W2169662778","https://openalex.org/W2169812053","https://openalex.org/W2169964435","https://openalex.org/W2170704717","https://openalex.org/W2188200797","https://openalex.org/W2230902569","https://openalex.org/W2318969030","https://openalex.org/W2334583744","https://openalex.org/W2398952751","https://openalex.org/W3143060430"],"related_works":["https://openalex.org/W2603586365","https://openalex.org/W7029106406","https://openalex.org/W2417989905","https://openalex.org/W4231579933","https://openalex.org/W2030136924","https://openalex.org/W2049605430","https://openalex.org/W4405164240","https://openalex.org/W3123417965","https://openalex.org/W2410493405","https://openalex.org/W4229980899"],"abstract_inverted_index":{"A":[0],"variety":[1],"of":[2,15,21,33,39,82,140,184],"changes":[3,123],"in":[4,28,46,88,99,163],"skeletal":[5,41,95,118,165],"muscle":[6,16,52,83,96,119,166],"occur":[7],"with":[8,56,63],"aging.":[9],"Sarcopenia":[10],"is":[11,19,54,60],"the":[12,22,29,37,80,100,125,161,197],"age-associated":[13,105,164],"loss":[14,81],"mass":[17,53,84],"and":[18,58,65,102,134,137,192],"one":[20,190],"main":[23],"contributors":[24],"to":[25,177,179],"musculoskeletal":[26],"impairments":[27],"elderly.":[30],"Traditional":[31],"definitions":[32,78],"sarcopenia":[34],"focused":[35],"on":[36,94,189,196],"size":[38],"human":[40],"muscle.":[42],"However,":[43],"increasing":[44],"evidence":[45,116],"older":[47],"adults":[48],"suggests":[49],"that":[50,117],"low":[51],"associated":[55,62],"weakness,":[57],"weakness":[59],"strongly":[61],"function":[64,97,167],"disability.":[66],"In":[67],"recent":[68],"years":[69],"a":[70,182],"global":[71],"trend":[72],"has":[73],"shifted":[74],"toward":[75],"more":[76],"encompassing":[77],"for":[79,151],"which":[85],"include":[86],"decreases":[87],"physical":[89],"function.":[90],"This":[91],"review":[92],"focuses":[93],"deficits":[98,106,120],"elderly":[101],"how":[103,156],"these":[104],"can":[107,159],"be":[108],"ameliorated":[109],"by":[110],"resistance":[111,157],"training.":[112],"We":[113],"set":[114],"forth":[115],"arise":[121],"from":[122],"within":[124],"muscle,":[126],"including":[127],"reduced":[128],"fiber":[129,135],"size,":[130],"decreased":[131,138],"satellite":[132],"cell":[133],"numbers,":[136],"expression":[139],"myosin":[141],"heavy":[142],"chain":[143],"(MHC)":[144],"isoform":[145],"IIa.":[146],"Finally,":[147],"we":[148],"provide":[149],"recommendations":[150],"clinical":[152],"geriatric":[153],"practice":[154],"regarding":[155],"training":[158],"attenuate":[160],"increase":[162],"deficits.":[168],"Practitioners":[169],"should":[170],"consider":[171],"encouraging":[172],"patients":[173],"who":[174],"are":[175],"reluctant":[176],"exercise":[178],"move":[180],"along":[181],"continuum":[183],"activity":[185],"between":[186],"\"no":[187],"acticity\"":[188],"end":[191],"\"recommended":[193],"daily":[194],"amounts\"":[195],"other.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-03T00:00:00"}
