{"id":"https://openalex.org/W2581464762","doi":null,"title":"Inhibitory kinetics of enterolactone on mushroom tyrosinase","display_name":"Inhibitory kinetics of enterolactone on mushroom tyrosinase","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2581464762","mag":"2581464762"},"language":"en","primary_location":{"id":"mag:2581464762","doi":null,"is_oa":false,"landing_page_url":"https://www.derpharmachemica.com/abstract/inhibitory-kinetics-of-enterolactone-on-mushroom-tyrosinase-2493.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306507770","display_name":"Der pharma chemica","issn_l":"0975-413X","issn":["0975-413X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Der pharma chemica","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101707036","display_name":"Sang Suk Kim","orcid":"https://orcid.org/0000-0002-1934-671X","observed_orcids":["https://orcid.org/0000-0002-1934-671X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang Suk Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077046228","display_name":"Kyung Jin Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyung Jin Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000571766","display_name":"Hyun JooAn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyun JooAn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061537205","display_name":"Young Hun Choi","orcid":"https://orcid.org/0000-0002-1842-9062","observed_orcids":["https://orcid.org/0000-0002-1842-9062","https://orcid.org/0000-0002-0137-5440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Hun Choi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1842-9062","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1379,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47890039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"19","first_page":"124","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterolactone","display_name":"enterolactone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mushroom-tyrosinase","display_name":"mushroom tyrosinase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tyrosinase-inhibition","display_name":"tyrosinase inhibition","score":0.843999981880188},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.8259999752044678},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/diphenolase-activity","display_name":"diphenolase activity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/inhibition-kinetics","display_name":"inhibition kinetics","score":0.47200000286102295},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.8654652237892151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7888425588607788},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.6765873432159424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6141189932823181},{"id":"https://openalex.org/C53007507","wikidata":"https://www.wikidata.org/wiki/Q2760809","display_name":"Browning","level":2,"score":0.5809409618377686},{"id":"https://openalex.org/C150757390","wikidata":"https://www.wikidata.org/wiki/Q1985205","display_name":"Non-competitive inhibition","level":3,"score":0.5250881910324097},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4547639489173889},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.44597649574279785},{"id":"https://openalex.org/C2776474821","wikidata":"https://www.wikidata.org/wiki/Q83093","display_name":"Mushroom","level":2,"score":0.4425586462020874},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4359791576862335},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4144338369369507},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3947073519229889},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2914712429046631},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25124257802963257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1670607030391693},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2581464762","doi":null,"is_oa":false,"landing_page_url":"https://www.derpharmachemica.com/abstract/inhibitory-kinetics-of-enterolactone-on-mushroom-tyrosinase-2493.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306507770","display_name":"Der pharma chemica","issn_l":"0975-413X","issn":["0975-413X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Der pharma chemica","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2357626177","https://openalex.org/W2163911962","https://openalex.org/W4377089192","https://openalex.org/W2370301938","https://openalex.org/W2070679945","https://openalex.org/W2348596809","https://openalex.org/W4224023783","https://openalex.org/W2358929378","https://openalex.org/W2044515123","https://openalex.org/W2139887792"],"abstract_inverted_index":{"Tyrosinase":[0,18],"(EC":[1],"1.14.18.1)":[2],"is":[3],"a":[4,97,118],"key":[5],"enzyme":[6],"in":[7,15,22,105],"post-harvest":[8],"browning":[9],"of":[10,34,41,49,62,68,121,130,137],"fruit":[11],"and":[12,24,38,59,70,91,110,127],"melanin":[13,103,131],"formation":[14,104],"human":[16],"skin.":[17],"inhibitors":[19],"are":[20],"important":[21],"agricultural":[23],"cosmetic":[25],"chemistry.":[26],"In":[27],"the":[28,31,46,122,134],"present":[29],"study,":[30],"inhibitory":[32,99,123],"kinetics":[33,76],"enterolactone":[35,56,79,95],"on":[36,101],"themonophenolase":[37,58],"diphenolase":[39,60],"activities":[40,61],"mushroom":[42,63],"tyrosinasewere":[43],"investigated":[44],"using":[45,138],"kinetic":[47],"method":[48],"substrate":[50],"reaction.":[51],"The":[52,74,83],"results":[53,116],"showed":[54,77],"that":[55,78],"inhibited":[57],"tyrosinase,":[64],"with":[65],"IC50":[66],"values":[67],"0.42":[69],"0.124":[71],"mM,":[72],"respectively.":[73,93],"inhibition":[75,84,129],"displayed":[80],"non-competitive":[81],"mechanism.":[82],"constants":[85],"were":[86],"determined":[87],"to":[88],"be":[89],"0.8315":[90],"0.6956mM,":[92],"Furthermore,":[94],"exerted":[96],"potent":[98],"effect":[100],"intracellular":[102],"B16/F10":[106],"murine":[107],"melanoma":[108],"cells":[109],"did":[111],"not":[112],"cause":[113],"cytotoxicity.":[114],"These":[115],"provide":[117],"comprehensive":[119],"understanding":[120],"mechanisms":[124],"underlying":[125],"enterolactoneactivity":[126],"its":[128],"formation,":[132],"suggesting":[133],"potential":[135],"benefits":[136],"this":[139],"compound.":[140]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-02-03T00:00:00"}
