{"id":"https://openalex.org/W2581442873","doi":"https://doi.org/10.3390/molecules22030462","title":"Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin","display_name":"Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin","publication_year":2017,"publication_date":"2017-03-14","ids":{"openalex":"https://openalex.org/W2581442873","doi":"https://doi.org/10.3390/molecules22030462","mag":"2581442873","pmid":"https://pubmed.ncbi.nlm.nih.gov/28335434","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5547191"},"language":"en","primary_location":{"id":"doi:10.3390/molecules22030462","doi":"https://doi.org/10.3390/molecules22030462","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules22030462","pdf_url":"https://www.mdpi.com/1420-3049/22/3/462/pdf?version=1489487245","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/22/3/462/pdf?version=1489487245","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108625986","display_name":"Danielle Jandial","orcid":"https://orcid.org/0009-0006-3247-8131","observed_orcids":["https://orcid.org/0009-0006-3247-8131"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle D. Jandial","raw_affiliation_strings":["Department of Obstetrics & Gynecology , University of California , Irvine , Orange , CA 92868 , USA","Department of Obstetrics &amp; Gynecology, University of California, Irvine, Orange, CA 92868, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology , University of California , Irvine , Orange , CA 92868 , USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Obstetrics &amp; Gynecology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049178289","display_name":"Lauren S. Krill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren S. Krill","raw_affiliation_strings":["Department of Obstetrics & Gynecology , University of California , Irvine , Orange , CA 92868 , USA","Department of Obstetrics &amp; Gynecology, University of California, Irvine, Orange, CA 92868, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology , University of California , Irvine , Orange , CA 92868 , USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Obstetrics &amp; Gynecology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100679476","display_name":"Lixia Chen","orcid":"https://orcid.org/0000-0003-2196-1428","observed_orcids":["https://orcid.org/0000-0003-2196-1428"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lixia Chen","raw_affiliation_strings":["Department of Urology, University of California, Irvine, Orange, CA 92868, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102888589","display_name":"Chunli Wu","orcid":"https://orcid.org/0000-0003-1809-6752","observed_orcids":["https://orcid.org/0000-0003-1809-6752"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunli Wu","raw_affiliation_strings":["Department of Urology, University of California, Irvine, Orange, CA 92868, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719455","display_name":"Yu Ke","orcid":"https://orcid.org/0000-0001-9854-0360","observed_orcids":["https://orcid.org/0000-0001-9854-0360"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Ke","raw_affiliation_strings":["Department of Urology, University of California, Irvine, Orange, CA 92868, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102786181","display_name":"Jun Xie","orcid":"https://orcid.org/0000-0003-4122-5129","observed_orcids":["https://orcid.org/0000-0003-4122-5129"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Xie","raw_affiliation_strings":["Department of Urology, University of California, Irvine, Orange, CA 92868, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077636119","display_name":"Bang H. Hoang","orcid":"https://orcid.org/0000-0002-2950-3221","observed_orcids":["https://orcid.org/0000-0002-2950-3221"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bang H. Hoang","raw_affiliation_strings":["Department of Pharmacology , University of California , Irvine , Orange , CA 92868 , USA","Department of Orthopedic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10476, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , University of California , Irvine , Orange , CA 92868 , USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10476, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036496290","display_name":"Xiaolin Zi","orcid":"https://orcid.org/0000-0002-5312-7158","observed_orcids":["https://orcid.org/0000-0002-5312-7158"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaolin Zi","raw_affiliation_strings":["Department of Obstetrics &amp; Gynecology, University of California, Irvine, Orange, CA 92868, USA","Department of Pharmacology, University of California, Irvine, Orange, CA 92868, USA","Department of Urology, University of California, Irvine, Orange, CA 92868, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics &amp; Gynecology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Pharmacology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Urology, University of California, Irvine, Orange, CA 92868, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036496290"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":4.2005,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.94215653,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"22","issue":"3","first_page":"462","last_page":"462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.2766000032424927,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavokawain-a","display_name":"flavokawain A","score":0.9490000009536743},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9079999923706055},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cdc2-kinase","display_name":"cdc2 kinase","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cdc25c-phosphorylation","display_name":"Cdc25C phosphorylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/wee1","display_name":"WEE1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/myt1","display_name":"Myt1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6420000195503235},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.7099999785423279},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.753000020980835},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.6679999828338623},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.871729850769043},{"id":"https://openalex.org/C191560914","wikidata":"https://www.wikidata.org/wiki/Q7390592","display_name":"SKBR3","level":5,"score":0.8119578957557678},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.7288100719451904},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6768195629119873},{"id":"https://openalex.org/C2781252693","wikidata":"https://www.wikidata.org/wiki/Q7979264","display_name":"Wee1","level":5,"score":0.6012732982635498},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5018208026885986},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49351584911346436},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.47491440176963806},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.44005540013313293},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37638044357299805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37498873472213745},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.35419613122940063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3315826952457428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28477370738983154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27726638317108154},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2678624093532562},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.0695989727973938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.058278679847717285},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002599","descriptor_name":"Chalcone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002599","descriptor_name":"Chalcone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059565","descriptor_name":"G2 Phase Cell Cycle Checkpoints","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.3390/molecules22030462","doi":"https://doi.org/10.3390/molecules22030462","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules22030462","pdf_url":"https://www.mdpi.com/1420-3049/22/3/462/pdf?version=1489487245","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"doi:10.20944/preprints201701.0098.v1","doi":"https://doi.org/10.20944/preprints201701.0098.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201701.0098.v1","pdf_url":"https://www.preprints.org/manuscript/201701.0098/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:5547191","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5547191","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:28335434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28335434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:be2a6fc6b1da427aa023434669206777","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be2a6fc6b1da427aa023434669206777","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 22, Iss 3, p 462 (2017)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt1tr372xw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1tr372xw","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules (Basel, Switzerland), vol 22, iss 3","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1tr372xw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1tr372xw","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, vol 22, iss 3","raw_type":"article"},{"id":"pmh:qt1tr372xw","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/1tr372xw","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jandial, DD; Krill, LS; Chen, L; Wu, C; Ke, Y; Xie, J; \u00c2\u00a0et al.(2017). Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin.. Molecules (Basel, Switzerland), 22(3). doi: 10.3390/molecules22030462. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1tr372xw","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules22030462","doi":"https://doi.org/10.3390/molecules22030462","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules22030462","pdf_url":"https://www.mdpi.com/1420-3049/22/3/462/pdf?version=1489487245","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1016348479","display_name":"The NEDD8 pathway mediated Skp2 degradation in chemoprevention by FKA","funder_award_id":"R01CA193967","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1457236888","display_name":"Rhodiola Rosea Extracts, Salidroside and Bladder Cancer Chemoprevention","funder_award_id":"R21CA152804","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2217805828","display_name":"Chemoprevention of urinary bladder carcinogenesis by flavokawain A","funder_award_id":"R01CA122558","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2581442873.pdf","grobid_xml":"https://content.openalex.org/works/W2581442873.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1583186","https://openalex.org/W1604346393","https://openalex.org/W1769188903","https://openalex.org/W1813571362","https://openalex.org/W1849285658","https://openalex.org/W1873317171","https://openalex.org/W1947593211","https://openalex.org/W1965518808","https://openalex.org/W1969468773","https://openalex.org/W1983455542","https://openalex.org/W2014223653","https://openalex.org/W2016908879","https://openalex.org/W2019216010","https://openalex.org/W2022632543","https://openalex.org/W2029581665","https://openalex.org/W2033496263","https://openalex.org/W2033595975","https://openalex.org/W2040935952","https://openalex.org/W2044078154","https://openalex.org/W2044182846","https://openalex.org/W2044702943","https://openalex.org/W2049546912","https://openalex.org/W2056164539","https://openalex.org/W2063357635","https://openalex.org/W2063570387","https://openalex.org/W2063864717","https://openalex.org/W2088388419","https://openalex.org/W2095689910","https://openalex.org/W2098544382","https://openalex.org/W2098944611","https://openalex.org/W2101024529","https://openalex.org/W2109526314","https://openalex.org/W2112035541","https://openalex.org/W2113277571","https://openalex.org/W2115759102","https://openalex.org/W2116709318","https://openalex.org/W2127376103","https://openalex.org/W2127558577","https://openalex.org/W2141232624","https://openalex.org/W2141393790","https://openalex.org/W2149908785","https://openalex.org/W2160146951","https://openalex.org/W2165411440","https://openalex.org/W2249991663","https://openalex.org/W2252710675","https://openalex.org/W2271008339","https://openalex.org/W2293838703","https://openalex.org/W2411143310","https://openalex.org/W2460251460","https://openalex.org/W2553340330","https://openalex.org/W2563813226","https://openalex.org/W4239989216","https://openalex.org/W4254152438","https://openalex.org/W6637974229"],"related_works":["https://openalex.org/W2889558653","https://openalex.org/W2049546912","https://openalex.org/W2277262831","https://openalex.org/W2156430804","https://openalex.org/W7047216297","https://openalex.org/W2272108953","https://openalex.org/W1552375166","https://openalex.org/W2328267497","https://openalex.org/W2415811595","https://openalex.org/W4367556016"],"abstract_inverted_index":{"HER2/neu":[0],"positive":[1],"breast":[2,12,27,50,64,78,155,194],"tumors":[3],"predict":[4],"a":[5,56,173],"high":[6],"mortality":[7],"and":[8,33,43,86,89,95,118,120,127,137,166,175,179],"comprise":[9],"25%\u201330%":[10],"of":[11,25,62,76,84,91,93,116,123,135,161,192],"cancer.":[13,195],"We":[14],"have":[15],"shown":[16],"that":[17],"Flavokawain":[18],"A":[19],"(FKA)":[20],"preferentially":[21],"reduces":[22],"the":[23,60,113,132,190],"viabilities":[24],"HER2-overexpressing":[26,77,193],"cancer":[28,51,79,156],"cell":[29,52,73,80,157],"lines":[30,53,81,158],"(i.e.,":[31,41],"SKBR3":[32,109],"MCF7/HER2)":[34],"versus":[35],"those":[36],"with":[37,186],"less":[38],"HER2":[39],"expression":[40,92,115,122,134],"MCF7":[42],"MDA-MB-468).":[44],"FKA":[45,68,105,129,143,171],"at":[46],"cytotoxic":[47],"concentrations":[48],"to":[49,98,146],"also":[54,130],"has":[55],"minimal":[57],"effect":[58,151],"on":[59,152],"growth":[61,149],"non-malignant":[63],"epithelial":[65],"MCF10A":[66],"cells.":[67],"induces":[69,106],"G2M":[70],"arrest":[71],"in":[72,108,184],"cycle":[74],"progression":[75],"through":[82,159],"inhibition":[83],"Cdc2":[85,100],"Cdc25C":[87],"phosphorylation":[88],"downregulation":[90,160],"Myt1":[94],"Wee1":[96],"leading":[97],"increased":[99],"kinase":[101],"activities.":[102],"In":[103],"addition,":[104],"apoptosis":[107,177],"cells":[110],"by":[111],"increasing":[112],"protein":[114,133],"Bim":[117],"BAX":[119],"decreasing":[121],"Bcl2,":[124],"BclX/L,":[125],"XIAP,":[126],"survivin.":[128],"downregulates":[131],"HER-2":[136,153],"inhibits":[138],"AKT":[139],"phosphorylation.":[140],"Herceptin":[141],"plus":[142],"treatment":[144,191],"leads":[145],"an":[147],"enhanced":[148],"inhibitory":[150],"overexpressing":[154],"Myt1,":[162],"Wee1,":[163],"Skp2,":[164],"survivin,":[165],"XIAP.":[167],"Our":[168],"results":[169],"suggest":[170],"as":[172],"promising":[174],"novel":[176],"inducer":[178],"G2":[180],"blocking":[181],"agent":[182],"that,":[183],"combination":[185],"Herceptin,":[187],"enhances":[188],"for":[189]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-03T00:00:00"}
